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All Journal Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Pharmaciana: Jurnal Kefarmasian The Journal of Pure and Applied Chemistry Research Damianus Journal of Medicine Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Chemistry Jurnal Aplikasi Teknologi Pangan MITRA: Jurnal Pemberdayaan Masyarakat CARADDE: Jurnal Pengabdian Kepada Masyarakat PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kimia dan Kemasan Makara Journal of Health Research Jurnal Farmasi Indonesia Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat

Dion Notario

Program Studi Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Jakarta

Author-ID : 2604737

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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ANALISIS FAKTOR PERLINDUNGAN MATAHARI (FPM) DARI SEDIAAN TABIR SURYA SECARA SPEKTROFOTOMETRI DENGAN METODE KUADRAT TERKECIL SEBAGIAN JACK-KNIFE Notario, Dion; Aditya, Martanty; Rollando, Rollando; Prilianti, Kestrilia Rega
Natural Science: Journal of Science and Technology Vol 6, No 1 (2017): Volume 6 Number 1 (March 2017)
Publisher : Univ. Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (437.851 KB)

Penentuan nilai Faktor Perlindungan Matahari (FPM) dengan metode spektrofotometri sangat dibutuhkan untuk melakukan penapisan awal kandidat bahan aktif tabir surya. Meskipun demikian, ditemukan kesalahan yang relatif besar ketika dilakukan penentuan SPF secara spektrofotometrik terhadap beberapa sediaan tabir surya yang beredar secara komersial. Oleh karena itu, dalam penelitian ini dilakukan analisis FPM secara spektrofotometrik pada panjang gelombang 290 ? 320 nm yang dilanjutkan dengan regresi multivariat yaitu kuadrat terkecil sebagian jack-knife untuk meningkatkan akurasi estimasi nilai prediksi FPM secara in vitro. Selanjutnya, model matematik yang diperoleh, digunakan untuk melakukan penapisan bahan aktif tabir surya dari beberapa sampel botani. Hasil penelitian menunjukkan bahwa model matematik yang dihasilkan mempunyai nilai kesalahan prediksi yang lebih rendah daripada metode sebelumnya (RMSECV = 3,15; r = 0,915) dan dapat diaplikasikan untuk penapisan kandidat bahan aktif tabir surya dari tanaman.

The risk of Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB) used on Obstructive Sleep Apnea (OSA) incidence in hypertension patients Fibe Yulinda Cesa; Martanty Aditya; Rehmadanta Sitepu; Dion Notario
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art1

AbstractBackground: The administration of angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) therapy is known to have a side effect of a dry cough that would trigger OSA. Further research is needed to compare the effect of these two drugs on the side effects of OSA, which could trigger high-risk patient conditions. Objective: To determine the risk of using ACE and CCB on the incidence of OSA using a case-control study method at Dau Primary Health Center.Methods: Demographic data were collected on 207 respondents aged 40-60 years by collecting Data Collection Sheets and Berlin questionnaires to determine the risk of OSA in respondents. Then, statistical analysis was carried out by determining the odds ratio (OR).Results: The results showed that one of the factors BMI (obese BMI; OR=1.33; 95% CI=0.11-15.70) induces OSA with the highest OR value compared to other factors.Conclusion: Obese patient has a 1.33 times greater risk of OSA with ACEI and CCB therapy than non-obese. It is necessary to conduct further research with a larger sample size related to OSA’s assessment associated with this therapy to improve patients’ quality of life.Keywords: Obstructive sleep apnea, ACE inhibitors, calcium channel blockers, hypertension IntisariLatar belakang: Obtructive Sleep Apnea (OSA) yang terjadi pada pasien hipertensi dapat disebabkan karena efek samping dari penggunaan antihipertensi angiotensin converting enzyme inhibitor (ACEI) dan calcium channel blocker (CCB), namun analisis hubungan keduanya belum diketahui dengan pasti.Tujuan: Penelitian ini bertujuan untuk mengetahui risiko penggunaan ACE dan CCB terhadap kejadian OSA dengan metode case control study di Puskesmas Dau.Metode: Pengambilan data demografi pada 207 responden usia 40-60 tahun dilakukan dengan mengumpulkan Lembar Pengumpul Data (LPD) dan kuesioner Berlin untuk mengetahui risiko OSA pada responden kemudian dilakukan analisis statistik dengan penentuan odds ratio (OR).Hasil: Hasil penelitian menunjukkan bahwa pasien yang menjalani pengobatan dengan antihipertensi ACEI dan obesitas memiliki risiko lebih besar mengalami OSA (OR=1,33; CI 95%=0,11-15,70) yaitu 1,33 kali dibandingkan pada pasien yang tidak obesitas.Kesimpulan: Obesitas menjadi factor risiko terhadap kejadian OSA pada pasien hipertensi yang mendapatkan antihipertensi golongan ACEI dan CCB.Kata kunci: Obstructive sleep apnea, ACE inhibitor, calcium channel blocker, hipertensi

