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All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan Media Pendidikan Matematika JK Unila (Jurnal Kedokteran Universitas Lampung) E-JRM Organisms: Journal of Biosciences AMMA : Jurnal Pengabdian Masyarakat
Septiani, Linda
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Uji Efektivitas Biolarvasida Pada Minyak Atsiri Daun Tembelekan (Lantana camara) Terhadap Larva Anopheles sp. Sebagai Upaya Pengendalian Vektor Malaria Marcellia, Selvi; Ramdini, Dwi Aulia; Setiawan, Gigih; Septiani, Linda; Setyaningrum, Endah; Rosa, Emantis; Annasya, Benazhir Saninah
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 12 (2024): Volume 11 Nomor 12
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i12.18425

Abstract

Indonesia merupakan salah satu negara dengan jumlah kasus malaria yang tertinggi di dunia. Penyakit malaria merupakan jenis penyakit yang penularannya melalui gigitan nyamuk Anopheles sp. yang mengandung protozoa Plasmodium sp. Daun lantana (Lantana camara L.) memiliki kandungan senyawa aktif lantadine, minyak atsiri, flavonoid, alkaloid, saponin, dan tannin. Penggunaan biolarvasida merupakan upaya untuk mengurangi preventif Penelitian ini bertujuan untuk mengetahui efektivitas minyak atsiri daun lantana sebagai biolarvasida terhadapvektor penyakit Malaria.Metode yang digunakan pada penelitian ini adalah destilasi untuk proses ekstraksi, dan menghitung jumlah kematian dari larva yang telah diberi perlakuan dengan konsentrasi minyak atsiri daun lantana 0,5%, 0,75%, 1%, 1,25% sehingga didapatkan nilai persen mortalitas dan dilanjutkan dengan menghitungan nilai LC50 dan LC90 menggunakan uji probit. Hasil penelitian menunjukkan bahwa minyak atsiri daun lantana (Lantana camara) efektif sebagai biolarvasida. LC50 yang di dapat yaitu0,505% pada jam ke-21. Untuk uji ANOVA menunjukkan terdapat perbedaan yang signifikan pada masing-masing konsentrasi 0,5%, 0,75%, 1%, 1,25%, control negative dan control positif karena nilai p-value 0,000<0,05. Dari hasil penelitian ini dapat dikatakan bahwa senyawa yang terkandung pada minyak atsiri daun lantana (Lantana camara) berpotensi sebagai biolarvasida terhadap larva Anopheles sp.
Characteristics of Thyroid Carcinoma Patients at Dr. H. Abdul Moeloek Hospital for the Period of January 2023 – August 2024 Qurani, Istiqomatul; Septiani, Linda; Kurniati, Intanri; Windarti, Indri
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1333

Abstract

Thyroid carcinoma is the most common cancer found in the endocrine system that arises from thyroid parenchymal cells.  Its prevalence has increased over the past few decades with a mortality rate of 0.5% per 100,000 cases. The incidence of thyroid carcinoma in 2020 ranks 7th in the world as the 9th most frequent incidence occurs from all types of cancer. Objective: This study aims to determine the characteristics of thyroid carcinoma patients at Dr. H. Abdul Moeloek Regional General Hospital for the period of January 2023 – August 2024. Method: This study used a descriptive observational design and Total Sampling technique with a data source in the form of secondary data on medical records from 82 thyroid carcinoma patients at the Dr. H. Abdul Moeloek Regional General Hospital for the period January 2023 to August 2024.  Results: In this study, thyroid carcinoma patients were mostly female, with an age group in the range of 41-60 years. The most common type of thyroid carcinoma is papillary carcinoma and the least common type is anaplastic carcinoma. Conclusion: In this study, the characteristics of thyroid carcinoma patients were obtained based on gender, age group, and type of histopathological diagnosis.
Infeksi Protozoa Usus dan Anemia Sebagai Ancaman Kesehatan Global: Literature Review Rahmah, Nisrina Nur; Mutiara, Hanna; Septiani, Linda; Himayani, Rani
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1291

