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All Journal Bionatura Dentika Dental Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Oceana Biomedicina Journal Padjadjaran Journal of Dental Researchers and Students Journal of Case Reports in Dental Medicine Jurnal Material Kedokteran Gigi MDJ (Makassar Dental Journal) Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal of Syiah Kuala Dentistry Society
Riani Setiadhi
Departemen Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Padjadjaran, Bandung, Jawa Barat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Manifestasi dan tatalaksana lesi oral pada pasien penderita systemic lupus erythematosus (SLE): laporan kasus Heldayani, Iin; Setiadhi, Riani
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 36, No 4 (2024): Januari 2024 (Suplemen 4)
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v36i4.49461

Abstract

Oral Complications Due to Medication in Stevens-Johnson Syndrome Patient with Systemic Involvement Rahmi Harmiyati; Fika Faradillah Drakel; Riani Setiadhi
Denta Journal Kedokteran Gigi Vol 18 No 2 (2024): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v18i2.6

Abstract

Background: Stevens-Johnson Syndrome (SJS) is a drug-induced hypersensitivity reaction involving mucocutaneous with various trigger factors including drugs and herpes simplex virus. Objective: This case report aimed to discuss oral complications due to medication in SJS patients with systemic disease involvement. Case: A 51-year-old man was referred to the Department of Oral Medicine, Faculty of Dentistry, Padjadjaran University, at Hasan Sadikin Hospital from the dermatology and venereology department complaining of pain in the oral cavity, especially when eating and drinking two months before, with a history of phenytoin, salbutamol and theophylline therapy. Extraoral examination showed erosive lesions and tended to bleed serosanguinolenta crusts on the lips. Intraoral there were erosive lesions and white plaque on the tongue, buccal mucosa, labial mucosa, and palate, as well as dental caries and calculus. Blood examination showed low hemoglobin, hematocrit, erythrocytes, lymphocytes, monocytes, SGOT, and sodium levels, while HbA1c, random, fasting, and 2 HPP glucose levels were high. Reactive Anti-HSV-1 IgG and rheumatoid factor. KOH examination showed positive spores, hyphae, pseudohypha, and budding cells. The diagnosis was SJS-associated oral lesions with HSV-1 virus infection, oral candidiasis accompanied with diabetes mellitus. For diabetes mellitus treatment, he was referred to the internal medicine department. Case Management: The therapy was 0.9% NaCl for lip compress, acyclovir tablet, nystatin oral suspension, chlorhexidine digluconate 0,12% mouthwash, folic acid, and vitamin B12. Oral lesions were improved significantly after diabetes mellitus was treated. Conclusion: The SJS patient was susceptible to complications in the oral cavity, especially fungal and viral infections due to the received medication.
SALIVARY IL-6 AND IL-8 AS POTENTIAL BIOMARKERS FOR ORAL SQUAMOUS CELL CARCINOMA Bakti, Fitrah Utari; Setiadhi, Riani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 10, No 2 (2023): Vol 10 No 2, Desember 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/jbd.v10i2.1460

Abstract

Introduction: Early identification of oral squamous cell carcinoma (OSCC) is a crucial factor influencing the disease's prognosis. The elevated levels of IL-6 and IL-8 in saliva are a result of their overproduction in the cancer microenvironment. The production of salivary cytokines, particularly IL-6 and IL-8, has a role in cancer development. These cytokines may also be used as biomarkers. The use of saliva as a biomarker is quite interesting because it is in direct contact with cancer cells, easy to access, non-invasive, and cost-effective. Aim: The aim of this literature review was to assess the potential of salivary IL-6 and IL-8 as biomarkers for OSCC early diagnosis. Review: The initiation of carcinogenesis in the oral cavity is actively repressed by inflammation and cell-mediated immunity. IL-6 and IL-8 are two important molecules involved in stromal-to-cancer cell communication. These cytokines play a major part in the growth, progression, metastasis, and recurrence of OSCC. Several studies have found that OSCC patients have higher levels of salivary IL-6 and IL-8 than healthy people and patients with an oral potentially malignant disorder (OPMD). Conclusion: Salivary IL-6 and IL-8 are very promising potential biomarkers for the early diagnosis of OSCC. Further research is still needed to validate and use these biomarkers clinically.
Tantangan Dalam Perawatan Stomatitis Uremia Pada Pasien Dengan Penyakit Ginjal Kronis Adi Ahmad Yusuf; Yanie Febby Martina Lefaan; Riani Setiadhi
Denta Journal Kedokteran Gigi Vol 16 No 2 (2022): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v16i2.7

