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All Journal Jurnal Ilmiah Farmasi Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan MPI (Media Pharmaceutica Indonesiana) Jurnal IPA Terpadu MUHARRIK: JURNAL DAKWAH DAN SOSIAL JFIOnline Jurnal Ilmu Kefarmasian Indonesia Proceedings of Annual Conference for Muslim Scholars Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Chemistry and Materials Pharmaceutical Sciences and Research (PSR) Al-Istinbath: Jurnal Hukum Islam Jurnal Farmasi Indonesia Jurnal Penelitian dan Pengabdian Masyarakat Multidisciplinary Journal of Education, Economic and Culture Miftah Journal of Islamic Education
Mun'im, Abdul
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Pharmacological and molecular mechanism of Syzygium polyanthum leaves as antihypertensive with network pharmacology approach Tirtanirmala, Prisnu; Mun'im, Abdul; Firdayani
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art5

Abstract

Background: In Central Sulawesi, Indonesia, Syzygium polyanthum leaves (SPL) have been traditionally used by society to reduce high blood pressure. However, the molecular mechanism behind this effect still remains unclear.Objective: This study aims to explore the antihypertensive molecular mechanisms of SPL using a network pharmacology approach.Method: Previous studies have investigated some bioactive compounds contained in SPL. Those studies identified 57 bioactive compounds, of which 31 were filtered for further analysis. Target proteins from SPL and disease were identified using GeneCards. Then, 62 selected target proteins which overlapped through Venn diagrams would be analyzed using Cytoscape software to produce compounds-target proteins’ network. Protein-protein interactions were assessed using STRING and visualized by Cytoscape. GO Function and KEGG Pathways were obtained using ShinyGo.Results: The results of this study revealed pathways associated with hypertension through the cellular senescence pathway with target proteins mTOR, ERK (also known as MAPK), p53, CycD, and IL6. The chemical constituents associated with these target proteins are hydroxychavicol, farnesol, naphthalene, phloretin, pyrogallol, and decanal, which were identified as compounds closely related to the target protein of hypertension.Conclusion: The bioactive compounds in SPL play a significant role in regulating hypertension by influencing various target genes, particularly those associated with cellular senescence. Keywords: Antihypertensive, bay leaf, cellular senescence, network pharmacology, Syzygium polyanthum
Writing Assistance Through Canva Application for Class IX Students of SMP Mambaul Ihsan Gresik Ulum, Miftachul; Mun'im, Abdul
Jurnal Penelitian dan Pengabdian Masyarakat Vol. 1 No. 1 (2023): February 2023
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/jp2m.v1i1.34

Abstract

Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk mengatasi beberapa permasalahan antara lain kurangnya kemampuan siswa dalam seni menulis Arab di kelas. Kesulitan mereka sebab kurang percaya diri dalam praktik menulis serta merasa tidak mudah untuk focus dan jenuh. Salah satu usaha yang dapat dilakukan oleh tim ini adalah mengajak siswa mengenal aplikasi Canva. Berdasarkan hasil kegiatan menunjukkan bahwa sebanyak 16 orang peserta telah mampu memahami materi menulis Arab. Materi-materi yang disajikan melalui aplikasi Canva memiliki daya tarik dan seni yang baik.   This Community Service activity aims to overcome several problems, including the lack of students' ability in the art of Arabic writing in class. Their difficulties are due to their lack of confidence in writing practice and feeling that it is not easy to focus and get bored. One of the efforts that can be done by this team is to invite students to get to know the Canva application. Based on the results of the activity, it showed that as many as 16 participants were able to understand Arabic writing material. The materials presented through the Canva application have good appeal and artistry  
Pendampingan Penggunaan Reference Management Software dalam Penyusunan Jurnal dan Karya Ilmiah Ulum, Miftachul; Mun'im, Abdul
Jurnal Penelitian dan Pengabdian Masyarakat Vol. 2 No. 1 (2024): February 2024
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/jp2m.v2i1.211

