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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Ners JOURNAL LA MEDIHEALTICO Open Access Indonesian Journal of Medical Reviews Cermin Dunia Kedokteran Journal of Social Research COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat MEDICINUS Proceeding ISETH (International Summit on Science, Technology, and Humanity) Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia
Widhiati, Suci
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Relationship of Over the Counter (OTC) Facial Soap Usage and Acne Risk in Sebelas Maret University Medical Students Jalasena Mysea, Marsyanda; Kusumawardani, Arie; Murasmita, Alamanda; Widhiati, Suci
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 3 (2024): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.3.2024.191-195

Abstract

Background: Acne vulgaris (AV) is a common inflammatory skin disorder among young adults. The use of over-the-counter (OTC) facial soap is a common practice for managing AV, but the impact of its frequency on acne severity remains unclear. Purpose: This study aims to determine the relationship between the frequency of OTC facial soap usage and the severity of acne vulgaris among medical students at Sebelas Maret University. Methods: This observational analytical study utilized a cross-sectional approach and involved 57 medical students at Sebelas Maret University. The questionnaire focused on the frequency of OTC face wash usage among participants. Data were analyzed using Chi-square tests and Spearman-Pearson correlation methods. Result: There is a significant relationship (p = 0.089) between the frequency of OTC face wash usage and the risk of acne vulgaris, with a weak negative correlation (r = -0.226, p = 0.092). This study set a significance level of 0.1, higher than the conventional 0.05, which limits the generalizability of the results. This decision was made to balance the accuracy of the findings with the available resource constraints. Conclusion: There’s a significant correlation between OTC facial soap usage and acne risk in Sebelas Maret University medical students, with more frequent use linked to reduced acne severity.
Topical Fermented Lactobacillus acidophilus Lysate Accelerates Second-Degree Burn Healing: An In Vivo Study in Wistar Rats Kamilah, Lian; Kusumawardani, Arie; Widhiati, Suci; Dharmawan, Nugrohoaji; Ellistasari, Endra Yustin
Open Access Indonesian Journal of Medical Reviews Vol. 5 No. 4 (2025): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v5i4.725

Abstract

Second-degree burns, affecting the epidermis and dermis, constitute a major category of thermal injuries globally, presenting significant clinical challenges including pain, infection risk, and potential scarring. While standard treatments like silver sulfadiazine (SSD) exist, limitations including potential cytotoxicity and emerging resistance necessitate exploration of novel therapeutic strategies. Recent interest has focused on topical applications derived from probiotics, such as Lactobacillus spp., due to their suggested roles in modulating inflammation, combating oxidative stress, and providing antimicrobial activity to accelerate wound repair. This study investigated a fermented lysate derived from Lactobacillus acidophilus (L. fermented) as a potential topical agent for burn healing. This study aimed to evaluate the therapeutic efficacy of a 5% topical L. fermented ointment on the healing process of experimentally induced second-degree burns in a Wistar rat model, primarily by assessing the rate of wound closure compared to standard SSD treatment and an untreated control. A true experimental in vivo study utilizing a post-test only control group design was performed following ethical approval. Fifteen male Wistar rats were subjected to a standardized second-degree thermal burn injury on their dorsal aspect. The animals were then randomized (n=5 per group) to receive twice-daily topical applications of either 5% L. fermented ointment (Group A), SSD ointment (Group B), or no treatment (Control, Group C). Wound healing was quantitatively assessed by measuring the wound surface area (mm²) on days 1, 3, 7, and 14 post-injury using digital imaging and ImageJ software analysis. Statistical comparisons between groups were conducted using one-way ANOVA followed by LSD post-hoc tests, with statistical significance set at p<0.05. All treatment groups demonstrated a significant reduction in wound size over the 14-day observation period (p=0.001 within each group). Inter-group comparisons revealed significantly accelerated wound closure in Group A starting from day 3 onwards (p<0.005). At day 14, the mean wound area in Group A (17.5 ± 8.06 mm²) was significantly smaller than in Group B (119.22 ± 45.41 mm²) and Group C (305.18 ± 25.21 mm²) (p=0.001). Post-hoc analysis confirmed the superiority of L. fermented treatment over both SSD (mean difference 101.72 mm², p=0.001) and control (mean difference 287.68 mm², p=0.001). SSD treatment also resulted in significantly better healing than the control group (mean difference 185.96 mm², p=0.001). In conclusion, topical application of 5% fermented Lactobacillus acidophilus lysate significantly accelerated the closure of second-degree burn wounds in Wistar rats, demonstrating superior efficacy compared to both silver sulfadiazine treatment and no treatment. These findings highlight the potential of L. fermented lysate as a promising novel therapeutic agent for burn wound management.
Reduction of Interleukin-6 after PRP-Exosomes Treatment in A Mouse Model of Androgenetic Alopecia Ellistasari, Endra Yustin; Widhiati, Suci; Julianto, Indah; Rosmarwati, Ervina; Monica, Pristia Widya; Yasmin, Aulia
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5508

