cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota surabaya,
Jawa timur
INDONESIA
MPI (Media Pharmaceutica Indonesiana)
Published by Universitas Surabaya
ISSN : 25276208     EISSN : 25279017     DOI : -
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Pharmaceutica Indonesiana (MPI) is a journal focusing on pharmaceutical aspects. MPI is dedicated to update and support the development of information and knowledge on pharmaceutical fields. This journal is published twice a year (June and December).
Arjuna Subject : -
Articles 162 Documents
 10   11   12   13   14 
Efektivitas Tonikum Tepung Ikan Sepat Rawa (Trichopodus thricopterus) Dengan Metode Rotarod Test Astuti, Karunita Ika; Fitriyanti; Alista, Siti
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5625

Abstract

Ikan Sepat Rawa (Trichopodus thricopterus) memiliki senyawa asam amino yang berpotensi sebagai tonikum. Tujuan penelitian ini adalah untuk mengetahui efek tepung ikan sepat rawa sebagai tonikum. Penelitian ini bersifat eksperimental menggunakan Rotarod Test yang dilakukan pada hari ke 1 dan hari ke 7 dengan menggunakan mencit jantan sebanyak 25 ekor, yang dibagi menjadi 5 kelompok masing-masing kontrol negative (NaCMC), positif (Kafein 100mg/kgBB), dan kelompok dengan dosis 50,100 dan 150 mg/kgBB. Hasil menunjukan rata-rata jumlah jatuh kumulatif dalam 3×10 menit dan % efek tonikum hewan uji pada hari ke 1 pada kelompok kontrol negatif, positif dosis 50,100, dan 150mg/kgBB masing-masing sebesar 88,6 & 0%; 26,8 & 69,7%; 23 & 74,04%; 24 & 72,91%, 40,8 & 53,73% sementara pada hari ke 7 nilainya sebesar 88,6 & 0%; 17,8 & 79,90%; 15,4 & 82,61%; 17 & 80,81%, dan 19,6 & 77,87%. Berdasarkan hasil analisis Kurskal-Wallis pada hari ke 1 dan ke 7 sama-sama menunjukan tidak adanya perbedaan bermakna antara dosis pemberian (50 mg, 100 mg, 150 mg)/kgBB dan kontrol positif dengan nilai sig>0,05. Sehingga dapat disimpulkan dosis pemberian 50 mg/kgBB memiliki efek tonikum yang terbaik dibandingkan dengan dosis pemberian 100 mg/kgBB dan 150 mg/kgBB. Sepat Rawa (Trichopodus thricopterus) has amino acid compounds considered to have potential as a tonic. This study aimed to determine the sepat rawa fish powder as a tonic. The experiment was performed with the Rotarod Test method in 3×10 minutes, carried out on day 1 and day 7 using 25 male mice that divided into 5 groups, namely negative control group (Na-CMC); positive control group (Caffeine 100 mg/BW); and group with 50,100 dan 150 mg/kgBB doses. The results showed that the average number of cumulative in 3×10 minutes and percentage of tonic effect on first day on negative control until 150 mg/kgBW Doses were 88,6 & 0%; 26.8 & 69.7%; 23 & 74.04%; 24 & 72.91%; 40.8 & 53.73% and at the seventh showed 88,6 & 0%; 17.8 & 79.90%; 15.4 & 82.61% 17& 80.81%; 19.6 & 77.87%. Based on the results of SPSS analysis using Kurskal-Wallis on day 1 and 7, both showed no significant difference between the dose of administration (50 mg, 100 mg, 150 mg)/kgBB and a positive control with a sig>0,05. It can be concluded that the tonic effect in dose 50 mg/kgBW has better than others.
Formulasi dan Evaluasi Edible Film dari Ekstrak Terpurifikasi Daun Beluntas (Pluchea indica L.) Sebagai Anti-Sariawan Pratiwi, Mustika Endah; Tobi, Claudius Hendraman Boli
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5653

