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All Journal Jurnal Farmasi Andalas Jurnal Sains dan Teknologi Farmasi Jurnal Riset Kimia Pharmascience Jurnal Surya Medika As-syifaa Jurnal Farmasi Jurnal Kesehatan Medika Saintika JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Katalisator JFIOnline Majalah Kedokteran Andalas Jurnal Farmasi Higea Medical and Health Science Journal Human Care Journal Jurnal Ners JPK: Jurnal Proteksi Kesehatan Indonesian Journal of Multidisciplinary Science

Helmi Arifin

Universitas Andalas

Author-ID : 232638

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Pengaruh Pemberian Vanadil Sulfat dan Kromium (III) Klorida terhadap Fungsi Ginjal Mencit Putih Diabetes Dwisari Dillasamola; Surya Dharma; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 1, No 1 (2014): J Sains Farm Klin 1(1), November 2014
Publisher : Fakultas Farmasi Universitas Andalas

The objective of this study was to identify the effect of two heavy metals, vanadyl sulphate and chromium (III) chloride on creatinine level of hyperglycemic mice induced by dexamethasone 11mg/kg. The experimental animals were grouped into five groups comprised of 5 white mice. Group I was used as control group, only received standard feeding and food supplement. Group II-V were induced with dexamethasone 11mg/kg to increase the blood glucose level. Group III was also given chromium (III) chloride 5.2 ug/20g. Group IV was also given vanadyl sulphate at the dose of 0.78 mg/20g. Group V received combination of vanadyl sulphate 0.39 mg/20g and chromium (III) chloride 2.6 ug/20g. The level of blood creatininewas determined by enzymatic method conducted for 42 days and observations were taken at day 7, 21 and 42. This study concluded that administration of vanadyl sulphate and chromium (III) chloride combination significantly reduced blood creatinine level of white mice (p<0,05).

Hubungan Depresi Terhadap Tingkat Kepatuhan dan Kualitas Hidup Pasien Sindrom Dispepsia di RSUP Dr. M. Djamil Padang Bobbi Hemriyantton; Helmi Arifin; Arina Widya Murni
Jurnal Sains Farmasi & Klinis Vol 3, No 2 (2017): J Sains Farm Klin 3(2), Mei 2017
Publisher : Fakultas Farmasi Universitas Andalas

The objective of this study was to examine the correlation of depression, adherence, and quality of life in dyspepsia patient. Cross-sectional data were collected from 61 outpatient with dyspepsia at a special clinic in M. Djamil Hospital Padang. Patients were interviewed based on BDI II (Back Depression Inventory II) to assess depression, Morisky scale to assess adherence. Patient with BDI scores more than 12 was consulted to a special clinic of psychosomatic to diagnose for depression. Correlation between depression, adherence, and quality of life was analyzed with Spearman correlation. Coefficient correlation of depression and adherence was 0.272, while the correlation between depression and quality of life was 0.655. This finding demonstrates that there is a high correlation between depression and quality of life, while there is a low correlation between depression and adherence. Keywords: Depression, adherence, quality of life, dyspepsia.

Kajian Regimen Dosis Penggunaan Obat Asma pada Pasien Pediatri Rawat Inap di Bangsal Anak RSUP. Dr. M. Djamil Padang Rahmi Yosmar; Meri Andani; Helmi Arifin
Jurnal Sains Farmasi & Klinis Vol 2, No 1 (2015): J Sains Farm Klin 2(1), November 2015
Publisher : Fakultas Farmasi Universitas Andalas

A study on dosage regimens of asthma medications in pediatric patients hospitalized at the pediatrics ward DR. M. Djamil Padang hospital has been carried out. The purpose of this study was to determine and compare the suitability of dosage regimen given to pediatric patients in the pediatrics ward of Dr. M. Djamil Padang hospital with the literature. This study was conducted retrospectively with consecutive sampling technique. Samples were obtained from medical records during 2013. The results showed that the appropriate dosage administration of asthma medication for the prednisone, Combivent® and ambroxol were 100%, salbutamol 75%, and theophylline 0%. On the other hand, the entire medications showed 100% suitability concerning the route of administration. While for the interval of administration, the study showed that dexamethasone, prednisone, salbutamol, theophylline and ambroxol were 100% appropriate, but Combivent® was lower at 95.24%. The study concludes that the dose and interval of administration are not in accordance with the literature, while the route of administration is considered to be in accordance with the literature.

