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Evaluation of the Use of Antibiotics in the COVID-19 Ward at A North Jakarta Hospital Arrang, Sherly Tandi; Buntoro, Leonardo; Notario, Dion
Jurnal Kefarmasian Indonesia VOLUME 13, NUMBER 2, AUGUST 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i2.6539

The misuse of antibiotics can lead to antibiotic drug resistance, which can increase morbidity and mortality. In order to stop the emergence of antibiotic drug resistance, the WHO recommends routinely assessing the usage of antibiotics. When the COVID-19 epidemic broke out, antibiotic consumption significantly increased compared to the prior year. The panic buying phenomenon also appeared during the COVID-19 pandemic. As a result of this circumstance, medications like antibiotics become rare. The abuse of antibiotics during the COVID-19 pandemic may have contributed to the spread of antibiotic resistance more frequently. This study was conducted to evaluate and describe the use of antibiotic drugs in COVID-19 ward patients at a North Jakarta regional hospital for the period April 2020 – April 2021. This study was an observational study design. The Gyssens method and the Anatomical Therapeutic Chemical/Defined Daily Doses (ATC/DDD) methodology, respectively, evaluate the effectiveness of antibiotic use on a quantitative and qualitative level. There were 24 different types of antibiotics used, and 161 respondents all met the criterion for inclusion. The most widely used antibiotic was azithromycin, with a DDD/100 patient days value of 25.15. According to Gyssen’s evaluation, 92.6% of antibiotic usage was rational and 7.4% was irrational.

PERBEDAAN EFEKTIVITAS EDUKASI BEYOND USE DATE MELALUI BUKU SAKU DAN VIDEO TERHADAP TINGKAT PENGETAHUAN Veronica, Elsa Ignatia; Arrang, Sherly Tandi; Notario, Dion
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The stability of drug preparations is very important to maintain because it can affect the quality, effectiveness, and safety of these drug preparations. If the product's primary packaging is opened, the stability of the preparation is changed. The product's stability duration is correlated with the expiration date. The expiration date of the product after opened from its original packaging or mixed with other preparations is known as the beyond-use date (BUD). Research on the level of public knowledge about BUD still needs to be improved, and the results of several studies show that the community needs to learn and understand BUD. Therefore, a study was conducted to assess differences in the effectiveness of educational media (pocketbook and video) on knowledge related to BUD. Quasi-experimental research design with the type of pre-test & post-test two groups. The number of respondents in this research was 70, divided into two: pocketbooks (35 respondents) and videos (35 respondents). Based on the analysis results, it was found that there was a change in the respondents' knowledge after being given education. As many as 60% of respondents in the pocketbook group had insufficient knowledge before being given education, and after being given education, 74% of respondents had good knowledge (p=0.01). In the video group, there was an increase in the good knowledge respondent group; namely, before being given education, the number was 37%, increasing to 43% after being given education (p=0.01). The regression analysis showed that educational media significantly influenced respondents' knowledge related to BUD (p=0.04). The ducation with a pocketbook and video increases knowledge about BUD, but videos provide a better increase in knowledge.

Formulation and Evaluation of Clay Mask Preparations Containing Robusta Coffee (Coffea canephora Yovitasari, Tiara Aprilli; Notario, Dion; Rachmawati, Putriana
Bahasa Indonesia Vol 24 No 1 (2025): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v24i1.5833

Pendahuluan: Clay mask merupakan masker yang cocok untuk kulit berminyak dan rentan berjerawat, sedangkan kopi merupakan bahan alami yang memiliki senyawa aktif polifenol dan alkaloid. Kopi robusta (Coffea canephora) merupakan jenis kopi yang memiliki kandungan fenolik lebih tinggi dibandingkan jenis kopi lainnya. Penelitian ini dilakukan untuk membuat formula clay mask yang mengandung kopi robusta yang stabil dengan tujuan untuk merawat kulit berjerawat. Metode: Penelitian eksperimental menggunakan metode Response Surface Methodology. Evaluasi sediaan clay mask untuk memastikan mutu sediaan seperti uji organoleptik dan homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji viskositas. Uji stabilitas clay mask dengan metode Freeze Thaw Cycle dan sentrifugasi. Hasil: Formulasi optimal clay mask yang mengandung tween 20 11,5% dan xanthan gum 1,4% menghasilkan nilai viskositas sebesar 10310 ± 314 cps dan daya sebar 1,75 ± 0,03 cm. Variasi konsentrasi tween 20 dan xanthan gum memengaruhi nilai viskositas dan daya sebar, namun tidak pada daya lekat. Uji sentrifugasi dan freeze thaw menunjukkan bahwa sediaan stabil secara fisik. Simpulan: Sediaan optimal clay mask yang mengandung Coffea canephora berhasil dibuat dan dapat menjadi opsi dalam produk kosmetik untuk perawatan kulit berjerawat.