Sintesis Senyawa Koordinasi Astaxanthin Dengan Bantuan Gelombang Ultrasonik Rokiy Alfanaar; Dion Notario
Jurnal Kimia dan Kemasan Vol. 41 No. 2 Oktober 2019
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v41i2.3366

Astaxanthin merupakan senyawa turunan karotenoid xantofil yang sangat potensial dalam pengobatan kanker. Salah satu upaya meningkatkan aktivitas anti kanker dari astaxanthin adalah dengan menggabungkan senyawa astaxanthin dengan ion logam. Upaya sintesis senyawa koordinasi astaxanthin dengan ion logam Fe3+, Mn2+, dan Zn2+ telah dilakukan dengan bantuan gelombang ultrasonik. Panjang gelombang maksimal senyawa kompleks Mn(II)-Astaxanthin adalah 473 nm, Fe(III)-Astaxanthin adalah 355 nm, dan Zn(II)-Astaxanthin adalah 473 nm. Hasil FTIR menunjukan munculnya gugus fungsi khas astaxanthin pada semua kompleks dan munculnya serapan pada 535 cm-1, untuk kompleks Mn(II)-Astaxanthin, 397 cm-1 untuk Fe(III)-Astaxanthin, dan 535 cm-1 untuk Zn(II)-Astaxanthin yang mengindikasikan adanya ikatan logam dengan atom donor dari Astaxanthin.

Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies Rollando Rollando; Dion Notario; Eva Monica; Martanty Aditya; Rehmadanta Sitepu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC50 20.76 mg/mL), Staphylococcus aureus (IC50 70.15 mg/mL), Salmonella typhi (49.13 mg/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC50 10.76 mg/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell.

Pengukuran Risiko Gangguan Tidur pada Penggunaan Angiotensin Converting Enzyme Inhibitor dan Calcium Channel Blocker: Case Control Study di Puskesmas Dau, Malang Martanty Aditya; Rehmadanta Sitepu; Dion Notario; Fibe Y. Cesa
Indonesian Journal of Clinical Pharmacy Vol 8, No 3 (2019)
Publisher : Universitas Padjadjaran