Abstract

Sariawan adalah luka akibat iritasi pada gusi, lidah, dan lapisan dalam mulut. Tanaman yang dapat dimanfaatkan sebagai obat sariawan yaitu beluntas (Pluchea indica Less). Salah satu sediaan yang efektif untuk mengobati sariawan yaitu edible film. Tujuan penelitian ini adalah membuat edible film dari ekstrak terpurifikasi daun beluntas dan mengetahui aktivitas antibakteri edible film terhadap Staphylococcus aureus. Penelitian dimulai dari ekstraksi dan purifikasi ekstrak, pembuatan edible film, evaluasi fisik sediaan dan uji aktivitas antibakteri sediaan menggunakan metode dilusi padat. Formula edible film terdiri dari ekstrak terpurifikasi 2,5%, 5%, 7,5% dan formula tanpa ekstrak. Hasil evaluasi fisik menunjukkan berat rata-rata edible film dari masing-masing fomula yaitu 0,25-0,41 g. Ketebalan edible film yaitu 0,07-0,14 mm. Daya lipat yang dihasilkan lebih dari 300 kali, pH permukaan senilai 6,47-6,73. Waktu larut dari edible film yaitu 25-32 detik. Uji aktivitas antibakteri menggunakan semua formula edible film, formula tanpa ekstrak (kontrol negatif) dan Betadine obat kumur (kontrol positif ). Hasil pengujian antibakteri diperoleh semua formula memiliki aktivitas antibakteri terhadap S. aureus, dengan konsentrasi hambat minimum dan konsentrasi bunuh minimum yaitu 2,5%. Kesimpulan penelitian ini yaitu edible film ekstrak terpurifikasi daun beluntas memenuhi kriteria mutu fisik edible film yang baik dan memiliki aktivitas antibakteri terhadap S. aureus. Stomatitis are sores caused by irritation of the gums, tongue and lining of the mouth. A plant that can be used as a medicine for stomatitis is beluntas (Pluchea indica Less). One of the effective preparations for stomatitis treatment is edible film. The aim of this research were making edible film from purified extract of beluntas leaves and determining the antibacterial activity of edible film against Staphylococcus aureus. The research started from extraction and purification of the extract, making the edible film, physical evaluation of the products and testing the antibacterial activity using solid dilution method. Edible film formula consists of purified extract 2.5%, 5%, 7.5% and a formula without extract. The results of physical evaluation showed that the average weight of edible film from each formula were 0.25-0.41 g. The thickness of the edible film were 0.07-0.14 mm. Folding power were more than 300 times. The surface pH were 6.47-6.73 and the dissolution time were 25-32 seconds. The antibacterial activity test used all edible film formulas, formulas without extract (negative control) and Betadine mouthwash (positive control). The antibacterial test results showed that all formulas had antibacterial activity against S. aureus, with a minimum inhibitory concentration and a minimum bactericidal concentration of 2.5%. The conclusion of this research is edible film from purified extract of beluntas leaves qualified good physical quality of edible film and has antibacterial activity against S. aureus.
Antihypertension Activity of Averrhoa bilimbi Fruit Juice on Sodium Chloride and Prednisone-Induced Rats Yuniarto, Ari; Alviolita, Dini; Kurniasukmawati, Ika; Rasydy, La Ode Akbar
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5798

Abstract

Hypertension is a condition where systolic and diastolic blood pressure continuously increases, causing heart disease, kidney disease, hardening of the arteries, eye damage, and stroke (brain damage). Bilimbi (Averrhoa bilimbi L.) is traditionally used to lowering high blood pressure. The research objective was evaluating the activity of A. bilimbi as an antihypertensive. The research was conducted in vivo using rats and the CODA blood pressure analysis instrument. The doses used for A. bilimbi juice were 150, 300, and 600 mg/kg BW, respectively. A. bilimbi juice at a dose of 600 mg/kg BW/day for 14 days can reduce systolic and diastolic blood pressure in male Wistar rats induced by 2.5% NaCl and 1.5 mg/kg BW prednisone. The results of the study showed that A. bilimbi juice at a dose of 600 mg/kg BW. had antihypertensive activity.
Hubungan Pelayanan Farmasi dengan Kepatuhan Pengobatan Pasien Penyakit Paru Obstruktif Kronik (PPOK) Fitriarahmah, Giyan; Peranginangin, Jason Merari; Keswara, Yane Dila
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5808

