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All Journal LINK Pharmacon Jurnal Pemberdayaan Masyarakat Madani (JPMM) Prosiding University Research Colloquium Nanggroe: Journal Of Scholarly Service Journal of Pharmacy Science and Technology Batik-Mu : Jurnal Pengabdian Masyarakat Nanggroe: Journal of Scholarly Service Benzena Pharmaceutical Scientific Journal Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Baktimu : Jurnal Pengabdian Kepada Masyarakat Journal of Nutraceuticals and Herbal Medicine
Pambudi, Dwi Bagus
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Optimalisasi Pemanfaatan Terapi Komplementer dalam Kehamilan Suparni, Suparni Bagus; Aisyah, Risqi Dewi; Pambudi, Dwi Bagus
Jurnal LINK Vol 21 No 1 (2025): MEI 2025
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/link.v21i1.12507

Abstract

Terapi komplementer adalah metode pengobatan yang tidak menggunakan obat-obatan konvensional dan dapat bermanfaat dalam mengatasi masalah kesehatan ibu hamil, seperti emesis gravidarum. Tinjauan literatur menunjukkan bahwa terapi komplementer dapat meningkatkan kesehatan fisik, psikologis, sosial, dan spiritual ibu hamil. Namun, perlu dipertimbangkan pula keamanan dan risiko penggunaan terapi komplementer pada ibu hamil. Kelas ibu hamil merupakan sarana yang penting untuk meningkatkan pengetahuan dan keterampilan ibu hamil tentang kehamilan, persalinan, dan perawatan bayi. Tujuan PKM ini adalah untuk mengoptimalkan pemanfaatan terapi komplementer dalam kehamilan di kelas ibu hamil di wilayah kerja Puskesmas Buaran Kabupaten Pekalongan. PKM dilakukan melalui penyuluhan kesehatan tentang terapi komplementer, demonstrasi praktik senam dan peregangan khusus untuk ibu hamil. Kegiatan dilaksanakan selama 3 bulan dengan melibatkan 51 ibu hamil di Posyandu. Hasil pengabdian menunjukkan adanya peningkatan yang signifikan dalam pengetahuan ibu hamil, dari nilai rata-rata 60,43 sebelum penyuluhan menjadi 81,54 setelah penyuluhan. Hal ini mengindikasikan bahwa metode penyuluhan yang digunakan efektif dalam meningkatkan pemahaman ibu hamil mengenai materi yang disampaikan. PKM ini berhasil meningkatkan pengetahuan ibu hamil tentang terapi komplementer dalam kehamilan, yang dapat membantu mereka mengatasi ketidaknyamanan selama masa kehamilan dengan lebih baik.
EVALUATION OF HYDROGEL MASK PREPARATION OF RED MANGROVE LEAF ETHANOL EXTRACT (Sonneratia caseolaris Engl.) Sa’diyah, Aminatus; Pambudi, Dwi Bagus
BENZENA Pharmaceutical Scientific Journal Vol 3 No 01 (2024): BENZENA PHARMACEUTICAL SCIENTIFIC JOURNAL
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/benzena.v3i01.4638

Abstract

Hydrogel preparations are preparations that have a fairly high water content, ranging from 80-90%. Sonneratia caseolaris Engl is a type of mangrove plant, locally this tree is often called kapidada. Ecologically, kapidada grows in the less salty parts of the mangrove forest. This study aims to find out whether the red pidada mangrove leaf extract can be formulated into a hydrogel mask preparation. The test method used is a hydrogel mask made by mixing the basic ingredients of the mask in the form of carbopol 940 and TEA. The results of the evaluation test were in the form of an organoleptic test with greenish clear color parameters, odorless, with a thick gel form. The resulting pH test was formula 1 with a pH value of 5, formula 2 with a pH value of 6 and formula 3 with a pH value of 5. Test the homogeneity of all preparations from the three homogeneous formulas. The spreadability test produced from formula 1 was 5.1 cm, formula 2 was 4.9 cm and formula 3 was 3.6 cm. The adhesion test resulting from the three formulas obtained a value of 1.16; 1.52; and 1.63 seconds. Viscosity test obtained from the three formulas, namely 3,967; 2,989; and 1,737 cps. The results showed that the hydrogel mask preparations met the evaluation requirements, namely formula 1.
Stabilitas Membran Sel Eritrosit Ekstrak, Fraksi Kloroform, Etil Asetat dan Metanol Herba Patah Tulang (Euphorbia Tirucalli L.) Fika, Irma; Wirasti, Wirasti; Pambudi, Dwi Bagus; Waznah, Urmatul
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Volume 5 No. 1: Juli 2024
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v5i1.402

