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Journal : Jurnal Veteriner

Tingkat Insidensi Malaria di Wilayah Pemanasan Kelambu Berinsektisida Tahan Lama dan Wilayah Kontrol (MALARIA INCIDENCE RATE OF HEAT ASSISTED REGENERATION LONG LASTING INSECTICIDAL NETS AREA AND CONTROL) Etih Sudarnika; Mirnawati Sudarwanto; Asep Saefuddin; Umi Cahyaningsih; Upik Kesumawati Hadi; Rita Kusriastuti; Jodi Vanden Eng; Daowen Zhang; William A. Hawley
Jurnal Veteriner Vol 12 No 1 (2011)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Long lasting insecticidal nets (LLIN) is one effective way to prevent malaria. Permethrin treatedLLIN is one type of LLIN which is recommended by WHO. Several studies have shown that these types ofLLIN requiring heat assisted regeneration after washing to enhance the biological activity of insecticidethat contained in the LLIN fibers. This study aimed to compare the incidence rates of malaria in childrenunder five years old who live in the intervention area (where the heat assisted regeneration on LLIN afterwashing was applied) and control area (where the heat assisted regeneration on LLIN after washing wasnot applied). Data of malaria cases was collected from laboratory log book at all health centers in BangkaDistrict, in the period of June June 2007 until July 2008. Data were analyzed with Poisson regressionmodels. The results showed that the incidence rate of malaria in children under five years old was notsignificantly different between the treatment and control areas.
Ekstrak Sambiloto Menurunkan Patogenesitas Ookista Eimeria Tenella Yulia Yellita; Umi Cahyaningsih; Dyah Iswantini Pradono; Wiwin Winarsih; Wasmen Manalu
Jurnal Veteriner Vol 12 No 4 (2011)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Eimeria tenella is one of the nine of Eimeria species, a pathogenic intraseluler protozoa causing aviancoccidiosis. Infection was initiated by the ingestion of sporulated oocysts. The aim of this study was toinvestigate the effect of E. tenella oocyst incubation in methanol extract of Andrographis paniculata beforeinfection in broiler performance. This research used 115 broiler DOC (CP 707) devided into five groups,each group consisted of 23 broilers. The infection with 1x105 oocyst were done at the 14th day old of chicken.The 1st group was placebo (KN), while the 2nd group was infected with unincubated oocyst (KP), and theother three groups i.e. : 3rd, 4th, 5th were infected with incubated oocyst in A. paniculata extract for 2, 4, and6 hours, respectively. The number of oocysts in feces were counted on day 5th to 14th post-infection, theheterophile and macrophages were counted from caecum histology preparation, by slaughtered threechickens of each of groups on the day 0,3,6.9, and 14 post infection, and accretion body weight wasmeasured by weighing chickens per week to five-week old chickens. The results of this study indicated thatthe incubation period the sporulated oocyst in the extract of A.paniculata for six hours before infection,reduced the number of oocysts production in the feces, the number of inflammatory cells (macrophages andheterophile) in the cecum, and increases body weight (gain). In conclusion A.paniculata extract decreasedthe pathogenisity of E.tenella oocyst, so the extract of A.paniculata has good potential as anticoccidia. Itis high likely that A. paniculata extract has a potential to be anticoccidia.
Molecular Docking Senyawa Jahe Merah dan Kunyit pada Dense Granules Protein-1 Toxoplasma gondii dengan Metode In Silico Fitrine Ekawasti; Siti Sa'diah; Umi Cahyaningsih; Ni Luh Putu Indi Dharmayanti; Didik Tulus Subekti
Jurnal Veteriner Vol 22 No 4 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.209 KB) | DOI: 10.19087/jveteriner.2021.22.4.474