Abstract

Pelayanan farmasi dibutuhkan untuk mendorong pengobatan yang optimal guna mengurangi resiko kejadian Penyakit Paru Obetruktif Kronik (PPOK). Pelayanan farmasi yang berkualitas mampu meningkatkan kepatuhan pengobatan melalui kepuasan pasien setelah mendapatkan pelayanan yang baik, sehingga mempengaruhi minat pasien dalam menjalankan dan melanjutkan pengobatan. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis hubungan pelayanan farmasi dengan kepatuhan pengobatan pasien PPOK di RSUD dr. Soeratno Gemolong. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian analitik cross sectional. Teknik sampling menggunakan consecutive sampling agar sesuai kriteria inklusi dalam kurun waktu tertentu. Pengambilan data dilakukan menggunakan kuesioner dan data rekam medik pasien PPOK rawat inap di RSUD dr. Soeratno Gemolong. Jumlah sampel sebanyak 48 orang pasien PPOK rawat inap. Data dianalisis menggunakan analisis univariat, bivariat, dan multivariat. Hasil penelitian menunjukkan kualitas pelayanan farmasi rawat inap RSUD dr. Soeratno Gemolong tergolong baik. Pelayanan farmasi dimensi bukti langsung/fisik (tangible), dimensi ketanggapan (responsiveness), dimensi jaminan kepastian (assurance), dan dimensi kepedulian (emphaty) berhubungan signifikan dengan kepatuhan pengobatan. Kesimpulan, pelayanan farmasi memiliki hubungan dengan kepatuhan pengobatan pasien PPOK di RSUD dr. Soeratno Gemolong dengan korelasi rendah dan arah hubungan yang positif. Pharmaceutical services are needed to encourage optimal treatment to reduce the risk of COPD. Quality pharmacy services are able to improve treatment adherence through patient satisfaction after getting good service, thus affecting patient interest in carrying out and continuing treatment. The purpose of this study were determining and analyzing the relationship between pharmaceutical services and treatment compliance of COPD patients at RSUD dr. Soeratno Gemolong. This research is a quantitative research with a cross-sectional analytical research design. The sampling technique uses consecutive sampling to fit the inclusion criteria within a certain period of time. Data collection was carried out using questionnaires and medical record data of inpatient COPD patients at RSUD dr. Soeratno Gemolong. The number of samples were 48 inpatient COPD patients. The data was analyzed using univariate, bivariate, and multivariate analyses. The results showed that the quality of inpatient pharmacy services at RSUD dr. Soeratno Gemolong was good. Pharmaceutical services dimensions of direct/physical evidence (tangible), dimensions of responsiveness (responsiveness), dimensions of assurance (assurance), and dimensions of concern (emphaty) were significantly related to treatment adherence. In conclusion, pharmaceutical services have a relationship with treatment compliance of COPD patients at RSUD dr. Soeratno Gemolong with low correlation and positive relationship direction.
Analisis Penggunaan Antibiotik pada Pasien Rawat Inap Dengan Metode Defined Daily Dose Oktavia, Maria; Suharjono; Virdiyanti, Windi
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5862

