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Hyperbaric Oxygen Therapy for Traumatic Brain Injury: A Review Of History, Development, Current Techniques, and Future Directions Wiwoho, Yudi Yuwono; Sadikin, Abdul Halim; Jusuf, Ahmad Aulia; Mulyawan, Wawan; Mudjihartini, Ninik; Ibrahim, Nurhadi; Jusman, Sri Widia A.; Sadikin, Mohamad
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.321

Abstract

Hyperbaric oxygen therapy (HBOT) has gained increasing attention as a potential adjunctive treatment for traumatic brain injury (TBI) patients. This narrative review discusses the historical background, current preclinical and clinical studies, and explores its underlying mechanisms from biomolecular, histological, and clinical perspectives. HBOT promotes neural recovery by improving oxygenation, preserving mitochondrial integrity, enhancing neurotrophic support and synaptic connectivity, mitigating secondary injury pathways (including oxidative stress, inflammation, and apoptosis), and promoting angiogenesis and vascular stability. These mechanisms have demonstrated improvements of motor, cognitive, and memory functions both in preclinical and clinical studies, although outcomes and treatment protocols vary. However, challenges remain regarding optimal protocols, patient selection, and adverse effects. Further high-quality clinical trials are required to define the optimal HBOT regimen are required.
Co-Authors . Rusdi Abdul Halim Agus Setiyono Ahmad A Jusuf Ahmad Aulia Andi Arus Victor Andriani Andriani Angelina Stevany Regina Masengi Ani R Prijanti Ani Retno Prijanti Cindy Fawwaz Roviqoh Damar Prasmusinto Deasyka Yastani Desdiani Dewi Sukmawati Dwi Hastuti DWI HASTUTI Dwi Retna Lestari Ernie Purwaningsih Evy Ayu Arida Fadilah Fadilah Fanny Septiani Farhan Febriana Catur Iswanti Ferdiana Yunita Frans D Suyatna Frans Ferdinal Frans Ferdinal H, Novi Silvia Helmi Rizal Hendrik Kurniawan Heri Wibowo Ika Superti Daruningrum Indriati P Harahap Irawan Satriotomo Iris Rengganis Joedo Prihartono Joedo Prihartono Johannes Cornelius Mose K Kartini Kenny Cantika Abadi Labibah Qotrunnada Lailan Safina Nasution Lindi G Haritsyah Lis Rosmanah M Ekawati Maftuhatun Fista Amalia Mohamad Sadikin Mohamad Saekhu Mohammad Sadikin Mohammad Sadikin Muhammad Yamin Murdani Abdullah Ninik Mudjihartini Noroyono Wibowo Novi Resistantie Novi Silvia Hardiany Novianti, Titta Noza Hilbertina Nur Ita Margyaningsih Nurhadi Ibrahim Nurhadi Ibrahim Nurjati Chairani Siregar Nurjati Chairani Siregar Putri C. Eyanoer Rahayuningsih Dharma Raisa Nauli Reni Paramita Reni Paramita Ressa Yuneta Retno Kuntarti Rizqa Febriliany Putri Sadikin, Abdul Halim Saidah Rauf Samsuridjal Djauzi Saptuti Chunaeni, Saptuti Sarsanti, Pungguri Ayu Nega Septelia I. Wanandi Siregar, Fajri Marindra Siti Rahmawati Achyat Sri Sukmaniah Suhendro Suhendro Suradi Susi Rahmiyati Syarifah Dewi Tiara Mayang Pratiwi Lio Tjahjono Darminto Gondhowiardjo Vetnizah Juniantito Wardaya Wardaya Wawaimuli Arozal Wawan Mulyawan Wawan Mulyawan Werdhasari, Asri Wido Sari Nawangsih, Idah Wiji Lestari Wiwoho, Yudi Yuwono