Abstract

Euphorbia tirucalli L. (patah tulang) contains secondary metabolites with potential anti-inflammatory activity. This study aimed to identify its bioactive compounds and evaluate erythrocyte membrane stabilization of the extract and fractions. Extraction was performed by maceration with 96% ethanol, followed by fractionation using chloroform, ethyl acetate, and methanol. Total flavonoid and phenolic contents were measured by UV-Vis spectrophotometry, while erythrocyte membrane stabilization was tested in vitro. Phytochemical screening revealed flavonoids, phenols, saponins, steroids, triterpenoids, and tannins. The phenolic content was 432.1 ± 99.4 mg/g in the extract, 1,057 ± 88.02 mg/g in the chloroform fraction, 254.4 ± 48.84 mg/g in the ethyl acetate fraction, and 643.2 ± 267.3 mg/g in the methanol fraction. The highest flavonoid content was found in the chloroform fraction (4.26 ± 0.12 mg/g), followed by the extract (3.63 ± 0.35 mg/g), ethyl acetate (3.56 ± 0.36 mg/g), and methanol (2.6 ± 0.03 mg/g). Membrane stabilization assays showed the extract provided the strongest protection (95.04%), followed by chloroform (89.51%), ethyl acetate (87.71%), and methanol (87.52%), approaching the positive control diclofenac sodium (90.59%). Kruskal-Wallis and Tukey tests indicated the ethanol extract at 100 μg/mL (p=0.997 >0.001) and chloroform fraction at 500 μg/mL (p=0.023 >0.001) were not significantly different from the control, while ethyl acetate and methanol fractions differed significantly (p<0.001). These results demonstrate that the ethanol extract and chloroform fraction possess the highest anti-inflammatory potential, supported by high phenolic and flavonoid levels and consistent statistical analysis.
Peningkatan Pengetahuan Ibu-Ibu ‘Aisyiyah Wiradesa Tentang Keamanan Penggunaan Bahan Tambahan Pangan Melalui Pelatihan Dan Edukasi Interaktif Waznah, Urmatul; Oktaviani, Riska; A’yun, Qurrata; Rahmasari, Khusna Santika; Wibowo, Danang Novianto; Pambudi, Dwi Bagus
Batik-MU : Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2025): Jurnal Batikmu
Publisher : Fakultas Ilmu Kesehatan Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/batikmu.v5i2.2267

Abstract

Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan ibu-ibu ‘Aisyiyah Wiradesa mengenai keamanan penggunaan Bahan Tambahan Pangan (BTP) melalui pelatihan dan edukasi interaktif. Permasalahan utama yang dihadapi adalah rendahnya pemahaman masyarakat terkait jenis, fungsi, dosis, serta dampak kesehatan dari penggunaan BTP yang tidak sesuai standar. Kegiatan dilaksanakan pada Minggu, 2 November 2025 di TK ABA Gumawang dan diikuti oleh para anggota ‘Aisyiyah yang berperan sebagai pengelola konsumsi keluarga. Metode yang digunakan meliputi ceramah interaktif, demonstrasi identifikasi BTP pada produk pangan, diskusi kelompok, serta pre-test dan post-test untuk mengukur tingkat pemahaman peserta. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada skor pengetahuan peserta, ditandai dengan kenaikan rata-rata nilai post-test dibandingkan pre-test. Peserta juga menunjukkan kemampuan yang lebih baik dalam mengenali label pangan, membedakan BTP yang diizinkan dan dilarang, serta memahami batas penggunaan yang aman. Kegiatan ini disimpulkan efektif dalam meningkatkan literasi pangan masyarakat, khususnya terkait keamanan BTP, serta dapat menjadi model edukasi yang berkelanjutan di komunitas ‘Aisyiyah maupun kelompok masyarakat lainnya.
Phytochemical Insights into Rhizophora stylosa: pH-Dependent Extraction, Antioxidant Activity, and Enzyme Inhibition Potential Pambudi, Dwi Bagus; Muhtadi, Muhtadi; Maryati, Maryati
Borneo Journal of Pharmacy Vol. 9 No. 1 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i1.11158

