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Ulya, Tuhfatul
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Review Article: Analysis of Drug-Related Problems (DRPs) in Diarrheal Disease Therapy Putranto, Diouf Maulana Dwi; Pebrianti, Dea Riski; Zaneta, Nabila Destia; Ulya, Tuhfatul; Hasina, Raisya; Sari, Tri Purma
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10968

Abstract

Diarrhea is one of the most common diseases in children and has the potential to cause various complications if not treated properly. Inappropriate treatment can trigger Drug Related Problems (DRPs) that affect the effectiveness of therapy. To identify and analyze the types of Drug Related Problems (DRPs) and recommended interventions in the treatment of diarrhea to support safe, effective, and rational drug use. A literature review was conducted by searching the PubMed and Google Scholar databases. A total of 10 articles that met the inclusion criteria were analyzed. The most common types of DRPs found were indications without therapy (7-45%), inappropriate dosing (both underdose 8-27% and overdose 7-35%), therapy without indication (10-85%), and drug interactions (12-56%). The main problems lie in the inaccuracy of clinical evaluation and irrational drug administration. DRPs in the treatment of childhood diarrhea are still common and have an impact on patient outcomes. Optimizing the role of pharmacists through medication reviews, dose adjustments, monitoring potential drug interactions, and educating health workers are key strategies for minimizing DRPs and improving treatment success.
Review Article: Drug-Related Problems in Hypertensive Patients in Pharmaceutical Practice Agustiani, Eti; Marasabessy, Keysha Nabilla Putri; Dwiyanti, Dhea Syafitri; Mutthoimah, Ulfatul; Ulya, Tuhfatul
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11407

Abstract

Hypertension is a chronic disease with a high global prevalence and often requires combination therapy, which increases the risk of Drug-Related Problems (DRPs). This review aims to identify the types of DRPs, the most frequently implicated medications, causative factors, and pharmaceutical interventions based on various studies conducted in hypertensive patients. The literature review results indicate that common DRPs include drug interactions, ineffective therapy, the need for additional therapy, adverse drug reactions (ADRs), and inappropriate medication selection. Amlodipine, candesartan, valsartan, beta-blockers, and diuretics are among the medications most frequently associated with DRPs. Polypharmacy, non-adherence, comorbidities, and inadequate monitoring are the main contributing factors. Pharmaceutical interventions such as medication review, therapy monitoring, patient counseling, and adherence to clinical guidelines have been shown to be effective in reducing DRPs. The role of pharmacists is crucial to ensure the safety and effectiveness of hypertension therapy.
Literature Review: The Potential of Soft Coral Lobophytum sp. as a Source of Pharmaceutical Ingredients Purnomo, Indra; Lisnasari, Baiq Risky Wahyu; Ulya, Tuhfatul; Maulidya, Selvira Anandia Intan; Budastra, Wayan Cintya Ganes
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11469

Abstract

Lobophytum sp. is a soft coral found in Indonesian waters, mainly distributed on coral reef slopes. Lobophytum sp. contains various terpenoid compounds, including sesquiterpenes and terpenoid glycosides, which have a variety of biological activities. This literature review examines the pharmacological potential of Lobophytum sp. based on ten studies reporting its pharmacological activities, such as antibacterial, antimicrobial, hepatoprotective, anti-arthritic, antioxidant, anti-inflammatory, antimalarial, and neuroprotective properties. The diterpene cembranoids in Lobophytum sp. show potential as candidate active substances for the development of pharmaceutical products through various in vitro and in vivo studies. The antioxidant activity of cembranoids has the potential to be developed as an anti-aging agent. In addition, its anti-inflammatory, antibacterial, and cytotoxic activities can be developed in the form of topical preparations. However, the development of Lobophytum sp. As a source of active ingredients still faces various challenges, especially the limited isolation of cembranoids, which requires a biotechnological approach.
Co-Authors Adriyan Suhada Agustiani, Eti Aini, Aini Aini, Siti Rahmatul Ajeng Dian Pertiwi, Ajeng Dian Alamanda, Baiq Irzana Putri Ananta, Muhammad Naufal Farras BaiqIsti Hijriani Budastra, Cintya Budastra, Wayan Cintya Ganes Candra Eka Puspitasari Dwiyanti, Dhea Syafitri Fardani, Roushandy Asri Hamdin, Candra Dwipayana Hardani, H Hasina, Raisya Idham Halid Lisnasari, Baiq Risky Wahyu Mahacita Andanalusia Marasabessy, Keysha Nabilla Putri Maulidya, Selvira Anandia Intan Mentari, Ika Nurfajri Mutthoimah, Ulfatul Ni Nyoman Ariwidiani Novianty, Wanda Nurul Indriani Pauzan Pauzan, Pauzan Pebrianti, Dea Riski Permatasari, Lina Purmafitriah, En Purnomo, Indra Putranto, Diouf Maulana Dwi Putri, Dheden Nurhani Bija Ratnasari, Titin Ratulangi, Wulan Ratia Rohmatillah, Siti Rosnalia Widyan Safitri, Afifa Dian Saputra, Yoga Dwi Sari, Tri Purma Sasvania, Anisa Sri Idawati ustiawaty, jumari Utami, Evi Fatmi Yazid Maula Yuni, Rohma Zaneta, Nabila Destia