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All Journal JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) THE JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST Journal Of Vocational Health Studies Jurnal Media Analis Kesehatan Manuju : Malahayati Nursing Journal Journal of Health Sciences 2-TRIK: TUNAS-TUNAS RISET KESEHATAN INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Poltekita : Jurnal Ilmu Kesehatan Jurnal Ilmiah Tatengkorang JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) CENDEKIA : Jurnal Ilmu Pengetahuan HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Jurnal Pengabdian Kepada Masyarakat Mulawarman Gema Lingkungan Kesehatan Jurnal Rakat Sehat : Pengabdian Kepada Masyarakat Frontiers in Community Service and Empowerment Vitamin: Jurnal Ilmu Kesehatan Umum IPSSJ Jurnal Teknokes
Sasongkowati, Retno
Jurusan Teknologi Laboratorium Medis Poltekkes Kemenkes Surabaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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HUBUNGAN INFEKSI SOIL TRANSMITTED HELMINTH DENGAN ANGKA RETIKULOSIT, KADAR HEMOGLOBIN DAN PERILAKU HIDUP BERSIH & SEHAT PADA ANAK SEKOLAH DASAR Maudita, Nauril; Sasongkowati, Retno; Suliati, Suliati; Anggraini, Anita Dwi
CENDEKIA: Jurnal Ilmu Pengetahuan Vol. 5 No. 2 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/cendekia.v5i2.5710

Abstract

Soil-transmitted helminth (STH) infections are a significant public health problem, especially in tropical and subtropical countries with limited sanitation. Transmission occurs through soil contaminated with the feces of infected individuals, which contain helminth eggs such as Ascaris lumbricoides (roundworm) and Trichuris trichiura (whipworm), as well as hookworm larvae. This study aims to analyze the relationship between STH infection and hematological status (reticulocyte count and hemoglobin level) and Clean and Healthy Living Behavior (PHBS) in vulnerable elementary school students. Using a cross-sectional design, the study involved 44 students at SDN Sobontoro 2. The results showed that 23% of students (10 children) tested positive for STH infection. Statistical analysis using the Spearman test found no significant correlation between STH infection and reticulocyte count (p=0.072) or hemoglobin level (p=0.124). However, a very significant relationship was found between STH infection and PHBS (p=0.000). These findings underline that poor PHBS practices are a major risk factor that directly contributes to high rates of STH infections. ABSTRAKInfeksi cacing usus yang ditularkan melalui tanah, atau Soil Transmitted Helminth (STH), merupakan masalah kesehatan masyarakat yang signifikan, terutama di negara-negara tropis dan subtropis dengan sanitasi terbatas. Penularannya terjadi melalui tanah yang terkontaminasi tinja penderita, yang mengandung telur cacing seperti Ascaris lumbricoides (cacing gelang) dan Trichuris trichiura (cacing cambuk), serta larva cacing tambang (hookworm). Penelitian ini bertujuan untuk menganalisis hubungan antara infeksi STH dengan status hematologis (angka retikulosit dan kadar hemoglobin) serta Perilaku Hidup Bersih dan Sehat (PHBS) pada siswa sekolah dasar yang rentan. Menggunakan desain cross-sectional, penelitian melibatkan 44 siswa di SDN Sobontoro 2. Hasil menunjukkan 23% siswa (10 anak) positif terinfeksi STH. Analisis statistik menggunakan uji Spearman tidak menemukan korelasi signifikan antara infeksi STH dengan angka retikulosit (p=0,072) maupun kadar hemoglobin (p=0,124). Namun, ditemukan hubungan yang sangat signifikan antara infeksi STH dan PHBS (p=0,000). Temuan ini menggarisbawahi bahwa praktik PHBS yang buruk adalah faktor risiko utama yang berkontribusi langsung terhadap tingginya angka infeksi STH.  
Gen Exfoliatif A (EtA) Staphylococcus aureus Pada Isolat Luka Pasien Diabetes Mellitus Suliati, Suliati; Sasongkowati, Retno; Endarini, Lully Hanni; Anggraini, Anita Dwi
2-TRIK: TUNAS-TUNAS RISET KESEHATAN Vol 12, No 2 (2022): Mei 2022
Publisher : FORUM ILMIAH KESEHATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/2trik12204