Abstract

This community assistance activity aims to provide assistance to lecturers and academics in compiling scientific papers and journals using reference management applications. This service method is carried out with assistance and training using the Mendeley Desktop application. The activity was held on February 14 2021, attended by 40 lecturers. The results of the research show that using Mendeley is very helpful in the process of writing journals and scientific work. Participants are very enthusiastic about participating in this activity and it is very important for the activity to be carried out.
Social Interaction and Coping Models of Child Sexual Violence in Ponorogo Rokamah, Ridho; Uswatun Hanifa, Irma Rumtianing; Mun'im, Abdul
MUHARRIK: Jurnal Dakwah dan Sosial Vol. 5 No. 1 (2022): Muharrik: Jurnal Dakwah dan Sosial
Publisher : Fakultas Dakwah Institut Agama Islam Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

There has been an increase in cases of sexual violence against children in the Ponorogo Regency, some of which have been made public through social media. Due to the courage of both those who commit sexual violence and the victims, this issue makes for an exciting area of research using the interaction theory, the social factor theory, and the coping theory. This study aimed to analyze the interactions of social factors and parents' coping models of the victims and perpetrators of sexual violence. It employed a qualitative approach through interviews, observations, and documentation. The findings revealed that all victims and perpetrators of sexual violence have an honest relationship with their parents. As a result, this act of sexual violence occurs due to factors in the victim's personality being close to their parents. The social factors of victims, parents, and perpetrators related to education are diverse. This crime occurs at all levels of education because, as Muzaham argues, family education is an essential element of character development that has not been implemented. The fact that all victims and perpetrators are from Java indicates a cultural shift in Javanese society due to social changes. While the concept of family is good, it falls short in building character. Focused coping is the primary mode of coping in the model. Some parents use emotional coping in the beginning, but they eventually switch to a more focused approach
Moderation of Islamic Education in The Digital Space Ulum, Miftachul; Mun'im, Abdul
Proceedings of Annual Conference for Muslim Scholars Vol 6 No 1 (2022): AnCoMS, APRIL 2022
Publisher : Koordinatorat Perguruan Tinggi Keagamaan Islam Swasta Wilayah IV Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36835/ancoms.v6i1.353

Abstract

This Narrative of hatred, provocation and fights of sheep built by some digital media users without considering other users can easily broadcast hatred and even cause brutality. Users of digital media must be wiser and more moderate in understanding and not easily provoked. Research on moderation of Islamic education is very important for digital media users. How to understand the moderation of Islamic education within the scope of digital space. How to form a moderate attitude in the scope of digital space. How strategies realize moderation of Islamic education in digital space. The understanding of moderate souls for digital media users will greatly affect the attitude and decision so it is not easy to be provoked in reading the narratives that corner one of the groups
Tradition, Wisdom and Negotiating Marriage and Inheritance Disputes on Javanese Muslim Huda, Miftahul; Purnomo, Agus; Mun'im, Abdul; Aminuddin, Lutfi Hadi; Santoso, Lukman
AL-ISTINBATH : Jurnal Hukum Islam Vol 9 No 1 (2024)
Publisher : Institut Agama Islam Negeri Curup

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29240/jhi.v9i1.9887

Abstract

This study aims to find a negotiation model in the tradition of Javanese Muslim communities in resolving disputes regarding marriage and inheritance restrictions. When the reality of resolving marriage and inheritance disputes impacts family and community strife, this becomes crucial. The qualitative paradigm was used to construct this research, which included a series of observations and in-depth interviews with the disputed families and focus group discussions with informants in the East Java community. This research discovers three models for resolving the tradition of avoiding marriage and inheritance disputes in Javanese Muslim society with social components in a heterogeneous society. 1) negotiating the traditional cum theology model, 2) negotiating the tradition and law model, and 3) negotiating the traditional wisdom model. Furthermore, when many cultural traditions fade, the growing negotiation model can serve as the foundation for policy for local governments in generating variants of the nation's cultural traditions.
Leadership and Performance of Teachers and Employees of SMK Sunan Drajat Lamongan Ulum, Miftachul; Mun'im, Abdul
Multidisciplinary Journal of Education , Economic and Culture Vol. 1 No. 1 (2023): March 2023
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/mjeec.v1i1.48