Abstract

Antibiotik adalah obat yang digunakan untuk mencegah dan mengobati infeksi bakteri. Penggunaan antibiotik yang kurang tepat dapat memicu resistensi antibiotik yang merupakan masalah terbesar bagi kesehatan manusia. Resistensi antibiotik dapat meningkatkan length of stay (LOS), meningkatkan biaya pengobatan, dan meningkatkan angka mortalitas. Salah satu cara untuk menanggulangi resistensi antibiotik adalah dengan penggunaan antibiotik secara bijak. Metode Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) digunakan untuk menilai kuantitas penggunaan antibiotika. Tujuan dari penelitian ini untuk mengetahui nilai DDD dan Drug Utilization (DU) 90% dari antibiotik. Penelitian ini merupakan penelitian cross-sectional dengan pengambilan data secara retrospektif yang dilakukan pada Januari 2021-Desember 2021 di Rumah Sakit dr. Soedarso Pontianak. Data dianalisis menggunakan metode DDD dan DU 90%. Kriteria inklusi yaitu pasien rawat inap penyakit dalam dengan diagnosa infeksi yang menggunakan antibiotika. Jumlah sampel didapatkan 37 pasien yang selanjutnya dianalisis menggunakan metode ATC/DDD. Hasil penelitian menunjukkan nilai total DDD pemakaian antibiotika adalah 83,3/100 pasien-hari dengan total length of stay (LOS) pasien adalah 215 hari. Antibiotika dengan nilai DDD paling tinggi adalah seftriakson yaitu 42,3/100 pasien-hari. Antibiotika yang masuk ke dalam segmen DU 90% yaitu seftriakson, levofloksasin, dan metronidazol, sehingga harus dipantau penggunaannya karena berpotensi pada risiko resistensi bakteri terhadap antibiotika. Antibiotics are drugs used to prevent and treat bacterial infections. Improper use of antibiotics can trigger antibiotic resistance, which is the biggest problem for human health. Antibiotic resistance can increase the length of stay (LOS), increase treatment costs, and increase mortality rates. One way to overcome antibiotic resistance is to use antibiotics wisely. The Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method is used to assess the quantity of antibiotic use. The purpose of this study was determining the value of DDD and drug utilization (DU) 90% of antibiotics. This study was a cross-sectional study with retrospective data collection conducted in internal January – December 2021 at Dr. Soedarso Pontianak Hospital, and the data was analyzed using the DDD and DU 90% methods. The inclusion criteria were internal medicine inpatients with a diagnosis of infection treated with antibiotics. The number of samples obtained were 37, which were then analyzed using the ATC/DDD method. The results showed that the total value of DDD for antibiotic use was 83.3/100 patients/day and the total length of stay (LOS) of patients was 215 days. Ceftriaxone, with a DDD of 42.3/100 patient-day, had the highest DDD value. Meanwhile, antibiotics that fall into the 90% DU segment were ceftriaxone, ciprofloxacin, and levofloxacin, so their use must be monitored because of the potential risk of bacterial resistance to antibiotics.
Pengaruh Obat Antituberkulosis Kombinasi RHZE Terhadap Peningkatan Kadar Asam Urat Azzahra, Ika Prima; Winarsih, Sri; Yunita, Ema Pristi
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5925

Abstract

Tuberkulosis paru merupakan penyakit infeksius yang diakibatkan oleh bakteri Mycobacterium tuberculosis. Pasien tuberkulosis paru memperoleh pengobatan kombinasi obat antituberkulosis (OAT). Pada pengobatan kategori I, pasien mendapatkan kombinasi RHZE pada tahap intensif selama 2 bulan. Adanya obat pirazinamid (Z) dan etambutol (E) dalam regimen terapi berisiko menyebabkan efek samping berupa peningkatan kadar asam urat di dalam darah. Efek samping tersebut dapat menyebabkan problem medis berupa gout maupun gangguan fungsi ginjal. Oleh karena itu, apoteker harus memantau risiko efek samping OAT pada pasien. Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan OAT kombinasi RHZE terhadap kadar asam urat pasien. Penelitian yang dilakukan di Puskesmas Citangkil Kota Cilegon ini merupakan penelitian observasional kohort. Penelitian dilakukan selama bulan April – Juni 2023. Jumlah subjek penelitian yang memenuhi kriteria inklusi dan eksklusi sebanyak 36 pasien. Pemeriksaan kadar asam urat dilakukan sebelum pasien minum OAT (minggu ke-0) dan minggu ke-4 setelah minum OAT. Hasil penelitian menunjukkan bahwa rerata kadar asam urat pasien laki-laki pada minggu ke-0 dan minggu ke-4 masing-masing sebesar 5,09 ± 0,9 mg/dL dan 12,02 ± 1,59 mg/dL. Sementara itu, pada pasien perempuan masing-masing sebesar 5,06 ± 0,94 mg/dL dan 11,98 ± 1,69 mg/dL. Hasil uji t berpasangan menunjukkan adanya perbedaan yang signifikan secara statistik terhadap rerata kadar asam urat pada minggu ke-0 dan ke-4 (p < 0,001). Dari hasil penelitian ini diketahui bahwa penggunaan OAT RHZE pada pasien tuberkulosis paru selama 4 minggu dapat menyebabkan peningkatan kadar asam urat. Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis bacteria. Patients with pulmonary tuberculosis undergo combination anti-tuberculosis drug (ATD) therapy. In category I treatment, patients receive a combination of RHZE during the intensive phase for 2 months. The inclusion of pyrazinamide (Z) and ethambutol (E) in the therapy regimen carries the risk of side effects, including an increase in uric acid levels in the bloodstream. These side effects can result in medical issues, such as gout and kidney function disturbances. As a result, it is crucial for pharmacists to monitor the potential side effects of ATD in patients. This study aimed to analyze the impact of RHZE combination ATD use on patients’ uric acid levels. This research was conducted at Citangkil Community Health Center in Cilegon City, and was an observational cohort study started from April to June 2023, involving a total of 36 patients who met the inclusion and exclusion criteria. Uric acid levels were assessed both before patients initiated ATD treatment (week 0) and at week 4 after commencing ATD. The findings indicated that the mean uric acid levels for male patients at week 0 and week 4 were 5.09 ± 0.9 mg/dL and 12.02 ± 1.59 mg/dL, respectively. For female patients, the corresponding levels were 5.06 ± 0.94 mg/dL and 11.98 ± 1.69 mg/dL. Paired t-test results revealed a statistically significant difference in mean uric acid levels between week 0 and week 4 (p < 0.001). In conclusion, the use of RHZE combination ATD in pulmonary tuberculosis patients for 4 weeks could lead to an elevation in uric acid levels.
Hubungan Penggunaan Kombinasi Antihipertensi Dengan Luaran Neonatal pada Pasien Preeklamsia Awaludin, Adila; Nurzaman, Mochamad Herdi; Annisa; Herdianti, Nita
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.6072