Gangguan tidur atau insomnia yang muncul pada pasien hipertensi dapat disebabkan oleh efek samping obat-obat antara lain golongan Angiotensin Converting Enzyme Inhibitor (ACEI) dan Calcium Channel Blocker (CCB), namun besarnya pengaruh masing-masing golongan belum banyak diperbandingkan. Oleh karena itu, dilakukan penelitian dengan menggunakan rancangan case control untuk menilai risiko penggunaan ACEI dan CCB terhadap angka kejadian insomnia. Data demografi dan status insomnia dikumpulkan melalui Lembar Pengumpul Data (LPD) dan kuesioner Athens Insomnia Scale (AIS), kemudian dilakukan analisis univariat, bivariat, dan multivariat. Hasil analisis menunjukkan bahwa pada kelompok usia 56–60 tahun, pasien yang menjalani pengobatan dengan ACEI memiliki risiko insomnia lebih kecil yaitu sekitar 0,38 kali (p=0,026, 95% CI=0,15–0,94) dibandingkan dengan pasien lain yang menggunakan CCB, sedangkan pada kelompok kategorial yang lain tidak ditemukan hubungan yang signifikan. Dengan demikian, pemantauan efek samping insomnia menjadi penting untuk dilakukan oleh tenaga kesehatan terutama pada pasien yang menjalani pengobatan dengan CCB pada usia 56–60 tahun.Kata kunci: ACE inhibitor, calcium channel blocker, case control, gangguan tidur A Measurement of Sleep Disorder in the Use of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker: A Case Control Study at Dau Public Health Center, MalangAbstractSleep disorder or insomnia arisen in hypertensive patients might be derived as a side effect of antihypertensive mediations such as Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB), but the influence of each group had not been much compared. Therefore, a research was conducted using case control design to assess the risk of using ACEI and CCB against the incidence rate of insomnia. Demographic data and insomnia status were collected through Data Collector Sheet and Athens Insomnia Scale (AIS) questionnaire before univariate, bivariate, and multivariate analysis was conducted. The result showed that in the age group of 56–60 years patients undergoing treatment with ACEI have a smaller risk of insomnia of approximately 0.38 times (p=0.026, 95% CI=0.15–0.94) compared to the other patients who were treated with CCB, while in other categorial groups, no significant relationship was found. Thus, the monitoring of insomnia side effects becomes important to be conducted by healthcare professional especially in patients undergoing treatment with CCB at the ages of 56–60 years.Keywords: ACE inhibitor, calcium channel blocker, case control, sleep disorder

Penelusuran aktivitas antibakteri, antioksidan, dan sitotoksik fungi endofit genus fusarium sp. diisolasi dari daun meniran (Phyllantus niruri Linn.) Rollando rollando; Martanty Aditya; Dion Notario; Eva Monica; Rehmadanta Sitepu
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Endophytic fungi used as a new resource to produce bioactive compounds such as antibacterial, antioxidant and anticancer. This study aimed to analyze the antibacterial, antioxidant, cytotoxic fraction of the separation ethyl acetate extract of mycelium of endophytic fungi genus Fusarium sp. Diethyl ether fraction showed high antibacterial activity in E.coli (20,75 Âµg/mL), S.typhi (35,08 Âµg/mL), and S.aureus (51,96 Âµg/mL). Test showed that the antioxidant activity of ethanol 96% fraction has highest antioxidant activity and total phenolic content (75,85 Â± 0.87 mg GAE). Cytotoxic test on T47D breast cancer cells showed that the fraction of diethyl ether have highest activity with IC50 of 10,16 Â± 0,88 Âµg /mL.

Efek Penambahan Gula Kelapa dan Lemak Kakao terhadap Ekstrak Alga Cokelat yang Mengandung Fukosantin dalam Formulasi Foodbars Agustina Dwi Retno Nurcahyanti; Rianita Pramitasari; Intan Harmae Setiawan; Dion Notario
Jurnal Aplikasi Teknologi Pangan Vol 10, No 3 (2021): Agustus 2021
Publisher : Faculty of Animal and Agricultural Sciences, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17728/jatp.8366

