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All Journal The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Andalas obstetrics and gynecology journal Indonesian Journal of Global Health research Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal Riset Kebidanan Indonesia Plexus Medical Journal Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Jurnal Kesehatan
Defrin, Defrin
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Perbandingan Nilai Risk Malignancy Index Kanker Ovarium Tipe Serosum dan Musinosum RSUP Dr. M. Djamil Padang pada Tahun 2017 Luhuria, Frita Dwi; Defrin, Defrin; Friadi, Andi
Andalas Obstetrics And Gynecology Journal Vol 4, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.1.87-94.2020

Abstract

The Risk Malignancy Index (RMI) is one of the simplest assessments that can assist in diagnosing and determining the prognosis of benign and malignant adnexa masses. Epithelial carcinoma is the most common type of about 90% of ovarian cancers.  As many as 35-40% of the epithelial type are serous and 6-10% are musinosum.This study aims to compare the picture of RMI value on the incidence of ovarian cancer serosum and musinosum type. This study was cross sectinal comparative study from medical records of ovarian cancer patients at obstetrics and gynecology section in DR M Djamil Hospital Padang from January 1st, 2017 until December 31st, 2017. The population was found one hundred and forty of patients with ovarian cancer and only one hundred and twenty nine of patients met the inclusion criteria and there were no exclusion criteria. Next RMI value is calculated based on RMI 1 formula, result is described in tabular form and data processing with SPSS program. Conclucion of this study is there were no differences in age distribution, ascites occurrence and age of menopause in serous and musinosum ovarian cancer. There is a difference in Ca, 125 levels in serous with musinosum ovarian cancer which also contribute to the high value of RMI. The mean value of patients‘s RMI in serous type ovarian cancer is higher than the mean value of RMI in patients with type Musinosum ovarian cancer. Keywords: index of risk malignancy, menopause, ultrasonography, anatomic pathology, serous ovarian carcinoma
Amniotic Fluid Embolism in Post Caesarean Section Defrin, Defrin; Farnas, Heri
Andalas Obstetrics And Gynecology Journal Vol. 4 No. 2 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.2.161-166.2020

Abstract

Background: According to WHO, around 73% of maternal deaths globally are caused by direct obstetric causes. The amniotic fluid embolism is a life-threatening obstetric emergency characterized by sudden cardiopulmonary system failure and can be accompanied by Disseminated Intravascular Coagulation (DIC). The amniotic fluid embolism event usually occurs during labor and birth, but can also occur immediately in the post partum period or after pregnancy termination. About 56% of women will not survive for first 2 hours after the acute event. Amniotic fluid embolism is an unpredictable event, so that no prophylactic intervention can be carried out effectively and the handling and enforcement of a diagnosis that still debatable.Objective: To report maternal deaths due to amniotic fluid embolism post cesarean sectionMethod: Case ReportCase:  Reported case of a 30 years old woman with an initial diagnosis in emergency departement with decreased consciousness due to Severe hypoxia due to Pulmonary emboli due to Amniotic fluid emboli on P2A0L2 post Cesarean Section first day of puerperium. The patient experienced a sudden loss of consciousness accompanied by severe shortness of breath after 6 hours after cesarean section surgery in a private hospital. After initial examination and treatment by administering oxygen through the Nonrebreathing Mask, there was no improvement in the O2 saturation value and then the patient was intubated by the anesthetist. After intubation, the O2 saturation value still does not increase, then the patient suddenly experiences cardiac arrest and followed with cardiac resuscitation for 2 cycles accompanied by resuscitation drugs then the patient returns to spontaneous circulation. From the cardiology department, inotropic therapy was given and echocardiographic investigations were carried out. On echocardiographic examination, they found McConnel's sign which showed suspicios of pulmonary embolism. At the time the patient will be moved to the intensive care unit, the patient experiences a cardiac arrest for the second time, then resuscitation is performed again for 2 cycles, but it does not work and the patient is declared dead.Conclusion: Amniotic fluid embolism is an obstetric emergency condition that cannot be predicted and has a high mortality rate. Treatment is supportive to support the cardiopulmonary system and management of coagulopathy that may occur.Keywords: maternal mortality, amniotic fluid embolism 
The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia Perdana, David; Defrin, Defrin; Firdawati, Firdawati
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.82-89.2021

Abstract

The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsiaKeywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of  HIF-1α
Correlation of Brain Derived Neurotrophic Factors (BDNF) With Maternal and Perinatal Outcome in Preeclampsia Mayuliani, Mayuliani; Yusrawati, Yusrawati; Defrin, Defrin
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.148-160.2021

