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All Journal Bionatura Dentika Dental Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Oceana Biomedicina Journal Padjadjaran Journal of Dental Researchers and Students Journal of Case Reports in Dental Medicine Jurnal Material Kedokteran Gigi MDJ (Makassar Dental Journal) Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal of Syiah Kuala Dentistry Society
Riani Setiadhi
Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran, Bandung, Jawa Barat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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A RARE CLINICAL SYPHILIS ORAL MANIFESTATION DUE TO SEXUALLY TRANSMITTED DISEASE AMONG HOMOSEXUAL: CASE REPORT Agustin Ninintowe T. Santo; Riani Setiadhi; Fika Faradillah Drakel
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17529

Abstract

Background: Syphilis is a sexually transmitted disease caused by Treponema pallidum, often found in Human Immunodeficiency Virus (HIV) patients and homosexuals. The oral manifestations are chancres, mucous patches, focal epithelial hyperplasia (FEH) and papilloma/condyloma. FEH is a rare oral mucosa disorder that occurs in immunocompromised patient. Objective: To present a rare oral manifestation in syphilis patient due to sexually transmitted infections. Case: A 25-year-old homosexual male came to Oral Medicine Department complaining of sores on the palate for 3 weeks and 2 weeks later a painless lump appeared. He was an HIV patient and had been taking ARVs since 6 months ago. Pain when opening the mouth, itching on his face and genital area. Intraoral revealed a soft, pedunculated, non-bleeding, mobile mass at the palate with a diameter about 2 cm, had the same color as the surrounding tissue. There was a reddish band-like area on the maxillary anterior gingival margin, suspected as Linear Gingival Erythema (LGE). Case management: 0.2% Chlorhexidine gluconate mouthwash was administered to prevent secondary infection and he was referred to Dermatovenereology and Periodontology Department. HBsAg Immunochromatography (negative), VDRL titer (reactive), TPHA titer (reactive) therefore diagnosis of syphilis was made and he was treated with a single dose Benzathine penicillin G 2.4 million units intramuscular. The oral lesions healed after 1 month therapy. Conclusion: FEH is a rare oral mucosa disorder in syphilis patients. Knowledge of the signs and symptoms of the disease is needed to make a diagnosis and a multidisciplinary approach to achieve successful treatment. Keywords: Oral manifestation, Sexual transmission, Syphilis, Treponemal infection
NECROTIZING ULCERATIVE GINGIVITIS AS A COMPLICATION OF FEBRILE NEUTROPENIA IN ACUTE MYELOID LEUKEMIA PATIENT Desi Elvhira Rosa; Riani Setiadhi
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17535

Abstract

Background: Necrotizing ulcerative gingivitis (NUG) is a periodontal disease characterized by gingival pain, interdental gingival necrosis, and bleeding. NUG is closely related to immunosuppression, smoking, poor oral hygiene, malnutrition, and stress. Acute myeloid leukemia (AML) is a bone marrow malignant neoplasm. Chemotherapy as the treatment for AML often causes febrile neutropenia which results in immunosuppression conditions and is a risk factor for NUG. This case report aimed to discuss NUG as a complication of febrile neutropenia. Case: A 22-year-old woman was referred from hemato-oncology with acute myelomonocytic leukemia (AML-M4) and febrile neutropenia due to her oral complaints. She had undergone one cycle of chemotherapy and developed febrile neutropenia. Intra-oral showed ulcers covered with white-grayish plaques on the gingival region 35 to 45 and 15 to 25. There were white plaques that could be removed leaving an erythematous area on the dorsal tongue. Blood laboratory tests showed pancytopenia and severe neutropenia. The diagnoses were necrotizing ulcerative gingivitis and pseudomembranous candidiasis. Case management: Debridement using 1.5% hydrogen peroxide solution, rinsing with 0.2% chlorhexidine gluconate, as well as cleaning teeth and tongue 2 times daily. The internal medicine department gave meropenem. The lesions and gingiva were healed after three weeks of therapy. Conclusion: Febrile neutropenia due to chemotherapy reduces the body's ability to fight infection, oral homeostasis is disturbed therefore bacterial growth increases, neutrophils carry out phagocytosis forming reactive oxygen species which causing necrotic cells and then NUG occurred. Appropriate, adequate, and immediate therapy is needed to avoid further complications.  Keywords: Acute myeloid leukemia, Febrile neutropenia, Necrotizing ulcerative gingivitis
Herbal Medicines as Adjunctive Therapy for Oral Squamous Cell Carcinoma Management: a Case Report: Obat Herbal sebagai Terapi Tambahan untuk Manajemen Karsinoma Sel Skuamosa Oral: Laporan Kasus Ani Megawati; Riani Setiadhi
Dentika: Dental Journal Vol. 25 No. 2 (2022): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v25i2.9410