Alga cokelat mengandung pigmen karotenoid yang didominasi oleh fukosantin dengan aktivitas antioksidan yang tinggi. Karotenoid dari alga cokelat, termasuk fukosantin, belum sepenuhnya dimanfaatkan dalam formulasi pangan karena sifatnya yang kurang stabil. Karotenoid yang akan diaplikasikan dalam produk pangan perlu ditambah dengan bahan penstabil. Penelitian ini bertujuan untuk menganalisa kestabilan ekstrak alga cokelat dengan penambahan gula kelapa dan lemak kakao yang diformulasikan dalam bentuk foodbars, menguji aktivitas antioksidan, proksimat, tekstur, dan daya simpan produk foodbars yang mengandung fukosantin. Alga cokelat dari Pulau Sumbawa diekstrak menggunakan etanol 96% untuk memperoleh kandungan fukosantin. Analisa fukosantin dilakukan menggunakan high performance liquid chromatography (HPLC) dengan detektor diode array SPD-M20A (Shimadzu). Aktivitas antioksidan ekstrak alga cokelat dan selurruh bahan penyusun foodbars diuji aktivitas antioksidannya menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil) dan ekstrak alga cokelat menunjukkan aktivitas tertinggi. Foodbars formula 2 paling disukai oleh panelis semi terlatih melalui uji organoleptik. Selain itu, formulasi foodbars memiliki tingkat kekerasan tidak berbeda secara signifikan dengan produk komersial. Hasil uji daya simpan menunjukkan pertumbuhan mikroba yang rendah sebanding dengan aktivitas air yang juga rendah. Penelitian ini adalah pertama yang menunjukkan ekstrak alga cokelat mengandung fukosantin dapat dimanfaatkan sebagai foodbars.Brown algae contains fucoxanthine as dominant carotenoid with high antioxidant activity. However, this carotenoid, including fucoxanthine, has not been fully utilized in food formulations because of their unstable property. Carotenoid needs stabilizing ingredient to be suitably used in food products. This study aims to analyze the stability of brown algae extract by adding coconut sugar and cocoa fat that are formulated in the foodbars product, testing the antioxidant activity, proximate, texture, and stability of foodbars product containing fucoxanthine. Brown algae from Sumbawa Island are extracted using ethanol 96% to obtain fucoxanthine. Fucoxanthine analysis was performed using high performance liquid chromatography (HPLC) with a SPD-M20A diode array detector (Shimadzu). The antioxidant activity was tested using the DPPH method and the brown algae extract showed highest activity amongst all foodbars ingredients. Foodbars formula 2 (FB2) is most preferred by semi-trained panelists through organoleptic testing. In addition, the formulation of foodbars has similar texture to commercial product. The result of the shelf-life test show low microbial growth in proportion to low water activity. This is the first study showing brown algae containing fucoxanthine used in the foodbars product.

Towards Green Rusunawa: Clean Water Utilization, Composting, and Urban Farming in Muara Baru Flats Dion Notario; Ferdian Suprata; Meda Canti; Listya Utami Karmawan
MITRA: Jurnal Pemberdayaan Masyarakat Vol 5 No 1 (2021): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v5i1.1077

Waste disposal and clean water management are some of the common social issues arising in densely populated settlements, including Muara Baru flats, Jakarta. Some programs have been carried out to overcome these two issues in Muara Baru, such as the construction of a Rain Water Harvesting (RWH) facility and the provision of Trash Banks. Nevertheless, adequate support for the residents is still needed to boost their awareness of proper clean water management and waste disposal and to encourage the formation of urban agriculture, which is expected to elevate their living standards. Therefore, a community empowerment program in Muara Baru was developed, consisting of three sections: education on clean water management, compost making training, and urban farming. The success of this program was then measured using questionnaires and focus group discussions. A majority of residents responded positively to the program and were willing to actively participate by preparing the land, making compost, planting seeds, or caring for the harvest. There were indeed some obstacles hampering the program's success, such as lack of commitment from the local community, climate change, water availability, and arable land availability. To overcome these barriers and to promote the program’s sustainability, some suggestions are to be proposed, including proper selections of plant types and provision of support and motivation for the local community.

