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Journal : INDONESIAN JOURNAL OF PHARMACY

PHARMACODYNAMICS STUDY OF ETHANOL EXTRACT OF CYCLEA BARBATA (MIERS.) LEAVES ON SRF AND COX-2 GASTRIC MICE WITH NSAID GASTROPATHY Florence Pribadi; Suhartati Suhartati; Achmad Basori
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (880.862 KB) | DOI: 10.14499/indonesianjpharm28iss3pp131

Abstract

Epidemiology of NSAIDs gastropathy is increasing as increase number of usage. From arthritis to cardiovascular events and cancer prevention, the versatility of NSAIDs is not questioned. However, no dose of NSAIDs is safe. No matter low dose, or single use, NSAIDs will cause gastric damage upto 3-7 days after use. In inflammation and healing process of gastropathy there are various proteins involved, but treatment with COX-2 and SRF are associated with an immediate healing and better quality of gastric mucosa. Cyclea barbata (miers.) has been declared as functional food for preventing and treatment gastropathy yet, its mechanism of actions have not yet clearly discovered. Hence the aim of this study is to analyze the effects of Cyclea barbata (miers.) ethanol extract to COX-2 and SRF in gastric tissue, in time series basis. Laboratory mice was induced with aspirin to produce gastropathy and then treated with Cyclea barbata (miers.) extract for 1, 3, 7, 10 or 14 days. Gastric tissue then harvested and analysed with elisa procedure to determine tissue SRF and COX-2 level. Treatment was proven to increase COX-2 and SRF higher than control group. This concludes one of Cyclea barbata (miers.) mechanism for NSAIDs gastropathy is by increasing tissue COX-2 and SRF. 
Co-Authors Achmad Basori, Achmad Adam, Kamila Adinda Zharifah Putri Setiawan Agnes Atmadjaja Almer Fathoni Syahda Amadea Arum Natasha Angelarita Djami Raga Areta Idarto Arini Dyah Saputri Arisanti, Shinta Atalya Riawani Iring Azyvati Karensa Putera Azyvati Karesna Putera Bachtiar Rizki Nardiansyah Bella Meylani Lifindra Bella Meylani Lifindra Bella Meylani Lifindra Berlian Ester Wakas Berlian Ester Wakas Budi, Stephanie Laurensia Bueya, Eirene Putri Febriani Pratama Casey Clarissa Gondo Casey Clarissa Gondo Cassey Clarissa Gondo Citra Videla, Ardelia Darmanto, Arief Gunawan Denys Putra Alim Desy Natalia F. Maskim Dion, Aldy Dyaniko Prio Basudewo Ellysia Yuvena Maheswari Eric Dino Tandoyo Erik Jaya Gunawan Eva M. Anigomang Gede T.W. Suara Glenn Gilang Manyering Glory Ta’bi Palloan Gondo, Casey Clarissa Harijanto, Cyrena Theophania Hebert Adrianto Helen Octavia Djoenaydy Hudi Winarso Imam Santosa Imam Santosa, Rahajoe Imanuel D. K. Aji Intan Murni Arifah Irwin Prijatna Kusumah Irwin Priyatna Kusumah Karina Dewi, Karina Karmila A. Wardani Kencanawati, Nathania Dwi Kevin Luke Kevin Luke Kharisma A. Perdana Kusumah, Irwin Priyatna Laning, Joseph Christian Lidya Anin Lidya Handayani Lifindra, Bella Meylani Lola Adriani Lorent P. Ridfan Luke, Kevin Lyndia Effendy Manurung, Riska Enjelica Mardhika, Della Maria K. A. Klau Mega Nilam Sari Mitha A. P. Handojo Mohamad, Fawaid Mufti Yuana, Hindri Muhammad Fadhil Ihsan Pratama Muliasari Kartikawati Natalia Yuwono Nathania Dwi Kencanawati Nendra Ateja, Kerta Ni Luh Shalia Eka Pratiwi Njoto, Juli Karijati Noer, Tjandrakirana M Sjaifullah Novia Yolanda Nur Aini Nur, Farah Shania Olivia Tantana Permata Ayu Sofyan Posuma, Anastasia Ellena Pramita, Desy Hinda Raden Roro Shinta Arisanti Rafa Daniel Walukow Rahajoe Imam Santoso Raniar Nasyira Reynaldi Hardianto Saputra Ridzal Wahid Ronald Torang Marsahala Panggabean Salmon Charles Pardomuan Tua Siahaan Sampe, Jonah Alberto Santosa, Rahajoe Imam Santoso, Rahajoe Imam Sari, Nurul Illahi Kusuma Sayogo, Wiliam Setiawan, Adinda Setiawan, Adinda Zharifah Putri Siahaan, Salmon Charles Siahaan, Salmon Charles Pardoman Tua Siusanto Hadi Sofyan, Permata Ayu Stefani Nurhadi Suameitria, Desak Nyoman Surya Sucahyo, Yoselyn Sudargo, Iie Suhartati Suhartati Syahida, Nawira Tambuang, Christ Tandean, Victor Ummu Habibah, Ummu Ummul Fadika Victor Tandean Wahid, Ridzal William Tandio Putra Wiraputri, Arini Wirya, Stephen Akihiro Yasmine P. Fadhilah Yoewono, Jessica Renata Yohan Christian Suisan Zefanja Andera Gondo