Abstract

Oral Squamous Cell Carcinoma (OSCC) is the most frequent oral cancer. The management for OSCC are surgery, chemotherapy, and radiotherapy. Chemotherapy and radiotherapy have high toxicity and side effects, therefore effort are needed to reduce them. Several studies show that herbal medicines have anticancer effects with lower toxicity and side effects. The objective is to discuss about management of OSCC using chemotherapy and anticancer herbal medicines as adjunctive therapy.  A 59-year-old man came to the oral medicine clinic complaining a painful ulcer on the right tongue since 8 months ago. The ulcer had been enlarged in the last 3 months and the tongue was difficult to be moved. He used pain relievers and aloe vera gel but there was no improvement. He smoked one pack a day since 40 years ago. Intraoral showed an irregular indurated endophytic mass with an ulcer on the right lateral of the tongue. An incisional biopsy was performed and the histopathological diagnosis was poorly differentiated OSCC. The patient was referred to the oncology department and advised for chemotherapy 6 cycles per 3 weeks. He also used herbal medicines containing Panax ginseng radix, Panax pseudoginseng radix, Ophiopogonis japonicus, Ganoderma lucidum, Ligusticum wallichii rhizoma, and Atractylodes macrocephala rhizoma. The content of these herbal medicines have anticancer and immunomodulatory effects. After the second cycle of chemotherapy, there was a significant improvement. OSCC management with chemotherapy combined with anticancer herbal medicines can increase the success of therapy and reduce the side effects of chemotherapy.
Traumatic Ulcer Associated with Iatrogenic Trauma After Basal Cell Adenoma Surgery Siregar, Fitri Dona; Setiadhi, Riani
Dentika: Dental Journal Vol. 26 No. 2 (2023): Dentika Dental Journal
Publisher : TALENTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/dentika.v26i2.12115

Abstract

Traumatic ulcer is an oral cavity lesion characterized by loss of epithelial lining, reaching the lamina propria. This condition presents a single lesion with irregular borders, surrounded by diffuse erythema, and covered with pseudo-membrane. In specific case, the traumatic ulcer was caused by iatrogenic trauma after basal cell adenoma surgery. This case report aimed to discuss the causes of traumatic ulcer. A 39-year-old female was referred to the Oral Medicine Clinic from the Ear, Nose, and Throat Department, complaining of pain in the oral mucosa after basal cell adenoma surgery. On extraoral examination, the facial symmetry was intact along with dry and exfoliative lips. A solitary, oval, yellowish-white intraoral ulcer covered with pseudomembrane, irregular borders surrounded by diffuse erythema on the palate, left buccal mucosa and upper labial mucosa was present. The patient was diagnosed with traumatic ulcer due to iatrogenic trauma after surgery for basal cell adenoma located within the parotid gland that extended to the left palate. The treatment administered comprised instructions to clean the oral cavity using gauze and a cotton stick soaked in 0.2% chlorhexidine gluconate. Additionally, compressing the affected areas with gauze soaked in 0.9% NaCl and applying a thin coating of Vaseline album on the lips were part of the therapeutic measures. Given the iatrogenic nature of traumatic cancer, comprehensive therapy was considered essential to prevent secondary infection and address issues related to speech, appearance, and masticatory functions.
MANAGEMENT OF COATED TONGUE RESEMBLES PSEUDOMEMBRANOUS CANDIDIASIS IN A MULTIDRUG-THERAPY PATIENT Santoso, Astrid Widhowaty; T. Santo, Agustin Ninintowe; Setiadhi, Riani
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18863