Abstract

Hipertensi selama kehamilan meningkatkan risiko terjadinya komplikasi maternal. Preeklamsia merupakan komplikasi yang umumnya paling sering terjadi selama masa kehamilan. Komplikasi pada masa kehamilan berdampak pada pemburukan luaran neonatal. Manajemen terapi yang tepat pada pasien preeklamsia dihubungkan dengan luaran neonatal yang lebih baik. Tujuan dari penelitian ini adalah untuk menggambarkan penggunaan antihipertensi pada pasien preeklamsia pada fasilitas kesehatan sekunder di Tasikmalaya dan menilai hubungan antara pemberian kombinasi antihipertensi dengan luaran neonatal yang dihasilkan. Penelitian ini merupakan studi multisenter menggunakan desain potong lintang secara retrospektif dari Juli 2018-Juni 2023. Selama periode penelitian didapat 88 pasien bersalin dengan diagnosa preeklamsia yang memenuhi kriteria inklusi dan eksklusi. Metildopa, nifedipin, dan amlodipin merupakan antihipertensi yang digunakan pada populasi studi dimana kombinasi antihipertensi yang digunakan diantaranya adalah kombinasi amlodipin dengan metildopa atau nifedipin dengan metildopa. Pada populasi studi, metildopa merupakan antihipertensi yang paling sering digunakan. Hasil analisis menunjukkan bahwa tidak terdapat hubungan antara penggunaan kombinasi antihipertensi dengan luaran neonatal. Namun, pasien dengan terapi kombinasi antihipertensi memiliki prevalensi lebih tinggi untuk luaran neonatal yang tidak diinginkan. Hypertension during pregnancy increases the risk of maternal complications. Preeclampsia is the most common complication that appears during pregnancy. Complications during pregnancy had a poor impact on neonatal outcomes. Appropriate therapy management in preeclampsia patients is suggested to improve neonatal outcomes. This study aimed to describe the use of antihypertensives in preeclampsia in Tasikmalaya and assess the association between the combination of antihypertensives with neonatal outcomes. This was a multi-center study with a cross-sectional design retrospectively from July 2018 to June 2023. In the study period, 88 maternal deliveries with preeclampsia met the inclusion and exclusion criteria. Methyldopa, nifedipine, and amlodipine were used in the study population whereas amlodipine with metildopa or nifedipine with metildopa were the option of antihypertensive combination. In the study population, metildopa was the most frequently used antihypertensive. The analysis results showed there was no association between using a combination of antihypertensives and neonatal outcomes. However, patients treated with combination antihypertensive had a higher prevalence of unfavorable neonatal outcomes.
RP-HPLC Method Validation for Purity Assay of α-Mangostin Isolate Ratih, Ratih; Budipramana, Krisyanti; Firmansyah, Adang
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.6108