Drug Information Service during Covid-19 Pandemic Sherly Tandi Arrang; Reynelda Juliani Sagala; Dion Notario; Erlia Anggrainy Sianipar; Fonny Cokro
MITRA: Jurnal Pemberdayaan Masyarakat Vol 5 No 1 (2021): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v5i1.1467

Pharmacists and pharmaceutical personnel need to support improving the people’s quality of life during the covid-19 outbreak by providing pharmaceutical services, one of which is the Drug Information Service (PIO). Many regions in Indonesia, including DKI Jakarta, have placed large-scale social restrictions since March 2020. In connection with that, the Department of Pharmacy of Atma Jaya Catholic University of Indonesia (PSFUAJ) organized an online PIO program. This program aimed to provide the service of Covid-19 drug-related information and education to the community. The PIO was carried out from April to July 2020 via whatsapp, email, and telephone. In addition, health education was provided through e-flyers, published on Instagram @pio_farmasi_uaj. Eighty percent of the questions were submitted via whatsapp, while the rest was sent via email. Most of the questions submitted (80%) were categorized into self-edication. Further examination shows that the common questions were related to drug choice (27.78%). These data indicate that most questioners tend to provide self-medication first and that they will only see a doctor if they have not recovered or experienced any improvement. PSFUAJ will continue running this program and disseminating this program to a broader audience.

A Rapid and Simple High-Performance Liquid Chromatographic Method for Determination of Levofloxacin in Human Plasma Dion Notario; Sudibyo Martono; Zullies Ikawati; Arief Rahman Hakim; Fathul Jannah; Endang Lukitaningsih
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

A simple and rapid high-performance liquid chromatography method was developed and validated for quantifying LEV in human plasma. Chromatographic separation was performed under isocratic elution on a Luna Phenomenex® C18 (150 × 4.6 mm, 5 µm) column. The mobile phase was comprised of acetonitrile, methanol, and phosphate buffer 25 mM pH 3.0 (13:7:80 v/v/v) and pumped at a flow rate of 1.5 mL/min. Detection was performed by UV detector at a wavelength of 280 nm. Samples were pre-treated with acetonitrile followed by centrifugation, evaporation, and reconstitution step. The method proved linear (r = 0.995), sensitive (LLOQ and LOD was 1.8 and 0.6 µg/mL respectively), accurate (% error above LLOQ ≤ 12% and LLOQ ≤ 20%), precise (RSD ≤ 9%), robust in the ranges of 1.8-28.8 µg/mL, rapid (separation time not more than 10 min), and simple (use no organic additive in mobile phase). The method was showed reliable for quantifying LEV in human plasma.

Co-Authors Agnes Anania Triavika Sahamastuti Agustina Dwi Retno Nurcahyanti Alfanaar, Rokiy Anton Sumarpo Aprillia Suwita Arief Rahman Hakim Arrang, Sherly Tandi Buntoro, Leonardo Catherine Keiko Gunawan Chandra, Valencia Deka Prismawan Della, Genoveva Endang Lukitaningsih Erlia Anggrainy Sianipar Eva Monica Fathul Jannah Ferdian Suprata Fibe Y. Cesa Fibe Yulinda Cesa Fonny Cokro Frederica, Pricillia Genoveva Della Grafty Polin Intan Harmae Setiawan Jessica Amelia Jessica Amelia Jusni, Louis Fabio Jonathan Kelviyana Kelviyana Kestrilia Rega Prilianti Larasati, Theresia Leonardo, William Linawati Hananta, Linawati Listya Utami Karmawan Lusy Noviani Marc Valens Nicholas Martanty Aditya, Martanty Meda Canti Monica, Eva Nicholas Edmund Novita Suryamin Noviyani Noviyani Patricia, Allison Patrycia Setiawan Pretty Falena Atmanda Kambira Putriana Rachmawati Raymunanda Widya Kimla Ningrum Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Reynelda Juliani Sagala Rianita Pramitasari Rollando, Rollando Salsabila, Sabitha Sherina Dhamayanti Sherly Tandi Arrang Sondang G.O. Ambarita Sudibyo Martono Tena Djuartina, Tena Untung Gunawan Verda, Vanessia Veronica, Elsa Ignatia Veronica, Natalia Wanda Aurina Yohanes Joshua Istanto Yovitasari, Tiara Aprilli YUNITA Zita Arieselia Zullies Ikawati

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