Articles
<![CDATA[Evaluation of antibacterial activity and acute toxicity of pomegranate (punica granatum l.) seed ethanolic extracts in swiss webster mice ]]>
<![CDATA[Riani Setiadhi]]>;
<![CDATA[Irna Sufiawati]]>;
<![CDATA[Dewi Zakiawati]]>;
<![CDATA[Nanan Nur’aeny]]>;
<![CDATA[Wahyu Hidayat]]>;
<![CDATA[Dani R. Firman]]>
<![CDATA[ Journal of Dentomaxillofacial Science Vol. 2 No. 2 (2017): (Available online: 1 August 2017) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/jdmfs.v2i2.536
<![CDATA[Objective: To evaluate the safety of a pomegranate seeds ethanolic extract in Swiss Webster mice.Material and Methods: Pomegranate seed’s ethanolic extracts were evaluated for minimum inhibitory concentration against streptococcus sanguis ATCC 10556, using microdilution method through 96-wells microplate. In acute toxicity test, 12 females and 12 males Swiss Webster mice weighing 20–30 grams were divided into four groups, each consisting of 3 females and 3 males. Three groups were orally given of sample with concentrations 0.2% equivalent to 40 mg/kg, 0.4% equivalent to 80 mg/kg, and 0.8% equivalent to 160 mg/kg, while the control group was given distilled water. Observations were made at 30, 60, and 90 minutes, for 24 hours and 7 days.Results: The MIC against Streptococcus sanguis was on 2000 ppm concentration and until 24 hours observation no lethal effect occurred on the mice, but at the 7 days observation in the group of 0.8% per kilogram body weight, the lethal effect occurred at one mice.Conclusion: The ethanolic extract of pomegranate seeds has antibacterial effect and no acute systemic toxicity, which can be considered safe on the use as oral topical solution since the toxic dose is greater than 160 mg/kg of body weight.]]>
<![CDATA[Strawberry gingivitis as the first sign of wegener’s granulomatosis: a case report ]]>
<![CDATA[Yongky Tamigoes]]>;
<![CDATA[Riani Setiadhi]]>
<![CDATA[ Journal of Dentomaxillofacial Science Vol. 4 No. 1 (2019): (Available online: 1 April 2019) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/jdmfs.v0i0.741
<![CDATA[Objective: To describe that Wegener’s granulomatosis (WG) is an autoimÂmune multisystem disease with unknown etioloÂgy, characterized by the classic triad of necrotizing granulomas affecting the upper and lower respiratory tracts, disseminated vasculitis and glomerulonephritis. WG can affect any organ including kidneys, eyes or other organs. Oral involvement, like strawberry gingivitis, is an important sign of this disease even though it is rare.Methods: A 19 years old female was referred to oral medicine clinic with the chief complaint swelling on the gingiva which was increasing widespread. Since one month before the gingival enlargement did not respond to antibiotic.  Intraoral examination, showed gingival enlargement at the upper anterior, palate, and first left mandibular molar. The swollen tissue was characterized by its granularity, short bulbous projections and bright red colour. The gingival appearance mimicking an overripe strawberry and extra oral examination showed cutaneous vasculitis at the hands and feet. Laboratory evaluation presented erythrocyte sedimentation rate, CRP and eGFR (modified MORD) were elevated but the urinalysis was within normal ranges. Based on the anamnesis, clinical and laboratory examination, WG diagnosis was made. The patient was treated with oral corticosteroids and chlorhexidine gluconate 0.1% mouthwash.Results: The gingival inflammation improved after one month therapy and the patient still being followed-up at reguler time. Conclusions: Early detection of oral manifestation of WG is important for dentists, especially oral medicine specialist, in order to achieve adequate treatment and preventing systemic tissue or organ damage.]]>
<![CDATA[Time-kill assay of pomegranate (Punica granatum L) seed ethanolic extract against streptococcus sanguis; the cause of recurrent aphthous stomatitis ]]>
<![CDATA[Riani Setiadhi]]>;
<![CDATA[Irna Sufiawati]]>;
<![CDATA[Dewi Zakiawati]]>;
<![CDATA[Dani R. Firman]]>
<![CDATA[ Journal of Dentomaxillofacial Science Vol. 3 No. 3 (2018): (Available online: 1 December 2018) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/jdmfs.v3i3.787
