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All Journal International Journal of Public Health Science (IJPHS) e-CliniC Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Plastik Rekonstruksi Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia World Nutrition Journal Jurnal Ners Science Midwifery Jurnal Darma Agung IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Jurnal Sehat Indonesia (JUSINDO) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Strada Jurnal Ilmiah Kesehatan (SJIK)
Yohannessa Wulandari
Department Of Nutrition, Faculty Of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Pengaruh Suplementasi Omega-3 Terhadap Luaran Klinis Pasien Stroke Iskemik: Tinjauan Literatur Fadhilah, Dini; Wulandari, Yohannessa
Jurnal Sehat Indonesia (JUSINDO) Vol. 6 No. 02 (2024): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v6i02.92

Abstract

Stroke merupakan masalah kesehatan global yang signifikan dan kedua tertinggi dalam penyebab kematian dan disabilitas. Konsumsi ikan yang tinggi, kaya akan omega-3, dapat memberikan perlindungan terhadap stroke melalui penurunan tekanan darah, penekanan stres oksidatif dan inflamasi, serta perbaikan fungsi vaskuler, meskipun bukti klinis pada manusia masih terbatas. Tinjauan literatur ini disusun untuk mempelajari lebih lanjut mengenai pengaruh suplementasi omega-3 terhadap keluaran klinis pasien stroke iskemik. Pencarian literatur sesuai kata kunci dilakukan pada database PubMed, Scopus, dan Cochrane. Dua buah artikel berupa penelitian Randomized Controlled Trial (RCT) dan systematic review of RCT memenuhi kriteria eligibilitas dan dilakukan peninjauan lebih lanjut. Tinjauan terhadap kedua artikel menunjukkan bahwa suplementasi omega-3 pada pasien stroke iskemik dapat menurunkan risiko keterbatasan fungsional dan disabilitas fisis, namun tidak berpengaruh terhadap kematian dan kualitas hidup. Perbedaan hasil juga diperoleh pada pemantauan jangka pendek dan jangka panjang. Suplementasi omega-3 pada pasien stroke iskemik dapat menurunkan risiko keterbatasan fungsional dan disabilitas fisis, namun tidak berpengaruh terhadap risiko kematian dan kualitas hidup. Penelitian lebih lanjut dibutuhkan untuk merekomendasikan suplemen omega-3 pada pasien stroke iskemik.
Efektivitas Glutamin Oral Sebagai Terapi Mukositis Oral Pada Pasien Kanker Dengan Radioterapi Dan Atau Kemoterapi: Evidence-Based Case Report Adiningrat, Arina Fatharani; Wulandari, Yohannessa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 11 (2025): Volume 12 Nomor 11
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i11.21392

Abstract

Pasien yang menjalani radioterapi dan atau kemoterapi berisiko tinggi mengalami mukositis oral akibat toksisitas terapi. Efek samping mukositis oral ini berkontribusi terhadap peningkatan morbiditas, penurunan kualitas hidup, perpanjangan lama rawat inap, serta penundaan pengobatan kanker. Glutamin merupakan asam amino yang berperan sebagai sumber energi dan donor nitrogen dalam proses penyembuhan jaringan yang rusak akibat radioterapi dan atau kemoterapi. Tujuan penelitian ini adalah untuk mengetahui efektivitas glutamin oral sebagai terapi mukositis oral pada pasien dengan radioterapi dan atau kemoterapi. Pencarian literatur dilakukan pada tiga database besar yaitu Pubmed, Cochrane Library, dan Scopus menggunakan kriteria eligibilitas. Literatur dilakukan pada tahun 2000–2021. Terdapat dua artikel meta-analisis yang relevan dengan pertanyaan klinis dan kriteria eligibilitas. Kedua meta-analisis tersebut menunjukkan bahwa glutamin oral menurunkan kejadian mukositis berat sebesar 47–53% (RR 0,47–0,48), memperpendek durasi mukositis berat hingga 3–4 hari, serta menurunkan kebutuhan opioid (RR 0,65), penggunaan selang makan (RR 0,58–0,61), dan interupsi terapi (RR 0,63–0,70). Hasil penelitian menunjukkan glutamin oral efektif sebagai terapi mukositis oral pada pasien dengan radioterapi dan atau kemoterapi.
Hubungan antara Kadar Vitamin D dengan Kejadian Kanker Kolorektal: Studi Kasus dengan Pendekatan Berbasis Bukti Kairupan, Timothy S.; Sukarno, Inka A. T.; Wulandari, Yohannessa; Manikam, Nurul R. M.
e-CliniC Vol. 14 No. 2 (2026): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v14i2.63120