Abstract

Intestinal protozoan infections are a global health issue that needs to be monitored due to the high morbidity and mortality rates, particularly in areas with poor hygiene and sanitation. Intestinal protozoan infections are diseases caused by protozoan parasites, which are single-celled eukaryotic microorganisms generally classified under the Kingdom Protista. The most frequently reported intestinal protozoa species responsible for human infections are Blastocystis hominis, Cryptosporidium parvum, and Giardia lamblia. There are two key factors contributing to the occurrence of intestinal protozoan infections: individual and environmental factors. Intestinal protozoan infections are known to cause various harmful consequences, particularly regarding the nutritional status of the affected individuals. As a result, intestinal protozoan infections are often associated with iron deficiency anemia, which can ultimately disrupt growth and development in children and decrease productivity in adults. This study aims to identify the pathways through which intestinal protozoan infections cause iron deficiency anemia. The study method involved a literature review and problem analysis. The results indicate that there are three main pathways through which intestinal protozoan infections lead to iron deficiency anemia: the metabolism of pathogenic microorganisms within the human body, the activation of the immune response to pathogenic microorganisms, and the reduction in micronutrient levels. To prevent these infections, the public is advised to improve personal hygiene, such as regularly washing hands, and to enhance environmental sanitation by treating water through filtration or disinfection.
Diagnosis dan Penatalaksanaan Trigeminal Neuralgia Zefanya, Ezekial; Berawi, Khairun Nisa; Septiani, Linda; Wardani, Dyah Wulan Sumekar Rengganis
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1411

Abstract

Trigeminal Neuralgia (TN) is a sudden pain in the facial area, short duration for about one second to two minutes, being-stabbed feels like, and occurs repeatedly in one or more branches of the trigeminal nerve. Type 1 (one) as intermittent pain and type 2 (two) as constant pain with different clinical, pathological, and prognostic complaints. The causes of Trigeminal Neuralgia involve peripheral pathology in the roots (compression or traction), brainstem dysfunction, basal ganglia, and cortical pain modulation mechanisms, but the most common is due to neurovascular factors. The diagnosis of Trigeminal Neuralgia is basically clinical, to rule out secondary causes, detect pathological changes in the affected roots and neurovascular compression (NPC), Magnetic Resonance Imaging (MRI) may be used. The choice of first-line drug therapy is carbamazepine, and for the second line patient may use oxcarbazepine, baclofen, lamotrigine, phenytoin, and topiramate. Microvascular decompression (MVD) is the surgical treatment of choice for TN that is resistant to medical management. Patients with significant medical comorbidities, without neurovascular compression and multiple sclerosis are generally advised to undergo gamma knife radiosurgery, percutaneous balloon compression, glycerol rhizotomy, and radiofrequency thermocoagulation procedures. The most effective medical therapy is with carbamazepine with a reported reduction in facial pain after taking it as much as 47 percent. For patients who do not respond to medical treatment, microvascular decompression surgery is performed with an effectiveness rate in patients as much as 90 percent.
A Case Report: Multidrug-Resistant Tuberculosis in A 53-Year-Old Patient Mustofa, Syazili; Ananta, Yoga; Ginting, Bisart; Septiani, Linda; Busman, Hendri
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 2 (2025): Volume 12 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i2.18173

Abstract

A 53-year-old man with multidrug-resistant tuberculosis (MDR-TB) presented with clinical symptoms such as cough with yellow-white sputum for a month, shortness of breath, fever, night sweats, and weight loss. After completing six months of TB treatment in 2010, he developed MDR-TB, proven by resistance to rifampicin. Initial diagnosis by chest X-ray showed signs of pulmonary TB and right pleural effusion, while the sputum test confirmed Mycobacterium tuberculosis with moderate bacterial load. Laboratory results showed anemia, leukocytosis, and hypoalbuminemia. The patient's therapy included a combination of bedaquiline, levofloxacin, linezolid, clofazimine, cycloserine, and vitamin B6, along with additional treatments such as antibiotics, symptomatic therapy, and nutritional support. The medical team conducted regular monitoring and consultation with pulmonary, psychiatry, and nutrition specialists to ensure treatment compliance. This case highlights the challenges in managing MDR-TB, especially in patients with a history of TB. Early detection of drug resistance and prompt implementation of appropriate therapy are essential to improve treatment outcomes and prevent further spread. This report emphasizes the need for a multidisciplinary approach and close monitoring in the management of MDR-TB.
Pembuatan Kompos Daun Kering Dari Sampah Lingkungan Dusun Pal 6 Desa Karang Sari, Kecamatan Jati Agung Rosa, Emantis; Yulianti; Marcelia, Selvi; Septiani, Linda
AMMA : Jurnal Pengabdian Masyarakat Vol. 4 No. 3 : April (2025): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Compost is a material produced from the decomposition process of organic matter, such as wet or dry, husk, garbage and so on. The benefits of compost, apart from reducing organic waste by turning it into useful materials, can improve soil quality and increase plant productivity.. The purpose of this community service activity is to provide knowledge, understanding and skills in making compost fertilizer from dry leaves found in the environment to residents in Dusun Pal 6, Desa Karang Sari, Kecamatan Jati Agung. The results of the assessment show that there is an increase in knowledge and understanding of the materials provided with an initial percentage of 52.0% increased by 77.05% with an average increase of 28.3%, the highest increase range is 41% and the lowest is 16%
Glasgow Coma Scale: Tinjauan terhadap Kegunaan, Keterbatasan, dan Perkembangannya Aquila Graham; Setiorini, Anggi; Septiani, Linda; Perdani, Roro Rukmi Windi
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1396