<![CDATA[Objective: To examine the antimicrobial activity of pomegranate seed using a time-kill-assay by measuring the number of bacteria left at a various time points after exposure to the substance.Material and Methods: Pomegranate seeds were extracted by a maceration method using 70% ethanol as the solvent. The extract was evaluated for minimum inhibitory concentration and minimum bactericidal concentration against streptococcus sanguis ATCC 10556, using a microdilution method. The concentration used in time-kill-assay were 2 to 4 times MBC value and 48 hours incubation time as the initial value. Correlation of the concentration and time duration using semi-log graph, i.e. the x-axis as time duration with variation interval of 30, 60 and 90-seconds. Y-axis is the logarithmic value of the bacterial colonies number.Results: Bacteriostatic effect was observed at 4000 ppm concentration at 30, 60 and 90-seconds time intervals. The bactericidal effect was observed at 8000 ppm of concentration at the 90-second time interval, whereas 30 and 60-seconds remained bacteriostatic.Conclusion: The pomegranate seeds ethanolic extract is considered as antibacterial with a concentration-dependent category.]]>
<![CDATA[Identification of active component in red pomegranate (punica granatum L.) seeds ethanolic extract ]]>
<![CDATA[Riani Setiadhi]]>;
<![CDATA[Irna Sufiawati]]>;
<![CDATA[Wahyu Hidayat]]>
<![CDATA[ Journal of Dentomaxillofacial Science Vol. 4 No. 2 (2019): (Available online: 1 August 2019) ]]>
Publisher : <![CDATA[DiscoverSys Inc. ]]>
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DOI: 10.15562/jdmfs.v4i2.934
<![CDATA[Objective: Pomegranate (punica granatum L.) have many benefits for health and used as traditional medicine. The pomegranate seeds are rich in antioxidants, namely flavonoids and tannins as well as alkaloid which is an antibacterial. The aim of this study was to identify the pure isolate/active component of red pomegranate seeds ethanolic extract. Material and Methods: Two-ways TLC of the purified crystals which were obtained from the hexan fraction of ethanolic extract red pomegranate seeds, were used to make sure there was only 1 active compound of red pomegranate seeds. The isolate was identified using dragendorff, Mg and HCl, NaOH, Bunchard, Liebermen, FeCL3 and HCl concentrated reagents.Results: Isolate identification test using dragendorf reagents showed positive result (an orange-coloured).Conclusion: The pure isolate/active component of red pomegranate seeds is alkaloid.]]>
<![CDATA[PENGARUH OBAT KUMUR TERHADAP KONDISI MUKOSITIS PASIEN KANKER RONGGA MULUT YANG MENERIMA KEMOTERAPI DAN RADIOTERAPI ]]>
<![CDATA[fika faradillah drakel]]>;
<![CDATA[riani setiadhi]]>
<![CDATA[ B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Vol 9, No 1 (2022) ]]>
Publisher : <![CDATA[Universitas Baiturrahmah ]]>
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DOI: 10.33854/jbd.v9i1.1020
<![CDATA[Introduction: Oral cancer, also known as mouth cancer, is a malignancy that develops in any part of the oral cavity. Oral cancer can occur on the lips, tongue, gums, cheek, and mucosa of the palate. Oral cancer therapy includes chemotherapy and radiotherapy which can cause side effects, one of them is oral mucositis. Oral mucositis is one of the most common complications of cancer therapy. The main complaint of patients with mucositis is pain which is characterized by clinical features in the form of an erythema, bleeding, and ulceration. Mouthwash has been widely used as an antimicrobial compound and topical prophylactic agent against oral mucositis. The purpose of this literature is to explain the differences between mouthwashes used and the one that produce a better therapeutic effect. Review: Mouthwash used to treat mucositis in several studies in the literature is saline, 0.12% chlorhexidine and 5% bicarbonate, and propolis. The results showed that the use of saline only provided moisture to the ulcerative area but did not suppress any pain. While the combination of 0.12% chlorhexidine and 5% bicarbonate has a healing effect for five to seven days. The propolis mouthwash has a healing effect for 14 days but only for adult patients. Conclusion: The study of mouthwash had many advantages and disadvantages against oral mucositis, but the mouthwash with a combination of 0.12% chlorhexidine and 5% bicarbonate had a good analgesic effect for patient with oral cancer.]]>