Abstract

Diabetes mellitus is a degenerative disease that has many complications, one of which is diabetic ulcers. People with diabetes mellitus who have open wounds will be more susceptible to infection because an increase in blood sugar can make the wound a nutrient and a place for bacterial growth. One of the bacteria that causes infection in open wounds is Staphylococcus aureus. Toxins released by Staphylococcus aureus can cause Staphylococcal Scaled Skin (SSS). This quantitative descriptive study was conducted at the Diabetes Wound Specialist House, involving patients with diabetes mellitus at the Diabetes Wound Specialist Hospital. Bacterial culture from patient wound swabs was carried out at the Microbiology Laboratory, Poltekkes Kemenkes Surabaya; while the detection of the Staphylococcus aureus EtA gene was carried out at the ITD (Institute of Tropical Diseases) Laboratory. Data were analyzed descriptively. The PCR results showed that from 30 samples of diabetes mellitus wound swabs, 2 samples were found positive for the presence of Staphylococcus aureus bacteria.Keywords: Exfoliative A gene; Staphylococcus aureus; diabetes mellitus  ABSTRAK Diabetes melitus merupakan salah satu penyakit degeneratif yang punya banyak diikuti dengan komplikasi, salah satu di antaranya adalah ulkus diabetik. Penderita diabetes melitus yang memiliki luka terbuka akan lebih rentan mengalami infeksi karena adanya kenaikan gula darah dapat menjadikan luka tersebut menjadi nutrisi dan tempat pertumbuhan bakteri. Salah satu bakteri yang menyebabkan infeksi pada luka terbuka adalah Staphylococcus aureus. Toksin yang dikeluarkan oleh Staphylococcus aureus dapat menyebabkan Staphylococcal Scaled Skin (SSS). Penelitian deskriptif kuantitatif ini dilaksanakan di Rumah Spesialis Luka Diabetes, dengan melibatkan pasien diabetes mellitus di Rumat Spesialis Luka Diabetes. Kultur bakteri dari usap luka pasien dilakukan di Laboratotium Mikrobiologi, Poltekkes Kemenkes Surabaya; sedangkan deteksi gen EtA bakteri Staphylococcus aureus dilakukan di Laboratorium ITD (Institute of Tropical Diseases). Data dianalisis secara deskriptif. Hasil PCR menunjukkan bahwa dari 30 sampel usap luka diabetes melitus, telah ditemukan 2 sampel positif adanya bakteri Staphyococcus aureus.Kata kunci: gen Exfoliatif A; Staphylococcus aureus; diabetes mellitus
Candida Albicans CT Value in Asthmatics with Prolonged Corticosteroid Inhaler Uses Cholidah, Ema Zahiroh Nur; Sasongkowati, Retno; Rahayuningsih, Christ Kartika; Suliati, Suliati
Jurnal Teknokes Vol. 16 No. 4 (2023): December
Publisher : Jurusan Teknik Elektromedik, Politeknik Kesehatan Kemenkes Surabaya, Indonesia

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Abstract

Corticosteroid inhaler is one of the first-line drugs given for the control and prevention of asthma attacks in the long term and continuously. The use of corticosteroid inhalers for a long time has systemic side effects in the oral cavity which can be a predisposing factor for normal fungal infection of Candida albicans microflora, an increase of Candida albicans’s amount in the oral cavity can cause oral candidiasis. Candida albicans detection using q-PCR to detect specific genes in oral swab specimens can provide an indirect picture of the amount of Candida albicans in the samples taken. The purpose of this study was to determine the relationship between the length of use of corticosteroid inhalers and the cycle threshold value in oral swab samples of asthma patient. This type of research is correlational research with data collection techniques using a purposive sampling technique on 30 respondents at the Lung Polyclinic at Bhayangkara Hospital H.S Samsoeri Mertojoso Surabaya who fit the inclusion criteria. Samples were examined using q-PCR to detect specific genes in the ITS-2 region to detect Candida albicans. This research was conducted at the Molecular Biology Laboratory of theMinistry of Health Surabaya Polytechnic during the period April – May 2023. The results showed that there were 26 samples(86.7%) positive for the ITS-2 gene and 4 samples (13.3%) negative for the ITS-2 gene. with sig. 0.307 so that it can be concluded that there is no relationship between the length of use of corticosteroid inhalers and the cycle threshold value of C. albicans in asthmatic’s oral swab sample.
Serodiagnosis Profiling of Anti SARS-CoV-2 Among Blood Donor Surabaya Indonesia Woelansari, Evy Diah; Sasongkowati, Retno; Christiyaningsih, Juliana
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 4 (2024): February
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i4.3367