Abstract

This study aims to determine the effect of leadership style on the work performance of teachers and employees at SMK Sunan Drajat Lamongan. Quantitative research method involving 98 respondents using the validity test, reliability test and multiple regression analysis. The results of research at SMK Sunan Drajat Lamongan showed the magnitude of the positive influence between the influence of leadership style on the work performance of teachers and employees at SMK Sunan Drajat Lamongan. The correlation coefficient value of 0.876 indicates a positive relationship between leadership style and employee performance at SMK Sunan Drajat Lamongan. While the coefficient of determination (R2) is 76.7% indicating the magnitude of the contribution of leadership style to work performance
Antioxidant Polyphenolics Extraction Techniques from Beluntas Leaves using Choline Chloride-Urea: Comparative Study with 70%-Ethanol Hikmawanti, Ni Putu Ermi; Yumita, Agustin; Amalia, Halisa; Cahyani, Siti Rosidah; Putri, Meira Amalia; Mun'im, Abdul
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7627

Abstract

Pluchea indica L. (Less), known as Indian camphorweed (common name) or Beluntas (Indonesia), is an antioxidant polyphenol-rich plant. In our previous studies, choline chloride-urea (CCU) at a molar ratio of 1:2 was one type of natural deep eutectic solvents (NADES) in the extraction of P. indica leaves (PIL) polyphenolics. The present study aims to evaluate the comparison of total phenolics (TPC) and flavonoids content (TFC) and antioxidant activity of CCU (1:2) extract of PIL obtained from ultrasonic-assisted extraction (UAE) and magnetic stirrer-assisted extraction (MSAE). Ethanol was used as a comparison to conventional extraction solvents. Determination of TPC and TFC was carried out using colorimetric with a microplate reader, while the antioxidant activity test was carried out using the ferric thiocyanate (FTC) method. The UAE is more effective in terms of PIL flavonoid extraction using CCU compared to MSAE, while PIL phenolic extraction with CCU is more effective with MSAE. CCU extract of PIL from extraction with MSAE at a concentration of 1.56% has an antioxidant capacity equivalent to 500 ppm ascorbic acid in inhibiting lipid peroxidation by about 70%. Thus, CCU combined with the MSAE can be recommended in further development of phenolic antioxidants extraction from PIL.
Enhancing capsaicin solubility in lidocaine-based therapeutic deep eutectic solvents (THEDES): a COSMO-RS predictive study: . Asma, Nur; Alwi, Ratna Surya; Ramadon, Delly; Mun'im, Abdul
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1665

Abstract

Capsaicin, a potent analgesic, suffers from poor aqueous solubility and low bioavailability. Therapeutic deep eutectic solvents (THEDES) have emerged as a promising platform to enhance the solubility of poorly soluble drugs. This study employed the conductor-like screening model for real solvents (COSMO-RS) for the in-silico screening of capsaicin solubility in 34 lidocaine-based THEDES, comprising 10 hydrogen bond acceptors (HBAs) and 26 hydrogen bond donors (HBDs) at 1:1 and 1:2 molar ratios. The σ-profiles and σ-potentials of the components were analysed to understand the intermolecular interactions governing solubility. Our predictions revealed a remarkable solubility range from below 1 g/L to over 437 g/L. The betaine-lidocaine (1:1) system was identified as the optimal solvent, achieving a capsaicin solubility of 437.47 g/L at 333.15 K, attributed to betaine's zwitterionic nature facilitating multifaceted hydrogen-bonding. Small polyols like ethylene glycol also performed excellently. A consistent enhancement in solubility was observed in HBD-rich (1:2) compositions and with increasing temperature. Molecular interaction analysis confirmed a robust network of conventional and non-conventional hydrogen bonds within the optimal betaine-lidocaine-capsaicin system. This work demonstrates the power of COSMO-RS as a rational design tool for formulating high-loading THEDES-based drug delivery systems, with betaine-lidocaine emerging as a top candidate for advanced capsaicin topical formulations.
Natural deep eutectic solvents (NaDES) improves extraction and antioxidant activity of stem bark of Garcinia cowa Roxb. Fahleni, Fahleni; Mun'im, Abdul; Saputri, Fadlina Chany; Surini, Silvia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1722