Perbandingan Dosis Warfarin terhadap Durasi Tercapainya Target INR pada Pasien CHF dengan Fibrilasi Atrial Tiara Tri Agustini; Helmi Arifin; Akmal M. Hanif
Jurnal Sains Farmasi & Klinis Vol 2, No 2 (2016): J Sains Farm Klin 2(2), Mei 2016
Publisher : Fakultas Farmasi Universitas Andalas

A study of comparison between warfarin dose with achieving target INR in patients with CHF and atrial fibrillation at RSUP. DR. M. Djamil Padang has been investigated. This study analyzed using one-way ANOVA and if the result is significant then followed by post hoc test. Of the total 27 patients, all the patients suffering from CHF and 11 patients suffering from hypertension. There were 15 patients aged <60 years, 11 patients aged between 60-74 years, and 1 patient aged ≥75 years. The number male and female patients are 11 and 16 people. The mean duration of achieving the target INR at dose 2 mg, dose (2 mg and 4 mg) and dose 5 mg are 38.22, 29.33, and 6.56 days. There is a significant difference in the mean duration of achieving the target INR in the dose group. 5 mg dose had a mean duration of achieving the target INR which significantly different compared to the other doses. A study of comparison betweenwarfarin dose with achieving target INR in patients with CHF and atrial fibrillation at RSUP. DR. M. Djamil Padang has been investigated. This study analyzed using one-way ANOVA and if the result is significant then followed by post hoc test. Of the total 27 patients,all the patients suffering fromCHF and11 patients suffering from hypertension. There were 15 patients aged <60 years, 11 patients aged between 60-74 years, and 1 patient aged ≥75 years. The number male and female patients are11 and 16 people. The mean duration of achieving the target INR at dose 2 mg, dose (2 mg and 4 mg) and dose 5 mg are 38.22, 29.33, and 6.56 days. There is a significant difference in the mean duration of achieving the target INR in the dose group. 5 mg dose had a mean duration of achieving the target INRwhich significantly different compared to the other doses.

Kajian Penggunaan Analgetik pada Pasien Pasca Bedah Fraktur di Trauma Centre RSUP M. Djamil Padang Susi Handayani; Helmi Arifin; Menkher Manjas
Jurnal Sains Farmasi & Klinis Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019
Publisher : Fakultas Farmasi Universitas Andalas

Mengatasi nyeri Pasca bedah fraktur merupakan tindakan penting dalam mencegah nyeri kronik, mengurangi lama perawatan demi meningkatkan kulitas hidup pasien. Karena itu perlu kajian penggunaan analgetik pasien Pasca bedah fraktur agar tepat guna, menguntungkan serta menghindari efek samping. Penelitian bertujuan mengkaji penggunaan analgetik yang meliputi jenis, dosis, penurunan derajad nyeri, serta efek samping yang ditimbulkan. Penelitian dilakukan pada pasien Pasca bedah fraktur di Trauma Centre RSUP M Djamil Padang Agustus hingga Oktober 2018 sebanyak 45 orang. dan yang menggunakan analgesik ketorolak injeksi 30mg/8jam 31 pasien (68,9%), tramadol injeksi 100mg/8jam 13 pasien (28,9%) dan paracetamol tablet 3x500mg 1 pasien (2,2%). Dari analisa statistik menggunakan Wilcoxon signed rank test, terdapat hubungan bermakna penurunan derajad nyeri, dimana p<0,05. Dari penelitian ini dapat disimpulkan analgetik terbanyak ketorolak injeksi 30mg/8 jam, dapat menurunkan nyeri dari sedang menjadi ringan 45,2%, 51,6% tidak berubah nyeri sedang. dan 3,2% masih dengan nyeri berat. Tramadol injeksi 100mg/8jam, menurunkan nyeri dari berat ke sedang 35,5%, berat ke ringan 61,5%. dan parasetamol tablet 3x500mg pada nyeri ringan 100%. Dengan penurunan derajad nyeri keseluruhan adalah 71,1%. Serta efek samping yang dirasakan berupa kontipasi (tramadol) sebanyak 13,33% dan mual muntah (ketorolak) sebanyak 8,89%.

