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All Journal Bionatura Dentika Dental Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Oceana Biomedicina Journal Padjadjaran Journal of Dental Researchers and Students Journal of Case Reports in Dental Medicine Jurnal Material Kedokteran Gigi MDJ (Makassar Dental Journal) Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal of Syiah Kuala Dentistry Society
Riani Setiadhi
Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran, Bandung, Jawa Barat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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SALIVARY IL-6 AND IL-8 AS POTENTIAL BIOMARKERS FOR ORAL SQUAMOUS CELL CARCINOMA Bakti, Fitrah Utari; Setiadhi, Riani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 10, No 2 (2023): Vol 10 No 2, Desember 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v10i2.1460

Abstract

Introduction: Early identification of oral squamous cell carcinoma (OSCC) is a crucial factor influencing the disease's prognosis. The elevated levels of IL-6 and IL-8 in saliva are a result of their overproduction in the cancer microenvironment. The production of salivary cytokines, particularly IL-6 and IL-8, has a role in cancer development. These cytokines may also be used as biomarkers. The use of saliva as a biomarker is quite interesting because it is in direct contact with cancer cells, easy to access, non-invasive, and cost-effective. Aim: The aim of this literature review was to assess the potential of salivary IL-6 and IL-8 as biomarkers for OSCC early diagnosis. Review: The initiation of carcinogenesis in the oral cavity is actively repressed by inflammation and cell-mediated immunity. IL-6 and IL-8 are two important molecules involved in stromal-to-cancer cell communication. These cytokines play a major part in the growth, progression, metastasis, and recurrence of OSCC. Several studies have found that OSCC patients have higher levels of salivary IL-6 and IL-8 than healthy people and patients with an oral potentially malignant disorder (OPMD). Conclusion: Salivary IL-6 and IL-8 are very promising potential biomarkers for the early diagnosis of OSCC. Further research is still needed to validate and use these biomarkers clinically.
Tantangan Dalam Perawatan Stomatitis Uremia Pada Pasien Dengan Penyakit Ginjal Kronis Adi Ahmad Yusuf; Yanie Febby Martina Lefaan; Riani Setiadhi
Denta Journal Kedokteran Gigi Vol 16 No 2 (2022): August
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v16i2.7

Abstract

Background: Uremic stomatitis is a rare oral manifestation of chronic and acute kidney disease. The incidence of uremic stomatitis is low, especially because process disease develops gradually over years and occurs in advanced renal failure. This disease is associated with high levels of blood urea. There are four forms of uremic stomatitis that have been identified, namely ulcerative, erythemopultaceous, hyperkeratotic and hemorrhagic. Usually the lesions were seen on buccal mucosa, dorsal or ventral surface of tongue, gingiva, lips and floor of mouth. Purpose: To discuss the challenges in treating uremic stomatitis patient with poor systemic condition. Case: A 73 year old male patient was referred from cardiology department to oral medicine department because there were painful lesions on lips, tongue, palate and buccal mucosa. He was a chronic kidney disease patient whose laboratory results showed high urea and creatinine values. Case management: The Patient was given oral hygiene instruction to clean his teeth and tongue with a gauze soaked in NaCl at least three times a day, compressing the lips and rinse with chlorine dioxide based mouthwash (Oxyfresh®, USA) three times a day. The improvement of oral lesions were not significant because the blood urea and creatinine value were still high. Conclusion: Management of uremic stomatitis needs multidisciplinary teamwork in order to achieve the kidney function and other comorbidities improvement as well as oral lesions to improve the quality of life.  
MANAGEMENT OF COATED TONGUE RESEMBLES PSEUDOMEMBRANOUS CANDIDIASIS IN A MULTIDRUG-THERAPY PATIENT Astrid Widhowaty Santoso; Agustin Ninintowe T. Santo; Riani Setiadhi
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18863

