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Application of Natural Deep Eutectic Solvents (NADES) in the Natural Product of Antioxidant Activity Hidayah, Andi Nurul Annisa; Ahmad, Aktsar Roskiana; Rasyid, Faradiba Abdul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1345

The extraction of bioactive compounds from plant-based materials poses significant challenges due to the limitations of traditional organic solvents, including toxicity and environmental impact. Natural Deep Eutectic Solvents (NADES), formed from natural components at defined molar ratios, have emerged as green, sustainable alternatives for efficient extraction. This literature review aims to investigate the applications, compositions, and effectiveness of NADES in extracting antioxidant-rich compounds from natural sources. Relevant peer-reviewed articles published within the last ten years were retrieved from Google Scholar and PubMed using keywords such as “NADES,” “natural product,” and “antioxidant activity.” Studies included using NADES to extract phytochemicals, pharmaceuticals, or food compounds and address their toxicity, safety, and physicochemical properties. Non-peer-reviewed articles, unrelated solvent systems, and duplicate studies were excluded. The review identified compelling NADES compositions, including choline chloride: lactic acid (1:2), choline chloride: oxalic acid (1:1), and citric acid: glycerol (1:1), which demonstrated high extraction efficiency and antioxidant activity. The tunability of hydrogen bond donor and acceptor ratios allows NADES to be optimized for specific bioactive compounds. In conclusion, NADES offers a promising and eco-friendly approach for future applications in natural product extraction.

PENETAPAN KADAR FENOLIK TOTAL TUMBUHAN ENDEMIK KALIMANTAN UTARA Salsabillah, Nasywa Amelsya; Ahmad, Aktsar Roskiana; Syarif, Rezki Amriati
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.22110

North Kalimantan is home to a unique biodiversity, including medicinal plants traditionally used by local communities such as the Dayak people. Several of these plants are endemic—found exclusively in this region. Two notable endemic species, Dayak onion (Eleutherine palmifolia (L.) Merr.) and rose myrtle (Rhodomyrtus tomentosa), are known to contain secondary metabolites, including phenolic compounds. This study aimed to determine the total phenolic content of these two endemic plants. Extraction was performed using Ultrasonic-Assisted Extraction (UAE), resulting in extract yields of 11.42% (11.42 g) for Dayak onion and 24.33% (24.33 g) for rose myrtle. Preliminary phytochemical screening using 1% FeCl₃ reagent indicated the presence of phenolic compounds, evidenced by a color change to bluish-green or dark green. The quantitative analysis was performed using UV–Vis spectrophotometry at a wavelength of 752 nm, applying the Folin–Ciocalteu method with gallic acid as the standard. The results showed that Dayak onion extract contained 1.410 mg GAE/g extract (0.141%), while rose myrtle extract contained 2.259 mg GAE/g extract (0.2259%) of total phenolic compounds. These findings highlight the phenolic potential of endemic medicinal plants from North Kalimantan and support their further exploration for pharmacological and nutraceutical applications

PENETAPAN KADAR FENOLIK TOTAL TUMBUHAN ENDEMIK KALIMANTAN UTARA Salsabillah, Nasywa Amelsya; Ahmad, Aktsar Roskiana; Syarif, Rezki Amriati
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.22110

North Kalimantan is home to a unique biodiversity, including medicinal plants traditionally used by local communities such as the Dayak people. Several of these plants are endemic—found exclusively in this region. Two notable endemic species, Dayak onion (Eleutherine palmifolia (L.) Merr.) and rose myrtle (Rhodomyrtus tomentosa), are known to contain secondary metabolites, including phenolic compounds. This study aimed to determine the total phenolic content of these two endemic plants. Extraction was performed using Ultrasonic-Assisted Extraction (UAE), resulting in extract yields of 11.42% (11.42 g) for Dayak onion and 24.33% (24.33 g) for rose myrtle. Preliminary phytochemical screening using 1% FeCl₃ reagent indicated the presence of phenolic compounds, evidenced by a color change to bluish-green or dark green. The quantitative analysis was performed using UV–Vis spectrophotometry at a wavelength of 752 nm, applying the Folin–Ciocalteu method with gallic acid as the standard. The results showed that Dayak onion extract contained 1.410 mg GAE/g extract (0.141%), while rose myrtle extract contained 2.259 mg GAE/g extract (0.2259%) of total phenolic compounds. These findings highlight the phenolic potential of endemic medicinal plants from North Kalimantan and support their further exploration for pharmacological and nutraceutical applications

PENETAPAN KADAR FENOLIK TOTAL TUMBUHAN ENDEMIK KALIMANTAN UTARA Salsabillah, Nasywa Amelsya; Ahmad, Aktsar Roskiana; Syarif, Rezki Amriati
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2427

