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All Journal E-Jurnal Medika Udayana Medical Journal of Indonesia Jurnal Kesehatan Majalah Kesehatan Pharmamedika UMI Medical Journal Narra J Media Publikasi Promosi Kesehatan Indonesia (MPPKI) jpki
Djaharuddin, Irawaty
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Medical Journal of Indonesia

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Syndecan-4 levels in bronchoalveolar lavage fluid and serum in non-small cell lung cancer Abdul Azis, Asrul; Santoso, Arif; Djaharuddin, Irawaty; Iskandar, Harun; Ilyas, Muhammad; Lihawa, Nurjannah
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247264

Abstract

BACKGROUND Lung cancer has the highest cancer-related mortality rate worldwide. Research has been conducted to improve early detection and markers of predictive value but only focused on the expression of syndecan-4 (SDC4) in serum. Studies in bronchoalveolar lavage (BAL) fluids of non-small cell lung cancer (NSCLC) patients are still limited. This study aimed to evaluate the clinical value of SDC4 in serum and BAL in NSCLC patients. METHODS Blood serum and BAL fluids were obtained from 44 patients with NSCLC and 41 non-cancer patients as the control. The level of SDC4 was measured. The relationships between SDC4 and clinicopathologic factors were also analyzed. RESULTS Serum SDC4 levels in NSCLC patients were significantly lower than the control group (p = 0.002). Furthermore, the disease stages and serum SDC4 levels had a negative correlation, which was lower in the advanced stage (IIIb/IV) than in the initial stage (I/II/IIIa) (p = 0.517). The same results were obtained from BAL fluids SDC4 levels, which were significantly lower in the advanced stage (IIIb/IV) than in the early stage (I/II/IIIa) (p = 0.007). CONCLUSIONS Serum SDC4 levels in NSCLC patients were lower than those of non-cancer patients. They also performed different results in disease stages. SDC4 could be a helpful biomarker in NSCLC.
Co-Authors Abdul Azis, Asrul Abustani, Muthiah Alfian, Andi Amir, Muzakkir Amru, Khaeriah Andi Alfian Zainuddin Anggita, Dwi Anto J. Hadi Arif Santoso Arsyad, Muhammad Aryadi Asih, Puji BS. Asriyani, Sri Asriyani, Sri Bachtiar Murtala Bachtiar, Nur Amelia Bukhari, Agussalim Dewi Rizki Nurmala Din Syafruddin Djabir, Yulia Yusrini Halik, Handayani Haslina Ahmad Hasyim, Ammar A. Hendarto, Joko IRFAN IDRIS Iskandar, Harun Ismail, Amirah Febrianti Itani, Kei Iyori, Mitsuhiro Kasim, Hasim Latief, Nikmatia Latief, Nikmatia Lihawa, Nurjannah Madolangan, Jamaluddin Muh. Ayyub Amin Muhammad Ilyas Muhammad Tahir Nakamura, Kurumi Nu'man AS Daud Nurisyah, Sitti Permatasari, Tiara Putrawan, Harry Akza Ridho Akbar, Muhammad Silvia Suminto, Silvia Sri Ramadany, Sri Tabri, Nur Ahmad Wiriansyah, Edward Pandu Wisudawan B, Owildan Yoshida, Shigeto Yusuf Yenni Zainal, Kartika H.