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All Journal JURNAL PROMOSI KESEHATAN INDONESIA Jurnal Kesehatan Andalas Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics & Gynecology Science Journal of Midwifery Majalah Kedokteran Andalas Jurnal Sehat Mandiri Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Andalas obstetrics and gynecology journal Jurnal Ners Science Midwifery Indonesian Journal of Global Health research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Kebidanan Indonesia Jurnal Sains dan Kesehatan Women Midwives and Midwifery Plexus Medical Journal Jurnal Sains Farmasi dan Kesehatan Malahayati International Journal of Nursing and Health Science
Defrin Defrin
Universitas Andalas
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The Association Between PIGF Level and Neonatal Outcomes in Normal Pregnancies, Early Onset and Late Onset Preeclampsia at Dr. M. Djamil General Hospital Padang Chika Aulia Husna; Defrin Defrin; Husna Yetti
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 2 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.2.322-329.2026

Abstract

Background: Preeclampsia is a major pregnancy complication that significantly contributes to maternal and neonatal morbidity and mortality. Impaired placentation leads to an imbalance between angiogenic and antiangiogenic factors, particularly a reduction in placental growth factor (PlGF) levels, which is believed to play an important role in adverse neonatal outcomes. Objective: To determine the relationship between maternal serum PlGF levels and neonatal outcomes in normal pregnancies, early-onset preeclampsia, and late-onset preeclampsia at Dr. M. Djamil General Hospital, Padang. Methods: This study was an observational analytic study with a cross-sectional design. The study population consisted of pregnant women with normal pregnancies, early-onset preeclampsia, and late-onset preeclampsia who met the inclusion criteria. Maternal serum PlGF levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Neonatal outcomes assessed included birth weight, birth length, and Apgar scores. Data were analyzed using univariate and bivariate statistical analyses. Results: A total of 48 pregnant women were included in this study, comprising 16 normal pregnancies, 16 cases of early-onset preeclampsia, and 16 cases of late-onset preeclampsia. The mean age of the subjects was within the reproductive age range of 20–35 years. The highest mean PlGF levels were found in the normal pregnancy group, followed by the late-onset preeclampsia group, and the lowest in the early-onset preeclampsia group, with a significant p-value indicating a meaningful difference in PlGF levels among the three groups. Neonatal outcomes showed that the lowest mean birth weight, birth length, and Apgar scores were observed in the early-onset preeclampsia group. Bivariate analysis demonstrated a significant association between PlGF levels and birth weight in the early-onset preeclampsia group (p = 0.0001). Conclusion: There is a significant association between PlGF levels and preeclampsia, suggesting that PlGF has potential as a predictive biomarker for preeclampsia. Regarding neonatal outcomes, a significant association was found with birth weight in early-onset preeclampsia, while no significant association was observed with birth length and Apgar scores across the three groups.
Co-Authors Abdiana Abdiana, Abdiana Adang Bachtiar Adang Bachtiar Adrial Adrial Afdal . Afdal, Afdal Amir, Arni Andi Friadi Anggun Pratissa Anisa Ulfah Ariadi Ariadi Ayu Nurdiyan Besty Berliana Boby Hartanto Boby Hartanto Calvindra Leenesa Chika Aulia Husna Citra Dewi Anitasari Citra Manela David Perdana Delmi Sulastri Desmawati Desmawati Dia Rofinda, Zelly Dia Drivaldo Mulya Ennesta Asri Erda Mutiara Halida Eva Chundrayetti Firdawati Firdawati Frita Dwi Luhuria Gestina Aliska Hafni Bachtiar Hardisman Haviz Yuad Hema Malini, Hema Heri Farnas Hudila Rifa Karmia Husna Yetti Ika Nur Saputri Joserizal Serudji Julizar Julizar Katelino Marpaung Lusiana El Sinta Bustami Marcella Marcella Masrul Masrul Mayetti Mayetti Mayuliani Mayuliani Megawati Sinambela Mohamad Reza Mondale Saputra Mudjiran Mudjiran Mudjiran Mudjiran Mudjiran Mudjiran Muhammad Alpin Azhar Neherta, Meri Nice Rachmawati Norman Ferdinal Nur Indrawaty Lipoeto Nur Mala Sari Rahmayani Afrah Rima Semiarty Rizanda Machmud Rosfita Rasyid Rozi Sastra Purna Siti Aisyah Sonia Wulan Dari Syarifah Tia Tahnia TITIN DEWI SARTIKA SILABAN Try Genta Utama Ulfa Badri Ulfa Farrah Lisa, Ulfa Farrah Ulya Uti Fasrini Waldatul Hamidah Wiyola Audina Yanti, Roza Sri Yusmalia Hidayati Yusrawati Yusrawati Zulfiqar MS