Abstract

Introduction: Coated tongue or tongue coating is characterized by white deposit covering dorsum of the tongue. The thick-coated tongue almost resembles oral candidiasis. It is challenging to make the diagnosis and provide the proper treatment especially when supporting examination tools are unavailable. Objective: To discuss the diagnosis making and management of coated tongue with suspicion of pseudomembranous candidiasis with a lack of supporting examination tools. Case(s): A 61-year-old man was referred to the Oral Medicine Clinic for oral examination. No complaints of  pain in the oral cavity. He had a history of type-2 diabetes mellitus, coronary heart disease (CHD), and pleuritis and was taking medication. During hospitalization, never cleaned his oral cavity. Case Management: Intraorally, white plaque covering almost the entire dorsum of the tongue, which could be scraped off on the anterior 1/3 but not on the posterior 2/3. The diagnosis was suspected coated tongue with oral candidiasis as the differential diagnosis. The treatments were compressing the tongue using gauze soaked in 3% hydrogen peroxide (H2O2) solution, scrapping off using a tongue scraper, then rinsing with water. The thick-coated tongue can be easily removed. He was also given 0,2% chlorhexidine gluconate (CHX) mouthwash as an antiseptic and petroleum jelly for dry lips. The tongue condition improved on 2nd day therapy after rinsing regularly using 0,2% CHX. Conclusion: Recognizing the signs, symptoms, and associated factors of Candida infection is important. Coated tongue which resembles pseudomembranous candidiasis was successfully treated using 3% H2O2 compresses, tongue scraping, and 0.2% CHX mouthwash. Keywords: Chlorhexidine gluconate, Coated tongue, Hydrogen peroxide, Infection, Oral candidiasis
MATRIX METALOPROTEINASE AS A POTENTIAL SALIVARY BIOMARKER FOR ORAL SQUAMOUS CELL CARCINOMA Santoso, Astrid Widhowaty; Setiadhi, Riani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 11, No 1 (2024): Vol 11 No 1, Juni 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v11i1.1470

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and the most prevalent form of oral cancer. The five-year survival rate for OSCC varies considerably depending on the stage of the disease, ranging from 40% to 60%. The majority of cases are diagnosed at an advanced stage, resulting in a significantly reduced life expectancy. Therefore, there is a clear need for effective strategies to detect cancer at an early stage. Aim: The objective of this article is to identify the potential of matrix metalloproteinase (MMP) as a salivary biomarker for the early detection of oral squamous cell carcinoma (OSCC). Review: Saliva is considered a potential source of biomarkers for oral cancer due to its continuous contact with cancerous lesions in the oral cavity and the various enzymes, hormones, antibodies, antimicrobial constituents, and cytokines it contains. MMP is an extracellular endopeptidase enzyme present in saliva and associated with the carcinogenesis process. It has been identified as a salivary biomarker for the early detection of OSCC. The levels of several MMP proteins in the saliva of OSCC patients have been found to be elevated, including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, and MMP-13. Conclusion: The increased levels of salivary MMP, which were most specifically found in OSCC patients, included MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-12, and MMP-13. This suggests that MMP may be a potential salivary biomarker for the early detection of OSCC
Pattern of oral lesions in multidrugs resistant tuberculosis patient and the management: a case report Djou, Rahmatia; Setiadhi, Riani
Journal of Case Reports in Dental Medicine Vol 2, No 2 (2020)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jcrdm.v2i2.106

