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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Transformasi: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Ilmiah Universitas Batanghari Jambi Journal Of Vocational Health Studies Jurnal Keperawatan Padjadjaran Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Medik Veteriner Jurnal Ilmu Kefarmasian Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology International Journal of Social Service and Research KESANS : International Journal of Health and Science Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Folia Medica Indonesiana
Indiastuti, Danti Nur
Department Of Anatomy, Histology, And Pharmacology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Antibacterial Effects of Basil (Ocimum sanctum) Leaf Extract in Combination with Meropenem against Extended Spectrum Beta-Lactamase (ESBL) Producing Klebsiella pneumoniae Lifindra, Billy Yanssen; Wiqoyah, Nurul; Indiastuti, Danti Nur
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.88-93

Abstract

Highlights: Ocimum sanctum leaf extract does not significantly increase its antibacterial effects when combined with meropenem against ESBL-producing K. pneumoniae. Ocimum sanctum leaf extract has different antibacterial effects depending on geological and environmental factors.   Abstract Introduction: Antibiotic usage for bacterial infections causes antibiotic resistance in bacteria. One is extended-spectrum beta-lactamase (ESBL), which produces Klebsiella pneumoniae, a pathogen responsible for increased antibiotic resistance. Basil (Ocimum sanctum) is a candidate for combination therapy. It has been proven to have antibacterial effects. However, its combination with antibiotics is rarely researched. This study evaluated the antibacterial effects of O. sanctum leaf extract and meropenem combination against ESBL-producing K. pneumoniae. Methods: This study used the disk diffusion method. The extract was tested for each experiment at 6%, 4%, 2%, 1%, and 0.5% concentration. The research was divided into two experiments to evaluate the antibacterial effects of O. sanctum leaf extract (n=18) and its combination with meropenem against ESBL-producing K. pneumoniae (n=18). The data was analyzed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 26.0 for Windows. A probability p<0.050 was considered significant. Results: The first experiment showed that the extract had the largest antibacterial effect at 0.5% concentration (n=18, p=0.007). Meanwhile, the second experiment showed that the combination of the extract and meropenem did not have significant antibacterial effects (n=18, p=0.597). Conclusion: Ocimum sanctum leaf extract has viable antibacterial effects, but its combination with Meropenem does not significantly improve its antibacterial effects against Extended Spectrum Beta-Lactamase (ESBL) producing K. pneumoniae.
INHIBITORY ACTIVITY OF ALLIUM SATIVUM L. EXTRACT AGAINST STREPTOCOCCUS PYOGENES AND PSEUDOMONAS AERUGINOSA Savitri, Natasha Hana; Indiastuti, Danti Nur; Wahyunitasari, Manik Retno
Journal of Vocational Health Studies Vol. 3 No. 2 (2019): November 2019 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.829 KB) | DOI: 10.20473/jvhs.V3.I2.2019.72-77

Abstract

Background: One of the most common health problems is infectious diseases. Infectious disease can be caused by bacteria. There were two groups of bacteria based on the staining, Gram-positive and Gram-negative bacteria. Purpose: Antibiotics are the main therapy used in the incidence of bacterial infections. But over time, some antibiotics became resistance. Several studies have shown that garlic has an antibacterial effect. The content of allicin, ajoene, saponins, and flavonoids is found in garlic which has antibacterial properties. The antibiotic activity test of garlic was carried out on the bacteria Streptococcus pyogenes and Pseudomonas aeruginosa. The goal of this study is to investigate the antibacterial effect of Allium sativum L. extract against Streptococcus pyogenes and Pseudomonas aeruginosa. Method: Garlic extract was made using the maceration method using 96% alcohol as the solvent. Tube dilution method elected to observe garlic antibiotic activity. This test aims to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). There were eight different concentration used, i.e. 2 grams/ml, 1 gram/ml, 0.5 gram/ml, 0.25 gram/ml, 0.125 gram/ml, 0.0625 gram/ml, 0.03125 gram/ml, and 0.015625 gram/ml. Replication is done three times. Result: In this experiment, the extract produced was turbid that MIC could not be determined and there was no momentous differentiation between before and after treatment. There was no growth of Streptococcus pyogenes in 1 gram/ml and Pseudomonas aeruginosa in 0.5 gram/ml. This number indicates the MBC for each bacteria. Conclusion: Garlic (Allium sativum L.) has an effect of bactericidal activity, it can perform as an antibacterial for Streptococcus pyogenes and Pseudomonas aeruginosa. Garlic extract was more effective for Pseudomonas aeruginosa than Streptococcus pyogenes.
The Role of Vitamin C Supplementation in Preventing Severity Progression in Mild and Moderate COVID-19 Patients at Universitas Airlangga Hospital Arifandi, Yoga Akbar; Rosyid, Alfian Nur; Indiastuti, Danti Nur; Effendi, Wiwin Is
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.63-69

