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All Journal Dentika Dental Journal Jurnal Sains dan Teknologi Farmasi Science and Technology Indonesia Jurnal Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea Jurnal Prima Medika Sains JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Journal of Multidisciplinary Applied Natural Science FORTE JOURNAL Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Andalas Dental Journal Formosa Journal of Sustainable Research (FJSR) Jurnal Farmasi Indonesia
Yufri Aldi
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Pharmaceutical And Biomedical Sciences Journal (PBSJ)

 1 
Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Co-Authors . Yanwirasti AA Sudharmawan, AA Aan Ardiansyah Adinny Julmiza Aditya Alqamal Alianta Adrul Fauzan Afriwardi Afriwardi Akmal Djamaan Amri Bakhtiar Andani Eka Putra Ardiansyah, Aan Arfiandi Arfiandi Arif Setiawansyah Astari, Lita Tri Azukhruf, Wanda Sabila Ben, Elfi Sahlan Benardo Benardo Benardo, Benardo Dachriyanus Deni Anggraini Densi Selpia Sopianti Densi Selpia Sopianti Dewi Gulyla Hari Dian Handayani Dian Handayani Diana Laila Ramatillah Dwisari Dillasamola Elda Mayanti Elidahanum Husni Elisma Elisma Ellyza Nasrul Elsa Badriyah Enda Markus Aginta Sembiring Erizal Erizal Erizal Zaini Fadilla, Utami Budhi Fatma Sri Wahyuni Fatma Sriwahyuni Febria, Nurma Fifi Harmely Fildzah Nurul Fajrin, Fildzah Nurul Friardi Ismed Gita Susanti Gloria, Fransisca Gusriyani, Sri Hansen Nasif Havizur Rahman Herwinda Julia Putri Hulwa Salsabila Julmiza, Adinny Lukas, Stefanus M Asmadi Mahyudin Mahyudin Marlina . Michael Michael Muhammad Islamoyo Muhammad Syafrudin Nikita Surya Dharma Nila Kasuma Nindya Prastiwi Nisya Ogiana Nurliyasman Panggabean, Aminah Paulina, Ida Prastiwi, Nindya Rahmad Abdillah Rahmad Abdillah Rahmadevi Rahmi Nofita Rama Feriska Putra Ramatillah, Diana Laila Rozi Efendi Rury Trisa Utami Rustini Rustini Salman - Salman Salman Salman Umar Salman Umar Salman Umar Sayyida, Alya Sirda Yenni Srangenge, Yoneta Sri Oktavia Suci Sutma Suhatri Suhatri Surya Nelis Susi Susi Syofyan Syofyan Usman, Hendrizal Wahyudi, Agung Aji Widya Kardela Widya Nengsih Yahdian Rasyadi Yanelita Vipri Yanwirasti Yanwirasti Yaser Arafat Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Zet Rizal