Abstract

Objectives: to describe the pattern of oral lesions in MDR TB patient and the management. Methods: A 42-year-old man with history of TB since 8 months before and MDR TB since 1 month. The patient complained of sore tongue since 2 weeks before, accompanied with white plaque on the tongue which could be scrapped off leaving erythema areas. Intraoral examination showed multiple ulcers at lateral and dorsum of the tongue, white plaques on the tongue, buccal mucosa, labial mucosa, and palate. Swab examination from the tongue showed a positive result for Gram-positive Bacillus Bacteria. Tuberculosis ulcers and oral candidiasis were the diagnosis, so that the given treatment were nystatin oral suspension and 0.2% chlorhexidine gluconate mouthwash. Result: Ulcer and white plaques improved within 3 weeks. Conclusion: The clinical manifestation of oral tuberculosis lesions usually non-specific and sometimes similar with other lesions, making it difficult to be diagnosed
Antibacterial potential ethanol extract of beluntas leaves (Pluchea indica L) to Streptococcus sanguinis Wilma ADIWIJAYA; Riani SETIADHI; Vinna Kurniawati SUGIAMAN
Journal of Syiah Kuala Dentistry Society Vol 7, No 2 (2022): December 2022
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v7i2.30230

Abstract

Recurrent aphthous stomatitis (RAS) is one of the most common oral diseases in the community, with a prevalence of 5-66%, with one of the predisposing factors being Streptococcus sanguinis. Treatment for RAS has been symptomatic and supportive, including antiseptic mouthwash such as chlorhexidine gluconate 0.2% or topical corticosteroids (triamcinolone acetonide 0.1% in Orabase). However, these drugs have some side effects. Treating herbal ingredients such as Beluntas leaves low prices and minimal side effects. The active compounds in Beluntas leaves are phenols, tannins, flavonoids, saponins, triterpenoids, essential oils, terpenoids, and many compounds known to have antibacterial activity. Methods: This study aimed to determine the minimum inhibitory level (MIC), and minimum killing rate (MBC) of 96% ethanol extract of Beluntas leaves on the growth of Streptococcus sanguinis. MIC was measured by broth microdilution technique with DMSO solvent 10% and eight concentrations of beluntas extract. Chlorhexidine gluconate 0.2% was used as a positive control for the comparison compound. Furthermore, the MBC test was carried out using the total plate count method for treatments that gave the MIC value. One Way Anova analysis with Post Hoc Tukey was used to determine the significant difference between treatments. Results: The ethanol extract of Beluntas leaves (Pluchea indica L) has a Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for the growth of Streptococcus sanguinis with a minimum inhibitory concentration of 3.95 g/mL and a minimum concentration of 7.8 g/mL. Conclusion: The ethanol extract of Beluntas leaves (Pluchea indica L) has the potential as an antibacterial against Streptococcus sanguinis. KEYWORDS: Recurrent aphthous stomatitis, Streptococcus sanguinis, ethanol extract of beluntas leaves, Minimum Inhibitory Concentration, Minimum Bactericidal Concentration
The effectiveness of propolis on the healing period of recurrent aphthous stomatitis Han, Foo You; Setiadhi, Riani; Sudjarwo, Indrati
Padjadjaran Journal of Dentistry Vol 24, No 3 (2012): November 2012
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol24no3.26844

