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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Tropical and Infectious Disease MEDISAINS JURNAL FARMASIMED (JFM) Canrea Journal: Food Technology, Nutritions, and Culinary Journal Indonesian Journal of Global Health research Jurnal Ilmiah Pharmacy MEDIC MEdical Dedication Electronic Journal Scientific of Environmental Health And Diseases Riset Informasi Kesehatan
Humaryanto, Humaryanto
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health

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Correlation Clinicopathological and Immunohistochemical Expression of Interleukin-6 (IL-6) in Keloid Fairuz, Fairuz; Utami, Erisca; Dewi, Hasna; Fitriyanti, Fitriyanti; Miftahurrahma, Miftahurrahma; Justitia, Budi; Siregar, Mara Imam Taufiq; Humaryanto, Humaryanto
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.5844

Abstract

IL-6 has been shown to enhance collagen synthesis and prolong the fibroblast proliferative phase, potentially contributing to uncontrolled keloid growth. However, despite its frequent mention in the literature as a crucial factor in keloid formation, studies specifically exploring the molecular mechanisms of IL-6 in fibroblast regulation and its interaction with other cytokines within keloid tissue remain limited. This study aims to further investigate the role of IL-6 in keloid matrix formation. This study is an analytical study conducted cross-sectionally. The samples used were patients diagnosed with keloids histopathologically based on microscopic criteria. Clinical data were taken from medical records and microscopic and immunohistochemical assessments using paraffin blocks available in the anatomical pathology laboratory of hospitals in Jambi city. There were 36 cases of keloids, aged between 12 and 42 years, mostly in women (66.7%), occurring in the trunk area (77.8%) 30 cases of recurrence (83.3%). We found 24 cases (77.8%) with strong IL-6 immunoexpression. There were 3 cases (8.3%) with no immunoexpression. There was a strong correlation between IL-6 immunoexpression and gender (p=0.03), age(0.04) and recurrence (p=0.02). The role of fibroblast cells is very important for the process of collagen formation in wound healing. The role of fibroblast cells is very important for the process of collagen formation in wound healing, where interleukin-6 in various theories and studies supports the process of collagen formation.
PENYULUHAN KELAINAN DEGENERATIF DI BIDANG ORTHOPEDI MELALUI SENAM OSTEOPOROSIS Humaryanto, Humaryanto; Justitia, Budi; Mulyadi, Deri; Husnul, Husnul; Nuriyah, Nuriyah
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 1 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/medicaldedication.v7i1.32950

Abstract

ABSTRACTAn important aspect in improving quality of life is bone and joint health, especially as you age. Degenerative disorders in orthopedics such as osteoporosis have become a significant public health problem. Osteoporosis is characterized by a decrease in bone density, increasing the risk of bone fractures and causing various serious complications. For this reason, the service team carried out an activity in the form of counseling and osteoporosis exercises as well as conducting consultations regarding the participants' current disease complaints, especially problems related to osteoporosis in the sub-district services of the city across Jambi. Increase knowledge about degenerative diseases and types of food that are related to the causes of osteoporosis. This begins with osteoporosis exercises and continues with education about degenerative disorders and types of food related to osteoporosis. Participants were given pretest and posttest questions to measure knowledge about degenerative disorders and types of food related to osteoporosis. There was an increase in the number of correct points during the post-test compared to the pretest.Key words: degenerative disorders, osteoporosis, nutrition ABSTRAKAspek penting dalam meningkatkan kualitas hidup adalah Kesehatan tulang dan sendi terutama ditengah pertambahan usia. Kelainan degeneratif di bidang orthopedi seperti osteoporosis telah menjadi masalah Kesehatan masyarakat yang cukup signifikan. Osteoporosis yang ditandai dengan penurunan kepadatan tulang, meningkatkan risiko patah tulang dan menimbulkan berbagai komplikasi serius. Untuk itu tim pengabdian melakukan suatu kegiatan berupa penyuluhan dan senam osteoporosis serta melakukan konsultasi mengenai keluhan penyakit peserta yang saat ini dirasakan terutama masalah yang berkaitan dengan osteoporosis di kecamatan pelayangan kota seberang jambi. Tujuan meningkatkan pengetahuan tentang penyakit degeneratif dan jenis makanan yang berhubungan dengan penyebab terjadinya osteoporosis. Metode kegiatan ini diawali senam osteoporosis dan dilanjutkan penyuluhan kelainan degeneratif dan jenis makanan yang berhubungan dengan osteoporosis. Peserta diberikan soal pretest dan postest untuk mengukur pengetahuan tentang kelainan degenerative dan pola makan yang berhubungan dengan osteoporosis. Hasil terdapat peningkatan jumlah benar saat post-test dibandingkat pretest. Kata kunci: kelainan degenerative, osteoporosis, gizi
Test of 25% Ethanol Extract of Betel Nut as a Burn Wound Healing Agent in Male White Mice Farhan, Muhammad; Kasmadi, Fathnur Sani; Humaryanto, Humaryanto; Kusdiyah, Erni; Harahap, Huntari
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/adcwgh75

