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All Journal The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Andalas obstetrics and gynecology journal Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan Jurnal Kesehatan
Defrin, Defrin
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The Difference in Average of Maternal Serum Hypoxia-Inducible Factors-1α Levels between Early Onset and Late-Onset Severe Preeclampsia Perdana, David; Defrin, Defrin; Firdawati, Firdawati
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.82-89.2021

Abstract

The purpose of this study is to know the difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsia. This study used a cross sectional comparative study design that conducted in Februari 2020 - Agustus 2020 in the SMF / Obstetrics and Gynecology department of RSUP dr. M. Djamil Padang, RSUD Achmad Mochtar, RSUD Pariaman, RSUD M Zein Painan. We used consecutive sampling method which consists of 60 pregnant women who fulfill the inclusion and exclusion criteria. They were divided into two groups early-onset severe preeclampsia and late-onset severe preeclampsia. HIF-1α tests were done using ELISA method. The average of maternal serum levels of HIF-1α in late-onset severe preeclampsia is found to be the highest when compared to the early-onset severe preeclampsia, 1,37 ± 1,08 ng/ml vs 0,69 ± 0,11 ng/ml. This difference is significant with the Mann-whitney non parametrical statistical test (p <0.05). There is a significant difference average of maternal serum levels of HIF-1α between early-onset and late-onset severe preeclampsiaKeywords: early onset severe preeclampsia, late onset preeclampsia late onset, maternal serum levels of  HIF-1α
Correlation of Brain Derived Neurotrophic Factors (BDNF) With Maternal and Perinatal Outcome in Preeclampsia Mayuliani, Mayuliani; Yusrawati, Yusrawati; Defrin, Defrin
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.148-160.2021

Abstract

Objective: To analyze the correlation between BDNF and maternal and perinatal outcomes in preeclampsia.Methods: This was an observational analytic study with a cross-sectional design on 73 pregnant women with preeclampsia. The study began in January 2020 to June 2020 in the Obstetrics and Gynecology Department of Dr M. Djamil Hospital Padang.Results: The mean BDNF levels of pregnant women with preeclampsia were 519.9 ± 325.4 pg/ml. The correlation between BDNF and systolic blood pressure, diastolic blood pressure, and Mean Arterial Pressure was negatively correlated (r = -0.145, -0.1, and -0.218), with a weak correlation. There was no statistically significant relationship between BDNF and systolic blood pressure, diastolic blood pressure, and mean arterial pressure (p> 0.05). BDNF correlation with infant birth weight and the birth length was positively correlated (0.196 and 0.205) with a weak correlation. The correlation between BDNF level and Apgar score was negatively correlated (-0.039 and -0.054) with a weak correlation. There was no statistically significant correlation between BDNF with birth weight, birth length, and Apgar score (p> 0.05).Conclusion: The mean BDNF level in preeclampsia was lower than normal pregnancy, there was a negative correlation between BDNF levels and maternal outcomes in preeclampsia with a weak correlation. There was a positive correlation between BDNF levels and perinatal outcomes (birth weight and birth length) in preeclampsia and there was a negative correlation between BDNF levels and Apgar score in preeclampsia with a weak correlation.Keywords: Brain Derived Neurotrophic Factors, Preeclampsia, Maternal Outcome, Perinatal Outcome
Differences of Increased Bishop Scores Between Neutrophil Swab Vaginal ≤ 5 and > 5 in 41 Weeks of Pregnancy Induced With Misoprostol Hartanto, Boby; Serudji, Joserizal; Defrin, Defrin
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.178-185.2021