Abstract

Highlights: The administration of different dosages of vitamin C significantly yields different outcomes in preventing the progression of disease severity. Most patients with mild and moderate coronavirus disease (COVID-19) did not demonstrate an escalation in disease severity.   Abstract Introduction: Coronavirus disease (COVID-19) is an infectious disease that increases pro-oxidant elements and decreases antioxidants. Vitamin C functions as a potent antioxidant in humans due to its electron-donating properties.  This study aimed to explain the impact of three distinct vitamin C supplementation dosages in preventing disease severity progression among mild and moderate COVID-19 patients. Methods: This retrospective study used secondary data from 100 medical records (n=100). The subjects were classified into three categories based on the vitamin C dosage. The data were analyzed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26.0 for Windows. Results: Most of mild and moderate COVID-19 patients (78%) did not experience increased disease severity. Vitamin C supplementation significantly demonstrated a different outcome in preventing disease severity progression among the three groups (p=0.018). However, it did not significantly show any difference in reducing the duration of hospital stay (p=0.680). Conclusion: The impact of vitamin C supplementation on COVID-19 severity appeared to vary depending on the dosage administered. However, it did not affect the duration of the hospital stay.
Knowledge level of the Society about Fear of Missing Out Through Webinar in COVID-19 Pandemic Prasetyo, Hersati; Putu Agus Arsana, I; Dewi Tri Utami, Mahrumi; Nur Indiastuti, Danti
Jurnal KESANS : Kesehatan dan Sains Vol 1 No 5 (2022): KESANS : International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v1i5.44

Abstract

The COVID-19 pandemic situation causes many people to be confined at home and triggers people to tend to spend more time accessing social media. Social media basically shows activities carried out by other people and this can trigger the phenomenon of Fear of Missing Out (FoMO). The purpose of this study is to know the level of knowledge of the Indonesian society about the FoMO and how to overcome it in the era of the COVID-19 pandemic. This study is a type of descriptive survey study; it describes the level of society knowledge about FoMO through webinars during the COVID-19 pandemic. The sample is 779 people who have met the inclusion and exclusion criteria. The data was obtained through a google form which was distributed to webinar participants, then processed and described in the form of a distribution table of respondents along with the average post-test results on a scale of 7 and 100 for the age group. The collected data were 779 respondents from different age groups (12-55 years). All existing age groups can answer more than half of the questions correctly. The average of questions answered correctly was almost the same in all age groups, with the 41–45-year-old group being in the top position. The average post-test result from all age ranges was 69.57. The average level of society knowledge about the FoMO phenomenon and how to solve it through webinar in the COVID-19 pandemic which was known from the post-test scores did not show much different results between each age range. This shows that all age ranges have the same susceptibility to experiencing FoMO.
Mental Health Status and Literacy of Adolescent in Rural Area of Mojokerto, East Java, Indonesia Ardana, Arin Aurilia; d'Arqom, Annette; Puteri, Fira Adilah; Indiastuti, Danti Nur; Nasution, Mhd Zamal; Hasanatuludhhiyah, Nurina; Qorib, Mohammad Fathul; Setiawati, Yuani; Junaidah Yusof
Jurnal Psikiatri Surabaya Vol. 14 No. 2 (2025): November
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v14i2.64237

Abstract

Introduction: Adolescence is a crucial period for the development of mental health. Enhancing mental health literacy can reduce stigma and support early intervention and treatment. This study aims to examine the mental health status and mental health literacy among middle and late adolescents in a rural area of Mojokerto District, East Java, Indonesia. Methods: A total of 81 high school students from Mojokerto District participated in the study. The Depression Anxiety Stress Scale – Youth version (DASS-Y) was used to assess symptoms of depression, anxiety, and stress. Mental health literacy was measured using the Adolescent Mental Health Literacy Questionnaire (AMHL). The validity of the AMHL was tested on 30 students using Pearson correlation. Descriptive statistics were used to analyze the prevalence of mental health conditions and levels of mental health literacy. Inferential statistics were applied to explore associations between mental health status, literacy, and sociodemographic variables. Results: The results showed that 53% of students experienced symptoms of mental health problems. While most students demonstrated moderate to satisfactory mental health literacy, significant gaps remain. Enhancing literacy may help reduce stigma and improve knowledge and attitudes toward mental health. Sociodemographic factors and mental health literacy showed limited influence on mental health status. However, sex was significantly associated with both mental health literacy and mental health status (p = 0.016 and p = 0.032, respectively). Conclusion: Mental health during adolescence significantly influences adult well-being. Improving adolescent mental health literacy is crucial for early recognition, stigma reduction, and better access to mental health care.
THALASSEMIA LITERACY: INCREASING KNOWLEDGE OF ORPHAN ADOLESCENTS ON THALASSEMIA Indiastuti, Danti Nur; Doman, Zahras Azimuth; Fatimah, Nurmawati; Nasution, Mhd Zamal; d'Arqom, Annette
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 1 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i1.2024.086-095