<![CDATA[PERTIMBANGAN TERAPI KORTIKOSTEROID PADA STOMATITIS HERPETIK REKUREN ]]>
<![CDATA[Fitria Mailiza]]>;
<![CDATA[Riani Setiadhi]]>
<![CDATA[ B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 2, Nomor 2, Desember 2015 ]]>
Publisher : <![CDATA[Universitas Baiturrahmah ]]>
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DOI: 10.33854/JBDjbd.23
<![CDATA[Corticosteroid is a group of drugs used as anti-inflamatory and immunosuppresive. Most of the disease which treated with steroids have inflammatory characteristics.This paper is about the management of a 25 year old woman who complained of multiple oral ulcers since 2 months before. Patient had difficulty in eating, drinking and speaking. Before referred to RSUP DrHasan Sadikin she was treated at Hospital X and only got a slight improvement. Diagnosis oral infection Herpes Simplex virus type 1 was made based on anamnesis, clinical examination and laboratory examination (IgG anti HSV-1). Oral lesions showed significant improvement after administration of comprehensive treatment including communication, information and education about the disease as well as topical corticosteroid drug and multivitamin.Corticosteroid was used to limit the inflamatory process caused by the action of T-lymphocytes. However, this drug have many side effects so that practitioners need to consider carefully to use it.Corticosteroid could be considered in the management of oral infections herpes virus type 1 (HSV-1) and showed efficacy in the treatment of this patient.]]>
<![CDATA[MANIFESTASI DAN PENATALAKSANAAN PEMFIGUS VULGARIS DI RONGGA MULUT ]]>
<![CDATA[Indra Gunawan]]>;
<![CDATA[Riani Setiadhi]]>
<![CDATA[ B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 2, Nomor 2, Desember 2015 ]]>
Publisher : <![CDATA[Universitas Baiturrahmah ]]>
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DOI: 10.33854/JBDjbd.19
<![CDATA[Background : Pemphigus Vulgaris (PV) is an autoimmune intraepithelial blistering disease involving the skin and mucous membranes. Oral lesions could be the first sign of the disease followed by the involvement of skin and other mucosa sites.Objectives : This is oral manifestations of pemphigus vulgaris case report, intended to help clinicians to recognize and treat the oral lesions.Case Reported : Male 27 yo admitted to RSUP Dr.Hasan Sadikin hospital with multiple blisters on the skin and oral mucosa, was diagnosed with Pemphigus Vulgaris.Case Management : Patient was treated with steroid mouth wash and oral paste. After two months of treatment, the patient was fully recovered from oral lesion.Discussion : In PV, autoantibodies are produced against desmosomes spesifically desmoglein 3 which responsible for holding the cells of the epithelium together. The loss of adhesive function due to anti Dsg 3 antibodies result in bulla formation on the oral mucosa.The aetiology for PV is still uncertain. Conclusion :Early recognition and treatment of oral lesions is important as it may prevent skin involvement. Early treatment, patient’s compliance and multi disciplinal teamwork ensure the treatment succes for this disease]]>
<![CDATA[Efek Penggunaan Produk Perawatan Gigi Dan Mulut Yang Dijual Bebas (Otc) Pada Mukosa Oral ]]>
<![CDATA[Riani Setiadhi]]>
<![CDATA[ Jurnal Material Kedokteran Gigi Vol 5 No 2 (2016): JMKG Vol 5 No 2 September 2016 ]]>
Publisher : <![CDATA[Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI) ]]>
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DOI: 10.32793/jmkg.v5i2.253
<![CDATA[Over-the-Counter (OTC) drug is a drug which is sold freely in the market and can be purchased without a prescription. Special markings on the packaging and etiquette of OTC drug is a green circle with a black edge. Over-TheCounter (OTC) Dental Care Products are dental care products sold directly to consumer without a prescription from the dentist. Nowadays, there has been a significant increase in the number of OTC products in the market for oral health such as mouth washes, breath fresheners, tooth whitening, tooth paste, denture cleaners etc. To find out the effect of inappropriate use of OTC dental care products on the oral mucosa. Many OTC dental products are freely sold, make easier for people to obtain the desired products without visiting the dentist. Besides those advantage, they may also cause undesirable effects due to the inappropriate use and indications which could actually risk the oral health of patients. Side effects that may occur in the oral cavity including altered taste, tooth staining, burning sensation, gingival irritation, desquamation, erosion, numbness and dryness of the oral mucosa. Discontinuing the use of these products usually will recover the oral mucosa conditions. The inappropriate use and indications of OTC dental care products could cause unwanted side effects.]]>