Abstract

Abstract: Colorectal cancer is the third most common malignancy worldwide and the second leading cause of cancer-related death in developing countries. Vitamin D is known to play a role in inhibiting the progression of cancer cells. Vitamin D deficiency is prevalent in both developed and developing countries. Several studies have suggested an association between vitamin D levels and the incidence of colorectal cancer. This study aimed to determine the association between vitamin D levels and the incidence of colorectal cancer. A comprehensive literature search was conducted across PubMed, Cochrane Library, EBSCOhost, and ProQuest databases. Article selection followed predefined eligibility criteria through title and abstract screening, full-text review, and assessment of inclusion and exclusion criteria. Critical assessment tools and levels of evidence of the final articles are based on the Oxford Center for Evidence-Based Medicine. Four studies met the inclusion criteria, consisting of one meta-analysis and three cohort studies. The results showed that all studies reported an association between vitamin D levels and colorectal cancer. All studies indicated that vitamin D deficiency is associated with an increased risk of colorectal cancer. In conclusion, there is an association between vitamin D deficiency and the incidence of colorectal cancer. Keywords: adults; vitamin D; colorectal cancer   Abstrak: Kanker kolorektal merupakan kanker ketiga terbanyak didunia dan penyebab kematian kedua terbanyak yang menyebabkan kematian di negara berkembang. Vitamin D memiliki peran dalam menghambat perkembangan dari sel kanker. Defisiensi vitamin D cukup tinggi di negara maju dan berkembang. Beberapa penelitian menunjukkan hubungan vitamin D dengan kejadian kanker kolorektal. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar vitamin D dengan kejadian kanker kolorektal. Pencarian literatur dilakukan pada Pubmed, Cochrane Library, EBSCOhost, dan ProQuest dengan kriteria eligibiltas yang ditentukan oleh penulis. Penyeleksi artikel dilakukan dengan penapisan judul atau abstrak, telaah teks lengkap, dan menentukan terpenuhinya kriteria inklusi dan eksklusi. Critical assessment tools and levels of evidence dari artikel terpilih mengacu pada Oxford Centre for Evidence-Based Medicine. Pencarian literatur mendapatkan empat studi yang memenuhi kriteria, yaitu satu studi meta-analisis dan tiga studi kohort. Keempatnya menunjukkan adanya hubungan kadar vitamin D dan kanker kolorektal. Hasil telaah keempat studi menunjukkan bahwa kadar vitamin D yang rendah dapat meningkatkan kejadian kanker kolorektal. Simpulan penelitian ini ialah terdapat hubungan antara kadar vitamin D dengan kejadian kanker kolorektal. Kata kunci: dewasa; vitamin D; kanker kolorektal
Hubungan Antara Asupan Energi dengan Rasio Neutrofil Limfosit pada Pasien Sakit Kritis Dian Purwantini; Yohannessa Wulandari; Diana Sunardi; Krisadelfa Sutanto; Wina Sinaga; Diyah Eka Andayani
Majalah Kedokteran Indonesia Vol 75 No 2 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.2-2025-1760

Abstract

Introduction: Critically-ill patients experience catabolic stress and inflammatory responses resulting in increased catabolism to meet energy demands. Neutrophil lymphocyte ratio (NLR) is used to assess immune and stress responses. Method: This study was a cross-sectional study of subjects aged ≥18 years admitted to the intensive care unit of Dr. Cipto Mangunkusumo National Central General Hospital and University of Indonesia Hospital. The characteristics of the study subjects included age, gender, nutritional status, diagnosis of ICU admission, protein intake, fat intake, and carbohydrate intake. Bivariate analysis was performed to evaluate the correlation between energy intake and neutrophil-lymphocyte ratio.Result: There were 44 subjects with a median age of 55 years (19-86). Nutritional status based on body mass index (BMI) obtained 31.8% normal nutritional status, 20.5% severe malnutrition, 25% obesity grade 1. The most common diagnoses were surgery and trauma 20.5% of subjects and sepsis 20.5% of subjects. Median RNL was 10.39 (2.51-59.5), energy intake was 10.5 (3-29) kcal/kg BW/day, protein intake was 0.4 (0-1.2) g/kg BW/day, fat intake was 18 (0-29)% and carbohydrate intake was 92 (23-184) g/day.Conclusion: There was no correlation between energy intake and NLR.
Hubungan Antara Asupan Vitamin A dan Seng dengan Penanda Inflamasi pada Pasien Tuberkulosis Paru di Rumah Sakit Umum Pusat Persahabatan Mitrasari, Surya; Nurwidya, Fariz; Wulandari, Yohannessa; Agustin, Heidy
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 1 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i1.1222