Abstract

Purpose: This study aim to determine the role of platelet-rich plasma (PRP) exosomes as anti-inflammatory (IL-6) in a mouse model of androgenetic alopecia. Methodology: There are four group of androgenetic alopecia mice model with no treatment group (control group, K1), group treated with PRP-exosomes (K2), group treated with 5% topical minoxidil (K3) and the last group treated with combination of PRP-exosomes and 5% topical minoxidil (K4). All of the group was evaluated clinically and immunohistochemical examination of IL-6 was performed on the 32nd day. Results: Better hair growth results were obtained in the treatment group compared to the control group. In clinical evaluation, K4 had the best results, followed by K2 and K3. The expression of IL-6 is highest in the K1, followed by K4, K2 and K3 and statistically significant. Applications/Originality/Value: PRP-exosomes can enhance hair growth in androgenetic alopecia mice model. IL-6 expression in the control group is significantly higher than in the treatment group.
STUDI RETROSPEKTIF HEMANGIOMA INFANTIL DI RUMAH SAKIT PUSAT RUJUKAN DI SURAKARTA JAWA TENGAH Widhiati, Suci; Rahma, Alfina; Ellistasari, Endra Yustin; Nareswari, Adniana
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.398

Abstract

   Pendahuluan: Hemangioma infantil (HI) merupakan tumor jinak vaskular yang muncul dalam beberapa minggu pertama kehidupan. Prevalensi HI secara global sekitar 4,5%. Umumnya HI tidak memerlukan terapi dan mengalami regresi spontan, namun 10-15% akan mengakibatkan komplikasi seperti obstruksi, ulserasi atau cacat. Tujuan penelitian ini untuk mengetahui karakteristik pasien baru HI di instalasi rawat jalan RSUD Dr. Moewardi Surakarta periode 1 Januari 2019 - 31 Desember 2021. Metode: Metode penelitian ini merupakan retrospektif dengan desain potong lintang, Data diambil dari rekam medis pasien hemangioma yang datang ke Instalasi Rawat Jalan RSUD Dr. Moewardi Surakarta periode 1 Januari 2019 - 31 Desember 2021. Hasil: Terdapat 135 pasien yang didiagnosis HI dengan kisaran usia 7 hari hingga 13 tahun. Kelompok usia terbanyak adalah 0-1 tahun sebanyak 69 pasien (51,11%), perempuan sebanyak 88 pasien (65,19%). Awitan terbanyak usia < 2 bulan yaitu 94 pasien (69,63%). Ujud kelainan kulit terbanyak berupa nodul sebanyak 101 pasien (74,81%), soliter pada 124 pasien (91,85%). Predileksi pada kepala dan leher sebanyak 76 pasien (56,29%). Pasien lahir aterm sebanyak 111 pasien (82,22%), berat badan lahir cukup 123 pasien (91,11%). Riwayat persalinan pervaginam 100 pasien (74,07%). Modalitas terapi terbanyak propranolol pada 37 pasien (27,42%). Kesimpulan: Gambaran HI di RSUD Dr. Moewardi Surakarta berdasarkan awitan, predileksi, jumlah lesi, manifestasi klinis dan terapi sesuai dengan deskripsi teori, namun faktor risiko yang diteliti tidak sejalan dengan teori. 
Gambaran Penuaan Kulit Ditinjau dari Tingkat Keparahan Kerutan Wajah pada Perokok di Lingkungan Karyawan Kantor Universitas Sebelas Maret Purnomo, Frederick Johan; Sari, Endra Yustin Ellista; Widhiati, Suci
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 1 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i1.3077

Abstract

Penuaan kulit merupakan proses yang dipengaruhi oleh faktor intrinsik dan ekstrinsik. Merokok, sebagai faktor ekstrinsik, diketahui dapat mempercepat penuaan kulit melalui penurunan produksi kolagen dan peningkatan aktivitas matriks metalloproteinase (MMP). Penelitian ini bertujuan untuk menganalisis hubungan antara kebiasaan merokok dan tingkat keparahan kerutan wajah pada karyawan kantor di Universitas Sebelas Maret. Penelitian ini merupakan studi observasional analitik dengan desain cross-sectional yang melibatkan 68 laki-laki perokok aktif berusia 30–39 tahun. Kebiasaan merokok dikategorikan berdasarkan pack-years menjadi perokok ringan, sedang, dan berat. Penilaian kerutan wajah dilakukan dengan Daniell’s 6-point wrinkle scale oleh dua dokter spesialis kulit. Analisis hubungan dilakukan dengan uji korelasi Spearman (p<0,05). Hasil menunjukan sebanyak 45,6% subjek tergolong perokok ringan, 39,7% perokok sedang, dan 14,7% perokok berat. Penilaian menunjukkan 70,6% memiliki kerutan ringan, 25% kerutan sedang, dan 4,4% kerutan berat. Terdapat korelasi signifikan antara kebiasaan merokok dan keparahan kerutan wajah (p=0,001; P=0,474). Terdapat hubungan positif yang signifikan antara kebiasaan merokok dan tingkat keparahan kerutan wajah. Hasil ini memperkuat bukti bahwa merokok mempercepat penuaan kulit, khususnya dalam pembentukan kerutan.
Topical Polypeptide Gel in Diabetic Ulcers: Clinical Insights Into a New Adjunctive Treatment Modality Octarica, Stella Gracia; Widhiati, Suci; Ellistasari, Endra Yustin; Dharmawan, Nugrohoaji; Julianto, Indah
Journal of Social Research Vol. 4 No. 9 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i9.2794