Abstract

SARS-CoV-2 antibody detection is used as a response to natural infection and vaccination. Antibody response is very important in viral seroepidemiology and the potential role of antibodies in disease. This study was to determine serodiagnosis anti SARS-CoV-2 among blood donor Surabaya detect antibodies with protein molecular weight as serodiagnosis and immune response to SARS-CoV-2 in donors in Surabaya. The research used in this study was exploratory descriptive design. Samples from blood donors as many as 150 samples at UTD PMI Surabaya. The examination was carried out by detecting IgG SARS-CoV-2 antibodies ELISA method and followed by protein molecular weight examination SDS-PAGE method (semi-log The results of the ELISA method antibody examination showed that 67 people had IgG antibody titers against SARS-CoV2 (44.7%) and 83 people were negative (55.3%) (COI: 0.1535-0.1569). Furthermore, the results of the SDS- PAGE method examination obtained the average molecular weight in band 1: 49.73 kDA, band 2: 25.26 kDA; band 3: 19.63.4 kDA; band 4: 12.35 kDA and band 5: 7.33 kDA. There were IgG antibody of SARS CoV-2 in blood donor Surabaya meanwhile from protein screening results we could not find protein of spike SARS-CoV-2 in Blood donor Surabaya.
KORELASI ANTARA NEUTROPHIL LYMPHOCYTE RATIO (NLR) DAN C-REACTIVE PROTEIN (CRP) PADA PASIEN ANAK SUSPEK SEPSIS Purnomowati, Anik; Woelansari, Evy Diah; Sasongkowati, Retno
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 3 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i3.6611

Abstract

ABSTRACT Sepsis neonatorum is one of the biggest triggers of neonatal deaths in Indonesia. The Diagnosis of sepsis is difficult to establish due to non-specific symptoms, so accurate, affordable, and easily accessible biomarkers are needed. Commonly used biomarkers such as C-Reactive Protein (CRP) and Procalcitonin (PCT) have limited cost and availability. Neutrophil lymphocyte Ratio (NLR) is a promising alternative because it can be obtained from a routine complete blood count. The study intends to determine the correlation between the value of NLR and CRP in children indicated sepsis in RSUD dr. Sayidiman Magetan. The study was classified as cross sectional based analytical observational in 33 pediatric patients suspected of sepsis during October 2024 to March 2025. Spearman correlation testing is used in the data analysis of this study because the distribution of data is not normal based on the Shapiro-Wilk test. The average value of NLR was 6.72% and CRP was 70.16 mg/L. Spearman correlation test results showed a moderate correlation between NLR and CRP with a correlation coefficient of 0.407 (p = 0.019). There is a significant moderate correlation between NLR and CRP in pediatric patients with suspected sepsis, so NLR can potentially be used as an alternative inflammatory marker to detect pediatric sepsis. ABSTRAK Sepsis neonatorum ialah satu di antara pemicu terbesar terhadap kematian neonatal di Indonesia. Diagnosis sepsis sulit ditegakkan karena gejala yang tidak spesifik, sehingga dibutuhkan penanda biologis (biomarker) yang akurat, terjangkau, dan mudah diakses. Biomarker yang umum digunakan seperti C-Reactive Protein (CRP) dan Procalcitonin (PCT) memiliki keterbatasan biaya dan ketersediaan. Rasio Neutrofil Limfosit (Neutrophil Lymphocyte Ratio/NLR) menjadi alternatif yang menjanjikan karena dapat diperoleh dari hitung darah lengkap rutin. Penelitian bermaksud mengetahui korelasi antara nilai NLR dan CRP pada anak terindikasi sepsis di RSUD dr. Sayidiman Magetan. Penelitian tergolong observasional analitik berbasis cross sectional pada 33 pasien anak suspek sepsis selama Oktober 2024 hingga Maret 2025. Pengujian korelasi Spearman dimanfaatkan dalam analisis data penelitian ini sebab distribusi data tidak normal berdasarkan uji Shapiro-Wilk. Nilai rata-rata NLR sebesar 6,72% dan CRP sebesar 70,16 mg/L. Hasil uji korelasi Spearman menunjukkan adanya korelasi sedang antara NLR dan CRP dengan koefisien korelasi sebesar 0,407 (p = 0,019). Terdapat korelasi sedang yang signifikan antara NLR dan CRP pada pasien anak suspek sepsis, sehingga NLR berpotensi digunakan sebagai penanda inflamasi alternatif untuk mendeteksi sepsis anak.
SENSITIVITY TEST OF KLEBSIELLA PNEUMONIAE FROM SPUTUM OF SUSPECTED PNEUMONIA PATIENTS TO THE ANTIBIOTIC CIPROFLOXACIN Salis Irawati; Suliati; Retno Sasongkowati; Juliana Christianingsih
Integrative Perspectives of Social and Science Journal Vol. 3 No. 06 Juni (2026): Integrative Perspectives of Social and Science Journal
Publisher : PT Wahana Global Education

