cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muhammad Syahrir
Contact Email
m.syahrir7406@unm.ac.id
Phone
-
Journal Mail Official
nurkhasanah@pharm.uad.ac.id
Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164
Location
Kota yogyakarta,
Daerah istimewa yogyakarta
INDONESIA
Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 796 Documents
 72   73   74   75   76 
Utilization of purple sweet potato synbiotic drink as a source of lactic acid bacteria exopolysaccharides for immunomodulation Almira, Rehan; Winarsih, Sri; Manshur, Hanif Alamudin
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.25393

Abstract

Immunomodulators, such as exopolysaccharides (EPS), can be found in products processed through lactic acid bacteria (LAB) fermentation. Purple sweet potatoes have the potential to be used as ingredients for making synbiotic drinks because of the high content of oligosaccharides. This study aimed to determine the effectiveness of purple sweet potato synbiotic drinks in improving the immune system in vivo. The experiment was conducted on male mice (Balb-C, 12 weeks old, 25±5 g BW) which were given purple sweet potato synbiotic drink for 14 days with doses of A1, A2, and A3 (50, 100, 150 mg/kg BW) given once a day. On the 14th day, the mice were induced with S. aureus bacteria given intraperitoneally (1 mL, 108 cfu/mL). The immunomodulation-related parameters measured were phagocytic activity, the number of lymphocyte cells, and the relative spleen weight of mice. The results showed that the synbiotic drink of purple sweet potato (A1, A2, and A3) can increase phagocytic activity and lymphocyte cell count and have a significant effect on relative spleen weight (p<0.05). The higher the dose of synbiotic drink, the higher the phagocytic activity and the number of lymphocyte cells, and the smaller the relative spleen weight of the mice.
Nanoparticle formulation of ethanolic extract of Syzygium polyanthum leaf using chitosan and cross-linking method Hidayati, Evi Nurul; Rahayyu, Annisa Maulidia; Masruriati, Eni
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.25834

Abstract

Syzygium polyanthum (bay leaves) is widely used in Indonesia and has been shown to have pharmacological activity, such as antihyperlipidemia. The nanoparticle is a delivery system that enhances therapy effectiveness, minimizes side effects, and ensures safety. Therefore, this study aimed to improve the antihyperlipidemic efficacy of Syzygium polyanthum extract by formulating it into nanoparticles. The polymer that is used in this nanoparticle formulation is chitosan, while the cross-linking agent that is used is sodium tripolyphosphate. Three formulations have been developed, each with different stirring times after crosslinking: F1 (20 minutes), F2 (90 minutes), and F3 (150 minutes). At the same time, nanoparticles produced were examined for particle size, ζ potential, polydispersity index, entrapment efficiency, and release study. Syzygium polyanthum extract is abundant in secondary metabolites, including alkaloids, flavonoids, saponins, triterpenoids, tannins, and quinones. The particle size data for F1, F2, and F3 were 257±6.68 nm, 232±2.54 nm, and 303±1.3 nm respectively, while the polydispersity index ranged from 0.242 to 0.383. The entrapment efficiency represented by quercetin, used to assess the extracted content of the nanoparticles, yielded results between 39.59% and 67.48%. A release study of nanoparticle Syzygium polyanthum (nanoparticle SP) showed that the extract represented by quercetin can be released from the system is 64-82% in 120 min. The ζ potential measurement in F2 indicated a value of 30.9±0.416 mV, suggesting that the nanoparticle SP formed possesses excellent stability. Among the formulas studied, F2 emerged as the most promising due to its combination of factors such as the smallest size, favorable polydispersity index, high entrapment efficiency, and desirable release profile values. All of the formula has the potential to provide a good therapeutic effect, such as antihyperlipidemia but it needs to be proven by further studies.
Pharmacist counseling improves medication compliance of schizophrenia patients Pranata, Meki; Perwitasari, Dyah Aryani; Noerhidayati, Elly; Iskak, Iskak; Darmawan, Endang; Angella, Widi
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.25912