Abstract

The quality of natural products regarding the purity of their active compounds, such as α-mangostin isolate from mangosteen pericarp, may vary depending on cultivation, harvest season, and isolation process. Thus, extensive isolation procedures are involved in obtaining a certain level of purity of the active compounds. Studies on the yield of α-mangostin isolate and its effectiveness as an active compound in health care have been reported. The quality parameter of the isolate as the intended active compound can be indicated by its purity level. Measuring the purity of the active compound is proposed to define the grade α-mangostin isolate as a starting material or even reference standard. The higher the purity level of α-mangostin isolate, the greater its potential as a reference standard candidate. Therefore, a selective analytical method is required to measure the purity level accurately. For this reason, a rapid analytical method to ensure α-mangostin isolate was developed and validated to confirm its purity. Separation condition semployed an X-Terra® C18 column 5 μm, 4.6 x 150 mm under an isocratic system with a mobile phase composition of MeCN:water (85:15) at a flowrate of 0.5 mL/ min and a detector wavelength of 243 nm were selected. Acceptable validation parameters of linearity in the range of 2.6 –52 μg/mL with r2 = 0,9994, Vx0 = 2.64%; accuracy 96.38 – 100.99%; precision 1.36%; and LOD/LOQ = 4.6 μg/mL/ 13.7μg/mL were achieved. The validated method was successfully applied to the purity assay α-mangostinisolate with a run time of less than 9 minutes.
Karakterisasi Fisikokimia dan Organoleptik Tablet Effervescent Ashitaba (Angelica keiskei) Laitupa, Fajriyanti Azzura; Dewi, Ardhia Deasy Rosita; Erawati, Christina Mumpuni; Kusumawardhany, Prita Ayu; Widjaja, Lanny Kusuma; Iswadi, Hazrul
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.5648

Abstract

Ashitaba (Angelica keiskei) merupakan tanaman yang mengandung senyawa flavonoid (kalkon) dan tanin yang dapat berperan sebagai antioksidan. Kandungan antioksidan pada ashitaba akan mudah dikonsumsi dalam bentuk sediaan tablet effervescent. Penelitian ini bertujuan untuk mengetahui formula terbaik tablet effervescent ashitaba. Tablet effervescent merupakan bentuk sediaan yang menghasilkan gelembung gas karbondioksida sebagai hasil dari reaksi kimia dalam larutan yang mengandung senyawa asam dan senyawa karbonat atau bikarbonat hingga terdapat rasa sparkly pada minuman setelah tablet larut sempurna dalam air. Proses pembuatan diawali dengan ekstraksi senyawa flavonoid dengan metode maserasi dalam pelarut etanol 70%, lalu dikeringkan menggunakan spray dryer dengan maltodekstrin sebagai drying aid. Tablet effervescent dibuat berdasarkan formula yang telah ditentukan menggunakan penambahan ekstrak sebesar 10; 15; 20; 25% (b/v). Berdasarkan hasil analisis statistik karakteristik fisikokimia yang telah dilakukan, ditemukan adanya perbedaan signifikan. Perlakuan dengan penambahan ekstrak 15% merupakan perlakuan terbaik menurut uji indeks efektivitas dengan aktivitas antioksidan sebesar 29,43±1,84%, kadar air 3,68±0,28%, waktu larut 40±0,99 detik dan warna tablet kuning merah. Ashitaba (Angelica keiskei) is a plant that contains flavonoid compounds (chalcone) and tannins which can act as antioxidants. The antioxidant content in ashitaba can be easily consumed in the form of effervescent tablets. This research aims to determine the best formula for ashitaba effervescent tablets. Effervescent tablets are a dosage form that produces carbon dioxide gas bubbles as a result of a chemical reaction in a solution containing acid compounds and carbonate or bicarbonate compounds so that there is a sparkly taste in the drink after the tablet dissolves completely in water. The manufacturing process begins with the extraction of flavonoid compounds using the maceration method in 70% ethanol solvent, then dried using a spray dryer with maltodextrin as a drying aid. Effervescent tablets are made based on a predetermined formula using an extract addition of 10; 15; 20; 25% (w/v). Sample treatment with the addition off 15% extract was the best treatment according to the effectiveness index test with antioxidant activity of 29.43 ± 1.84%, water content of 3.68 ± 0.28%, dissolving time of 40 ± 0.99 seconds and colour of the tablet was yellow red.
Studi Etnomedisin Tanaman Obat sebagai Penurun Rasa Nyeri Sendi pada Suku Dayak Hardiyanti, Andi Sry; Sulistiyono, Ilham Robbynoor; Widiyaningsih, Arum; Sukardiman, Sukardiman; Widyowati, Retno
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6213