Hubungan Gaya Kepemimpinan Kepala Ruangan dengan Kinerja Perawat Pelaksana dalam Menerapkan Asuhan Keperawatan di Ruang Rawat Inap Rumah Sakit Umum Mayjenn HA Thalib Kerinci Reni Trevia; Helmi Arifin; Dewi Eka Putri
Jurnal Kesehatan Medika Saintika Vol 10, No 2 (2019): Desember 2019
Publisher : Stikes Syedza Saintika Padang

Kinerja perawat merupakan faktor penentu dalam mutu pelayanan di sebuah rumah sakit, perawat akan selalu dituntut melakukan kinerjanya yaitu memberikan asuhan keperawatan secara optimal dan sesuai standar yang telah ditentukan. Salah satu faktor yang mempengaruhi kinerja adalah gaya kepemimpinan. Tujuan penelitian ini adalah untuk mengetahui hubungan gaya kepemimpinan dengan kinerja perawat pelaksana dalam menerapkan asuhan keperawatan di RSU Mayjend HA Thalib Kabupaten Kerinci. Desain penelitian deskriptif analitik, pendekatan cross sectional. Sampel adalah 101 perawat pelaksana di ruang rawat inap RSU Mayjend HA Thalib dengan teknik pengambilan sampel adalah simple random sampling. Pengumpulan data dilakukan dengan menggunakan kuesioner. Hasil penelitian adalah kinerja perawat pelaksana baik sebesar 67,3% dan didapatkan gaya kepemimpinan demokratis kuat sebesar 57,4%. Otokratik lemah 68,3%, partisipatif lemah sebesar 52,5% dan laisez faire lemah sebesar 69,3%. Terdapat hubungan yang bermakna (p<0,05) antara gaya kepemimpinan demokratik (p=0.001) dan otokratik (p=0,013)dengan kinerja perawat pelaksana menerapkan asuhan keperawatan di ruang rawat inap RSU Mayend HA Thalib Kabupaten Kerinci. Saran bagi pihak manajemen rumah sakit agar memberikan pelatihan tentang asuhan keperawatan kepada perawat pelaksana terutama pada tahap pengkajian dan evaluasi.

EFEK ANALGETIK EKSTRAK ETANOL RIMPANG GANDASULI (HEDYCIUM CORONARIUM) PADA MENCIT PUTIH JANTAN Fajrian Aulia Putra; Netty Suharti; Helmi Arifin
HUMAN CARE JOURNAL Vol 6, No 2 (2021): Human Care Journal
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v6i2.1225