Abstract

Schizophrenia is a disorder characterized by abnormal behavior, impaired thinking, disorganized speech, and a reduced ability to perceive reality. One of the key factors influencing the success of schizophrenia therapy is patient adherence. Pharmacy plays a crucial role in the treatment of schizophrenia patients. This study aimed to determine the effect of pharmacist counseling on drug adherence of schizophrenia patients from the first month to the second month. The method used in this study was a one-group pre-test and post-test design that used quasi-experimental research. The subjects of this study were schizophrenia patients in the outpatient installation of Prof.Dr.Soerojo Mental Hospital, Magelang. This study used the Medication Adherence Rating Scale (MARS) questionnaire to measure the level of adherence and drug use monitoring sheet (pill count) to monitor the amount of patient medication. The population in this study was calculated using the Lameshow formula. Data analysis was performed using the chi-square test and the Wilcoxon test. After analyzing data of 108 patients, it was found that there was a significant difference between before and after counseling conducted by pharmacists on medication adherence in schizophrenia patients, with a significance value of p <0.05. Counseling conducted by pharmacists has a good impact on patient medication adherence and monitoring the amount of medication taken. These results indicate the effect of counseling conducted by pharmacists on adherence to taking medication and the monitoring of the amount of medication taken by patients.
Formulation of a sheet mask essence incorporating Betel leaf (Piper betle L.) ethanol extract and its antibacterial efficacy against Propionibacterium acnes Wulandari, Annisa Dyah; Sunarto, Sunarto; Kurniawan, Dhadhang Wahyu
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.27466

Abstract

Betel leaf (Piper betle L.) encompasses a multitude of bioactive constituents, including tannins, saponins, flavonoids, alkaloids, and terpenoids, which possess significant antibacterial properties. An ethanol extract derived from betel leaf was meticulously formulated and assessed for its potential as an antibacterial agent specifically targeting Propionibacterium acnes, a bacterium associated with the etiology of acne. This investigation was undertaken with the aim of mitigating the antibiotic resistance commonly observed with traditional acne therapies. The ethanol extract of betel leaf was incorporated into a sheet mask essence, resulting in the development of four distinct formulations (F0, F1, F2, and F3), which were subsequently subjected to comprehensive evaluations of their physical quality and stability. The formulation exhibiting optimal physical characteristics and stability was further scrutinized for its antibacterial efficacy against Propionibacterium acnes. The antibacterial performance of the selected formulation was benchmarked against a positive control comprising a sheet mask infused with clindamycin gel, as well as another containing tea tree oil. Empirical results identified Formula 2, containing 1.5% ethanol extract of betel leaf, as the most efficacious formulation. Formula 2 demonstrated pronounced antibacterial activity against Propionibacterium acnes, with an inhibitory zone measuring 24.67 mm. Although this inhibitory zone was slightly less extensive than that produced by the clindamycin gel sheet mask (32.00 mm), it was comparable to the tea tree oil sheet mask, which exhibited an inhibitory zone of 23.00 mm. In conclusion, the selected sheet mask formulation (Formula 2) exhibits significant antibacterial activity against Propionibacterium acnes, surpassing the efficacy of commercially available tea tree oil sheet masks, thereby presenting a promising alternative for acne management with a diminished risk of promoting antibiotic resistance.
The influence of perceived values on intentions to use halal cosmetics among engineering students at Universitas Muhammadiyah Yogyakarta: partial least squares-structural equation modeling Octavia, Mega; Septiana, Chantika Altian; Huriyah, Titih; Permana, Iman
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.28747

Abstract

The Ministry of Industry of the Republic of Indonesia has emphasized the importance of cosmetics as an essential need due to the increasing awareness of the general population. Various values, including functional, conditional, emotional, social, epistemic, and religious, influence individuals in selecting cosmetics, particularly halal cosmetics, given Indonesia's predominantly Muslim population. This study aims to identify the factors influencing the adoption of halal cosmetics among students of the Faculty of Engineering at Muhammadiyah University of Yogyakarta. This research employs a non-experimental quantitative design using a survey method with a cross-sectional approach and a questionnaire as the primary instrument. The sample consists of 137 students who use halal cosmetics, selected through purposive sampling based on inclusion criteria, namely active students who have used or are currently using halal cosmetics. Data analysis was conducted using the Partial Least Squares Structural Equation Modeling (PLS-SEM) approach. The PLS-SEM analysis revealed that functional, conditional, emotional, and epistemic values have a positive and statistically significant influence on the usage of halal cosmetics, with p-values of 0.089, 0.001, 0.001, and 0.004, respectively. In contrast, social and religious values showed no significant relationship with halal cosmetics usage, with p-values of 0.706 and 0.374, respectively. Therefore, this study concludes that the adoption of halal cosmetics among students of the Faculty of Engineering at Muhammadiyah University of Yogyakarta is primarily driven by functional, conditional, emotional, and epistemic values rather than social or religious values.
Assessment of medication-related liver and kidney impairment in admitted patients in Depok, Indonesia: an observational study employing the Naranjo algorithm Syafhan, Nadia Farhanah; Aldora, Ghea Shafa; Kamila, Shinta
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29012

