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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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Evaluation of adherence, distress and quality of life for type 2 diabetes melitus patients In Puskesmas Wedarijaksa I and Puskesmas Trangkil Kabupaten Pati Perwitasari, Dyah Aryani; Urbayatun, Siti; Wilisa, Oni Yulianta
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.10573

Abstract

Diabetes mellitus is chronic disease that needs the complex and a long term medical treatment. Patient adherence and level of distress can affect patient quality of life. The purposes of this study is to examine patients adherence, distress, and quality of life patients type 2 diabetes mellitus in Kabupaten Pati. This study used cross sectional design and data patients collection techniques were conducted prospective data. The subjects of research were patients with Type 2 diabetes amounted to 126 people. Instruments used in this research is Medication Adherence Respon Scale (MARS) questionnaire to measure patients adherence, Diabetes Distress Scale (DDS) to measure distress, and EQ-5D-5L questionnaire to measure quality of life. Data analysis statistic used Mann Whiney test, and linier regression. This study was dominated by female patients 78.6%. The mean age of DMT2 patients was 54.49 ± 6.19 years. The average value of adherence (MARS) was 21.33 ± 2.90 including in moderate adherence. The mean total of DDS score was 1,56±0,42 including not distress level and the highest is the emotional burden domain. The mean value of EQ5D5L index was 0.729 ± 0.161. The results showed a significant association (p <0.05) between patient characteristics age and duration of sick with adherence. There were significant association (p <0.05) between age to physician distress, gender with emotional, marital status with emotional and interpersonal distress, duration of sick to physician distress and management therapy distress. Marital status and income had significant relationship to quality of life. Emotional burden domain had significant relationship to quality of life. Multivariate analysis showed that the relationship of adherence and distress by the emotional burden to quality of life. This study concluded the significant relationship between adherence, distress and quality of life.
Reducing ulcerogenic effect of self-nano emulsifying drug delivery system of piroxicam Wahyuningsih, Iis; Widyaningsih, Wahyu; Wulandari, Silviana
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.11478

Abstract

Piroxicam is antiinflammatory non-steroidal (AINS) drug group that has anti-inflammatory, analgesic and antipyretic effects. Like most other AINS drugs, piroxicam has low solubility and has gastrointestinal (ulcerogenic) side effects on long-term use. The nano-emulsifying drug delivery system (SNEDDS) is one of the technologies that can be used to overcome it. This study aims to determine the effect of ulcerogenic SNEDDS piroxicam compared with piroxicam formulas instead of SNEDDS. This study uses white rats male strain SD age 2-3 months and weight 100-200 grams of 40 rats. Rats divided into 5 groups. Group I was a normal control group, the test animals were given only water. Group II was a suspending control group treated with a 1% polyvinylpyrrolidone (PVP) solution, group III is a carrier control group treated with SNEDDS carrier which is a mixture of tween 80, virgin coconut oil (VCO) and polyethylene glycol (PEG) 400, group IV was a group of piroxicam drugs suspended with piroxicam 1.08 mg/kg in 1% PVP, group V was treated with SNEDDS piroxicam.Treatment was done for 28 days. After treatment, the gastric of rats were taken to be observed for ulcerogenic effects. Observations were made macroscopically by looking at ulcer scores followed by histopathological observations of tissue. The ulcer score data from each group were analyzed using one-way ANOVAand LSD test. The results showed that the normal control group, 1% PVP suspension and carrier group had a ulcer index of 0.0, 0.0 and 0.0, while the piroxicam suspension group and the SNEDDS group had an ulcer index of 0.88 and 0.0. These results were confirmed by histopathologic results of SNEDDS piroxicam to decrease the effect of pyroxicam ulcerogenic with results in the piroxicam suspension group has ulcer with necrosis by neutrophil infiltration, lymphocytes and mast cells in the mucosal tunica to submucosa. In the SNEDDS piroxicam group there is erosion with necrosis of the mucosal tunica epithelium with infiltration of lymphocytes and mast cells in submucosal tunica. It can be concluded the SNEDDS piroxicam can decrease the ulcerogenic effect.
Determination of sun protection factor and antioxidant properties of cream formulation of kencur (Kaempferia galanga L) and temu kunci (Boesenbergia pandurata (Roxb.) Schlecht) rhizomes extract Charisma, Shintia Lintang; Rahayu, Wiranti Sri; Wahyuingrum, Retno
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.11891