Abstract

Background: Uremic stomatitis is a rare oral manifestation of chronic and acute kidney disease. The incidence of uremic stomatitis is low, especially because process disease develops gradually over years and occurs in advanced renal failure. This disease is associated with high levels of blood urea. There are four forms of uremic stomatitis that have been identified, namely ulcerative, erythemopultaceous, hyperkeratotic and hemorrhagic. Usually the lesions were seen on buccal mucosa, dorsal or ventral surface of tongue, gingiva, lips and floor of mouth. Purpose: To discuss the challenges in treating uremic stomatitis patient with poor systemic condition. Case: A 73 year old male patient was referred from cardiology department to oral medicine department because there were painful lesions on lips, tongue, palate and buccal mucosa. He was a chronic kidney disease patient whose laboratory results showed high urea and creatinine values. Case management: The Patient was given oral hygiene instruction to clean his teeth and tongue with a gauze soaked in NaCl at least three times a day, compressing the lips and rinse with chlorine dioxide based mouthwash (Oxyfresh®, USA) three times a day. The improvement of oral lesions were not significant because the blood urea and creatinine value were still high. Conclusion: Management of uremic stomatitis needs multidisciplinary teamwork in order to achieve the kidney function and other comorbidities improvement as well as oral lesions to improve the quality of life.  
PHYSIOLOGICAL SOLUTION (NaCl 0,9%) AS ONE OF THERAPIES IN PATIENTS WITH ORAL LESIONS ASSOCIATED WITH STEVEN-JOHNSON SYNDROME Putra, I Nyoman Gede Juwita; Setiadhi, Riani
Dentino: Jurnal Kedokteran Gigi Vol 10, No 2 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i2.24173

Abstract

Background. Steven-Johnson Syndrome (SJS) is a hypersensitivity reaction characterized by acute blisters and necrosis of the skin and mucous membranes, triggered by drugs. This case occurs in 1 or 2: 1000,000 cases. Objectives. This case report aims to describe the role of NaCl 0,9% solution as one of the therapies in patients with oral lesions associated with SJS. A 40-year-old woman was consulted by the Internal Medicine Department with complaints of pain on lips approximately 3 days before, difficulty opening mouth and bleeding lips easily. Patients consumed Carbamazepin, Amitriptiline, Paracetamol, and Cefixime. Extraoral examination showed lips with erosive lesions accompanied by blackish sanguinolenta crusting, pain, tend to bleed. Intraoral examination showed white plaque on the dorsum of the tongue. The patient was diagnosed with oral lesions associated with SJS et causa Carbamazepin, and/or Amitriptiline and/or Cefixime, and/or Paracetamol. Treatment. Based on the diagnosis, the pharmacological management is intravenous dexamethasone 5mg by the Dermatology and Venereology division, while Oral Medicine treatment is compressing the lips with a NaCl 0,9% solution three times a day. After the 4th day of therapy, oral lesions were repaired. NaCl 0,9% solution as moist wound healing has the principle of moisturizing by keeping the condition of the wound base moist to facilitate cell migration at the base of the wound. The moist environment allows neutrophils and macrophages to migrate better so as to provide the best environment for the healing process. Conclusion. NaCl 0,9% has an important role in the oral lesions healing process in SJS. Keywords: haling lesions, NaCl 0,9%, steven-johnson syndrome.
Co-Authors Adi Ahmad Yusuf Agustin Ninintowe T. Santo Amira Shafuria Ani Megawati Bakti, Fitrah Utari Cucu Zubaedah Cucu Zubaedah, Cucu Cynthia Vieta Dani R. Firman Dani R. Firman Desi Elvhira Rosa Devi Nasution Dewi Kania Intan Permatasari Dewi Zakiawati Dewi Zakiawati Dewi Zakiawati, Dewi Djou, Rahmatia Eddea Marselyna A.D. Eliza Kristina Munthe Embun Manja Sari Etis Duhita Rahayuningtyas Fika Faradilla Drakel Fika Faradillah Drakel fika faradillah drakel Fitria Mailiza Hamdatun Rakhmania Han, Foo You Heldayani, Iin Her Basuki Margono Hilda Hindasah I Nyoman Gede Juwita Putra Indah Suasani Wahyuni Indra Gunawan Irna Sufiawati Kartika Indah Sari Kosterman Usri Maghfira Indriawati Iswiningtyas Muhammad A. Farisyi Nanan Nur’aeny Nanan Nur’aeny Nanan Nur’aeny Novia Tri Hasanah Nur'aeny, Nanan Nuri Fitriasari Rahmi Harmiyati Revi Nelonda Revi Nelonda Rosiliwati Wihardja Rosiliwati Wihardja, Rosiliwati Santoso, Astrid Widhowaty Siregar, Fitri Dona Sudjarwo, Indrati Suniti Suniti T. Santo, Agustin Ninintowe Tuty Amalia Vieta, Cynthia Vinna Kurniawati Sugiaman Wahyu Hidayat Wahyu Hidayat Wahyu Hidayat Willyanti Soewondo - Wilma ADIWIJAYA Yanie Febby Martina Lefaan Yannie Febby Martina Lefaan Yongky Tamigoes Yuti Malinda