Pemodelan Farmakokinetika Berbasis Populasi dengan R: Model Dua Kompartemen Ekstravaskuler: Population-Based Pharmacokinetics Modeling with R: Two Compartment Extravascular Model Notario, Dion
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

A Tutorial of two-compartment extravascular population-based pharmacokinetics modeling was performed by differential equations and non-linear mixed effect model approach. First, three-level differential equations of two-compartment pharmacokinetics were generated. Then, covariate and non-covariate models were developed by nlmeODE and nlme packages installed in R. The best model was selected according to AIC, BIC, and LogLik value. A model without covariates model was selected as the best model. The selected model showed a goodness of fit with experimental dataset and residual plot of the model revealed that no violations of model assumtions. In conclusion, nlme and nlmeODE is capable to generate an adequate predictive model of two-compartment population-based pharmacokinetics for extravascular route

A Validated RP-HPLC-PDA with Buffer-Free Gradient Elution for Simultaneous Plasma Analysis of Trimethoprim and Sulfamethoxazole Edmund, Nicholas; Gunawan, Untung; Notario, Dion
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.498

A simple, cost-effective, and validated reversed-phase high-performance liquid chromatography (RP-HPLC) method is crucial for accurately monitoring trimethoprim and sulfamethoxazole therapy. However, conventional HPLC methods often rely on buffered mobile phases and additives, which can lead to column blockage and shorten column lifespan. To address this issue, we developed and validated a reversed-phase HPLC method with a photodiode array (PDA) detector, using a buffer-free and additive-free mobile phase with gradient elution. Sample preparation was performed using organic solvent-based deproteinization to minimize matrix effects. Chromatographic separation was performed on a ZORBAX Eclipse Plus C18 column (250 × 4.6 mm, 5 µm) using a mobile phase of acetic acid (pH 2.3), methanol, and acetonitrile at a flow rate of 1 mL/min. Detection was carried out at 270 nm with a total run time of 17 minutes. The analytical method exhibited linearity, precision, and accuracy, with adequate sensitivity for the analytes of interest. Stability testing yielded favorable results under various storage conditions, including the autosampler, freeze-thaw cycles, and long-term storage. However, the trimethoprim stock solution was only stable for two days and must be freshly prepared. Full validation was conducted in accordance with FDA and ICH bioanalytical guidelines, confirming its suitability for clinical application.

Lawan Kolesterol dengan Bahan Alam Melalui Penyuluhan pada Masyarakat di Kecamatan Cilincing Jakarta Utara Notario, Dion; Yunita; Frederica, Pricillia; Salsabila, Sabitha; Larasati, Theresia; Patricia, Allison
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 1 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i1.5106

Hiperkolesterolemia merupakan salah satu penyebab penyakit kardiovaskuler yang memiliki proporsi tinggi di Indonesia. Hiperkolesterolemia dapat dicegah dengan mengonsumsi bahan alami yang sebagian besar terdapat dalam buah dan sayur, tetapi pola makan di Indonesia justru tinggi lemak/kolesterol/gorengan serta kekurangan sayur dan buah. Oleh karena itu, dilakukan kegiatan penyuluhan serta pengecekan kolesterol total dalam darah dengan tujuan untuk meningkatkan pengetahuan masyarakat tentang bahaya dan upaya pencegahan hiperkolesterolemia dengan memanfaatkan bahan alam. Kegiatan ini berlangsung pada 19 Mei 2023 dengan 2 bentuk acara antara lain, yaitu pemeriksaan kesehatan, dan penyuluhan dengan metode ceramah dan tanya jawab. Kegiatan dilakukan di Kecamatan Cilincing, sebanyak 51 peserta berkontribusi secara aktif mengikuti kegiatan penyuluhan dan pemeriksaan kesehatan. Berdasarkan hasil pemeriksaan kesehatan, didapatkan sebanyak 32 (62,74%) orang memilki kadar kolesterol total yang berada di atas nilai yang direkomendasikan. Di lain pihak, penyuluhan dengan metode ceramah dan tanya jawab mampu meningkatkan skor pengetahuan mengenai kolesterol dan upaya pencegahannya dengan memanfaatkan bahan alam sebesar 11,37 satuan secara bermakna (p<0,05).