Abstract

Etnomedisin merupakan studi tentang presepsi dan konsepsi masyarakat lokal dalam memahami kesehatan atau studi yang mempelajari sistem medis etnis tradisional. Nyeri sendi adalah peradangan sendi yang ditandai dengan pembengkakan, warna kemerahan, panas, nyeri, dan kesulitan untuk bergerak. Hingga saat ini, Suku Dayak masih menggunakan metode pengobatan tradisional yang dilakukan secara turun-temurun dengan memanfaatkan bahan-bahan alam seperti tanaman. Tujuan penelitian ini menggali informasi jenis tanaman yang digunakan oleh masyarakat Suku Dayak di Desa Sambi, Kabupaten Kotawaringin Barat, Kalimantan Tengah untuk mengobati nyeri sendi dan cara penggunaannya. Metode penelitian kuantitatif dengan pengambilan sampel secara purposive dan snowball. Informan yang ditargetkan berjumlah 20 orang yang mengetahui tentang pengobatan nyeri sendi melalui wawancara dan observasi. Hasil penelitian berdasarkan rute penggunaanya itu, secara oral terdapat 4 ramuan tanaman obat dan 8 tanaman tunggal, sedangkan digunakan secara topikal terdapat 1 tanaman. Berdasarkan jumlah tanaman dalam ramuan yang paling banyak digunakan oleh masyarakat Suku Dayak yaitu 3 tanaman dalam 1 ramuan. Kesimpulan penelitian ini adalah Suku Dayak di Desa Sambi banyak menggunakan Rhodomyrtus tomentosa, Arcangelisia flava (L.) Merr, dan Orthosiphon aristatus untuk mengobati nyeri sendi, sedangkan cara formulasinya sebagian besar direbus bersamaan dengan air sebanyak 750 mL. Ramuan tersebut dikonsumsi sebanyak 3x sehari hingga kondisi membaik untuk mengobati nyeri sendi. Ethnomedicine is a study of local people's perceptions and conceptions of health or the study of traditional ethnic medical systems. Joint pain is joint inflammation characterized by swelling, redness, heat, pain, and difficulty of moving. Dayak tribe still uses traditional healing methods that have been passed down from generation to generation using natural ingredients such as plants. This research aimed to explore the types of plants used by the Dayak tribe in Sambi Village, West Kotawaringin Regency, Central Kalimantan to treat joint pain and how they are used. Quantitative research method using purposive and snowball sampling. The targeted informants were 20 people who knew about joint pain treatment through interviews and observations. The results were based on the route of use, namely oral, there were 4 medicinal plant potions and 8 single plants,while when used topically there was 1 plant. Based on the number of plants in the potion, the most widely used by the Dayak people is 3 plants in 1 potion. The conclusion of this research was the Dayak tribe in Sambi Village mostly uses Rhodomyrtus tomentosa, Arcangelisia flava (L.) Merr, and Orthosiphon aristatus to treat joint pain, while the formulation method is mostly boiled together with 750 mL of water. The potion is consumed 3 times a day until the condition improves to treat joint pain.

Page 12 of 17 | Total Record : 162

 10   11   12   13   14 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol. 7 No. 1 (2025): JUNE Vol. 6 No. 2 (2024): DECEMBER Vol. 6 No. 1 (2024): JUNE Vol. 5 No. 2 (2023): DECEMBER Vol. 5 No. 1 (2023): JUNE Vol. 4 No. 2 (2022): DECEMBER Vol. 4 No. 1 (2022): JUNE Vol. 3 No. 4 (2021): DECEMBER Vol. 3 No. 3 (2021): JUNE Vol. 3 No. 2 (2020): DECEMBER Vol. 3 No. 1 (2020): JUNE Vol. 2 No. 4 (2019): DECEMBER Vol. 2 No. 3 (2019): JUNE Vol. 2 No. 2 (2018): DECEMBER Vol. 2 No. 1 (2018): JUNE Vol. 1 No. 4 (2017): DECEMBER Vol. 1 No. 3 (2017): JUNE Vol 1, No 2 (2016): drug development Vol. 1 No. 2 (2016): DECEMBER Vol. 1 No. 1 (2016): JUNE Vol 1, No 1 (2016): Media Pharmaceutica Indonesiana More Issue