Abstract

Objective: To analyze the correlation between BDNF and maternal and perinatal outcomes in preeclampsia.Methods: This was an observational analytic study with a cross-sectional design on 73 pregnant women with preeclampsia. The study began in January 2020 to June 2020 in the Obstetrics and Gynecology Department of Dr M. Djamil Hospital Padang.Results: The mean BDNF levels of pregnant women with preeclampsia were 519.9 ± 325.4 pg/ml. The correlation between BDNF and systolic blood pressure, diastolic blood pressure, and Mean Arterial Pressure was negatively correlated (r = -0.145, -0.1, and -0.218), with a weak correlation. There was no statistically significant relationship between BDNF and systolic blood pressure, diastolic blood pressure, and mean arterial pressure (p> 0.05). BDNF correlation with infant birth weight and the birth length was positively correlated (0.196 and 0.205) with a weak correlation. The correlation between BDNF level and Apgar score was negatively correlated (-0.039 and -0.054) with a weak correlation. There was no statistically significant correlation between BDNF with birth weight, birth length, and Apgar score (p> 0.05).Conclusion: The mean BDNF level in preeclampsia was lower than normal pregnancy, there was a negative correlation between BDNF levels and maternal outcomes in preeclampsia with a weak correlation. There was a positive correlation between BDNF levels and perinatal outcomes (birth weight and birth length) in preeclampsia and there was a negative correlation between BDNF levels and Apgar score in preeclampsia with a weak correlation.Keywords: Brain Derived Neurotrophic Factors, Preeclampsia, Maternal Outcome, Perinatal Outcome
Differences of Increased Bishop Scores Between Neutrophil Swab Vaginal ≤ 5 and > 5 in 41 Weeks of Pregnancy Induced With Misoprostol Hartanto, Boby; Serudji, Joserizal; Defrin, Defrin
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.178-185.2021

Abstract

The incidence of labor induction with various indications was to increase. The key to successful labor induction is a ripe cervix. Research shows that the degree of cervical rippening as assessed by the Bishop score is influenced by the level of neutrophils contained in the cervical stroma which can be detected by performing a vaginal swab. Neutrophils will produce collagenase in the form of matrix metalloproteinase - 8 (MMPs - 8) which will degrade cervical collagen fibers, so that the cervix becomes soft and ripe. Misoprostol is the drug most widely used in labor induction today. Purpose: This study was to determine the difference in Bishop score increase between vaginal swab neutrophils ≤ 5 and > 5 in pregnancy ≥ 41 weeks induced by misoprostol.Keywords: Bishop score, neutrophil, vaginal swab, misoprostol
Prevalence of pregnant women with reactive HBsAg in Padang City in 2019 Utama, Try Genta; Defrin, Defrin
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.21-26.2022