Abstract

The incidence of labor induction with various indications was to increase. The key to successful labor induction is a ripe cervix. Research shows that the degree of cervical rippening as assessed by the Bishop score is influenced by the level of neutrophils contained in the cervical stroma which can be detected by performing a vaginal swab. Neutrophils will produce collagenase in the form of matrix metalloproteinase - 8 (MMPs - 8) which will degrade cervical collagen fibers, so that the cervix becomes soft and ripe. Misoprostol is the drug most widely used in labor induction today. Purpose: This study was to determine the difference in Bishop score increase between vaginal swab neutrophils ≤ 5 and > 5 in pregnancy ≥ 41 weeks induced by misoprostol.Keywords: Bishop score, neutrophil, vaginal swab, misoprostol
Prevalence of pregnant women with reactive HBsAg in Padang City in 2019 Utama, Try Genta; Defrin, Defrin
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.1.21-26.2022

Abstract

Introduction: Hepatitis B is an infectious disease that occurs in the liver caused by the hepatitis B virus (HBV). Transmission vertically 95% occurs in the perinatal period (during delivery) and 5% intra uterine. Hepatitis B infection can be acute to chronic. Chronic infection was defined as hepatitis B surface antigen (HBsAg) persistently in blood or serum for more than 6 months with or without active viral replication and evidence of hepatocellular injury or inflammation. Indonesia as a country with high endemicity of Hepatitis B is currently focusing on preventing mother to child transmission (PPIA) because 95% of hepatitis B transmission is vertical, namely from hepatitis B positive mothers to their babies. The number of pregnant women who have been tested for Hepatitis B using the HBsAg Rapid Diagnostic Test (RDT) in 2018 in Indonesia is still relatively small, which is only 39.95% of the target pregnant women who should be examined. In West Sumatra itself occupies the 30th position out of 34 provinces with the percentage of HBsAg reactive pregnant women as much as 0.97%.Objective: This study aims to determine the incidence of pregnant women with reactive HBsAg in the city of Padang.Methods: This research is a descriptive study. The data was taken from the recap of the number of pregnant women who were screened for hepatitis B in all public health centers in the city of Padang during 2019.Result : There are 13,174 (72%) pregnant women who have been tested for HBsAg. Found 131 (0.95%) people with reactive HBsAg. The highest cases were found in the Lubuk Kilangan Public Health Center with 14 cases and the lowest in the opposite health center and Ulak Karang health center with 0 cases. The highest case finding occurred in June with 17 cases and the lowest in November with 7 cases.Conclusion: The prevalence of pregnant women with reactive HBsAg was 0.95% in Padang City in 2019.Keywords: Hepatitis B, HBsAg, Pregnant Women
Placental LEP Promoter Hypomethylation is Associated with Increased Leptin and Umbilical Artery Vascular Resistance in Maternal Obesity Fridsto, Zeino; Serudji, Joserizal; Defrin, Defrin; Hardisman, Hardisman
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3911

Abstract

BACKGROUND: Maternal obesity has been associated with altered fetal development involving metabolic, hormonal, vascular, and epigenetic processes. The leptin (LEP) gene is crucial for placental angiogenesis and fetal growth. However, evidence linking placental LEP promoter methylation status with both leptin levels and umbilical artery vascular resistance in the context of maternal obesity remains limited. Therefore, this study was conducted to investigate the association of placental LEP promoter hypomethylation with increased leptin levels and umbilical artery vascular resistance in maternal obesity.METHODS: A cross-sectional study was conducted in 35 obese and 35 normal-body mass index (BMI) pregnant women delivering at term. Genomic DNA was extracted from placental tissue for the placental LEP promoter methylation examination using bisulfite conversion and CpG pyrosequencing. Umbilical artery systolic/diastolic (S/D) ratio was measured by Doppler ultrasonography, and umbilical cord leptin levels were analyzed from umbilical cord blood using enzyme-linked immunosorbent assay (ELISA).RESULTS: Total LEP promoter methylation did not differ significantly between groups (p=0.252), but five CpG sites (CpG 5, 11, 13, 16, and 17) showed significant hypomethylation in the obesity group. Umbilical cord leptin levels were significantly higher in infants of obese mothers (p=0.002). The S/D ratio was also significantly higher in the obesity group (p<0.001), indicating increased placental vascular resistance. Maternal age, parity, and gestational age were comparable between groups.CONCLUSION: Placental LEP promoter hypomethylation at specific CpG sites (CpG 5, 11, 13, 16, and 17) in maternal obesity is associated with increased leptin levels and elevated umbilical artery vascular resistance, suggesting a potential epigenetic mechanism linking maternal obesity to placental vascular dysfunction and altered fetal development.KEYWORDS: maternal obesity, leptin, DNA methylation, placenta, umbilical artery Doppler, fetal programming
Factors Associated with Pregnancy Hypertension Risk Sinambela, Megawati; Hardisman, Hardisman; Yusrawati, Yusrawati; Bachtiar, Adang; Masrul, Masrul; Mudjiran, Mudjiran; Malini, Hema; Defrin, Defrin
Jurnal Kesehatan - STIKes Prima Nusantara Vol 14 No 1 (2023): Jurnal Kesehatan
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v14i1.938