Abstract

BACKGROUND: Indonesia has the second highest burden of tuberculosis (TB) worldwide, with an incidence of 354 per 100,000 population and approximately 969,000 cases reported in 2021. Micronutrients such as vitamin A and zinc play important roles in immune function and may influence inflammatory responses in TB. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential markers of systemic inflammation; however, evidence regarding their association with dietary micronutrient intake in pulmonary TB patients remains limited, particularly in Indonesia. AIMS: To examine the association between vitamin A and zinc intake and inflammatory markers in pulmonary TB patients. METHODS: A cross-sectional study was conducted among 133 pulmonary TB patients recruited consecutively from March to April 2024 at Persahabatan Hospital. Vitamin A and zinc intake were assessed using a semi-quantitative food frequency questionnaire (SQ-FFQ), while NLR and PLR values were obtained from medical records. Data normality was tested using the Kolmogorov–Smirnov test, and correlations were analyzed using Spearman’s test. The median vitamin A intake was 105.47 RE/day and zinc intake was 7.38 mg/day, with median NLR and PLR of 2.91 and 202.08, respectively. RESULTS: No significant correlations were found between vitamin A or zinc intake and NLR or PLR (p > 0.05). CONCLUSION: In conclusion, vitamin A and zinc intake were not associated with inflammatory markers in pulmonary TB patients, although host-related factors may contribute to the inflammatory response.
DIETARY FIBER IN MANAGING CONSTIPATION IN MAJOR BURN TRAUMA PATIENTS: A CASE-SERIES REPORT Gendis Sekarnegari Putri; Wina Sinaga; Yohannessa Wulandari; Aditya Wardhana
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 7 No 1 (2026): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Burn injuries result in tissue damage due to exposure to thermal sources or extreme cold. Following burn trauma, systemic inflammatory responses can impair gastrointestinal (GI) function, often leading to constipation. While dietary fiber supplementation is commonly recommended to prevent constipation in the general population due to its ability to enhance intestinal motility, there is limited literature regarding its role in managing constipation among patients with major burn injuries. This case series presents two patients admitted with 34% and 35% total body surface area (TBSA) burns, respectively. Both patients experienced delayed defecation during the first week of hospitalization, without experiencing hypovolemic shock, and had not been administered any sedative agents or vasopressors. Their average dietary fiber intake were 11.1 g and 6.5 g, respectively. One male patient, who was diagnosed with diabetes mellitus (DM), continued to experience constipation until the second week, which improved following dietary modification to a DM-specific regimen. Meanwhile, the female patient showed an improvement in bowel movements in the second week, despite her low fiber intake. Keywords: fiber intake, defecation, major burns
Vitamin D deficiency and risk of myasthenia gravis: An evidence-based case report Nadiyah Wijayanthie; Yohannessa Wulandari; Anni Rahmawati
World Nutrition Journal Vol. 8 No. 1 (2024): WNJ. Volume 08 Issue 1, August 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i1.0007