Abstract

Burns are a serious injury that requires effective therapy to accelerate the healing process. This study aims to evaluate the effectiveness of 25% ethanol extract of areca nut (Areca catechu L.) on healing second-degree burns in male white rats (Rattus norvegicus). The extract was obtained through a maceration method and characterized for its secondary metabolite content. A total of 25 rats were divided into five groups: a negative control (Vaseline flavum), a positive control (Bioplacenton®), and three treatment groups with extract concentrations of 2%, 4%, and 6%. The topical preparation was applied daily for 21 days, then clinical observations were carried out in the form of wound diameter measurements and histopathological analysis (re-epithelialization, collagenization, angiogenesis, and the number of fibroblasts). Phytochemical results showed that the extract contained flavonoids, alkaloids, tannins, phenols, and steroids. Clinically, the treatment group with a concentration of 6% showed the greatest reduction in wound diameter (56.6%) compared to the low concentration extract group and the negative control, although not exceeding the positive control. Histological analysis showed more even re-epithelialization, increased fibroblasts, and a more organized collagen fiber arrangement in the 6% group. These findings indicate that a 25% ethanol extract of areca nut has the potential to accelerate burn wound healing through antioxidant, antimicrobial, astringent, and anti-inflammatory mechanisms, although its effectiveness is still below standard therapy. Further research is needed to optimize the dosage and formulation for its development as an affordable, natural-based alternative phytotherapy.
INTERACTIVE VISUAL EDUCATION TO ENHANCE KNOWLEDGE OF LOW BACK PAIN AMONG THE ELDERLY AND CAREGIVERS AT OLAK KEMANG HEALTH CARE, JAMBI CITY Humaryanto, Humaryanto; Attiya istarini; Lipinwati, Lipinwati; Perkasa, Tengku Arief Buana; Ahmad Syauqy; Hasna Dewi; Fitriyanti; Juanda, Syahreza Hadi; Zikri, Rahmat
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 2 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Low back pain is a common degenerative illness among the elderly, significantly impacting their quality of life and independence. Insufficient understanding of effective management frequently worsens the disease. The objective of this community service program was to enhance comprehension of low back pain among elderly and their caregivers at the Olak Kemang Public Health Centre in Jambi City. The programme consisted of an instructional session with 41 participants utilising a multidisciplinary-developed interactive visual module, accompanied by a practical demonstration of stretching exercises. A pre- and post-test design was used to quantitatively evaluate the alteration in participants' knowledge. The data were examined with the Wilcoxon and Pearson chi-square tests. The findings indicated a statistically significant enhancement in participants' knowledge, with the median score increasing from 60 (range: 30-80) in the pre-test to 85 (range: 50-100) in the post-test (p < 0.001). The number of participants who attained a passing score (≥70%) rose considerably from 19 to 31 (p = 0.007). The interactive visual education program effectively enhances awareness regarding lowback pain among the elderly and their caregivers. This strategy is highly recommended for implementation in other community health programs. Keywords: Low back pain; caregiver; health education; elderly
Development dark chocolate enriched with mangrove leaf powder (Sonneratia alba): Physico-chemical properties, antioxidant activity, and sensory quality Nizori, Addion; Mursyid, Mursyid; Ananda, Rizki; Latief, Madyawati; Tarigan, Indra Lasmana; humaryanto, Humaryanto; azima, Fauzan; Cahyana, Yana; Budiyanto, Budiyanto; Wazzan, Huda; Seow, Eng Keng
jurnal1 VOLUME 8 ISSUE 2, DECEMBER 2025
Publisher : Hasanuddin University Food Science and Technology Study Program