Abstract

Diabetic ulcers are a common and challenging complication of diabetes, contributing to morbidity, infection, and a high risk of amputation. Innovative adjuncts, such as topical polypeptide gel, which contains amino acids to support tissue regeneration, are proposed to accelerate wound healing; however, supporting clinical data are limited. A quasi-experimental analysis was conducted in 11 patients. Each received a daily topical 7% polypeptide gel in addition to standard care. Ulcer area was measured at baseline (day 0) and after 14 days using digital documentation analysis using ImageJ. The primary outcome was the percentage reduction in ulcer size. Patients were analysed for associations between percentage of improvement with age, gender, diabetes type, and ulcer site. Eleven patients with diabetic ulcers completed the 14-day treatment protocol. The cohort comprised 54.5% females with a mean age of 54.1 ± 7.3 years and predominantly insulin-dependent diabetes (72.7%). Baseline ulcer area averaged 982.1 ± 1315.1 mm², reducing to 184.0 ± 297.7 mm² by day 14, representing an 86.2 ± 6.7% mean area reduction. All patients achieved ?76% healing, with 45.5% achieving ?90% area reduction and 9.1% achieving complete healing. The Wilcoxon signed-rank test demonstrated statistically significant ulcer area reduction (Z = -2.934, p = 0.003). No significant associations were found between healing percentage and patient demographics, diabetes type, ulcer location, or comorbidity burden (all p > 0.05). No treatment-related adverse events were reported during the study period. Topical polypeptide gel demonstrated rapid wound surface area reduction in the majority of the subjects over 14 days, independent of patient age, gender, diabetes type, or ulcer location. These findings suggest its promise as an adjunctive early-phase therapy for diabetic ulcers.
Maternal Atopy Diathesis on The Newborn’s Skin Acidity and Hydration Putri, Osdatilla Esa; Widhiati, Suci; Mawardi, Prasetyadi; Kusumawardani, Arie; Mulianto, Nurrachmat; Hidayah, Dwi; Endraputra, Pristiawan
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50222

Abstract

Background: Atopic diathesis, a hereditary predisposition to allergic disorders such as atopic dermatitis, asthma, and allergic rhinitis, is more strongly transmitted maternally. Maternal atopy may influence neonatal skin barrier development, but evidence on its effect on neonatal skin pH and hydration is limited. Methods: This cross-sectional study was conducted at Dr. Moewardi General Hospital, Surakarta, Indonesia, between March–April 2025. Neonates (28–41 weeks gestation), <24 hours old, and delivered by cesarean section were included. Skin pH was measured on the volar forearm and axilla using a calibrated pH meter, and hydration (water and oil content) was assessed with a Skin Tester. Maternal atopy diathesis was classified by the Erlangen Atopy Score (EAS). Results: Twenty-nine neonates were enrolled, comprising 12 with and 17 without maternal atopy. No significant association was found between maternal atopy and neonatal hydration (water: p = 0.460; oil: p = 0.997) or skin pH (p = 0.876). Conclusion: Maternal atopy diathesis was not associated with neonatal skin pH or hydration in the first 24 hours of life. Early neonatal skin physiology appears to be influenced more by intrinsic maturation than maternal atopic status. Longitudinal studies are needed to assess potential delayed effects.
Co-Authors Alia, Vrenda Aliwardani, Ambar Aulia Yasmin, Aulia Bunga, Gita Hening Dewi, Putti Fatiharani Dewi, Susanti Rosmala Dharmawan, Nugrohoaji Dita Eka Novriana Dwi Hidayah Ellistari, Endra Yustin Ellistasari, Endra Yustin Endraputra, Pristiawan Febriani, Dina Hapsari, Jasmine Rahmi Harahap, Irene Jessica Pinarsinta Indah Julianto, Indah Irawanto, Muhammad Eko Jalasena Mysea, Marsyanda Kamilah, Lian Kariosentono, Harijono Kusumawardani, Arie Lidjaja, Lifesia Natali Marcella, Benazier Mochtar, Moerbono Monica, Pristia Widya Mulianto, Nurachmat Murasmita, Alamanda Nareswari, Adniana Noviani, Laura Nurrachmat Mulianto Octarica, Stella Gracia Paramitasari, Anggana Rafika Prasetyadi Mawardi Purnomo, Frederick Johan Purwoko, Agus Putri, Osdatilla Esa Rahma, Alfina Rosita, Fiska Rosmarwati, Ervina Sari, Endra Yustin Ellista Triasari Oktavriana Yudhistira, Muhammad Yurizar