<![CDATA[Oral Lesion Caused by Improper Removable Partial Denture ]]>
<![CDATA[Riani Setiadhi]]>;
<![CDATA[Kosterman Usri]]>
<![CDATA[ Jurnal Material Kedokteran Gigi Vol 7 No 1 (2018): JMKG Vol 7 No 1 Maret 2018 ]]>
Publisher : <![CDATA[Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI) ]]>
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DOI: 10.32793/jmkg.v7i1.275
<![CDATA[Oral lesions are relatively common findings in clinical practice, can occur due to various factors such as trauma, systemic diseases, autoimmune disorders, malignancies. Local trauma as one of the cause of oral lesions majority due to poor dentures, fractured restorations and sharp edges of teeth. The lesions are commonly found on the mucosa that is subjected to the source of trauma such as buccal mucosa, lateral border of the tongue or lips. Removable partial denture is a denture that can be removed and reinserted without professional help. Poor removable denture which is an ill-fitting denture, rough/sharp/overextended flanges, or lack of retention/stability could cause oral lesions. This case report describes a 76 old year man complained of pain on his right lateral tongue since 6 months ago. He was wearing a removable upper right denture which cannot be remove for about a year. It was a rough and sharp self-curing acrylic denture. There was erythematous and pain on his lateral right of the tongue but no induration on palpation. Triamcinolone acetonide 0,1% in orabase was the given treatment for the right lateral of the tongue and referred him to the prosthodontic department for replacing the denture. The oral lesion was healed after one week of treatment and the poor denture was removed. As a conclusion dentures should be made properly by the expert in order to prevent oral lesions.]]>
<![CDATA[The Challenge of Accurate Diagnosis of Oral Lichenoid Lesions in Diabetic Patient: A Case Report ]]>
<![CDATA[Her Basuki Margono]]>;
<![CDATA[Riani Setiadhi]]>
<![CDATA[ Jurnal Material Kedokteran Gigi Vol 5 No 1 (2016): JMKG Vol 5 No 1 Maret 2016 ]]>
Publisher : <![CDATA[Ikatan Peminat Ilmu Material dan Alat Kedokteran Gigi (IPAMAGI) ]]>
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<![CDATA[Mercury in amalgam restoration is one of allergen-induced oral lichenoid lesions which resemble oral lichen planus clinically and histopathologically. Thus, an accurate clinical diagnosis is frequently challenging for clinicians, and it is further complicated because similar oral lesions in oral lichenoid lesions can occur as a manifestation of oral lichenoid drug reactions. This case report illustrates the difficulty of an accurate diagnosis of oral lichenoid lesions due to amalgam restorations in type II diabetes mellitus patient. A 59-year-old male patient presented with a 12-month history of oral ulceration and white striations on left lateral tongue, bilateral distribution of white non scrapable plaque-like lesion mixed together with erosion on buccal mucosa adjacent to amalgam restorations on 37 and 47. The patient’s history for any associated skin lesions was negative. The patient had type II diabetes mellitus with inconsistent intake of oral hypoglycemic drugs, and atopy history of house dust mite and shrimp. We initially diagnosed the case as oral lichen planus. Systemic and topical corticosteroids were instituted, but after a month follow-up, all lesions still showed slight improvement. The final diagnosis of oral lichenoid lesions due to amalgam restorations was made following a positive patch test for amalgam. All lesions were gradually resolved in 3-month follow-up after the causative teeth being extracted. Patch test is useful to differentiate between oral lichenoid lesions and oral lichen planus. The treatment of oral lichenoid lesions due to amalgam restorations is simply removal or replacing the offending materials.]]>