ABSTRACTGandasuli rhizome (Hedycium coronarium, J. Koening.) Is one of Indonesia's native plants that has been used as medicine by various generations of people from generation to generation. This study aims to obtain information about the effect of giving gandasuli rhizome ethanol extract on increased analgesic activity. This research is a purely experimental research using test animals male white mice (Mus muculus) as the object of the experiment. A was used as many as 25 mice for analgesic activity. The ethanol extract used is an extract that has been standardized, by testing specific and non-specific parameters. To test the analgesic activity, the dosage variants of 200 mg / KgBB, 400 mg / KgBB and 600 mg / KgBB were used by observing the response time of the test animals to the heat from the hot plate, by entering the observations into the analgesic activity equation, from this study the results of analgesic activity were obtained. at a dose of 600 mg / KgBW with a value of 79.62% ± 1.68% at 90 minutes. Comparison of analgesic activity data between dose variants and the response of test animals after analysis with the two-way ANOVA statistical test obtained P results (<0.05) which proved that giving gandasuli rhizome ethanol extract (Hedycium coronarium, J. Koening.) In several dose variants had an effect. in real terms in the response of mice to pain (analgesic activity).Keywords : Gandasuli rhizome extract, hot plate, white mice, analgesic activity ABSTRAKRimpang Gandasuli (Hedycium coronarium, J.Koening.) merupakan salah satu tumbuhan asli indonesia yang telah digunakan sebagai obat oleh berbagai generasi masyarakat secara turun temurun. Penelitian ini bertujuan untuk memperoleh informasi tentang efek pemberian ekstrak etanol rimpang gandasuli terhadap peningkatan aktifitas analgetik. Penelitian ini merupakan penelitian eksperimental murni dengan menggunakan hewan uji mencit putih jantan (Mus muculus) sebagai objek eskperimen. Dimana 25 ekor mencit putih digunakan untuk pengujian aktivitas analgetik. Ekstrak etanol yang digunakan merupakan ekstrak yang telah terstandarisasi, dengan melalui uji parameter spesifik dan non spesifik. Untuk pengujian aktivitas analgetik digunakan varian dosis 200 mg/KgBB, 400 mg/KgBB dan 600mg/KgBB dengan cara mengamati waktu respon hewan uji terhadap rasa panas dari hot plat, dengan memasukkan hasil pengamatan kedalam persamaan aktivitas analgetik, dari penelitian ini didapatkan hasil aktivitas analgetik pada dosis 600 mg/KgBB dengan nilai 79,62 % ± 1,68 % pada menit ke 90. Perbandingan data aktivitas analgetik antara varian dosis dengan respon hewan uji setelah dianalisis dengan Uji statistik Anova dua arah didapatkan hasil P(<0,05) yang membuktikan bahwa pemberian ekstrak etanol rimpang gandasuli (Hedycium coronarium, J.Koening.) pada beberapa varian dosis berpengaruh secara nyata pada Respon Mencit terhadap rasa sakit (Aktivitas analgetik).Kata kunci :Ekstrak rimpang gandasuli, hot plate, mencit putih,aktivitas analgetik

Studi Farmakovigilans Pengobatan MDR-TB pada Pasien Rawat Jalan di RSUD Embung Fatimah Kota Batam Tahun 2020: Study of MDR-TB Treatment Pharmacovigilans in Outpatients at Embung Fatimah Hospital Batam City in 2020 Sri Ana Setianingsih; Delladari Mayefis; Helmi Arifin
Jurnal Surya Medika (JSM) Vol. 8 No. 2 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i2.3909

Pharmacovigilance is a science related to collecting, detecting, monitoring, assessing, and preventing side effects of pharmaceutical products. The design of this research is retrospectively descriptive. To understand the characteristics of MDR-TB patients and the side effects of the drug that MDR-TB patients feel. The research was conducted between January 2020 – June 2020. The research was conducted at Embung Fatimah Hospital. The number of confirmed patients with MDR TB was 24 patients, 9 male (37.5%) and 15 women (62.5%); the average MDR-TB patient aged 26-45 years (54.20%), Batu Aji (45.83%) be the place most exposed to MDR-TB with a social history of smoking, drugs, and alcohol. The results showed patients who experienced 41.7% anorexia side effects, 100% nausea, 100% vomiting, reduced appetite by 37.5%, 79.2% pain at the injection site, 79.2% joint pain, 58.3% reduced hearing and 25% vertigo. In conclusion, most side effects are nausea and vomiting.

Analyzing ACEI-Furosemide and ARB-Furosemide Drugs Combination on Hypertension and Chronic Kidney Disease Patients Hesti Effendi; Helmi Arifin; Nasrul Zubir
Indonesian Journal of Multidisciplinary Science Vol. 2 No. 4 (2023): Indonesian Journal of Multidisciplinary Science
Publisher : International Journal Labs