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/canrea.v8i2.1929

Abstract

The incorporation of mangrove leaf powder into food systems offers an emerging strategy for enhancing the functional value of confectionery products. This study evaluated the effects of Sonneratia alba (S. alba) mangrove-leaf powder on the physicochemical properties, antioxidant capacity, and sensory quality of dark chocolate. Leaves were processed into fine 60-mesh powder and added at concentrations of 0–5.5% (w/w). The analytical assessments included moisture content, total phenolic content (TPC), antioxidant activity using the DPPH method, CIELAB colour parameters, texture hardness, and consumer acceptance. The product underwent enrichment with S. alba produced significant (p < 0.05) increases in TPC (49.06–64.37 mg GAE/g) and antioxidant activity (60.45–69.45%). A strong linear relationship between TPC and DPPH inhibition (R² = 0.934) indicated that phenolics contributed directly to enhanced radical-scavenging performance. Colour measurements showed elevated a* and b* values with increasing leaf concentration, reflecting intensified red–yellow chromaticity from plant pigments. Meanwhile, hardness decreased from 135.33 to 98.95 g/F, suggesting that fibre components disrupted fat crystallisation and softened the chocolate matrix. Sensory evaluation demonstrated that intermediate enrichment levels (4.5%–5.5%) provided the most favourable consumer responses, yielding the highest scores for flavour, texture, and overall acceptance. Collectively, these results indicate that powder from S. alba leaves serves as an effective natural fortifying agent capable of improving the functional profile of dark chocolate without compromising sensory desirability. The findings highlight opportunities to use mangrove biomass as a sustainable, phenolic-rich ingredient for developing clean-label, functional chocolate products.
Topical anti-inflammatory effect of 25% ethanol extract of areca nut (Areca catechu L.) on the diameter and histopathology of osteoarthritis rat knees Humaryanto, Humaryanto; Sanik, Fathnur; Fairuz, Fairuz
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.28135

Abstract

Osteoarthritis of the knee often requires pharmacological treatments when non-pharmacological methods are insufficient. Yet, these medications can have serious side effects and be costly. Therefore, exploring alternative therapies and herbal remedies becomes a crucial aspect in the management of osteoarthritis. Areca nut is a plant known to possess numerous pharmacological properties. Areca nut (Areca catechu L.) seed extract with 25% ethanol has lipoxygenase enzyme inhibitory activity, one of the mediators of inflammation in the body. This research aimed to evaluate the in vivo anti-inflammatory effect of the topical application of a 25% ethanol extract of areca nut seeds in male white rats with an induced osteoarthritis model. The research employed an experimental pre-post design. Each treatment group consisted of five animals. The induction used in this study was Monosodium Iodoacetate (MIA) with a concentration of 1 mg/200 grams BW. The animals were divided into five groups: positive control (Natrium Diclofenac® Cream), negative control (Vaseline flavum), Treatment I (2.5% extract concentration), Treatment II (5% extract concentration), and Treatment III (7.5% extract concentration). Statistical analysis was conducted using one-way ANOVA (p<0.05) with Duncan’s post hoc test. The ethanol extract of areca nut seeds displayed an anti-osteoarthritis effect, with the 7.5% concentration providing efficacy nearly equivalent to that of the positive control. This was followed by extract concentrations of 5% and 2.5%.
Health Awareness And Youth Empowerment Program In The Digital Era Fitriyanti; Harahap, Huntari; Humaryanto, Humaryanto; Amalya Nasution, Riska; Nofrianda, Rion; Dwi Puspita, Puspa; Eka Putra, Nofrans; Maharini, Indri; Kalsum, Ummi; Aswin, Budi
Scientific Of Environmental Health and Diseases Vol. 5 No. 2 (2025): Scientific of Environmental Health And Diseases
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/e-sehad.v5i2.50935

Abstract

Background: The fast-paced digital era presents unique challenges to youth health, including gadget addiction, a lack of clean and healthy living behaviors (PHBS), and the risk of bullying. This community service aimed to enhance health awareness and empower children of Indonesian migrant workers (PMI), parents, and teachers at the PPWNI Klang, Selangor, Malaysia, to foster a healthy and smart generation in the digital age. Method: The research employed a community-based approach, involving initial coordination with the partner and using interactive lectures and direct practice for the training. The core activities included psychoeducation sessions on mitigating gadget addiction, PHBS, and bullying, alongside basic health checks. Evaluation and monitoring were conducted using pre- and post-training questionnaires and behavioral observation. The target participants included PMI children, parents, and teachers. Result: From 48 participants attended the basic health checks, which revealed an average cholesterol level of 205.85, a blood glucose average of 107.23, and a uric acid average of 7.05. The findings indicate a prevalence of hypercholesterolemia among the participants. Conclusion: The program is relevant to the research objectives and is expected to reduce bullying rates, increase PHBS awareness, and promote more controlled use of gadgets. This collaboration with PPWNI Klang demonstrates a commitment to forging a healthy, strong, and smart younger generation capable of navigating the digital era.
Uji Aktivitas Sediaan Gel Berbasis Ekstrak Daun Kayu Manis (Cinnamomum burmannii) sebagai Agen Antiinflamasi pada Model Tikus Putih Jantan dengan Induksi Karagenan Kasmadi, Fathnur Sani; Putri, Azelia; Pratiwi, Puspa Dwi; Humaryanto, Humaryanto; Ekaputri, Tia Wida
Jurnal Ilmiah Pharmacy Vol 13, No 1 (2026)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v13i1.917