Abstract

Toksoplasmosis merupakan penyakit zoonosis yang disebabkan oleh parasit Toxoplasma gondii yang berdistribusi luas di seluruh dunia. Penyakit ini, selain mengkhawatirkan manusia juga dapat berdampak pada ekonomi peternakan karena menyebabkan penurunan produksi, gangguan pertumbuhan dan fertilitas termasuk aborsi, prematur, dan lahir mati. Prevalensi toxoplasmosis di Indonesia sangat tinggi, pada manusia sekitar 40–85%, dan pada hewan berkisar antara 5–80%. Jahe merah dan kunyit merupakan tanaman zingiberaceae yang mengandung antioksidan tinggi, yang diketahui memiliki aktivitas menghambat proses inflamasi dan berpotensi sebagai anti-toxoplasma. Namun, sampai saat ini belum diketahui mekanisme kerja senyawa aktif kunyit dan jahe merah dalam berikatan dengan reseptor protein T. gondii sebagai target pada terapi toxoplasmosis. Dilakukan uji aktivitas senyawa yang terkandung dalam jahe merah dan kunyit sebagai anti-toxoplasma terhadap protein GRA1 T. gondii dengan molecular docking secara in silico. Protein GRA1 berperan penting dalam kelangsungan hidup T. gondii. Preparasi data dasar dari struktur protein GRA1 menggunakan software PyRx, preparasi dan optimasi struktur 3D ligan jahe merah dan kunyit menggunakan aplikasi web server SWISS model prediction, serta metode molecular docking dan docking ligan pada protein GRA1 menggunakan software Autodock Vina. Hasil simulasi menunjukkan bahwa senyawa pada jahe merah dan kunyit memiliki potensi sebagai anti toxoplasmosis. Senyawa potensial demethoxycurcumin pada kunyit memiliki nilai binding affinity dan interaksi ikatan yang paling kuat terhadap protein GRA1 T. gondii.
Ekstrak Sambiloto (Andrographis paniculata) Menurunkan Jumlah Skizon, Mikrogamet, Makrogamet, dan Oosista Eimeria tenella (EXTRACT OF ANDROGRAPHIS PANICULATA DECREASED SCHIZONTS, MICROGAMETES, MACROGAMETES AND OOCYSTS NUMBER OF EIMERIA TENELLA) UMI CAHYANINGSIH; RESSY RIANDCI; DYAH ISWANTINI
Jurnal Veteriner Vol 13 No 3 (2012)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The aim of this research was to observe the effect of ethanol extract of Andrographis paniculata givenin grading doses to the schizonts, microgamete, macrogamete, and oocytes counts of Eimeria tenella inchicken caecum. A total of ninety day old broiler chicks were used in the study. At two weeks old the broilerswere divided into six groups. Each group consisted of 15 broilers, the 6 groups were: (i) negative control(broilers did not receive any treatment); (ii) positive control (each animal were infected with 104 E. tenellaoocytes); (iii) medicine control (each animal were infected with 104 E. tenella oocytes and coccidiostat); (iv)A1 (each animal were infected with 104 E. tenella oocytes and paniculata extract 90 mg/kg body weight); (v)A2 (each animal were infected with 104 E. tenella oocytes and paniculata extract 180 mg/kg body weight);and (vi) A3 (each animal were infected with 104 E. tenella oocytes and paniculata extract 360 mg/kg bodyweight). At day 6, 9, 13, 16, and 22 post infection three broilers from each group were sacrificed and theirceca were collected for histopathological examination. The results showed that paniculata extract at dose90 mg/kg body weight and 180 mg/kg body weight was able to decrease the numbers of shizont, microgamete,macrogamete, and oocytes of E. tenella in the chicken caecum.
Co-Authors A.S. Satyaningtijas Agik Suprayogi Ali Rahayu Anne Carolina Arif Rahman Jabal Arifin Budiman Nugraha Arifin Nugraha Arini Ratnasari ASEP SAEFUDDIN Azizah, Hanifah Nur Azmi, Zul Damiana Rita Ekastuti Daowen Zhang Dedi Duryadi Solihin Denny Widaya Lukman Desem, Muhammad Ibrahim Didik T Subekti Didik T Subekti Didik Tulus Subekti Didik Tulus Subekti Didik Tulus Subekti Didik Tulus Subekti Dyah Ayu Kurniawati Dyah Iswantini Effionora Anwar Eko Setyo Purwanto Ekowati Handharyani Etih Sudarnika Eva Harlina Fajar Kawitan Farlin Nepho Fitri, Arni Diana Fitrine Ekawasti Fitrine Ekawasti Fitrine Ekawasti Fitrine Ekawasti, Fitrine Fong, Sulinawati Hadri Latif HERA MAHESHWARI Ichwan Yuniarto Isdoni Bustaman Isrok Malikus Sufi Jodi Vanden Eng koekoeh santoso Kurniawati, Dyah Ayu Laela N. Anisah M. Jamaluddin Assidiqi M. Jamaluddin Assidiqi, M. Jamaluddin M. Mirsageri M. Mirsageri, M. Mahdi Jufri MIRNA WATI DEWI Mirnawati Sudarwanto MIRNAWATI SUDARWANTO MUHAMMAD ADIB MUSTOFA muhammad ibrahim desem MULYATI EFFENDI Nepho, Farlin Ni Luh Putu Indi Dharmayanti Nisrina Rosyida Noor Rifai NLP Indi Dharmayanti Nugraha, Arifin Nugraha, Arifin Budiman Nuradji, Harimurti Nurcahyo, Raden Wisnu Nurridho Wahid, Muhammad Pudji Achmadi Purwantiningsih Sugita Purwanto, Eko Setyo Putri, Maritrana Qing Wen, Jyn Soong RESSY RIANDCI Rini Damayanti Risa Tiuria Rismayani Saridewi Rismayani Saridewi, Rismayani Rita Kartika Sari Rita Kusriastuti Riza Zainuddin Ahmad Sadiah, Siti Satyawardana, Wirokartiko Sa’diah , Siti Sa’diah, Siti Siti Sa'diah Siti Sa'diah Siti Sa'diah Siti Sa’diah Siti Sa’diah Sri Familasari Sufi, Isrok Malikus Susi Soviana Taher, Dharmawaty M. Tara Puri Ducha Rahmani Tarigan, Ronald Tjahja Muhandri Upik Kesumawati Hadi Valinata, Sisca Veenu Kumar Veerasamy, Suganti Vetnizah Juniantito Wasmen Manalu Wasrin Syafii William A. Hawley Winarsongko, Agus Wiwin Winarsih YENI KEZIA BEKALANI Yulia Yellita Yuniarto, Ichwan Zul Azmi Zulfiqri Z Zulfiqri Z, Zulfiqri