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All Journal Indonesian Journal of Pharmaceutical Science and Technology Media Ilmu Kesehatan Pharmaceutical Journal of Indonesia Jurnal Pengabdian Farmasi Malahayati (JPFM) Jurnal Pengabdian Kepada Masyarakat (Mediteg) Stannum : Jurnal Sains dan Terapan Kimia Jurnal Ilmiah Farmako Bahari Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang JPI (Jurnal Pendidikan Inklusi) INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) TRANSFORMASI : JURNAL PENGABDIAN PADA MASYARAKAT Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Klinik dan Sains Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian Masyarakat: Jurnal Pengabdian
Fatmawati, Annisa
Universitas Alma Ata
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Formulation and Antibacterial Activity of a Gel Containing Combined Binahong and Betel Leaf Extracts Against Staphylococcus aureus Vina Sufitri; Adhi Gunawan; Bayu Bakti Angga Santoso; Sutrimo Usali R; Annisa Fatmawati; Muhimmatul Khoiriyah
MEDIA ILMU KESEHATAN Vol 15 No 2 (2026): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v15i2.2141

Abstract

Background: Open wounds are susceptible to bacterial infection, including infection caused by Staphylococcus aureus. Binahong and betel leaves contain secondary metabolites with antibacterial potential, but their combination in gel dosage form remains limited.Objective: To evaluate the physical characteristics and antibacterial activity of a combination gel containing binahong and betel leaf extracts against Staphylococcus aureus. Methods: This laboratory experimental study prepared gels containing a total extract concentration of 5% at binahong-to-betel ratios of 1:3 (F1), 2:2 (F2), and 3:1 (F3). A gel base and clindamycin 1% were used as negative and positive controls. Physical evaluation included organoleptic properties, homogeneity, pH, spreadability, adhesion, and viscosity. Results: All formulations met the physical requirements for topical gel. Mean inhibition zones were 11.15±0.31 mm for F1, 9.85±0.48 mm for F2, 8.85±0.68 mm for F3, 20.82±0.38 mm for the positive control, and 0 mm for the negative control. The differences among groups were significant (p<0.001).Conclusion: F1 showed the strongest antibacterial activity among the extract gels, although it was lower than clindamycin 1%.
Co-Authors Adelia, Melina Freda Adhi Gunawan Aprilia, Veriani Ariski, Denis Ashari, Ayu - Aslam, M.Muzhil Asrori, Moh Astuti, Eka Dyah Ayu Ayu - Ashari Azza Elvana Bachri, Moch. Saiful Bahun, Nur Rohma Inayah Bayu Bakti Angga Santoso Depita Sucianingsih Depita Sucianingsih Didik Yuni Prasetya Elvana, Azza emelda, emelda Emelda, Emelda Estiningsih, Daru Fauzi, Rizal Gunawan, Adhi Hanifah, Wening Isti Chana Zuliyati Jannah, Nurul Juliana, Intan Lestari, Yessi Manusu, Abd Sukri S Mastamah, Mastamah Moch. Saiful Bachri Muhammad Abdurrahman Muhammad Abdurrahman Munir Muhimmatul Khoiriyah Mulyaningsih, Sundari Munir, Muhammad Abdurrahman Nadia, Melta Ainun Nur Rohma Inayah Bahun Nurhidayanti, Nurhidayanti Nurinda, Eva Nurinda, Eva Nurul Jannah Puspitasari, Ade Putri, Imram Radne Rimba Rahmawati, Feti Rendani, Ike Peny Riza Kurniawati Riza Kurniawati Rizal Fauzi Rizal Fauzi Safira Amalia Putri Safitri, Eka Asriani Sain Abrari Sarwadhamana, Raden Jaka Sati, Eva Laras Septiandi, Baiq Husnul Hotima Solikah, Wahyu Yuliana Sri Suprapti Suci Rahmawati, Suci Sucianingsih, Depita Sundari Mulyaningsih Sutrimo Usali R Veriani Aprilia Veronika, Nabela Vina Sufitri Wening Hanifah Wulandari, Ari Susiana Yessi Lestari Zendrato, Mei Albert Zuliyati, Isti Chana