Abstract

Thalassemia is the most common monogenic disease in Asia, including Indonesia that causes burdens for the government, patients, and families. As the sixth most non-communicable disease, thalassemia utilized IDR 600 billion in 2022 for more than 300 thousand cases. With, 3.8% of Indonesians carrying a mutation of thalassemia on their globin gene, this economic burden is projected will increase if no actions are taken. On the other hand, child marriage is reported to increase every year, including among orphans. Without proper knowledge and genetic testing on thalassemia, child marriage might contribute to the increasing of thalassemia patients. Thus, increasing knowledge on thalassemia among orphan adolescents is important. This community development uses several methods, including seminar, discussion, book, and poster, targeting the orphan adolescents (n= 40) in Mojokerta, East Java. A questionnaire on thalassemia was used to measure the knowledge, before and after the activity. The results show that the respondents have a moderate knowledge about thalassemia (median= 4 (0-9)), and increase to median=9 (3-10)) after the activities (p< 0.001). Even though overall knowledge is increased, several information including thalassemia is a genetic disease, not similar to blood cancer, not the only type of anemia (Q6), and how to diagnose thalassemia (Q9) still need to be emphasized. Taken together, direct and indirect approaches, such as seminar, discussion, book, and poster are effective in increasing thalassemia knowledge among orphan adolescents. These activities are more effective in targeting late adolescents, compared to early and middle adolescents. However, more effective methods are necessary to target Generation Z who are more familiar with the internet.
Fear Of Missing Out dan Media Sosial Saat Pandemi Covid-19 Wibowo, Idznika Nurannisa; Rusuldi, Reyna Cesariyani R.; Arnapi, Almara Diva Puteri; Adila, Vatine; Indiastuti, Danti Nur
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v7i1.5759

Abstract

Meningkatnya penggunaan media sosial selama pandemi COVID-19 telah membuat banyak individu mengalami “Fear of Missing Out (FoMO)”. Penelitian ini bertujuan untuk mengetahui hubungan antara FoMO dengan durasi penggunaan media sosial dan usia. Penelitian analitik cross-sectional ini menggunakan teknik snowball sampling serta melibatkan 836 individu. Kuesioner daring disebarkan pada tanggal 6-28 Juli 2021 di beberapa media sosial. Uji chi-square dan korelasi rank Spearman digunakan untuk mengolah data. Dominasi partisipan memiliki skor FoMO 25 atau kurang. Mayoritas sampel menggunakan media sosial 4-8 jam/hari dengan skor FoMO yang selaras, yaitu 31-36 (kuartil ketiga). Terdapat hubungan yang signifikan (χ2(6 ) = 18,967, nilai P = 0,004) serta korelasi (r = 0,116; nilai P 0,001) antara FoMO dengan durasi penggunaan media sosial. Namun tidak ditemukan hubungan yang signifikan antara FoMO dengan jenis kelamin (χ2 (3) = 4,652, P nilai = 0,199). FoMO dengan umur juga tidak berkorelasi signifikan (r-0,026; nilai P = 0,461). Terdapat hubungan yang signifikan antara nilai FoMO dengan durasi penggunaan media sosial. Tidak ada hubungan yang signifikan antara FoMO dengan jenis kelamin. FoMO memiliki hubungan yang signifikan berkorelasi positif dengan durasi penggunaan media sosial. FoMO tidak memiliki hubungan yang signifikan dengan usia.
Mortality Comparison of Using Anti Interleukin-6 Therapy and Using Standard Treatment in Severe Covid-19 Sutadji, Jonathan Christianto; Widodo, Agung Dwi Wahyu; Indiastuti, Danti Nur
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Severe Coronavirus Disease 19 (COVID-19) can cause serious lung inflammation and death. COVID-19 is characterized by a high mortality rate. This severity is associated with the overproduction of proinflammatory cytokines called "cytokine storms". One of the cytokines that play a central role is Interleukin-6 (IL-6). High IL-6 levels are associated with mortality. Expectedly, the IL-6 blockade could reduce cytokine storms and thus reduce deaths in severe COVID-19 patients. This systematic review aimed to summarize the comparison between mortality using anti-IL-6 therapy and mortality using standard treatment in severe COVID-19 patients. We systematically searched the PubMed, ScienceDirect, and ProQuest databases until 13 August 2020. After screening, twelve studies matched the inclusion criteria. The mortality of the anti-IL-6 therapy group was lower than the standard treatment group without anti-IL-6 therapy in COVID-19 patients in 10 of the 12 studies obtained. Four of the ten studies statistically found a significant difference in mortality of the anti-IL-6 therapy group and the standard treatment group. Confirmation of anti-IL-6 therapy effectiveness in reducing mortality in severe COVID-19 patients will require randomized controlled trials.
Effectiveness of a Quartet-Based Educational Game in Improving Thalassemia Knowledge and Screening Awareness Among Senior High School Students d'Arqom, Annette; Nasution, Mhd Zamal; Indiastuti, Danti Nur; Kostya, Kinesha; Savira, Nazwa Febry; Yusof, Junaidah
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 9 No. 2 (2026): February 2026
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i2.8889