Abstract

Background: An autoimmune condition known as myasthenia gravis (MG) targets the receptors for neurotransmitter acetylcholine at the neuromuscular junction, resulting in inhibition of muscle contraction. This results in muscle weakness resulting in a decrease in quality of life. Immunoregulation and muscle contractility are known to play a role in vitamin D. Literature on how vitamin D affects myasthenia gravis risk has not been widely carried out and the results are still controversial.Objective: To evaluate the association between vitamin D and MG risk.Methods: The search of the literature was conducted from PubMed, Cochrane Library, Embase, and EBSCOhost with the eligibility criteria determined by the authors. The literature search was using MeSH Term, text word, and title/abstract.Results: Two articles were selected and critically appraised. The first article shows an odds ratio of 3.96 (CI95 1.26 to 12.52), which means that myasthenia gravis has vitamin D levels almost 4 times lower than healthy population. A case-control study that followed described a comparison of mean levels of vitamin D (25(OH)D) in myasthenia gravis (mean, 18.8±8.4 ng/mL) compared to healthy controls (26.3±6.1). ng/mL) (p <0.05). Both studies revealed a strong interaction between MG and vitamin D inadequacy. Conclusion: Both studies above support the theory that vitamin D deficiency is associated with the risk of developing MG.
Role of Vitamin D in Medical Nutrition Therapy among Malnourished Patients with Interstitial Lung Disease: A Case Report Patricia S. Sinuraya; Diana Sunardi; Yohannessa Wulandari; Fariz Nurwidya
e-CliniC Vol. 14 No. 3 (2026): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/7w0j0q46

Abstract

Abstract: Interstitial lung disease (ILD) is a group of lung disorders characterized by chronic inflammation and fibrosis, with a global prevalence ranging from 6.3 to 71 cases per 100,000 population. One subtype, connective tissue disease–associated ILD (CTD-ILD), is closely related to immune system dysregulation and progressive fibrosis. We reported a 45-year-old woman with CTD-ILD prone to malnutrition due to increased metabolic demands and reduced intake caused by dyspnea, nausea, and vomiting. This condition may impair muscle function, reduce lung capacity, and worsen clinical outcomes. Therefore, nutritional assessment plays a crucial role in patient management. Interventions include a balanced diet and nutritional support to meet energy and protein requirements, targeting 1.2–1.5 g/kgBW/day. Supplementation with vitamin D at a dose of 5,000 IU once daily and micronutrients were provided to support metabolism and immune function. During treatment, the patient showed improvement in energy intake, reaching up to 95% of daily requirements and enhanced clinical response through continuous nutrition education. In patients with ILD, especially CTD-ILD, vitamin D plays a supportive therapeutic role by modulating immune responses, reducing fibrotic processes, preserving respiratory muscle function, and supporting bone health. In conclusion, vitamin D deficiency is prevalent in CTD-ILD patients and is linked to disease progression, making vitamin D supplementation an important component of maintenance therapy. Keywords: interstitial lung disease; malnutrition; vitamin D
Co-Authors Adiningrat, Arina Fatharani Aditya Rachman Aditya Rachman, Aditya Aditya Wardhana Aditya Wardhana Agustin, Heidy Amanda Pitarini Utari Amelia Jessica Anak Agung Eka Widya Saraswati Andayani, Diyah Eka Anni Rahmawati Anthony Eka Wijaya Ari Wijayanti Audria Graciela Ayu Diandra Sari Badrya, Leily Batara Bisuk Chintya Tedjaatmadja Daniel Martin Simadibrata Daya, Mulianah Dian Purwantini Diana Sunardi Diana Sunardi Dini Fadhilah Diyah Eka Andayani Diyah Eka Andayani Diyah Eka Andayani Dwirini Retno Gunarti Fadhilah, Dini Fariz, Nurwidya Fiastuti Witjaksono Gendis Sekarnegari Putri Haloho, Raja Mangatur Heny Puspita Ibrahim, Febiansyah Inka A. T. Sukarno Kairupan, Timothy S. Kaka Renaldi Krisadelfa Sutanto Lily Indriani Octovia Luana Lidwina Latief Manikam, Nurul R. M. Marcellus Simadibrata K Marcia Kumala Marvin Marino Metta Satyani Mitrasari, Surya Murdani Abdullah Mustikarani, Dewi Mutiara, Rizka Nadiyah Wijayanthie Nugrahayu Widyawardani Nurul Ratna Mutu Manikam Octaviani, Pauline Octovia, Lily Indriani Patricia S. Sinuraya Rabbinu Rangga Pribadi Raja Mangatur Haloho Ramadhania, Dian Araminta Rasyid, Nurhayati M Ribuan, Consistania Rizka Mutiara Santri Dwizamzami Faridahanum Santri Dwizamzami Faridahanum Simadibrata, Daniel Martin Sjarkowi, Anissa Syafitri Tedjaatmadja, Chintya Tjandraningrum - Trismiyanti, Trismiyanti Virly Nanda Muzellina Wardani, Putri Kusuma Wina Sinaga Wina Sinaga Wina Sinaga Yosua Yan Kristian