Abstract

Inflamasi merupakan mekanisme pertahanan fisiologis tubuh yang berperan dalam membatasi perluasan kerusakan jaringan, menekan pertumbuhan mikroorganisme patogen, serta memfasilitasi proses perbaikan jaringan yang mengalami cedera akibat suatu kondisi patologis. Proses ini tergolong respon biologis normal sebagai bagian dari sistem proteksi tubuh. Salah satu tanaman yang diketahui memiliki aktivitas dalam penyembuhan luka adalah daun kayu manis, yang dilaporkan mengandung berbagai metabolit sekunder yaitu fenolik, flavonoid, saponin, steroid, dan tanin yang berkontribusi dalam modulasi proses inflamasi. Formulasi ekstrak daun kayu manis dalam bentuk gel bertujuan untuk meningkatkan penetrasi zat aktif kejaringan target serta memberikan efek pendingin (cooling effect) yang mendukung proses penyembuhan inflamasi. Penelitian ini dilakukan untuk mengevaluasi aktivitas antiinflamasi sediaan gel ekstrak daun kayu manis serta menentukan konsentrasi yang paling optimal dalam menghasilkan efek terapeutik. Metode yang digunakan adalah penelitian eksperimental dengan desain post test only control group. Kelompok perlakuan dibagi menjadi 5 yaitu kontrol positif, kontrol negatif, formula I (ekstrak 2,5%), formula II (ekstrak 5%, dan formula III (ekstrak 10%) yang diaplikasikan secara topikal pada area punggung tikus yang telah diinduksi dengan karagenan 1%. Perlakuan dilakukan selama 4 hari parameter yang diamati berupa volume eksudat dan profil diferensiasi leukosit dalam darah. Hasil penelitian menunjukkan bahwa formulasi gel ekstrak daun kayu manis dengan konsentrasi 10% memberikan aktivitas antiinflamasi paling optimal yang dibuktikan dengan mampu menurunkan volume eksudat. Efektivitas terbaik di tunjukkan dengan nilai persen inhibisi inflamasi pada kosentrasi 10% adalah sebesar 89,47%.
Co-Authors Addion Nizori Ahmad Syauqy Ahmad Syauqy Amalya Nasution, Riska Anati Purwakanthi, Anati Attiya Istarini Ave Olivia Rahman Budi Aswin Budiyanto Budiyanto dewi, hasna Dwi Puspita, Puspa Eka Putra, Nofrans Ekaputri, Tia Wida Fairuz, Fairuz Fauzan Azima Fitriyanti Fitriyanti Fitriyanti Hanina, Hanina Hasna Dewi Huntari Harahap Husnul, Husnul Indra Lasmana Tarigan Iskandar, Mirna Marhami Juanda, Syahreza Hadi Justisia, Budi Justitia, Budi Kusdiyah, Erni Lipinwati ., Lipinwati Madyawati Latief Maharini, Indri Maria, Ima Miftahurrahma, Miftahurrahma Muhammad Farhan Mulyadi, Deri Mursyid Djawas Nuriyah, Nuriyah Puspa Dwi Pratiwi Putri, Azelia Rion Nofrianda Rita Halim Rizki Ananda Sani K, Fathnur Sanik, Fathnur Seow, Eng Keng Simanjuntak, Charles Apul Simanjuntak, Patrick William Gading Siregar, Mara Imam Taufiq Suzan, Raihanah Tengku Arief Buana Perkasa Tobing, Maudy Rominar Br Ummi Kalsum Utami, Erisca Wahyu Indah Dewi Aurora Wazzan, Huda Yana Cahyana Zikri, Rahmat