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Abstract

Pneumonia is a pulmonary infection that may result in moderate to severe sickness across all age groups. The predominant microorganisms responsible for pneumonia are Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Klebsiella pneumoniae, Legionella species, Pseudomonas aeruginosa, and Acinetobacter species. Klebsiella pneumoniae is the bacterium most often responsible for pneumonia relative to other bacteria. This research is to assess the susceptibility of Klebsiella pneumoniae isolated from the sputum of patients suspected of pneumonia to the medication Ciprofloxacin. Sputum samples were collected from patients suspected of pneumonia between May and June 2024 at the Syarifah Ambami Rato Ebu Bangkalan Madura District Hospital, with further analysis conducted at the Surabaya Public Health Laboratory Center. The used methodology is sputum cultivation using aerobic techniques. The study used was a descriptive survey, determined by simple random sampling of 30 samples. The test findings indicated that 1 out of 30 samples (3.3%) exhibited Klebsiella pneumoniae bacteria, generating an inhibition zone of 32 mm, classified as sensitive according to CLSI recommendations. This study recommends that future studies use Klebsiella pneumoniae isolate samples from the sputum of probable pneumonia patients aged 2 to 64 years.
In Silico Analysis of Antiviral Activity and Pharmacokinetic Prediction of Brazilein Sappan Wood (Caesalpinia sappan L.) Against SARS-CoV-2 Spike Glycoproteins Dwi Krihariyani; Edy Haryanto; Retno Sasongkowati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1854

Abstract

Brazilein is one of the secondary sappan wood metabolites which can be used empirically as an antivirus. The SARS-CoV-2 spike (S) glycoproteins play significant roles in attaching and entering the virus into the host cell. This study aims to predict the antiviral activity and pharmacokinetic properties of brazilein of the sappan wood against the in-silico SARS-CoV-2 S glycoproteins with vitamin C as the reference compound. Molegro Virtual Docker 5.5 was used to predict antiviral activity by docking process. SARS-CoV-2 S glycoprotein with NAG ligand available in Protein Data Bank (PDB) (PDB ID: 7C01) was the receptor used. The pkCSM online tool was used to predict the pharmacokinetic properties and toxicity of brazilein. Data were analyzed on the target receptors by comparing the docking bond energies between NAG, brazilein, and vitamin C. The smaller the ligands’ bond energy to the target receptor, the more stable the bonds are. The bond energy of NAG, brazilein, and vitamin C was -59.2864 kcal/mol, -65.8911 kcal/mol, and -53.9093 kcal/mol, respectively. These results suggested that brazilein has a greater capacity as an antivirus compared to NAG and vitamin C. In silico test using the pkCSM online tool demonstrated that brazilein had strong pharmacokinetic properties and relatively low toxicity.
Co-Authors ., Pestariati AHDIAH IMROATUL MUFLIHAH Amalinda Mega Novasari Amelia, Noer Anggraini, Anita Dwi Anita Anggraini Anita Dwi Anggraini Anita Dwi Anggraini Ariana, Novi Astuti Setiyani Bambang Hadi Sugito Briansky, Sabira Alvayogi Choirudin, Nadia Pramesthy Choirudin Cholidah, Ema Zahiroh Nur Christiyaningsih, Juliana Darjati Deddy Adam Dedi Kurniawan Dellanis Arina Putri Demes Nurmayanti Edy Haryanto Edy Haryanto Endah Astuti, Sri Sulami Endarini, Lully Hani Endarini, Lully Hanni Ersanto, Novi Evi Yunita N Evy Diah Woelansari Hadi Suryono Haqqi, Faishol Heni Nuril Arfiyanti Indah Lestari, Indah Ira Puspita Sari Isfentiani, Dina Isnaini, Dian Istanto, Wisnu Juliana Christianingsih Juliana Christyaningsih Kartika Rahayuningsih, Christ Khambali, Khambali Kiaonarni OW Krihariyani, Dwi Kristiningsih, Elly Kusumaningrum, Debby Kuswanto, Muhammad Lella Rahmawati Lembunai Tat Alberta, Lembunai Tat Luthfi Rusyadi M. Zakarahman Makruf, Anang Mamik Mamik Maudita, Nauril Minarti Minarti Mitra Putri Mandiri Museyaroh, Museyaroh Mutiarawati, Diah Titik N. S. Widodo Novita, Devy Nur Hatijah Pengge, Nuning Marina Prisma Anjarlena Purnomowati, Anik Puspita Dewi, Teresia Retna Puspitasari, Erlita Revi Zakiyatul Maftukhah Rusmania, Liya Safrudin, Samsul Saktiyani, Fisari Salis Irawati Siagian, Hotmaida Siti Alfiah Sugihani Suhariyadi Suhariyadi Suliati Suliati Suliati Suliati Suliati Sumasto, Hery Toni Watoyani Trisnania, Iid Dani Vemy Rahmany Kurniawan Widyanur Wisnu Isntanto Wisnu Istanto Wisnu Istanto Yusianti Silviani