Abstract

Background: Hypertension in pregnancy needs to beware out because it can progress to more severe conditions, namely preeclampsia and eclampsia, thereby endangering the mother and the unborn baby. Risk factors in Hypertension in pregnancy are as age, education, occupation, parity, gestational age, economic factors, personal and family history of hypertension, obesity and activity/exercise.Objective: This study aims to determine the risk factors for Hypertension in pregnancy in Deli Serdang Regency, North Sumatra.Method: This study method used analytic observational with a cross sectional design. The study subjects were pregnant women at Public Health Center of Deli Serdang Regency who were considered the inclusion criteria and were selected as study subjects. The sampling technique by means of random sampling amounted to 164. Univariate analysis used to get an overview of the frequency distribution and percentage of the variables to be studied. Bivariate analysis used to determine the relationship between the independent variable and the dependent variable. The statistical test was Chi-Square with CI 95%.  If p < 0.05. Multivariate analysis with logistic regression statistical tests to determine the influence of the independent variables on the dependent variable. Independent variables with p value <0.25 were included in the multiple logistic regression test model and selected using the enter method. The strength of the influence of the independent variable on the dependent variable is the Exp value (ß).Result: The results of the study proved the results of Multivariate analysis, can be synthesized that the risk factors for pregnancy hypertension were influenced by factors: education (p=0.045), parity (p=0.047), gestational age (0p=0.040), personal history of hypertension (p=0.013), history family (p=0.049), and obesity (p=0.016). While the factors of age, occupation, economy and activity/exercise have no effect on risk factors for hypertension in pregnancy. Based on Exp value (B), the most influential factor was personal history of hypertension (p=0.013). This is indicated by the Exp value (B) = 2.710 which is in the interval 1.234 – 5.953, followed by obesity (p=0.016) with the Exp value (= 2.612) which is in the interval 1.192 – 5.725.
Co-Authors Adang Bachtiar ALADIN ALADIN Anavelda, Aura Putri Andani Eka Putra Andi Friadi Antonius, Puja Agung Arni Amir Azhari, Nabilah Azmira, Nazurah Basyir, Vaulinne David Perdana Desmawati Desmawati Elmatris Sy Erlina Rustam Farnas, Heri Firdawati Firdawati Fridsto, Zeino Gusti Revilla Hardisman Hartanto, Boby Hema Malini, Hema Ida Rahmah Burhan Insani, Aldina Ayunda Karmia, Hudilla Rifa Lisma Evareny Luhuria, Frita Dwi Masrul Djalal Mayuliani, Mayuliani Meilinda Agus, Meilinda Milano, Ryan Suheil Miranie Safaringga Mudjiran Mufiidah, Muthia Netti Suharti, Netti Nurhayati Nurhayati Putri, Fonny Kurnia Rosfita Rasyid Russilawati, Russilawati Selfi Renita Rusjdi Sinambela, Megawati Utama, Try Genta Yusrawati Yusrawati Yusri, Elfira