Abstract

Introduction: Propolis®, also known as bee glue, is a substance acquired from the bee hive, which contain antimicrobial, antiviral and antifungal properties. The aim of this research was to identify the best concentration of propolis® that is effective for healing period of Recurrent Aphthous Stomatitis (RAS). Methods: This research was experimental study and the sample are patients who have Recurrent Aphthous Stomatitis during the extent of the research at Rumah Sakit Gigi dan Mulut, Bandung, Indonesia. the patients were given Propolis® of either 0.5% or 1.0% concentration randomly. Results: Using the Kolmogorov-Smirnov test, the data is tested for normality of patients whom are applying Propolis® cream at concentration of 0.5% and 1%. The average time taken for the subject with 0.5% Propolis® cream to fully heal were 5 days, while those with 1.0% Propolis® cream required 6 days. From the t-test for equality of means, where 0.140 > 0.05, we can conclude that the difference is not significant between subjects that were given Propolis® cream at 0.5% concentration compared with subject given with 1.0% concentration of Propolis® cream.The result shows that Propolis at 0.5% concentration provides an average healing period of 5 days while propolis at 1.0% on an average of 6 days for the healing of RAS. Conclusion: Propolis at 0.5% is more effective compared to 1.0% for healing period of Recurrent Aphthous Stomatitis.
Distribution of oral ulceration cases in Oral Medicine Integrated Installation of Universitas Padjadjaran Dental Hospital Zakiawati, Dewi; Nur'aeny, Nanan; Setiadhi, Riani
Padjadjaran Journal of Dentistry Vol 32, No 3 (2020): November 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no3.23664

Abstract

Introduction: Oral ulceration defines as discontinuity of the oral mucosa caused by the damage of both epithelium and lamina propria. Among other types of lesions, ulceration is the most commonly found lesion in the oral mucosa, especially in the outpatient unit. Oral Medicine Integrated Installation (OMII) Department in Universitas Padjadjaran Dental Hospital serves as the centre of oral health and education services, particularly in handling outpatient oral medicine cases. This research was the first study done in the Department which aimed to observe the distribution of oral ulceration in OMII Department university Dental Hospital. The data is essential in studying the epidemiology of the diseases. Methods: The research was a descriptive study using the patient’s medical data between 2010 and 2012. The data were recorded with Microsoft® Excel, then analysed and presented in the table and diagram using GraphPad Prism® Results: During the study, the distribution of oral ulceration cases found in OMII Department was 664 which comprises of traumatic ulcers, recurrent aphthous stomatitis, angular cheilitis, herpes simplex, herpes labialis, and herpes zoster. Additionally, more than 50% of the total case was recurrent aphthous stomatitis, with a precise number of 364. Conclusion: It can be concluded that the OMII Department in university Dental Hospital had been managing various oral ulceration cases, with the most abundant cases being recurrent aphthous stomatitis.
Co-Authors Adi Ahmad Yusuf Agustin Ninintowe T. Santo Amira Shafuria Ani Megawati Bakti, Fitrah Utari Cucu Zubaedah Cucu Zubaedah, Cucu Cynthia Vieta Dani R. Firman Dani R. Firman Desi Elvhira Rosa Devi Nasution Dewi Kania Intan Permatasari Dewi Zakiawati Dewi Zakiawati Dewi Zakiawati, Dewi Djou, Rahmatia Eddea Marselyna A.D. Eliza Kristina Munthe Embun Manja Sari Etis Duhita Rahayuningtyas Fika Faradilla Drakel Fika Faradillah Drakel fika faradillah drakel Fitria Mailiza Hamdatun Rakhmania Han, Foo You Heldayani, Iin Her Basuki Margono Hilda Hindasah I Nyoman Gede Juwita Putra Indah Suasani Wahyuni Indra Gunawan Irna Sufiawati Kartika Indah Sari Kosterman Usri Maghfira Indriawati Iswiningtyas Muhammad A. Farisyi Nanan Nur’aeny Nanan Nur’aeny Nanan Nur’aeny Novia Tri Hasanah Nur'aeny, Nanan Nuri Fitriasari Rahmi Harmiyati Revi Nelonda Revi Nelonda Rosiliwati Wihardja Rosiliwati Wihardja, Rosiliwati Santoso, Astrid Widhowaty Siregar, Fitri Dona Sudjarwo, Indrati Suniti Suniti T. Santo, Agustin Ninintowe Tuty Amalia Vieta, Cynthia Vinna Kurniawati Sugiaman Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Willyanti Soewondo - Wilma ADIWIJAYA Yanie Febby Martina Lefaan Yannie Febby Martina Lefaan Yongky Tamigoes Yuti Malinda