Social media is the media most often used in the current era of digitalization, one of which is Tik Tok. Tik Tok is a social media that makes it easy for users to interact to give likes and comments on videos and photos between fellow users. However, this affects the mental health of its users, especially students. The effects of using Tik Tok on mental health include anxiety, stres, lack of confidence and overthinking. This study aims to determine the effect of the use of social media (Tik Tok) on adolescent mental health in public health students at Teuku Umar University. This study used quantitative methods with simple linear regression analysis with 76 respondents. The results of this study indicate that there is no influence between the use of social media (Tik Tok) on the health of adolescents in public health students at Teuku Umar University with a probability of 0.766.