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All Journal Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics & Gynecology Science Journal of Maternal and Child Health Indonesian Journal of Perinatology Indonesian Basic and Experimental Health Sciences Folia Medica Indonesiana
Bachnas, Muhammad Adrianes
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration Anggraini, Nutria Widya Purna; Sulistyowati, Sri; Bachnas, Muhammad Adrianes; Yuliantara, Eric Edwin; Prabowo, Wisnu; Budihastuti, Uki Retno
Folia Medica Indonesiana Vol. 57, No. 3
Publisher : Folia Medica Indonesiana

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Preeclampsia is hypertension in pregnancy that affects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.
Maternal Deaths caused by COVID-19 Infection in the First Year of the Pandemic Wave Akbar, Muhammad Ilham Aldika; Mulawardhana, Pungky; Wardhana, Manggala Pasca; Gumilar, Khanisyah Erza; Raheestyningtyas, Ecccita; Laksana, Muhammad Ardian Cahya; Anas, Jimmy Yanuar; , Ernawati; Joewono, Hermanto Tri; Bachnas, Muhammad Adrianes; Tjokroprawiro, Brahmana Askandar
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

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Highlights: • These cases of maternal deaths caused by COVID-19 infections illustrated the significant risk factors for maternal mortality during the early phases of the pandemic, while studies had not extensively reported this. • COVID-19 infections increase the risk of maternal and neonatal mortality, with infants having a lower chance of survival even if they are delivered. • Respiratory support, antiviral medications, antibiotics, anticoagulants, and supportive care are the primary treatments for severe COVID-19 in pregnancy. Abstract This article presents seven cases of maternal deaths attributed to COVID-19 during the first year of the pandemic wave. These cases provide insights into the natural progression of COVID-19 in pregnant women who were not vaccinated. This study showed that COVID-19 significantly increased maternal and neonatal mortality and morbidity. All of the patients exhibited symptoms of fever, cough, and dyspnea upon admission to the hospital. They were admitted with elevated respiratory rates (26–32 times/minute) and low oxygen saturation (<95%). Four patients had obesity, while one patient had pregestational diabetes. The COVID-19 diagnosis was established using a rapid antibody or antigen test and chest X-ray, which indicated pneumonia. Medical interventions administered to the patients included antiviral therapy (5 patients), antibiotics (6 patients), and anticoagulants (4 patients). From a total of five babies delivered, four babies were delivered via cesarean section. Two babies were not delivered due to previability and maternal deaths before delivery. The patients passed away within 3–10 days of hospital admission. In conclusion, adequate and early intervention and management of pregnant women infected with COVID-19 are crucial in preventing maternal and neonatal deaths, especially in unvaccinated women.
Co-Authors , Ernawati Adhi Pribadi Akbar, Uchti Alamsyah, Meuthia Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Ali, Agni Shalha Aloysius Suryawan Anas, Jimmy Yanuar Andonotopo, Wiku Anshari, Shafira Yasmine Asaduddin, Aiman Hilmi Askandar Tjokroprawiro Astetri, Lini Bambang Rahardjo Carissa, Dinda Cut Meurah Yeni Elita Rahmi Eric Edwin Yuliantara Evert Solomon Pangkahila Hermanto Tri Joewono I Nyoman Hariyasa Sanjaya Indarta, Ardhia Fefrine Julian Dewantiningrum Khanisyah Erza Gumilar Khoeronisa, Siti Kurjak, Asim Laksana, Muhammad Ardian Cahya Nurinasari, Hafi Nuswil Bernolian Nutria Widya Purna Anggraini Nuur, Aliffudin Pradana, Muhammad Denny Gagah Pramono, Mochammad Besari Adi PUNGKY MULAWARDHANA, PUNGKY Raheestyningtyas, Ecccita Rahmawati, Oktantia Dyah Ratih Puspita Febrinasari Ridwan, Robert Ryan Saktika Mulyana Sri Sulistyowati Sri Sulistyowati Stanojevic, Milan Supriyadi Hari Respati Theresia Monica Rahardjo Uki Retno Budihastuti Vitri Widyaningsih Wardhana, Manggala Pasca Wiradnyana, Anak Agung Gede Putra WISNU PRABOWO Yuliani, Saffana Oka