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Journal : Jurnal Pendidikan Matematika dan IPA

3D structure of NT-3 Protein (Neurotropin 3) of Pigeon (Columba livia) using Server-Swiss Model Zarkiyani, Tina; Budiarsa, I Made; Astija, Astija; Bialangi, Mursito S
Jurnal Pendidikan Matematika dan IPA Vol 12, No 2 (2021): July 2021
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1136.478 KB) | DOI: 10.26418/jpmipa.v12i2.39762

Abstract

The NT-3 protein plays an important role in the development and differentiation of neurons, and is unique in the neurotropin family, that it can bind to 3 Trk receptors, namely TrkC, TrkA and TrkB. This study aimed to analyze the characteristics and three-dimensional structure of NT-3 protein in Columba livia. The target protein was obtained from Uniprot server with the access code of PKK30025.1 using template 3buk.1A (PDB-ID) analyzed in-silico through homology method using SWISS-MODEL server. The results showed that the three-dimensional structure of the target NT-3 protein with a template formed a β-sheet and loop structure, which was composed of 304 amino acids, with the highest amino acid composition was serine at 8.88 mol polar, and the lowest amino acid was tryptophan at 1.32. moles which was relatively nonpolar. The analysis results of the structural quality revealed an identity value of 98.20%, QMEAN of 0.8, QMQE of 0.25, and the analysis on the Ramachandran plot presented an outlier value of 0.92%; the most favored region value was 94.5%, with good structural quality. The results of the 3-dimensional structure of the NT-3 Columba livia protein are expected to be useful for further research to determine the active side and interactions of proteins in carrying out their functions.
Co-Authors Aan, Febriawan Abd Hakim Laenggeng, Abd Hakim Abd Rauf Abd. Rauf Abd. Rauf Achmad Ramadhan Achmad, Mestawaty As. Aiman, Popi Umu Amiruddin Kasim Amran Rede Amran Rede Andi Tanra Tellu Anggy Rizky Januarista Anita Anita Arman Arman Ashari, Abdul Asmara, Dudun Candra Asnifa Asnifa Ayutriani, Ayutriani Banne, Fenia Rensa Bialangi, Mursito S. Dewi Tureni Djaswintari, Djaswintari Fatma Dhafir Febriani, Vita Indri Febriawan, Aan Freindina, Niken Gafar, Moh. Gamar B.N. Shamdas Hamsah, Muhammad Hasan, Isharyadi Hayyatun Mawaddah Herlina Herlina Hj. Musdalifah Nurdin I Made Budiarsa I Nengah Kundera Isharyadi Hasan Jannah, Uraefatul Januarista, Anggy Rizky Joshua Dwi Caesar Waruwu Laksono Trisnantoro Latifa, Latifa Lestari Alibasyah Lestari M.P Alibasyah Lilies Lilies Lilies N Tangge Mala, Nursanti A Manap Trianto Mestawaty As. Achmad Mestawaty Mestawaty Mohammad Jamhari Mursito S. Bialangi MUSLIMIN Ni Ketut Yuniasti Nikmatul Hidayah Nikmatul Hidayah Nizrah Nizrah Nurchamidah Nurhalimah, Rizki Pakanda, Nancy Rubby Paul Rumondor Pratiwi, Elly Qirey M Qadriah, Nur Rahmadani Ramadhan, Sahri Nur Ratman Raya Agni Ria, Amanda Rizki Nurhalimah Safarni, Safarni Samsurizal, M. Sulaeman Sandra, Tresia Virna Sari, Widya Permata Shamdas, Gamar B.N. Sri Wahyuni Supriyatman, Supriyatman Sutrisnawati Mardin Syech Zainal Tanryale, Masni Halimin Tiwow, Vanny M. Uraefatul Jannah Vita Indri Febriani Waruwu, Joshua Dwi Caesar Widya Permata Sari Windarsih, Yulia Yulisa Yulisa Yuni Masyita Dewi Yuniarti Zakiah Zulfitri Syam, Zakiah Zulfitri Zaky, Muhammad Zarkiyani, Tina