Abstract

Garcinia cowa Roxb. ex DC. is a plant belonging to the Clusiaceae family, and commonly dicovered in Southeast and South Asia. This study aimed to assess the efficiency of eight natural deep eutectic solvents (NaDES) in extracting total xanthones and phenolic compounds from the stem bark using ultrasound-assisted extraction as there is limited research on the use of NaDES in this plant extraction process. The study also examined their antioxidant properties. The NaDES were synthesized with choline chloride and betaine as hydrogen-bond acceptors, accompanied by various acids, alcohols, and glucose as hydrogen-bond donors. In comparison, ethanol was used as standard solvent. The NaDES exhibited higher densities than water, ranging from 1.059 to 1.244 g/cm³, with density increasing according to the number of hydroxyl groups present in the constituents. The total phenolic content (TPC) varied from 22.82 to 28.73 mg GAE/g extract, with NaDES1 (a combination of choline chloride, 1,2-propanediol, and water in a ratio of 1:3:1) showing the highest TPC at 28.73±0.18 mg GAE/g extract. It also exhibited significant antioxidant activities, as demonstrated by DPPH (28.98±0.03 µg/mL) and FRAP assays (43.66±1.51 mmol trolox/g dw). A significant negative correlation was observed between total xanthone, total phenolic content, and IC50 values. These findings suggest that NaDES, particularly NaDES1, have considerable advantages in extracting phenolic compounds and xanthones from G. cowa stem bark, resulting in enhanced antioxidant properties.This highlights the potential of NaDES as eco-friendly and effective solvents for the extraction of bioactive compounds from plant materials.
Co-Authors . Katrin Adisti, Adisti Agus Purnomo Aksa, Awaluddin Al Maghfuri, Rahmah Salsabila Alwi, Ratna Surya Amalia, Halisa Amalia, Sariayuningsi Aminuddin, Lutfi Hadi Aryani, Dewi Cahyani, Siti Rosidah Donna Maretta Ariestanti Erly Juliyani Fadhila, Redhalfi Fadlina Chany Saputri Fahleni Fahleni Febrina Amelia Saputri, Febrina Amelia Firdayani Hadi, Abd Hasan, Nahrul Hayun Hayun Herman, MJ. Hherman, M Hiola, Dewi Suryaningsi Hunawa, Rachmawaty Dirham Hutami, Riska Amalia Putri Irma Rumtianing Uswatul Hanifah James, Richard Johari Joshita Djajadisastra, Joshita Khoirun Nisa Kristanty, Ruth Elenora Lukman Santoso Magfirah, Anisah Maghfuri, Rahmah Salsabila Al Mamin, Ratnawaty Miftachul Ulum, Miftachul Miftahul Huda Musyabirah, Musyabirah Ni Putu Ermi Hikmawanti Noorwati Sutandyo Nur Asma Prisnu Tirtanirmala Putri, Chinthia Rahadi Putri, Meira Amalia Putri, Salsabila Nursyifa Raharni Raharni RAMADON, DELLY Ramlawati Ramlawati Ridho Rokamah Sarjaini Jamal Septiani, Rosalina Mesusi Silvia Surini Sri Wardatun Sriana Azis Sudibyo Supardi Suliasih, Babay Asih Suswidiantoro, Vicko Syam, Farha Mutia Wirda Y Dulahu Yahdiana Harahap Yumita, Agustin Yunus, Sitti Rahma Zawawi, Abdullah