Abstract

Introduction: Thalassemia is one of the most common genetic disorders in Indonesia, however, the knowledge and awareness are still low, especially in rural area. This study aimed to evaluate the effectiveness of a game-based educational tool to increasing knowledge and awareness about thalassemia among senior high school students in rural area. Methods: This quasi-experimental study explored the effectiveness of the Quartet card game in improving thalassemia knowledge and awareness among 93 high school students in rural East Java. An 11-item validated questionnaire was administered before and after the intervention. Their willingness to undergo the screening was measured in the end of the activity. Results: Prior to the intervention, the respondents had poor knowledge (2.3?±?2.8), which increased to a moderate level (7.4?±?2.9, p< 0.001) after the intervention. Even though there is an increase in knowledge and decrease in misconceptions, but some persisted, particularly regarding contagiousness and differentiation from leukemia. No associations were observed between knowledge improvement and demographic characteristics. Conclusion: The findings indicate that game-based education might enhance adolescent genetic literacy and may serve as a scalable strategy for health promotion. While effective in deliver fundamental concepts, additional strategies are needed to address persisted misconceptions and psychosocial aspects. Longer follow-up and more advanced or immersive serious games may help improve understanding and long-term knowledge retention.
Co-Authors Abdurrahman Hasyim Asy’ari Adila, Vatine Agung Dwi Wahyu Widodo Akbar Kurniawan, Mohammad Alarik L., Albertus Alimsardjono, Lindawati Anastassya Yuniar Setyo Putri Annette d’Arqom, Annette Ardana, Arin Aurilia Arifa Mustika Arifandi, Yoga Akbar Arnapi, Almara Diva Puteri Bajuber, Qonita Bakhtiar, Arief Desi Rahmah Sari Dewangga Sakti Satria Kinasih Dewi Tri Utami, Mahrumi Dinda Divamillenia Dini Indah Berlianti Doman, Zahras Azimuth Effendi, Wiwin Is Ekiyanti, Khisma Farhan Nurdiansyah Fatimah, Nurmawati Gabriel Pedro Mudjianto Gondo Mastutik Grawira Drana Putra Respati Hamzah Hamzah Hamzah Rafly Rahman Herdiyanti Herdiyanti Indri Safitri Mukono, Indri Safitri Jennifer Susanto Jihan Nur Fauziah Jonathan Christianto Sutadji Junaidah Yusof Kawilarang, Arthur Pohan Kostya, Kinesha Kusuma Eko Purwantari Kusuma, Edward Putra Lifindra, Billy Yanssen Linda Astari, Linda Maftuchah Maftuchah Mariska Nuriana Mhd Zamal Nasution Mia Ratwita Andarsini Muhammad Hafizh Muhammad Raihan Habibi Nabil Alfin Juhri Nadia Mardiana Hudan Natasya Ariesta Selyardi Putri NOOR CHOLIES Nurina Hasanatuludhhiyah Nurul Wiqoyah, Nurul Octaviana Galuh Pratiwi Pangkerego, Margareth Ayu Caroline Pascalis Fabian Peter Asa Prasetyo, Hersati Purwanta, Marijam Puteri, Fira Adilah Putu Agus Arsana, I Qorib, Mohammad Fathul Raden Mohamad Herdian Bhakti Rebekah Setiabudi, Rebekah Resti Yudhawati Rezi Ramawan Melbiarta Rezy Ramawan Melbiarta Rosyid, Alfian Nur Rusuldi, Reyna Cesariyani R. Savira, Nazwa Febry Savitri, Natasha Hana Shaohong Lai Shofiuddin Al Mufid Sri Purwaningsih Sri Ratna Dwiningshih Sutadji, Jonathan Christianto Trisnawati Trisnawati Trisniartami Setyaningrum Wahyunitasari, Manik Retno Wibowo, Idznika Nurannisa Wiwin Retnowati Yuani Setiawati Yusof, Junaidah Zamal Nasution