North Kalimantan is home to a unique biodiversity, including medicinal plants traditionally used by local communities such as the Dayak people. Several of these plants are endemic—found exclusively in this region. Two notable endemic species, Dayak onion (Eleutherine palmifolia (L.) Merr.) and rose myrtle (Rhodomyrtus tomentosa), are known to contain secondary metabolites, including phenolic compounds. This study aimed to determine the total phenolic content of these two endemic plants. Extraction was performed using Ultrasonic-Assisted Extraction (UAE), resulting in extract yields of 11.42% (11.42 g) for Dayak onion and 24.33% (24.33 g) for rose myrtle. Preliminary phytochemical screening using 1% FeCl₃ reagent indicated the presence of phenolic compounds, evidenced by a color change to bluish-green or dark green. The quantitative analysis was performed using UV–Vis spectrophotometry at a wavelength of 752 nm, applying the Folin–Ciocalteu method with gallic acid as the standard. The results showed that Dayak onion extract contained 1.410 mg GAE/g extract (0.141%), while rose myrtle extract contained 2.259 mg GAE/g extract (0.2259%) of total phenolic compounds. These findings highlight the phenolic potential of endemic medicinal plants from North Kalimantan and support their further exploration for pharmacological and nutraceutical applications

Studi Komparasi Potensi Antioksidan Green Extraction dan Ekstraksi Konvensional Ekstrak Daun Gandaria (Bouea macrophylla griff) Alifah, Nur; Ahmad, Aktsar Roskiana; Fawwaz, Muammar
Indonesian Research Journal on Education Vol. 5 No. 1 (2025): Irje 2025
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/irje.v5i1.2127

Tanaman gandaria (Bouea macrophylla griff) telah dilaporkan memiliki aktivitas antioksidan yang tinggi. Hal ini disebabkan tingginya kandungan senyawa antioksidan seperti polifenol, tanin, flavonoid, dan asam askorbat dalam studi skrining fitokimia. Tujuan penelitian ini yaitu untuk melihat perbedaan nilai dari uji aktivitas antioksidan berdasarkan metode ekstraksi modern dan konvensional dan berapa nilai IC50 dari uji aktivitas antioksidan daun gandaria dengan menggunakan metode DPPH berdasarkan perbedaan metode ekstraksi green extraction dan metode konvensional. Hasil penelitian menunjukkan bahwa esktrak daun gandaria (Bouea macrophylla griff) nilai IC50 dengan metode DPPH dengan ekstraksi UAE dan maserasi termasuk dalam kategori kuat berturut-turut 11,319 μg/mL dan 13,331 μg/mL, nilai IC50 pada metode FIC dengan ekstraksi maserasi dan UAE tergolong kuat berturut-turut sebesar 40,428 μg/mL dan 16,262 μg/mL. Hasil penelitian dapat disimpulkan bahwa esktrak daun gandaria (Bouea macrophylla griff) memiliki aktivitas antioksidan.

Phytochemical Screening and α-glucosidase Inhibitory of Secang Wood (Caesalpinia sappan L.) Ahmad, Aktsar Roskiana; Islamia, Tiara Katulista; Amin, Asni
Jurnal Fitofarmaka Indonesia Vol 10, No 3 (2023): JURNAL FITOFARMAKA INDONESIA (ENGLISH EDITION)
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v10i3.1101

Secang wood (Caesalpinia sappan L.) is a part of the Secang plant which is widely used to treat various diseases, including diabetes. Based on previous research, secang wood contains flavonoids which have the potential to inhibit the α-glucosidase enzyme. The research aims to determine the potential of ethanol extracted by meseration using 96% ethanol. Inhibition of activity was tested using microplate reader which was measured at a wavelength of 405 nm with acarbose as a comparison. The results of the research show that the ethanol extract of secang wood has inhibitory activity, including it in the active category based on the % inhibition value obtained at 83.63%. Meanwhile, acarbose has inhibitory activity, including it in the very active category with a %inhibition value of 79%.

Pengembangan Jelly dan Sayuran Instan Berbasis Pangan Lokal untuk Mendukung Pencegahan Stunting di Desa Sanrobone Handayani, Virsa; Murfat, Moh. Zulkifli; Asfar, Akbar; Razak, Rais; Ahmad, Aktsar Roskiana
Celebes Journal of Community Services Vol. 4 No. 2 (2025): June - November
Publisher : STIE Amkop Makassar, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37531/celeb.v4i2.3032