Abstract

Introduction: Hepatitis B is an infectious disease that occurs in the liver caused by the hepatitis B virus (HBV). Transmission vertically 95% occurs in the perinatal period (during delivery) and 5% intra uterine. Hepatitis B infection can be acute to chronic. Chronic infection was defined as hepatitis B surface antigen (HBsAg) persistently in blood or serum for more than 6 months with or without active viral replication and evidence of hepatocellular injury or inflammation. Indonesia as a country with high endemicity of Hepatitis B is currently focusing on preventing mother to child transmission (PPIA) because 95% of hepatitis B transmission is vertical, namely from hepatitis B positive mothers to their babies. The number of pregnant women who have been tested for Hepatitis B using the HBsAg Rapid Diagnostic Test (RDT) in 2018 in Indonesia is still relatively small, which is only 39.95% of the target pregnant women who should be examined. In West Sumatra itself occupies the 30th position out of 34 provinces with the percentage of HBsAg reactive pregnant women as much as 0.97%.Objective: This study aims to determine the incidence of pregnant women with reactive HBsAg in the city of Padang.Methods: This research is a descriptive study. The data was taken from the recap of the number of pregnant women who were screened for hepatitis B in all public health centers in the city of Padang during 2019.Result : There are 13,174 (72%) pregnant women who have been tested for HBsAg. Found 131 (0.95%) people with reactive HBsAg. The highest cases were found in the Lubuk Kilangan Public Health Center with 14 cases and the lowest in the opposite health center and Ulak Karang health center with 0 cases. The highest case finding occurred in June with 17 cases and the lowest in November with 7 cases.Conclusion: The prevalence of pregnant women with reactive HBsAg was 0.95% in Padang City in 2019.Keywords: Hepatitis B, HBsAg, Pregnant Women
Hubungan konformitas teman sebaya dengan perilaku seksual pada siswi SMPN 1 Ampek Angkek Aisyah, Siti; Defrin, Defrin; Lisa, Ulfa Farrah
Jurnal Riset Kebidanan Indonesia Vol 9, No 1 (2025): Juni
Publisher : AIPKEMA (Asosiasi Institusi Pendidikan Kebidanan Muhammadiyah-'Aisyiyah Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Perilaku seksual menjadi salah satu masalah dalam kehidupan remaja saat ini. Mulai dari perasaan tertarik hingga tingkah laku berkencan, bercumbu dan bersenggama, sehingga menimbulkan permasalahan yang diawali dengan perilaku seksual pranikah hingga terjadi kehamilan dan aborsi. Tujuan penelitian: Untuk mengetahui apakah ada hubungan konformitas teman sebaya dengan perilaku seksual pada siswi SMP di Ampek Angkek. Metode: Penelitian observasional dengan pendekatan cross sectional. Sampel dalam penelitian ini berjumlah 150 orang. Hasil: Hasil dalam penelitian ini menunjukkan responden berperilaku seksual berisiko memiliki konformitas teman sebaya dengan kategori tinggi (40,3%), berdasarkan uji chi-square menunjukkan nilai p=0,005.Sehingga dapat disimpulkan bahwa terdapat hubungan yang bermakna antara konformitas teman sebaya dengan perilaku seksual pada siswi di SMPN 1 Ampek Angkek (p=0,005). Simpulan: Disimpulkan bahwa adanya hubungan antara konformitas teman sebaya dengan perilaku seksual pada siswi SMPN 1 Ampek Angkek.
The Relationship Between Short Chain Fatty Acids and Menarche in Elementary School Students in Padang City Zulfiqar MS; Haviz Yuad; Yetti, Husna; Defrin, Defrin; Ferry, Ferdinal; Saputra, Mondale
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.145-152.2026

Abstract

Introduction: Early menarche is associated with long-term health problems. Currently, adolescent girls are increasingly experience the change of menarche age. Short chain fatty acids (SCFA) are known to play a role in the early release of GnRH which induces an earlier onset of menarche. However, so far there have been no human studies assessing SCFA levels in individuals with early menarche. Method: This is a case-control study in elementary school students in Padang which conducted from July 2024 to November 2024. The sample was all elementary school students in Padang who met the inclusion and exclusion criteria. The data collected were demographic data and SCFA levels measured in faecal samples using the ELISA method. Bivariate analysis was performed using the unpaired T-test. Result: In this study, there were 25 students with early menarche and 25 normal students. Students with early menarche experienced the earliest age of menarche in 9 years old, 56% had excessive BMI, 20% had mother history of early menarche, 20% were born prematurely, 52% had  high-fat diet, 100% lived with their parents and had no history of pornography exposure. This study found the differences in fecal SCFA levels based on age of menarche with the mean SCFA levels found to be higher in the early menarche group compared to normal menarche (39.09 ±  6.64 vs 26.91±5.01 μmol/gram; p=0.000) Conclusion: This study found the differences in fecal SCFA levels based on age of menarche
Placental LEP Promoter Hypomethylation is Associated with Increased Leptin and Umbilical Artery Vascular Resistance in Maternal Obesity Fridsto, Zeino; Serudji, Joserizal; Defrin, Defrin; Hardisman, Hardisman
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3911

