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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Medical Journal of Indonesia Jurnal Kesehatan Andalas Indonesian Journal of Cardiology Majalah Kedokteran Andalas Jurnal Biomedika dan Kesehatan Human Care Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Penelitian dan Pengkajian Ilmiah Jurnal Kedokteran Meditek Seroja Husada: Jurnal Kesehatan Masyarakat
Yanni, Mefri
Universitas Andalas
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Double set up technique as a bailout of diagonal branch coronary perforation: a case report Syukri, Muhammad; Yanni, Mefri; Syafri, Masrul; Phalguna, Shindu; Firmansyah, Alles; Indah, Merlin Sari Mutma; Mahendra, Ivan; Zulkarnain, Hadi
Medical Journal of Indonesia Vol. 33 No. 1 (2024): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.247266

Abstract

Coronary artery perforation is a rare but potentially life-threatening complication of percutaneous coronary intervention (PCI). A 55-year-old male with a history of implanted stent on the left main ostium to the proximal left circumflex artery (LCX) and distal right coronary artery, and chronic total occlusion (CTO) on ostium left anterior descending (LAD). PCI was performed using a stiff wire to cross the CTO body in LAD. We performed an injection and confirmed the presence of extravasation. We successfully managed to stop the bleeding by placing the tips of floppy wire that were cut into pieces. A drainage pathway was made through thoracotomy for pericardial effusion. Angiography showed persisting extravasation at the wire insertion site. We then made our own covered stent. We implanted on the osteal LAD until proximal LCX. Repeated angiography showed no contrast extravasated from the perforation site, and the patient was stabilized and discharged.
In Vitro Analysis of SCUBE1 Expression in Aortic Vascular Smooth Muscle Cells on Atherosclerosis Progression Rasya, Salsabila Faiha Wiendra; Ali, Hirowati; Yanni, Mefri; Rita , Rauza Sukma; Asri , Aswiyanti; Mahata , Liganda Endo; Putri , Biomechy Oktomalio; Yarni , Sisca Dwi
Jurnal Kedokteran Meditek Vol 32 No 3 (2026): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i3.4015

Abstract

Background:  Signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is a platelet–endothelial glycoprotein implicated in thrombosis and vascular inflammation, and has been detected within atherosclerotic lesions. Whether vascular smooth muscle cells (VSMCs) upregulate SCUBE1 under inflammatory stimuli remains unclear. Objective:  To quantify SCUBE1 mRNA expression in rat aortic VSMCs following lipopolysaccharide (LPS) exposure in an organ-culture model of atherogenesis. Methods: This study aimed to analyze SCUBE1 expression in aortic VSMCs in atherosclerosis using real-time PCR. This study was a true experimental-post test control group design using organ culture. The aorta from six wistar rats were divided into two groups, consisting of five samples that were not induced with LPS and five samples exposed to LPS at a concentration of 10 µg/mL for 48 hours. Expression of the SCUBE1 gene was then analyzed using real-time PCR. The data was then processed using the dependent T-Test. Results: The result showed LPS increased SCUBE1 transcript levels compared with control (mean ± SD: 0.78 ± 0.22 vs 0.44 ± 0.35), representing a non-significant trend toward induction (p=0.07). These preliminary data are consistent with SCUBE1’s inducibility in inflammatory states and its presence in atherosclerotic tissue. Conclusion: This study revealed increased SCUBE1 gene expression in aortic VSMCs in the LPS-treated group. These data suggest that SCUBE1 has the potential to be a marker of endothelial dysfunction in atherosclerosis.
Comparison of right ventricular global longitudinal strain between pacemaker lead position in patients with permanent pacemaker Muhamad Fakhri; Hauda El Rasyid; Mefri Yanni; Rizanda Machmud
Jurnal Kardiologi Indonesia Vol 47 No 2 (2026): April - June, 2026
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2233

Abstract

In “Comparison of right ventricular global longitudinal strain between pacemaker lead position in patients with permanent pacemaker” (Indonesian Journal of Cardiology, 46(2), 64-70. https://doi.org/10.30701/ijc.1592), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1592. The error occurs only in the PDF; the DOI listed in the article metadata is already correct. The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.1592
The Difference in Endothelial Nitric Oxide Synthase Levels in STEMI Patients With Comorbid Diabetes Mellitus And Those Without Comorbid Diabetes Mellitus at RSUP. Dr. M. Djamil Padang Muhammad Bhagus Andina Putra; Eka Fithra Elfi; Rauza Sukma Rita; Mefri Yanni; Miftah Irramah
CENDEKIA : Jurnal Penelitian dan Pengkajian Ilmiah Vol. 3 No. 6 (2026): CENDEKIA : Jurnal Penelitian Dan Pengkajian Ilmiah, Juni 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/cendekia.v3i6.2695