Desa Sanrobone, Kabupaten Takalar, memiliki potensi besar dalam produksi buah dan sayuran lokal yang belum dimanfaatkan secara optimal, terutama dalam upaya pencegahan stunting. Stunting masih menjadi permasalahan gizi kronis yang berdampak pada kualitas sumber daya manusia di wilayah tersebut. Tujuan dari kegiatan pengabdian ini adalah untuk mengembangkan produk pangan inovatif berupa jelly dan sayuran instan berbasis buah dan sayuran lokal serta meningkatkan kapasitas kelompok PKK dalam pengolahan pangan sehat. Metode kegiatan meliputi pelatihan pengolahan pangan sesuai standar CPPB-IRT, edukasi gizi berbasis komunitas, penyediaan alat produksi sederhana, dan pemasaran produk melalui kanal digital. Proses blansir dilakukan pada suhu 90–95°C untuk menjaga kandungan vitamin, khususnya vitamin C dan β-karoten. Hasil kegiatan menunjukkan adanya peningkatan keterampilan anggota PKK dalam produksi pangan sehat dan berkembangnya tiga jenis produk jelly dan sayuran instan yang diterima baik oleh anak-anak. Selain meningkatkan kesadaran gizi, kegiatan ini juga membuka peluang usaha berbasis pangan lokal. Inovasi ini diharapkan menjadi kontribusi nyata dalam penurunan angka stunting secara berkelanjutan.

Uji Aktivitas Antioksidan Ekstrak Deklorofilasi Daun Kelor (Moringa oleifera Lam.) Dengan Metode DPPH Ahmad, Aktsar Roskiana
Makassar Natural Product Journal (MNPJ) April 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i1.147

Djohrani Zamzami Siti Halifa. Uji Aktivitas Antioksidan Ekstrak Deklorofilasi Daun Kelor (Moringa oleifera Lam.) Dengan Metode DPPH (dibimbing oleh Aktsar Roskiana Ahmad dan Hasnaeni) Tumbuhan kelor (Moringa oleifera Lam.) merupakan tumbuhan yang termasuk dalam famili Moringaceae, yang dikenal sebagai The Miracle Tree atau pohon Ajaib, karena kaya akan sumber gizi, berkhasiat obat yang bermanfaat untuk kesehatan tubuh. Tujuan penelitian untuk mengetahui profil KLT dan aktivitas antioksidan ekstrak deklorofilasi daun kelor dengan metode DPPH menggunakan spektrofotometer UV-Vis. Sampel diperoleh dari Kota Makassar, diekstraksi menggunakan ultrasonic dengan 2 pelarut yaitu n-heksan 1L (deklorofilasi) dan pelarut etanol 96% 500 mL dengan sampel 30 g. Hasil penelitian menunjukkan bahwa ekstrak deklorofilasi daun kelor positif mengandung senyawa fenolik, flavanoid, terpenoid dan saponin dan memiliki aktivitas antioksidan dengan nilai IC50 242,341 µg/mL, sehingga dapat disimpulkan bahwa ekstrak deklorofilasi daun kelor (Moringa oleifera Lam.) kategori efek antioksidan dimiliki lemah.

MENCIPTAKAN DESA MANDIRI KESEHATAN DI DESA SALUKANAN KECAMATAN BARAKA KABUPATEN ENREKANG Ahmad, Aktsar Roskiana
Jurnal BALIRESO Vol 1, No 1 (2016)
Publisher : Lembaga Pengabdian kepada Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/balireso.v1i1.8

Kegiatan KKN-PPM dilaksanakan di Desa Salukanan Kecamatan Baraka Kabupaten Enrekang, Provinsi Sulawesi Selatan. Merupakan dataran tinggi dan desa unggulan agribisnis di Kabupaten Enrekang dengan hasil alam yang melimpah dan tanaman endemik berupa beras ketan pulu mandoti. Kelompok sasaran pada kegiatan ini adalah anak usia sekoah, remaja putri, ibu-ibu rumah tangga, ibu-ibu PKK dan karang taruna pada tiga dusun (Matarin, Gandeng, dan Tantido).Dari hasil diskusi dengan Pemerintah Desa dan tokoh-tokoh masyarakat ditemukan beberapa permasalahan masyarakat, sehingga ditawarkan beberapa kegiatan seperti :Penyuluhan kesehatan pada anak usia sekolah dan masyarakat umum. Pelatihan aplikasi tanaman obat (pengobatan herbal) dan pemanfaatan lahan untuk budidaya tanaman obat (pengelolaan TOGA). Pembuatan produk kesehatan sereal berbahan dasar pulu mandoti (beras ketan merah) untuk memberikan tambahan nilai ekonomis untuk masyarakat setempat. Menumbuhkan jiwa enterpreneurship masyarakat dengan mendorong terbentuknya kelompok-kelompok usaha pengolahan sumber daya alam sehingga masyarakat tidak hanya menjual hasil alam dalam bentuk bahan baku (bahan mentah) akan tetapi dapat menghasilkan produk produk yang bernilai ekonimis tinggi.Untuk mencapai target kegiatan KKN-PPM maka akan dilaksanakan beberapa kegiatan dengan tahapan sebagai berikut : sosialisasi kegiatan KKN-PPM, penyusunan program kegiatan (program pokok dan program tambahan), seminar awal untuk sosialisasi kegiatan, pelaksanaaan kegiatan dengan metode ceramah, diskusi, pelatihan dan praktek, seminar evaluasi, penyusunan laporan kegiatan, seminar akhir pada pekan terakhir kegiatan.

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