Abstract

The Glasgow Coma Scale (GCS) is a widely used neurological assessment tool for evaluating the level of consciousness in patients with brain injury. Introduced in 1974 by Teasdale and Jennett, it has become a standard in emergency departments, intensive care units, and neurosurgical wards worldwide. The GCS assesses patient responses in three domains: eye opening, verbal response, and motor response, with scores ranging from 3 (deep coma) to 15 (fully conscious). The GCS score is used to classify the severity of Traumatic Brain Injury (TBI) and predict clinical outcomes. However, several studies have highlighted limitations of the GCS, particularly in predicting patient outcomes and its application in specific populations. This article provides a critical review of the GCS, including its utility, limitations, and ongoing modifications and developments.
Tinjauan Pustaka : Kebiasaan Merokok dan Paparan Ultraviolet Sebagai Faktor Risiko Katarak Senilis Ghaitsa Lulua; Himayani, Rani; Septiani, Linda; Berawi, Khairunnisa
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1419

Abstract

Cataract ranks second as the most common visual impairment and first as a cause of blindness, as the lens hardens and causes a decrease in sharp vision. Based on age, cataracts are divided into several types: congenital cataract, juvenile cataract and senile cataract. Senile cataract is a cataract that often occurs in older people. The classification of senile cataracts is based on the progression of the cataract's opacity, namely, incipient, immature, mature, and hypermature. Some of the risk factors for senile cataracts include a history of diabetes mellitus, family history, smoking, and exposure to ultraviolet light. Smokers have a higher risk of developing senile cataracts than non-smokers. Ingredients in cigarettes such as cyanate, nicotine and tar can cause changes and denaturation of proteins in the lens of the eye. Meanwhile, sunlight absorbed by the eye produces free radicals and affects the tissues in the lens of the eye, triggering oxidative reactions, causing changes in amino acid reactions and leading to senile cataracts.
Potensi Ekstrak Kulit Nanas (Ananas comosus) Sebagai Antimikroba Sinaga, Herman Fransiskus; Apriliana, Ety; Septiani, Linda; Kurniati, Intanri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1427

Abstract

Pineapple is one of the traditional plants that may be used as an alternative treatment to reduce pathogenic microbes. Its content is rich in chlorine, iodine, phenol and the enzyme bromelain which functions to stop microbial growth. This research aims to determine the potential of pineapple peel extract (Ananas comosus) as antimicrobe agents. This research uses a literature review study method, namely by using research articles obtained through a literature search process related to the potential use of pineapple peel extract on microbe from 2015 to 2025. Pineapple peel extract contains the main compounds, namely flavonoids, polyphenols, bromelain and saponins. This content causes pineapple skin extract (Ananas comosus) to have an effect on microbes.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter
Co-Authors Adisa, Mutiara Putri Alghani, Sulthan Rafi Ananta, Yoga Andrifianie, Femmy Angga Wijaya, Angga Annasya, Benazhir Saninah Aquila Graham Cahyani, Faradhila Azqiah Damayanti, Ervina Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Ety Apriliana Fatahillah, Fatahillah Ghaitsa Lulua Ginting, Bisart Hanna Mutiara, Hanna Happy, Terza Aflika Hendri Busman Heni Pujiastuti Idris, Mohamad Indri Windarti Intan Kusumaningtyas Intanri Kurniati Jhons Fatriyadi Suwandi Khairun Nisa Marcelia, Selvi Marcellia, Selvi Nur Diana Oktavia Ningtias, Nabila Primasari Pertiwi Qanita Arindia, Naifa Hana Qurani, Istiqomatul Rahel, Clara Arta Uli Rahmah, Nisrina Nur Rahmawati, Rahmawati Ramdini, Dwi Aulia Rani Himayani Ratna Dewi Puspita Sari Risti Graharti Rizki Hanriko Roro Rukmi Windi Perdani, Roro Rukmi Rosa, Emantis Setiawan, Gigih Setiorini, Anggi Shinta Dewi, Brigitta Sinaga, Herman Fransiskus Syazili Mustofa Tri Umiana Soleha Winda Trijayanthi Utama, Winda Trijayanthi Wiwi Febriani Yulianti Zefanya, Ezekial