Abstract

Introduction: Coated tongue or tongue coating is characterized by white deposit covering dorsum of the tongue. The thick-coated tongue almost resembles oral candidiasis. It is challenging to make the diagnosis and provide the proper treatment especially when supporting examination tools are unavailable. Objective: To discuss the diagnosis making and management of coated tongue with suspicion of pseudomembranous candidiasis with a lack of supporting examination tools. Case(s): A 61-year-old man was referred to the Oral Medicine Clinic for oral examination. No complaints of  pain in the oral cavity. He had a history of type-2 diabetes mellitus, coronary heart disease (CHD), and pleuritis and was taking medication. During hospitalization, never cleaned his oral cavity. Case Management: Intraorally, white plaque covering almost the entire dorsum of the tongue, which could be scraped off on the anterior 1/3 but not on the posterior 2/3. The diagnosis was suspected coated tongue with oral candidiasis as the differential diagnosis. The treatments were compressing the tongue using gauze soaked in 3% hydrogen peroxide (H2O2) solution, scrapping off using a tongue scraper, then rinsing with water. The thick-coated tongue can be easily removed. He was also given 0,2% chlorhexidine gluconate (CHX) mouthwash as an antiseptic and petroleum jelly for dry lips. The tongue condition improved on 2nd day therapy after rinsing regularly using 0,2% CHX. Conclusion: Recognizing the signs, symptoms, and associated factors of Candida infection is important. Coated tongue which resembles pseudomembranous candidiasis was successfully treated using 3% H2O2 compresses, tongue scraping, and 0.2% CHX mouthwash. Keywords: Chlorhexidine gluconate, Coated tongue, Hydrogen peroxide, Infection, Oral candidiasis
PHYSIOLOGICAL SOLUTION (NaCl 0,9%) AS ONE OF THERAPIES IN PATIENTS WITH ORAL LESIONS ASSOCIATED WITH STEVEN-JOHNSON SYNDROME I Nyoman Gede Juwita Putra; Riani Setiadhi
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24173

Abstract

Background. Steven-Johnson Syndrome (SJS) is a hypersensitivity reaction characterized by acute blisters and necrosis of the skin and mucous membranes, triggered by drugs. This case occurs in 1 or 2: 1000,000 cases. Objectives. This case report aims to describe the role of NaCl 0,9% solution as one of the therapies in patients with oral lesions associated with SJS. A 40-year-old woman was consulted by the Internal Medicine Department with complaints of pain on lips approximately 3 days before, difficulty opening mouth and bleeding lips easily. Patients consumed Carbamazepin, Amitriptiline, Paracetamol, and Cefixime. Extraoral examination showed lips with erosive lesions accompanied by blackish sanguinolenta crusting, pain, tend to bleed. Intraoral examination showed white plaque on the dorsum of the tongue. The patient was diagnosed with oral lesions associated with SJS et causa Carbamazepin, and/or Amitriptiline and/or Cefixime, and/or Paracetamol. Treatment. Based on the diagnosis, the pharmacological management is intravenous dexamethasone 5mg by the Dermatology and Venereology division, while Oral Medicine treatment is compressing the lips with a NaCl 0,9% solution three times a day. After the 4th day of therapy, oral lesions were repaired. NaCl 0,9% solution as moist wound healing has the principle of moisturizing by keeping the condition of the wound base moist to facilitate cell migration at the base of the wound. The moist environment allows neutrophils and macrophages to migrate better so as to provide the best environment for the healing process. Conclusion. NaCl 0,9% has an important role in the oral lesions healing process in SJS. Keywords: haling lesions, NaCl 0,9%, steven-johnson syndrome.
Co-Authors Adi Ahmad Yusuf Agustin Ninintowe T. Santo Amira Shafuria Ani Megawati Astrid Widhowaty Santoso Bakti, Fitrah Utari Cucu Zubaedah Cynthia Vieta Dani R. Firman Dani R. Firman Desi Elvhira Rosa Devi Nasution Dewi Kania Intan Permatasari Dewi Zakiawati Djou, Rahmatia Eddea Marselyna A.D. Eliza Kristina Munthe Embun Manja Sari Etis Duhita Rahayuningtyas Fika Faradilla Drakel Fika Faradillah Drakel fika faradillah drakel Fitria Mailiza Hamdatun Rakhmania Han, Foo You Heldayani, Iin Her Basuki Margono Hilda Hindasah I Nyoman Gede Juwita Putra I Nyoman Gede Juwita Putra Indah Suasani Wahyuni Indra Gunawan Irna Sufiawati Kartika Indah Sari Kosterman Usri Maghfira Indriawati Iswiningtyas Muhammad A. Farisyi Nanan Nur’aeny Nanan Nur’aeny Nanan Nur’aeny Novia Tri Hasanah Nuri Fitriasari Revi Nelonda Revi Nelonda Rosiliwati Wihardja Rosiliwati Wihardja, Rosiliwati Santoso, Astrid Widhowaty Siregar, Fitri Dona Sudjarwo, Indrati Suniti Suniti Tuty Amalia Vieta, Cynthia Vinna Kurniawati Sugiaman Wahyu Hidayat Wahyu Hidayat Willyanti Soewondo - Wilma ADIWIJAYA Yanie Febby Martina Lefaan Yannie Febby Martina Lefaan Yongky Tamigoes Yuti Malinda