Abstract

Kencur (Kaempferia galanga, L.) rhizome contain ethyl-p-methoxycinnamate (EPMS) which has sunscreen properties. Temu kunci (Boesenbergia pandurata (Roxb) Schlecht) rhizome contains flavonoid and essential oils with radical scavenging properties. The aims of this study were to obtain the optimum physical properties of sunscreen and antioxidant cream and to compare the sun protection factor (SPF) values and antioxidant activity of kencur and temu kunci rhizomes extract before and after formulated. This research used Simplex Latice Design (SLD) model with 2 components of kencur extract and temu kunci extract. Based on the SLD model obtained optimum formula design, then the SPF values and antioxidant activity were studied by UV spectrophotometric method and DPPH method respectively. Based on SLD model obtained optimum formula that containing kencur : temu kunci extract 80%:20% (formula A) and 70%:30% (formula B). The SPF values of kencur extract, formula A and formula B were 4.505, 5.024 and 4.511 respectively. Antioxidant activity showed that the IC50 of formula A, formula B, temu kunci extract, BHT and Vitamin E were 109.15 μg/mL, 95.23 μg/mL, 10.20 μg/mL, 22.33 μg/mL and 8.78 μg/mL respectively. Cream formula A and formula B have optimum physical properties. The SPF value of the optimum formulations were higher than SPF value of kencur extract. Antioxidant activity of that combinations were lower than temu kunci extract, BHT and Vitamin E.
In silico study of Sambiloto (Andrographis paniculata) compounds from GC-MS and LC-MS/MS as alpha-glucosidase and DPP-4 enzyme inhibitor Kusriani, Herni; Purwaniati, Purwaniati; Bintang, Muhamad Ilham
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.26643

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, impaired insulin secretion, and insulin action. To overcome this disease, some people treat it with natural ingredients. Sambiloto (Andrographis paniculata) is reported to have a wide range of pharmacological activities, one of which is anti-diabetic. Sambiloto showed activity in lowering blood glucose which has the potential as an antidiabetic. Computational methods, such as molecular docking, can increase the effectiveness and reduce the cost of searching for new active compounds. The purpose of this study was to determine the component compounds contained in the ethanol extract of Sambiloto and obtain the potential compounds to inhibit the alpha-glucosidase and DPP-4 enzymes as anti-diabetics with molecular docking method. Sambiloto leaves were macerated for 3 x 24 hours using ethanol 96% as a solvent and concentrated with an evaporator. Sambiloto extract was analyzed using LC-MS, and GC-MS. In-silico analysis includes geometry optimization and molecular docking methods. Preparation of the test ligands was carried out by the ChemBioDraw Ultra and ChemBio3D applications, then optimization by Gaussian 09 application. The crystal structures of the target proteins used were those with PDB ID 5NN8 for alpha-glucosidase and 2QOE for DPP-4. Molecular docking was performed using Autodock 4.2.3 application. From analysis with LC- MS/MS and GC-MS methods, 18 compounds were identified. Molecular docking was performed on the identified compounds. The results of molecular docking showed that the compound S17 (11-(P- Bromoanilino)-5H-Dibenzo [B,E] [1,4] Diazepine), S1 (andrographolide) and S2 (andrographanin) have the potential to inhibit the activity of alpha-glucosidase enzyme; on the other hand S17 (11-(P-Bromoanilino)-5H-Dibenzo [B,E][1,4]Diazepine) and S5 (andrographolactone) have the potential to inhibit the activity of DPP-4 enzyme. These compounds have the potential to inhibit alpha- glucosidase and DPP-4 enzymes which act as antidiabetics.
The Potential of Swiftlet Bird's Nest Extract (Aerodramus fucipaghus) as an Antioxidant and Serum Formulation Widyaningrum, Naniek; Putri, Chintiana Nindya; Arief, Thendi Abdul; Sofa, Nada Aini; Virdaus, Monica
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27001