Abstract

Liver and kidney impairment caused by medications represents serious side effects that may extend hospital stays and increase the risk of patient death. Implementing strategies to recognize, document, and analyze cases of patient harm related to drug use is crucial for medicines optimization. This study aimed to evaluate the prevalence of medication-related liver and kidney impairment among hospitalized patients, while also identifying the specific medication categories implicated. A retrospective review of patient records was conducted at Universitas Indonesia Hospital (Depok, Indonesia), focusing on adult patients diagnosed with liver or kidney impairment during their 2021 hospital admission. The Naranjo algorithm was applied to assess the likelihood that these injuries were caused by medications. Among the 4,273 admitted patients, it was found that 1.01% experienced medication-related liver impairment (MRLI), while 0.77% experienced medication-related kidney impairment (MRKI). The most common medications associated with liver impairment were antibiotics (31.58%), cardiovascular medications (24.21%), pain relievers (14.74%), anti-ulcer medications (11.58%), antiviral medications (8.42%), antiemetics (8.42%), and antidiabetic medications (1.05%). In contrast, kidney disease was primarily linked to diuretics (29.76%), antibiotics (21.43%), ACE inhibitors/ARBs (21.43%), antiviral medications (9.52%), and NSAIDs (7.14%). Importantly, there was no statistically significant correlation between the occurrence of MRLI or MRKI and factors such as gender, age, body mass index (BMI), or the presence of other health conditions (p > 0.05). These findings underscore the need for heightened awareness regarding the potential for medication-related impairments in hospitalized patients and suggest that careful monitoring of medication use is essential to mitigate these risks.
Cross-resistance to antibiotics of Escherichia coli in the inpatient installation of general regional hospital “X” Bali, Indonesia Mahaputra, I Putu Yudistira; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr Asih; Siada, Nyoman Budiartha; Kamalia, Made Gek Adisti; Adrianta, Ketut Agus; Noviani, Lusy
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29209

Abstract

Escherichia coli (E. coli) is a critical-priority group of MDR bacteria and its spread can occur in hospital inpatient settings. Several studies showed that antibiotics consumption for inpatients can cause E. coli resistance to other antibiotics called cross-resistance. The aim of this study to determine the cross-resistance in E. coli to antibiotics in the inpatient installation of the regional general hospital "X" in Bali, Indonesia by analyzing the relationship between the antibiotic consumption and the percentage of antibiotic resistance of E. coli. This research is an ecological study with the independent variable is the antibiotics consumption defined as defined daily doses/100 bed-days and the dependent variable is the percentage of E. coli resistance during 2017-2020. The correlation between the level of antibiotic consumption and the percentage of E. coli resistance to antibiotics was analyzed using the Pearson correlation tests. The results showed that the consumption of tetracycline had a significant correlation with increased resistance of E. coli to meropenem and piperacillin-tazobactam (r=0.8-1.0; p<0.05). This showed that there is cross-resistance in E. coli. This incident is associated with selective pressure, horizontal and vertical gene transfer in E. coli. The consumption of tetracycline, apart from inducing the production of the tet gene which is the cause of resistance to tetracycline, can also induce the production of resistance genes to broad-spectrum beta-lactam antibiotics such as piperacillin-tazobactam and meropenem.
Acute oral toxicity test and determination of lethal dose (LD50) of Garcinia forbesii King leaf extract in wistar rats Rudiansyah, Mohammad; Rosida, Azma; Kania, Nia; Devi, Wivina Riza; Nirmalasari, Nila
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29616