Abstract

Background: Cardiovascular disease is a leading cause of global mortality, with Indonesia ranking third in the highest cardiovascular deaths. Acute myocardial infarction, divided into STEMI and NSTEMI, is part of the acute coronary syndrome due to total occlusion of coronary arteries requiring immediate revascularization. Diabetes Mellitus reduces endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, leading to endothelial dysfunction and an increased risk of vascular disease. DM-related endothelial dysfunction affects vascular relaxation and the formation of atherosclerotic plaques as well as thrombi in ST-elevation myocardial infarction (STEMI). Methods: This research was an analytical observational study with a cross-sectional approach, using normality tests and the Mann-Whitney U Test. The research sample was collected using consecutive sampling techniques and obtained from the medical records of 72 confirmed STEMI patients, with and without comorbid Diabetes Mellitus. Results: The research results indicated that the majority of patients were in the age range of 60-69 years (52.7%), male (86.1%), with a Body Mass Index (BMI) of 23-24.9 (45.8%), comorbid hypertension (52.7%), and a history of smoking (72.3%). The mean eNOS level in the control group was Median eNOS 38,839 U/mL with maximum level 584,762 U/ml and minimum 17,024 U/ml. Median eNOS level in the test group was 36,077 U/mL with the maximum level 679,754 U/ml and minimum 1,836 U/ml. Conclusions: There was no significant difference in eNOS levels between the two groups (Sig (2-Tailed) > 0.05).
Comparison of right ventricular global longitudinal strain between pacemaker lead position in patients with permanent pacemaker Muhamad Fakhri; Hauda El Rasyid; Mefri Yanni; Rizanda Machmud
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1592

Abstract

Background: The implantation of a permanent pacemaker (PPM) can reduce right ventricular function. Echocardiography using speckle tracking can detect a decreasing in right ventricular function earlier. The value of right ventricular global longitudinal strain (RVGLS) based on the location of the pacemaker lead between the apex and non-apex was currently unknown, although the placement of the correct pacemaker lead location was very important for evaluating right ventricular dysfunction to prevent right heart failure. This study aims to determined the comparison of RVGLS between pacemaker lead position in patients with permanent pacemaker. Methods: This study was a nested case-control study to assess the comparison of RVGLS between pacemaker lead position in patients with permanent pacemaker, who were divided into the right ventricular apex group (RVA) and the non-right ventricular apex group (NRVA). This study used data from the pacemaker registry and medical records of patients who had undergone pacemaker implantation since June 2021. The shapiro-wilk normality test was performed before analyzing all numerical data, followed by an independent t-test or Mann-Whitney test to determine the differences between groups. Results: In this study, there were 38 patients with permanent pacemakers, consisting of 18 samples with RVA group and 20 samples with NRVA group. In this study, no significant differences were found in age, sex, diagnosis, comorbidities, therapy, pacemaker mode, baseline QRS duration, pacing burden, puncture site, and initial echocardiography between of two groups. There was a significant difference in paced QRS duration between the RVA and RVNA groups (160 + 20 ms vs 140 + 28 ms, p=0.024). Based on statistical analysis, there was a significant difference in the value of RVGLS in the RVA group compared to the RVNA group (-14.87+4.48% vs -18.40+3.21%, p=0.015). Conclusion: The position of the apex right ventricular lead resulted in a lower value of RVGLS compared to the position of the non-apex right ventricular lead.
Soluble ST2 as a Marker of Subclinical Right Ventricular Dysfunction in Pulmonary Hypertension Associated With Congenital Heart Disease Fadhil Alfino Azmi; Mefri Yanni; Kino Kino; Hirowati Ali
Jurnal Kardiologi Indonesia Online First
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1930