Abstract

The white swiftlet bird's nest (Aerodramus fucipaghus) constitutes one of nature's treasures endowed with diverse health benefits. The swiftlet bird's nest is a potential source of antioxidants, capable of counteracting free radicals contributing to premature ageing. It can be harnessed as a serum formulation featuring small molecules, facilitating deeper skin penetration, efficient delivery of highly concentrated active agents, and expedited resolution of skin issues. This study aimed to ascertain the swiftlet bird's nest serum's physical properties, physical stability, and antioxidant activities. Serum formulations span a range of concentrations: 10%, 20%, 30%, and 40%. Physical attributes of the serum, including organoleptic properties, homogeneity, pH, spreadability, and viscosity, were observed. Serum stability was assessed over a 21-day storage period. The antioxidant activity of the serum was gauged via DPPH assay, determining the IC50 values. The serum, across varying concentrations, exhibited commendable physical characteristics, satisfying stipulated criteria. Antioxidant activity was detected in the serum across a spectrum of concentrations, revealing IC50 values of 250.00 µg/mL, signifying a range from weak to strong efficacy (90.137 µg/mL). The swiftlet bird's nest serum with its concentration variants demonstrated physical stability during the 21-day storage duration. Drawing from the research, it can be deduced that the swiftlet bird's nest holds promise for development into a serum formulation that fulfils both physical and stability criteria, endowed with robust antioxidant activity. Notably, the swiftlet bird's nest serum at a 40% concentration exhibited potent antioxidant activity, manifesting an IC50 value of 90.137 µg/mL
Gastroprotective activity of Banana peel (Musa paradisiaca var. sapientum) methanol extract purified on aspirin-induced gastric ulceration in Rats Pusmarani, Jastria; Putri, Risky Juliansyah; Dewi, Citra; Fitriani, Difa; Purwono, Setyo; Ikawati, Zullies
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27639

Abstract

Banana (Musa paradiasiaca var. sapientum) is the world's most popular fruit-bearing crop, with rising consumption and waste. This study aimed to measure the metabolite compound and evaluate the gastroprotective properties of a banana peel-purified methanol extract. Animals test used in this study were divided into six groups: Group One received NaCMC 0.5%, Group Two received sucralfate, Group Three received aspirin 1000 mg/kg body weight, and groups four, five, and six received PBP at doses of 200 mg/kg body weight, 400 mg/kg body weight, and 600 mg/kg body weight, respectively, for seven days. Except for group 1, all groups were induced with aspirin at 1000 mg/kg body weight on the eighth day. The result of this study exhibited banana peel containing total phenolic, flavonoid, and tannin compounds with concentrations of 33.45 mg GAE/g, 19.92 mg QE/g, and 0.16 %, respectively. The results showed that pure extract of Musa paradiasiaca var. sapientum fruit peel can reduce the incidence of gastric ulcers by decreasing the ulcer index (p<0.05).. The results suggested that Musa paradisiaca var. sapientum peel has a gastroprotective effect against aspirin-induced gastric ulceration.
DNA-based detection of Rat in the meatballs product using a real-time polymerase chain reaction method Permanasari, Etin Diah; Sunaryo, Hadi; Wirman, Adia Putra; Rahmadini, Nuriza; Aggasy, Savira Yustinah; Nikmatullah, Nurul Azmah
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27850

Abstract

The meat-based products are highly susceptible to counterfeiting, primarily due to high consumer demand of meat derivative products, such as meatballs. This demand creates opportunities for food fraud by specific industries, including adulterating meat with non-halal species, such as rats. This research aimed to detect rat meat contamination in meatball samples from the Indonesian local market using Real-time Polymerase Chain Reaction (RT-PCR). The RT-PCR amplification involved an initial denaturation step at 95°C for 3 minutes, followed by denaturation at 95°C for 15 seconds, and annealing/extension at 60°C for 1 minute. The rat-specific probe primer included in the kit produced an increasing curve in the External Positive Control (EPC) with a Ct value of 27.22, and no amplification occurred in the Negative Control (NTC). The analysis of 30 samples from meatball vendors yielded negative results, as there was no increase in the FAM (rat) curve, indicating that none of the meatballs were contaminated with rat DNA.
Optimization of nanoemulsion hair serum from chia seed oil using the Simplex Lattice Design method Rahmayanti, Mayu; Oktavia, Reza Putri; Amalina, Faidatul; Fadila, Safa Aulia Nur; Nastiti, Ginanjar Putri; Syarifuddin, Sadli
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27936