Abstract

Garcinia forbesii King, an endemic plant from Sumatra and Kalimantan, is traditionally used for treating skin infections and inflammation. Its potential use as a raw material for medicines needs to be supported by safety tests. The purpose of this study is to assess the acute toxicity of its 70% leaf extract in male Wistar rats, evaluating clinical symptoms, body weight changes, organ indices, and the lethal dose (LD50). The study administered extract doses orally at 5 (G2), 50 (G3), 300 (G4), and 2,000 (G5) mg/kg BW, monitoring toxicity signs over 14 days. Symptoms such as piloerection, respiratory distress, and soft feces were noted. Significant weight loss was observed at doses of 2,000 mg/kg BW. There was no significant effect on the kidney index, but the liver and heart indices exhibited significantly lower changes compared to the control. The LD50 value was estimated to be between 2,000-5,000 mg/kg BW. Further studies are recommended to assess histopathological effects and identify harmful chemicals in the plant.
Undesirable events in the use of high-alert medicine geriatric patients at RSUPN Dr. Cipto Mangunkusumo Malihi, La; Supadmi, Woro; Trisna , Yulia; Purwanto , Barkah Djaka
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29643

Abstract

High-Alert Medications (HAM) are drugs that have a high risk of causing significant harm to patients if misused. It is estimated that one in ten geriatric patients experiences undesirable events during hospitalization related to medication use. Detect undesirable events due to the use of high-alert insulin and high-alert heparin drugs in geriatric patients at Rumah Sakit Umum Pusat Nasional (RSUPN) Dr Cipto Mangunkusumo using the trigger tool method based on positive predictive value (PPV) and determine the effect of using high-alert insulin and high alert heparin drugs on undesirable events. A retrospective cohort study will review secondary data from patient medical records (MR). The sample used was from 300 geriatric patients, 82 patients used insulin and 79 patients used heparin which met the inclusion criteria. Data were analyzed in the form of frequencies and percentages (%), calculation of PPV values, and the effect of using high-alert insulin and high-alert heparin on undesirable events using the Chi-Square test. There were 8 trigger-positive patients with undesirable events in the form of hypoglycemia from 82 insulin patients and 4 trigger-positive patients with undesirable events in the form of extended activated partial thromboplastin time (aPTT) values from 79 heparin patients. Based on the PPV value, both insulin (9.75%) and heparin (5.33%), the trigger tool has not been able to detect undesirable events when using high-alert insulin and high-alert heparin. Based on statistical tests, the p-value= 0.033 (p<0.05) for insulin and heparin p-value= 0.043 (p<0.05) meaning that there is an influence of the use of high-alert insulin and high-alert heparin on undesirable events when using both drugs. The trigger tool method cannot detect undesirable events when using high-alert insulin and high-alert heparin drugs based on laboratory triggers.
Antioxidant and antiinflammatory of clove extract (Syzigium aromaticum) in skeletal muscle damage Ningrum, Tyas Sari Ratna; Wardhani, Riska Risty; Sugihartini, Nining
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29657

Abstract

Clove extract is a natural ingredient abundant in Indonesia that has various benefits, including being an antioxidant and anti-inflammatory. Although Research has been conducted, it has been limited to discussing the effects of clove extract on muscle damage. This study aims to determine the effect of clove extract on skeletal muscle damage due to excessive eccentric exercise in mice. We used experimental research methods by a post-test only with control group design. Fifteen male mice were randomized into 5 groups. Group I: Normal control, Group II: Negative control, treatment group with a dose of 100 mg/kg BW, treatment group with a dose of 150 mg/kg BW, and treatment group with a dose of 250 mg/kg BW. Measurement of Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) and Toll Like Receptor4 (TLR 4) levels were carried out using the ELISA method via Quadriceps muscle samples, and skeletal muscle damage was viewed through an x1000 light microscope. The results of this study carried out using ANOVA showed results of p 0.004 and 0.006, which means that there was a decrease in oxidative stress as measured using NOX and a decrease in the inflammatory stimulator TLR 4 in skeletal muscle damage due to eccentric exercise.ANOVA test results show that there are differences in influence between treatment groups and show that clove extract has benefits as an antioxidant and anti-inflammatory in muscle damage. According to this study, clove extract has the potential to be an antioxidant and anti-inflammatory which can reduce NOX levels and reduce the inflammatory, mediator TLR4 in muscle damage caused by excessive eccentric exercise.

Page 74 of 80 | Total Record : 796

 72   73   74   75   76 

Filter by Year

2011 2025


Reset
Filter By Issues
All Issue Vol. 15 No. 2 (2025): Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana Vol 14, No 1 (2024): Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1: Mei 2011 Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana More Issue