Abstract

BACKGROUND: Maternal obesity has been associated with altered fetal development involving metabolic, hormonal, vascular, and epigenetic processes. The leptin (LEP) gene is crucial for placental angiogenesis and fetal growth. However, evidence linking placental LEP promoter methylation status with both leptin levels and umbilical artery vascular resistance in the context of maternal obesity remains limited. Therefore, this study was conducted to investigate the association of placental LEP promoter hypomethylation with increased leptin levels and umbilical artery vascular resistance in maternal obesity.METHODS: A cross-sectional study was conducted in 35 obese and 35 normal-body mass index (BMI) pregnant women delivering at term. Genomic DNA was extracted from placental tissue for the placental LEP promoter methylation examination using bisulfite conversion and CpG pyrosequencing. Umbilical artery systolic/diastolic (S/D) ratio was measured by Doppler ultrasonography, and umbilical cord leptin levels were analyzed from umbilical cord blood using enzyme-linked immunosorbent assay (ELISA).RESULTS: Total LEP promoter methylation did not differ significantly between groups (p=0.252), but five CpG sites (CpG 5, 11, 13, 16, and 17) showed significant hypomethylation in the obesity group. Umbilical cord leptin levels were significantly higher in infants of obese mothers (p=0.002). The S/D ratio was also significantly higher in the obesity group (p<0.001), indicating increased placental vascular resistance. Maternal age, parity, and gestational age were comparable between groups.CONCLUSION: Placental LEP promoter hypomethylation at specific CpG sites (CpG 5, 11, 13, 16, and 17) in maternal obesity is associated with increased leptin levels and elevated umbilical artery vascular resistance, suggesting a potential epigenetic mechanism linking maternal obesity to placental vascular dysfunction and altered fetal development.KEYWORDS: maternal obesity, leptin, DNA methylation, placenta, umbilical artery Doppler, fetal programming
Factors Associated with Pregnancy Hypertension Risk Sinambela, Megawati; Hardisman, Hardisman; Yusrawati, Yusrawati; Bachtiar, Adang; Masrul, Masrul; Mudjiran, Mudjiran; Malini, Hema; Defrin, Defrin
Jurnal Kesehatan - STIKes Prima Nusantara Vol 14 No 1 (2023): Jurnal Kesehatan
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v14i1.938

Abstract

Background: Hypertension in pregnancy needs to beware out because it can progress to more severe conditions, namely preeclampsia and eclampsia, thereby endangering the mother and the unborn baby. Risk factors in Hypertension in pregnancy are as age, education, occupation, parity, gestational age, economic factors, personal and family history of hypertension, obesity and activity/exercise.Objective: This study aims to determine the risk factors for Hypertension in pregnancy in Deli Serdang Regency, North Sumatra.Method: This study method used analytic observational with a cross sectional design. The study subjects were pregnant women at Public Health Center of Deli Serdang Regency who were considered the inclusion criteria and were selected as study subjects. The sampling technique by means of random sampling amounted to 164. Univariate analysis used to get an overview of the frequency distribution and percentage of the variables to be studied. Bivariate analysis used to determine the relationship between the independent variable and the dependent variable. The statistical test was Chi-Square with CI 95%.  If p < 0.05. Multivariate analysis with logistic regression statistical tests to determine the influence of the independent variables on the dependent variable. Independent variables with p value <0.25 were included in the multiple logistic regression test model and selected using the enter method. The strength of the influence of the independent variable on the dependent variable is the Exp value (ß).Result: The results of the study proved the results of Multivariate analysis, can be synthesized that the risk factors for pregnancy hypertension were influenced by factors: education (p=0.045), parity (p=0.047), gestational age (0p=0.040), personal history of hypertension (p=0.013), history family (p=0.049), and obesity (p=0.016). While the factors of age, occupation, economy and activity/exercise have no effect on risk factors for hypertension in pregnancy. Based on Exp value (B), the most influential factor was personal history of hypertension (p=0.013). This is indicated by the Exp value (B) = 2.710 which is in the interval 1.234 – 5.953, followed by obesity (p=0.016) with the Exp value (= 2.612) which is in the interval 1.192 – 5.725.
Co-Authors Adang Bachtiar ALADIN ALADIN Anavelda, Aura Putri Andani Eka Putra Andi Friadi Antonius, Puja Agung Ariadi, Ariadi Arni Amir Azhari, Nabilah Azmira, Nazurah Basyir, Vaulinne David Perdana Delmi Sulastri Desmawati Desmawati Elmatris Sy Erlina Rustam Farnas, Heri Ferry, Ferdinal Firdawati Firdawati Firdawati, Firdawati Fridsto, Zeino Gusti Revilla Hardisman Hartanto, Boby Haviz Yuad Hema Malini, Hema Hidayati, Yusmalia Husna Yetti Ida Rahmah Burhan Insani, Aldina Ayunda Karmia, Hudilla Rifa Lisma Evareny Luhuria, Frita Dwi Masrul Mayuliani, Mayuliani Meilinda Agus, Meilinda Milano, Ryan Suheil Miranie Safaringga Mudjiran Mufiidah, Muthia Netti Suharti, Netti Nur Indrawaty Lipoeto Nurhayati Nurhayati Putri, Fonny Kurnia Rizanda Machmud Rosfita Rasyid Russilawati, Russilawati Saputra, Mondale Sari, Nur Mala Selfi Renita Rusjdi Sinambela, Megawati Siti Aisyah Sulastri , Delmi Ulfa Farrah Lisa, Ulfa Farrah Utama, Try Genta Yusrawati Yusrawati Yusri, Elfira Zulfiqar MS