Abstract

Background: Congenital Heart Disease with Pulmonary Hypertension (CHD-PH) increases Right Ventricular (RV) afterload, which may lead to subclinical myocardial impairment before overt systolic dysfunction becomes apparent. Early detection is crucial to prevent progression to right heart failure. Global Longitudinal Strain (GLS) by echocardiography is sensitive for identifying subclinical RV dysfunction despite preserved conventional systolic parameters, but the role of molecular biomarkers remains unclear. Soluble Suppression of Tumorigenicity 2 (sST2) has been proposed as a potential biomarker for subclinical RV dysfunction. This study aims to compare sST2 levels in CHD-PH patients with and without subclinical RV dysfunction as assessed by RV-Global Longitudinal Strain (RV-GLS). Methods: This cross-sectional study included adult CHD-PH patients (≥18 years) at the Integrated Heart Center, RSUP M. Djamil Padang, from January to June 2025. All participants underwent right heart catheterization and had preserved RV systolic function, as assessed by conventional echocardiography (Three-Dimensional Right Ventricular Ejection Fraction [3D RVEF] ≥45%). RV-GLS was assessed using Speckle-Tracking Echocardiography (STE), and serum sST2 levels were measured. Patients were categorized into subclinical RV dysfunction (GLS > –20%) and without subclinical RV dysfunction (GLS ≤ –20%) groups. Statistical analysis was performed to compare sST2 levels between groups. Results: Thirty-four patients were included (82% female, mean age 37.8 ± 15.6 years), with secundum Atrial Septal Defect (ASD) as the most common etiology (71%). Median sST2 levels in patients with CHD-PH without subclinical RV dysfunction were 15.65 (6.05–40.90) ng/mL, with a GLS of –20.50 (–27.20 to –20.00)%. In patients with CHD-PH with subclinical RV dysfunction, median sST2 was 15.15 (5.25–47.60) ng/mL, with a GLS of –11.80 (–19.90 to –6.20)%. No statistically significant difference in sST2 levels was observed between groups (p = 0.89). In contrast, patients with CHD-PH with subclinical RV dysfunction exhibited significantly higher indexed Pulmonary Arterial Resistance (PAR) and pulmonary-to-Systemic Vascular Resistance ratio (PAR/SVR ratio), indicating increased pulmonary vascular load despite preserved conventional RV systolic function. Conclusion: sST2 levels did not differ significantly between CHD-PH patients with subclinical RV dysfunction and those without. Subclinical RV dysfunction was associated with higher pulmonary vascular load, as reflected by increased indexed PAR and PAR/SVR ratio, despite preserved conventional RV systolic function. From this may conclude that subclinical RV myocardial impairment in CHD-PH is more closely related to hemodynamic afterload than to molecular stress biomarkers alone. These findings suggest that sST2 alone may have limited utility as a biomarker for detecting subclinical RV myocardial impairment in this population.
Perbedaan Fungsi Ventrikel Kanan pada Pasien Hipertensi Arteri Pulmonal Akibat Penyakit Jantung Bawaan dan Tanpa Penyakit Jantung Bawaan Fatimah Azzahra; Mefri Yanni; Erlina Rustam; Noverika Windasari; Shinta Ayu Intan
Jurnal Ilmu Kedokteran Vol 20, No 1 (2026): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v20i1.2026.94-104

Abstract

Pulmonary arterial hypertension (PAH) leads to right ventricular (RV) dysfunction due to chronic volume overload in congenital heart disease (CHD) or pressure overload in isolated PAH. This study aimed to evaluate differences in RV function between PAH patients with and without CHD, given their distinct pathophysiological mechanisms. A cross-sectional analytical study was conducted using medical records from Dr. M. Djamil Padang Hospital (2023–2024), including 54 patients (27 per group) selected via consecutive sampling. Bivariate analysis using the Chi-square test was employed to compare standard echocardiographic parameters: three-dimensional ejection fraction (3DEF), tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), S', and RV Strain. The results revealed no significant differences in RV function parameters between the two groups: 3DEF (p=0.773), TAPSE (p=0.293), FAC (p=0.224), S' (p=1.000), and RV Strain (p=0.559). Furthermore, median values for 3DEF, TAPSE, FAC, and S' were within normal limits, whereas mean RV Strain values were in the abnormal range for both study groups. In conclusion, despite the differing underlying pathophysiologies, there is no significant difference in right ventricular function between patients with PAH due to CHD and those without CHD.
Co-Authors Abdiana Abdiana, Abdiana Adhi Kurniawan Alya Binti Azmi Amel Yanis Andy Rahman Ariani, Novita Arina Widya Murni Asri , Aswiyanti Aulia Rahman Aulia Rahman Citra Kiki Krevani Deddy Saputra Dede Jumatri Tito Efrida Efrida Eka Fithra Elfi, Eka Fithra Ennesta Asri Erlina Rustam Fadhil Alfino Azmi Fatimah Azzahra Finesa Hasye Firmansyah, Alles Gunawan Gunawan Gusti Revilla Harahap, Hana Yulia Rahmi Hauda El Rasyid Hauda El Rasyid Hendra Permana Herman, Deddy Hirowati Ali Hirowati Ali, Hirowati Ihsan Otriami Ilmiawati, Ilmiawati Indah, Merlin Sari Mutma Intan, Shinta Ayu Jamil, Muhammad Irfan Kino Kino Linosefa Linosefa Mahata , Liganda Endo Mahendra, Ivan Masrul Syafri Masrul Syafri Masrul Syafri Mentari Brillianti Permataranny Miftah Irramah Mohamad Reza Muhamad Fakhri Muhamad Fakhri Muhammad Bhagus Andina Putra Muslimah Utami Raihani Nabila, Sarah Nandia Rizkita Nani Nani Nia Kasmiati Noer , Mustafa Noverika Windasari Phalguna, Shindu Prima, Yudhi Leo Putri , Biomechy Oktomalio Rasya, Salsabila Faiha Wiendra Rauza Sukma Rita Rayhansyah, Vito Rita , Rauza Sukma Rita Hamdani Rizanda Machmud Salsa Oktarin Letmi Saptino Miro Sitifa Aisara Syaiful Azmi Ulya Uti Fasrini Ulzim Fajar Ulzim Fajar Vera Yulia Wijaya, Harwin Wiwik Handayani Yarni , Sisca Dwi Yasmin Nabila Ramadhani Yayi Suryo Prabandari Yerizal Karani Yudhi Leo Prima Zulkarnain, Hadi