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Pambudi, Dwi Bagus
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EVALUATION OF HYDROGEL MASK PREPARATION OF RED MANGROVE LEAF ETHANOL EXTRACT (Sonneratia caseolaris Engl.) Sa’diyah, Aminatus; Pambudi, Dwi Bagus
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4638

Abstract

Hydrogel preparations are preparations that have a fairly high water content, ranging from 80-90%. Sonneratia caseolaris Engl is a type of mangrove plant, locally this tree is often called kapidada. Ecologically, kapidada grows in the less salty parts of the mangrove forest. This study aims to find out whether the red pidada mangrove leaf extract can be formulated into a hydrogel mask preparation. The test method used is a hydrogel mask made by mixing the basic ingredients of the mask in the form of carbopol 940 and TEA. The results of the evaluation test were in the form of an organoleptic test with greenish clear color parameters, odorless, with a thick gel form. The resulting pH test was formula 1 with a pH value of 5, formula 2 with a pH value of 6 and formula 3 with a pH value of 5. Test the homogeneity of all preparations from the three homogeneous formulas. The spreadability test produced from formula 1 was 5.1 cm, formula 2 was 4.9 cm and formula 3 was 3.6 cm. The adhesion test resulting from the three formulas obtained a value of 1.16; 1.52; and 1.63 seconds. Viscosity test obtained from the three formulas, namely 3,967; 2,989; and 1,737 cps. The results showed that the hydrogel mask preparations met the evaluation requirements, namely formula 1.
Stabilitas Membran Sel Eritrosit Ekstrak, Fraksi Kloroform, Etil Asetat dan Metanol Herba Patah Tulang (Euphorbia Tirucalli L.) Fika, Irma; Wirasti, Wirasti; Pambudi, Dwi Bagus; Waznah, Urmatul
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 5 No. 1: Juli 2024
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v5i1.402

Abstract

Euphorbia tirucalli L. (patah tulang) contains secondary metabolites with potential anti-inflammatory activity. This study aimed to identify its bioactive compounds and evaluate erythrocyte membrane stabilization of the extract and fractions. Extraction was performed by maceration with 96% ethanol, followed by fractionation using chloroform, ethyl acetate, and methanol. Total flavonoid and phenolic contents were measured by UV-Vis spectrophotometry, while erythrocyte membrane stabilization was tested in vitro. Phytochemical screening revealed flavonoids, phenols, saponins, steroids, triterpenoids, and tannins. The phenolic content was 432.1 ± 99.4 mg/g in the extract, 1,057 ± 88.02 mg/g in the chloroform fraction, 254.4 ± 48.84 mg/g in the ethyl acetate fraction, and 643.2 ± 267.3 mg/g in the methanol fraction. The highest flavonoid content was found in the chloroform fraction (4.26 ± 0.12 mg/g), followed by the extract (3.63 ± 0.35 mg/g), ethyl acetate (3.56 ± 0.36 mg/g), and methanol (2.6 ± 0.03 mg/g). Membrane stabilization assays showed the extract provided the strongest protection (95.04%), followed by chloroform (89.51%), ethyl acetate (87.71%), and methanol (87.52%), approaching the positive control diclofenac sodium (90.59%). Kruskal-Wallis and Tukey tests indicated the ethanol extract at 100 μg/mL (p=0.997 >0.001) and chloroform fraction at 500 μg/mL (p=0.023 >0.001) were not significantly different from the control, while ethyl acetate and methanol fractions differed significantly (p<0.001). These results demonstrate that the ethanol extract and chloroform fraction possess the highest anti-inflammatory potential, supported by high phenolic and flavonoid levels and consistent statistical analysis.
Co-Authors Achmad Vandian Nur, Achmad Vandian Ainun Muthoharoh Ainun Muthoharoh, Ainun Attasih, Monicia Ayu Dyah Purwati Ayu, Roro B., Mahdanya Puteri A. Cahyaningrum, Galuh Surya Danang Raharjo Eko Mugiyanto, Eko Fika, Irma Firman Faradisi Fuad, Asfal Herni Rejeki Huda, Muhammad Syahrian Khoiriyah, Nisa'ul Kholidah, Nur Khusna Santika Rahmasari Maulidah, Lia Khusnul Mufidah, Nur Muhammad Sa'ad Muhtadi Ningrum, Wulan Agustin Nisa, Husna Idza Auziadzatun Novita, Helfi Nuniek Nizmah Fajriyah Nurul Aktifah, Nurul Qulub, Muhammad Syifaul Raharjo, Setyo Tri Rahman, Fadila Rahmatullah, ST. Risqi Dewi Aisyah Rosyada, Jihan Amrina S Slamet, S Safitri, Wiga Arum Safitri, Yuliana Nurul Salsabila, Salma Fi Sa’diyah, Aminatus Setianto, Gigih Silvia Rizkiani Siti Khuzaiyah, Siti Slamet , Slamet Slamet . Sulaiman, Naila Iva Amalina Putri Suparni, Suparni Bagus Sya'bania, Muti' Ulfa, Nadia Salsabila Urmatul Waznah Wirasti Wirasti, W Wirasti, Wirasti Yulian Wahyu Permadi