The purpose of this study was to compare the efficacy of ACE-inhibitor + Furosemide and ARB + Furosemide in lowering creatinine, urea, and blood pressure in individuals with hypertension and chronic renal disease. This is a retrospective study in which data were extracted from the medical records of patients with hypertension and chronic kidney disease in the Internal Medicine Ward of the General Hospital dr. M. Jamil Padang in West Sumatera. A 2-by-3 ANOVA hypothesis test design was utilized. The hypothesis was evaluated using an alpha value of 0.05. The results demonstrated that the ARB + Furosemide combination was superior to the ACE-Inhibitor + Furosemide combination by 86.2%. In addition, this study demonstrated that the medication combinations ACE inhibitor plus furosemide and ARB plus furosemide were equally efficient in lowering creatinine, urea, and blood pressure in individuals with hypertension and chronic renal disease. The researchers found that antihypertensive medicines, including the ACE-Inhibitor + Furosemide combination and the ARB + Furosemide combination, can be administered at levels determined by the patient's clinical situation. Also, while selecting a pharmacological combination between an ACE inhibitor and furosemide or an ARB and furosemide, it is important to consider the adverse effects of the drugs. For instance, it is preferable to combine ARB with Furosemide.

Toksisitas Sub Akut Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap Fungsi Hati dan Ginjal Pada Mencit Putih Jantan Ifora Ifora; Helmi Arifin; Diana Idrifa
Jurnal Farmasi Higea Vol 7, No 2 (2015)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v7i2.124

Sub-acute toxicity testing of the ethanol extract of basil leaf (Ocimum sanctum L.) has been done to the liver and kidney function male white mice. This testing includes checks alanine aminotransferase activity, serum creatinine levels and the relative weight of organs (liver and kidney). Extract administered orally at a dose variation of 100 mg/kg, 200 mg/kg and 400 mg/kg for 7, 14 and 21 days. The results showed basil leaf extract at a dose of 100, 200 and 400 mg/kg no significant effect on the activity of SGPT, serum creatinine levels and relative organ weight (p > 0.05).

Co-Authors -, Risfaheri ., Nirwanto Agustini, Tiara Tri Akmal M. Hanif Almahdy Almahdy Ariadi, Aried Aried Ariadi Aried Eriadi Arina Widya Murni Asram Ahmad Barmitoni Barmitoni Benny Benny Bobbi Hemriyantton Candra Syuryani Dahlyanti, Rina Delladari Mayefis Deni Kurniati Deswinar Darwin Dewi Eka Putri Dian Ayu Juwita Diana Idrifa Dwisari Dillasamola Eddy Duarto Elisma Elisma Elisma Elisma Elka Elka Ella Handalia Endang Purwati RN Erlina Rustam Fajrian Aulia Putra Fathul Jannah Feni Efrianti Fitri Maya Sari Gina Sonia Harto H. Havizur Rahman Havizur Rahman Hengki Afdhal Henny Lucida Heppy Riyono Hesti Effendi Hidayat, Zoni Hidayati Hidayati Hilmarni Hilmarni Ifora Ifora Ira Oktaviani Rz Jaka Perdana Leli Sriyani Machdawaty Masri Masitah Masitah Menkher Manjas Meri Andani Meri Susilawati Merry C, Ann Murni, Yulia Nasrul Zubir Nela Andriani Nelfa Yulianti Nelwati, Nelwati Netty Suharti Nirwanto . Nirwanto Nirwanto Nofiza, Welli Novi Priyoka Putra Novika Maulina Octy Aisyahharma Rahimatul Uthia Rahimatul Uthia Rahman, Havizur Rahmi Yosmar Rahmi Yulia Nesia Randika Fransiska Raveinal Raveinal RAVEINAL RAVEINAL Raveinal Raveinal Rella Silvia Reni Trevia Ria Irawati Rina Dahlyanti Ririn Anjelin Risfaheri - Rizky Yulion Rosa Julia Wijaya Rostin Rostin Rusdi Rusdi Rusdi Saputra, Harry Saputra, Harry Satrina Chania Sinata, Novia Solly Aryza Sri Ana Setianingsih Sri Oktavia Sri Oktavia Suci Ahda Novitri Suhatri Suhatri Sumanti, Titi Sumaryati Syukur Surya Dharma Susi Handayani Tesa Inmerka Alwi Titi Sumanti Vivi Resviana Wesnawati, Wesnawati Widya Kardela Wildra Martoni Yulia Murni Yuliana Arsil Yuni Andriani Zet Rizal Zet Rizal ZK Abdurahman Baizal Zoni Hidayat

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