Abstract

Hair loss is a hair problem that men and women often experience. Chia seed oil (Salvia hispanica L.) contains linolenic acid, which can stimulate the sebum glands. This research aims to determine the composition of the optimum formula for chia seed oil nanoemulsion hair serum using the Simplex Lattice Design (SLD) method to prove that the characteristics and physical stability of the optimum formula meet the requirements for good preparation. The optimization method was carried out with the help of Design Expert 13 software to optimize the formula by varying Tween 80 (X1) and propylene glycol (X2). The characteristic parameters observed include organoleptic parameters such as pH, viscosity, homogeneity, emulsion type, particle size, zeta potential, polydispersity index, and percent transmittance. The physical stability test was carried out using a 6-cycle test method for organoleptic parameters, pH, and homogeneity. Optimization results show that the optimum composition consists of Tween 80 33.52% and propylene glycol 46.48%. The preparation meets all physical characteristic tests. Physical stability did not significantly change in the pH test, with a significance value of 0.027 in the paired t-test. Based on the research results, it can be concluded that the optimum surfactant and cosurfactant composition in the optimum formula based on optimization using SLD is Tween 80 (33.52%) and propylene glycol (46.48%) with a desirability value of 0.947. The optimum formula for preparing chia seed oil nanoemulsion hair serum meets good physical characteristics and stability requirements.
The effect of HPMC-K15M and guar gum as polymer-coated for sustained-released tablet: disintegration and release kinetics Nining, Nining; Amalia, Anisa; Riyanto, Raditya Naufal
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.28104

Abstract

Polymeric coating films are able to control tablet drug release rate depending on polymer physicochemical properties. Guar gum and HPMC-K15M (GG/HPMC-K15M) can be a coating polymer in sustained-release tablets. This study aims to characterize the disintegration and drug release kinetics on theophylline sustained-release tablets coated with GG/HPMC-K15M. The film coating was made with variations of the GG/HPMC-K15M ratio of 1:3 (F1), 1:4 (F2), and 1:5 (F3). Granules were preformulated regarding LOD, granule size distribution, packing, and flow properties. Film coating was carried out using a liquid spraying method. Coated tablets were tested for quality examination, and the drug release kinetics model was determined based on in-vitro dissolution. Granule pre-formulation result shows that the granules have excellent packing and flow properties with an LOD of 4.59–5.33% and a size of 553.28–627.28 πm. Tablets provided uniform size characteristics with a weight variation of 333.38–339.56 mg (CV 1.32–3.43% and acceptance value 6.53–13.58), hardness of 11.61–18.86 kgf, friability of 0.103–0.186%, disintegration time of 20.69–27.36 min, and drug content of 98.51–98.55%. The theophylline was dissolved by 95.24% (6h in FI), 97.04% (7h in F2), and 99.79% (8h in F3); all formulas followed zero-order kinetic (r2 ~ 1). Suitable quality theophylline tablets GG/HPMC-K15M coating have been successfully produced. Increasing the concentration ratio of HPMC-K15M in the coating solution resulted in a significant increase in disintegration time and a slowing of the drug release rate. The drug release kinetics of all formulations followed the zero-order kinetic model.
Use of bitter melon seed oil (Momordica Charantia) to Improve the photoprotective effect of Sunscreen Formulations Winarti, Lina; Refayani , Ema Prastiwi
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.28208

Abstract

Bitter melon seed oil (BMSO) was identified as having potential as an anti-UV radiation agent due to alpha-oleo stearic acid, flavonoids, tannins, polyphenols, and phytosterols, which have the potential as antioxidants. Antioxidants are the main protection for the skin from the dangers of solar radiation, making BMSO a good quality if developed in sunscreen cream. This research aims to determine the effect of adding variations in the concentration of BMSO on the physical characteristics and in vitro photoprotective effectiveness of cream of oxybenzone and octyl methoxycinnamate. Sunscreen creams are made with each BMSO concentration of 0%, 6%, 8%, 10%, and 12%. The result shows that the greater the concentration of BMSO added, the lower the viscosity and pH values, the spreadability and SPF (sun protection factor) values of the cream increase, and the %TP (percentage of transmission pigmentation) and %TE (percentage of transmission erythema) become smaller. The best formula is the formula that contains the highest concentration of BMSO (12%). The characteristics of the best formula are a slightly yellowish, soft cream appearance and a slight smell typical of bitter melon. The spreadability value of the best formula cream is 6.6 ± 0.1 cm, pH of 6.57 ± 0.01, and viscosity of 88.3 ± 4.1 dPa.s, SPF value of 24.27 ± 0.28, %TE of 0.931 ±0.084, and %TP of 0.981±0.0001. These results show that BMSO has the potential to be an active ingredient in sunscreen to reduce the negative effects of using synthetic sunscreen, such as allergenic and irritant.

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