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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kesehatan Lingkungan indonesia Jurnal Ilmu Dasar e-Journal Pustaka Kesehatan Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Tropical and Infectious Disease JITRO (Jurnal Ilmiah dan Teknologi Peternakan Tropis) Journal of Agromedicine and Medical Sciences Journal Of Vocational Health Studies NurseLine Journal Dinamisia: Jurnal Pengabdian Kepada Masyarakat JCES (Journal of Character Education Society) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Medik Veteriner Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kreativitas PKM Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Majalah Biomorfologi (Biomorphology Journal) Lumbung Inovasi: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Indonesia : Jurnal Abdimas Indonesia Nursing and Health Sciences Journal (NHSJ) Jurnal Ilmu Sosial dan Humaniora Journal of Health, Education, Economics, Science, and Technology (J-HEST) IPTEK: Jurnal Hasil Pengabdian kepada Masyarakat Dedication : Jurnal Pengabdian Masyarakat InSTEM
Yudha Nurdian
Departemen Parasitologi, Fakultas Kedokteran Universitas Jember, Jember 68121
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : e-Journal Pustaka Kesehatan

 1 
Efek Hepatoprotektif Ekstrak Etanol Brokoli (Brassica oleracea L. var. italica) terhadap Kadar Malondialdehid Hepar Tikus Wistar yang Diinduksi DMBA (Hepatoprotective Effect of Ethanolic Extract of Broccoli (Brassica oleracea L. var. italica) on Liver Ma Dear Farah Sielma; Elly Nurus Sakinah; Yudha Nurdian
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

DMBA (7,12-Dimethylbenz(α)antracene) is a prototype of Polycyclic Aromatic Hydrocarbons (PAHs) which is present in automobile exhaust, cigarette smoke, and wood stoves. DMBA is converted into its reactive metabolites DMBA-DE and cause liver cell membrane lipid peroxidation, which results in an increased of liver malondialdehyde (MDA) levels. Broccoli contains flavonoid that able to prevent lipid peroxidation. The current study was conducted to find out the different hepatoprotective effect of ethanolic extract of broccoli against DMBA-induced hepatotoxicity in wistar rats using liver MDA as a marker. A total of 24 male wistar rats were divided into six groups, consisting of normal control (distilled water), negative control (DMBA), and treatment (ethanolic extract of broccoli in doses of 250, 500, 1000, and 2000 mg/kgBW). Rats were treated for 7 days prior to a single dose of DMBA on the 8th day of treatment. Liver tissue samples were taken on the 12th day for measurement of liver MDA levels. Data were analyzed using One Way ANOVA followed by Post Hoc Test LSD. The present study showed significant differences on liver MDA levels between groups (p<0.001). This study concluded that there were different hepatoprotective effects of ethanolic extract of broccoli treatment on liver MDA levels in wistar rats induced by DMBA. Keywords: ethanolic extract of broccoli, DMBA, malondialdehyde, hepatoprotective
Efek Analgesik Kombinasi Kurkumin dan Parasetamol pada Mencit yang Diinduksi Asam Asetat menggunakan Isobologram (The Analgesic Effect of Combination of Curcumin and Paracetamol in Acetic acid-induced Mice using Isobolograms) Nugroho Priyo Utomo; Cicih Komariah; Yudha Nurdian
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Paracetamol is a drug that classified as NSAID and commonly used as analgesic agent. These drugs have toxic effects that lead to liver damage. This effects caused by accumulation the metabolite compound of paracetamol, N-acetyl-p-benzoquinone (NAPQI), by cytochrome P450 enzyme. Some studies reported that curcumin have analgesic effects and inhibit action of cytochrome P450 enzyme. The purpose of this study was to determine the analgesic effect of curcumin and paracetamol combination in 27 acetic-acid induced mice. The result of this study showed that 2358,815 µg of curcumin and paracetamol combination can inhibit pain up to 50%. This result is smaller than paracetamol that need 4200 µg to achieve the same pain inhibition. One Way Annova test showed siginificant difference between paracetamol group and combination group. Isobolographic analysis results showed curcumin and paracetamol have synergistic properties in mice acetic-acid induced pain. Keywords: curcumin, paracetamol, isobolograph
Pengaruh Pemberian Ekstrak Etanol Brokoli (Brassica oleracea) terhadap Kadar SGOT dan SGPT Tikus Wistar yang Diinduksi DMBA (The Effect of Ethanolic Extract of Broccoli (Brassica oleracea) on SGOT and SGPT of Wistar Rats Induced by DMBA) Rizka Nuzula Wardani; Elly Nurus Sakinah; Yudha Nurdian
Pustaka Kesehatan Vol 4 No 2 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