Abstract

The solvent properties, including pH, highly influence the extraction efficiency of these bioactive compounds. This study investigated the effect of pH modulation in the ethanol solvent on the recovery of antioxidants from Rhizophora stylosa. Ethanolic extraction was performed on R. stylosa samples using solvents adjusted to varying pH levels (4, 8, 9, 10, and 12). The total phenolic content (TPC) and total flavonoid content (TFC) of the extracts were quantified using standard colorimetric assays. The antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The inhibitory activity against carbohydrate-digesting enzymes was assessed through α-amylase and α-glucosidase inhibition assays. Additionally, data mining of established natural product databases (KNApSAcK and IMPPAT) and literature was conducted to identify and catalog the known bioactive constituents of R. stylosa. The results demonstrated a significant correlation between the pH of the extraction solvent and the yields of phenolic compounds, flavonoids, and the resulting antioxidant activity. Extract obtained at pH 10 yielded the highest TPC and exhibited the strongest antioxidant activity, whereas the highest TFC was observed at pH 4. Furthermore, enzymatic inhibition assays revealed that the pH 10 extract displayed moderate α-amylase inhibitory activity (IC₅₀ = 76.7 µg/mL) but substantially weaker α-glucosidase inhibition (IC₅₀ = 190 µg/mL), demonstrating a selective inhibition profile though less potent than that of acarbose. These findings establish pH-modulated extraction as a targeted strategy to produce potent, phenolic-rich antioxidant extracts from R. stylosa, highlighting its potential for nutraceutical and pharmaceutical applications.
Co-Authors Achmad Vandian Nur, Achmad Vandian Ainun Muthoharoh Ainun Muthoharoh, Ainun Attasih, Monicia Ayu Dyah Purwati Ayu, Roro A’yun, Qurrata B., Mahdanya Puteri A. Cahyaningrum, Galuh Surya Danang Raharjo Eko Mugiyanto, Eko Fika, Irma Firman Faradisi Fuad, Asfal Herni Rejeki Huda, Muhammad Syahrian Khoiriyah, Nisa'ul Kholidah, Nur Khusna Santika Rahmasari Maryati Maryati Maulidah, Lia Khusnul Mufidah, Nur Muhammad Sa'ad Muhtadi Muhtadi Muhtadi Ningrum, Wulan Agustin Nisa, Husna Idza Auziadzatun Novita, Helfi Nuniek Nizmah Fajriyah Nurul Aktifah, Nurul OKTAVIANI, RISKA Qulub, Muhammad Syifaul Raharjo, Setyo Tri Rahman, Fadila Rahmatullah, ST. Risqi Dewi Aisyah Rosyada, Jihan Amrina S Slamet, S Safitri, Wiga Arum Safitri, Yuliana Nurul Salsabila, Salma Fi Sa’diyah, Aminatus Setianto, Gigih Silvia Rizkiani Siti Khuzaiyah, Siti Slamet , Slamet Slamet . Sulaiman, Naila Iva Amalina Putri Suparni, Suparni Bagus Sya'bania, Muti' Ulfa, Nadia Salsabila Urmatul Waznah Wibowo, Danang Novianto Wirasti Wirasti, W Wirasti, Wirasti Yulian Wahyu Permadi