DMBA is a product of incomplete burning which can cause free radicals in human. The metabolism of DMBA by Cytochrome P450 in liver causes hepatocyte DNA damage and decrease endogenous antioxidant. Broccoli contains flavonoid which can act as an antioxidant by inhibiting formation of free radicals through hydrogen atom donation to free radicals. This research aimed to analyze the effect of ethanolic extract of broccoli on SGOT and SGPT of wistar rats induced by DMBA. This research used 24 rats divided into six groups: control group, negative control group, and four treatment groups with broccoli ethanolic extract of 250 mg/kgBW, 500 mg/kgBW, 1000 mg/kgBW, and 2000 mg/kgBW for 7 days. The SGOT and SGPT levels of control group were 70,36 U/L and 33,97 U/L; negative control group 107,16 U/L and 56,21 U/L; the first treatment 101,50 U/L and 49,33 U/L; the second treatment 85,32 U/L and 43,67 U/L; the third treatment 84,11 U/L and 40,84 U/L; and the fourth treatment 81,28 U/L and 35,18 U/L. The result of One Way Annova test for SGOT was p=0,012 while SGPT was p=0,003. In this study, ethanolic extract of broccoli could protect hepatocyte by decreasing SGOT and SGPT levels.   Keywords: ethanolic extract of broccoli, SGOT and SGPT levels, DMBA
Co-Authors . Suryono Abiyu, Nizar Arkana Adhyasta Yuda Adrianto Adilah Julinar Irianti Aditya Faradina Salsabilla Ahmad Ashidhiqie Pramana Ahmad Hasbi Al-Muzaky Akmal Fikri Setiaji Al-Hasany, Elang Avinindra Virgiananta Ali, Alya Maulidya Alif Mardijana Angga Mardro Raharjo Anis Fila Klaudia Ardani, Dhea Febrian Asmara, Chrisnandito Bagus Atik Kurniawati Aulifia Rahmawati Aurellia, Naurah Septa Azharra, Alifiah Zalika Aziz, Ayu Munawaroh Bagus Hermansyah Bayda Masayu Subiyanto Belia Selva Wulan Septyana Cholis Abrori, Cholis Cicih Komariah Cicih Komariyah Cinta Kharisma Sunarto Dasarina Rizqi Amalia Dear Farah Sielma Deriel Thio Miratmaka Desi Dwi Cahyani Dhea Elfitra Noza Dian Ayu Puspayanti Dian Firtana Putri Diana Chusna Mufida Dina Helianti Dini Agustina Drajad, Rahadinda Mutia Dhamar Dwi Mutia Hassny Dwita Aryadina Rachmawati Dyah Kirana Arianti Nugroho Edy Junaidi Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Erfan Efendi Erica Septafanny Eva Tyas Utami Fabiyyanza, Ralief Yusrial Falah, Pilar Menara Fandika Firman Wijaksana Farradhita Ambar Tauriestya FATIMATUS ZAHROH Fidelina, Salma Aisyawa Fitra Ayu Mardani Fitriyah, Ainun Nadiratul Gensen Brianda Rusoneri Hadziqi, Ilham Fahmi Haq, Hanifah S Hendi Rengga Akhsani Hidayatullah, Ferdi Hilda Pramesti Arminata Santoso Ida Srisurani Wiji Astuti Indi Jasmine Nurhaliza Intani, Rini Nur Irawan Fajar Kusuma Irfan Maulana Ivan Iqbal Baidowi Jauhar Firdaus Kania Rahma Meneling Kautsar, Azyumardi Azra Kristianningrum Dian Sofiana Kusuma, Ancah Caesarina Lanang Nashrullah Lelono, Asmoro M. Ali Shodikin Maria Teliana Sum Maulana, Muhammad Naufal Maulidya Dwi Nuraini Mita Prilla Devie Moh. Lutfi Hasbullah Mohamat Fatekurohman Mufida, Diana C Muhammad Faris Al Ghofiqi Muhammad Irfan Ardiansyah Muhammad Yongki Ivan Sugesta Nabil Reza Maulana Nadia Rahmawati Nafila Syahrani Nariswari, Asti Syahda Nashirudin Al Azizi Naurah Septa Aurellia Nidya Husna Kholidah Ningsih, Sinar Hariati Nisa Urrosidah Novando Aji Baskoro Novinka Sinta Isnainiyah Nuardiansyah, Fahreza Adam Nugraha, Reiza Fajar Nugroho Priyo Utomo Nur Annisa Wahdah Nur Asyia Alfiyani One Farida Arilasmi Peni, Lis Widodo Pinsensius Andreas Prameswari, Dinda Putri Primadana, Aditya Putra, Dwi Rizky Ardi Putri, Della Kharisma Radiah Ulil Absari Radifan Fahrul Akhyar Rahardjo, Angga Mardro Raharjo, Angga M Rahmadhan, Adiz Dwiputra Rahman, Naisya Anindya Ramadhani, Rafindra Rangga Bayu Satriya Rani Rhiana Putri Rayhana, Intan Muliawati Regita Oktavia Adi Ningsih Relang Rizky Mulyadi Reza Nur Aulia Rezza Putri Mahartika Risang Hadi Wasesa Rizka Nuzula Wardani Rizkiana Rasman Rizqi Fitria Damayanti Rumastika, Nindya Shinta Rutsiana Dessyanti Ndoen Setyaningtias, Siva Putri Silvia Putri Aurelia Siti Hamidah Sofiannisa Achmadila Suhendro, Joshua Revival Supangat Supangat Syahputri, Siti Ananda Hardita Syahrul Aprilia Fallah Al Aziz Syavira Ainur Rohma Systriana Esi Kamasita T Ariani Widiastini Tajriyan, Aynani Tri Mul Yono Tusiana Putri Nelumbium Wardhono, Pradipta Pawitradyaka Wicaksono, Arif Dwi Wicaksono, Muhammad Iqbal Allun Widya Lestari Wijaya, Rizky Surya Wiwien Sugih Utami Yani Corvianindya Rahayu Yoga Samudra Hendarta Yuli Hermansyah Yunita Armiyanti Zahrah Febianti Zulaikha Rizqina Rahmawati