Lawan Kolesterol dengan Bahan Alam Melalui Penyuluhan pada Masyarakat di Kecamatan Cilincing Jakarta Utara Notario, Dion; Yunita; Frederica, Pricillia; Salsabila, Sabitha; Larasati, Theresia; Patricia, Allison
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 1 (2024)
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v2i1.5106

Hiperkolesterolemia merupakan salah satu penyebab penyakit kardiovaskuler yang memiliki proporsi tinggi di Indonesia. Hiperkolesterolemia dapat dicegah dengan mengonsumsi bahan alami yang sebagian besar terdapat dalam buah dan sayur, tetapi pola makan di Indonesia justru tinggi lemak/kolesterol/gorengan serta kekurangan sayur dan buah. Oleh karena itu, dilakukan kegiatan penyuluhan serta pengecekan kolesterol total dalam darah dengan tujuan untuk meningkatkan pengetahuan masyarakat tentang bahaya dan upaya pencegahan hiperkolesterolemia dengan memanfaatkan bahan alam. Kegiatan ini berlangsung pada 19 Mei 2023 dengan 2 bentuk acara antara lain, yaitu pemeriksaan kesehatan, dan penyuluhan dengan metode ceramah dan tanya jawab. Kegiatan dilakukan di Kecamatan Cilincing, sebanyak 51 peserta berkontribusi secara aktif mengikuti kegiatan penyuluhan dan pemeriksaan kesehatan. Berdasarkan hasil pemeriksaan kesehatan, didapatkan sebanyak 32 (62,74%) orang memilki kadar kolesterol total yang berada di atas nilai yang direkomendasikan. Di lain pihak, penyuluhan dengan metode ceramah dan tanya jawab mampu meningkatkan skor pengetahuan mengenai kolesterol dan upaya pencegahannya dengan memanfaatkan bahan alam sebesar 11,37 satuan secara bermakna (p<0,05).

Hubungan Tingkat Pengetahuan dan Faktor Lainnya dengan Tingkat Kepatuhan Pasien Hipertensi di RSAL Dr. Mintohardjo Jakarta Arrang, Sherly Tandi; Veronica, Natalia; Notario, Dion
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.84908

Hypertension is a "silent killer". It is still one of the bigest challenges in Indonesia, where many cases are still found in primary health facilities. Hypertensive patients who require long-term therapy and adherence are very important factors to support the success of therapy. Based on the data from the Ministry of Health of the Republic of Indonesia (2018), 32.3% of hypertensive patients did not take medication regularly. Many factors influence medication adherence, such as level of knowledge, age, gender, working status, and length of illness. This study aimed to determine the effect of the level of knowledge and other factors on the level of medication adherence of hypertensive patients at the Dr. Mintohardjo Naval Hospital (RSAL). This research is a observasional study with a cross-sectional method and uses a questionnaire for data collection. Adherence level questionnaire uses MMAS-8. Analysis of the relationship between factors that influence the level of adherence uses logistic regression. The inclusion criteria of this study included hypertention outpatient aged ≤ 65 years old and are currently receiving antihypertensive therapy. The results of this study showed that out of 284 respondents, 92% of respondents had good knowledge regarding hypertension, while the level of adherence to taking medication was low at 47%. Factors that influence the level of patient adherence to taking medication in this study are gender (p-value = <0.001), education (p-value = <0.001), duration of hypertension (p-value = 0.033), and working status (p-value = <0.001). In contrast, the level of knowledge (p-value = 0.979) and age (p = 0.87) did not significantly influence the level of medication adherence. The Odds Ratio (OR) for working status was 5.73, OR for final education was 2.97, OR for the duration of hypertension was 2.24, and OR for gender was 0.34.

Potential Antihyperlipidemia Effect of Lactoferrin in Hyperlipidemia-Induced Male Sprague–Dawley Rats Jusni, Louis Fabio Jonathan; Chandra, Valencia; Djuartina, Tena; Notario, Dion; Arieselia, Zita; Hananta, Linawati
Makara Journal of Health Research Vol. 26, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Hyperlipidemia is a condition that is characterized as an increase in total cholesterol and triglyceride levels in the blood. Lactoferrin is a protein that can serve as an antioxidant. This study aims to determine whether lactoferrin can reduce total cholesterol and triglyceride levels. Methods: This study used 24 Sprague–Dawley rat strains, which were divided into six groups: normal group; negative control; positive control; and dose groups 1, 2, and 3. The normal group was given standard feed, whereas the other group was given high cholesterol and fat. The positive control group and dose groups 1, 2, and 3 were given 1.5 mg/kg BW of simvastatin and 100, 200, and 400 mg/kg of BW lactoferrin, respectively. After 6 weeks, total cholesterol and triglyceride levels were measured. Results: This study showed that lactoferrin doses of 100, 200, and 400 mg/kg BW could significantly reduce total cholesterol and triglyceride levels (p < 0.05). Lactoferrin could also significantly reduce activated Kupffer cell and steatosis area in the liver (p < 0.05). Conclusions: Lactoferrin can reduce total cholesterol and triglyceride levels. Thus, further research is needed to address the existing bias and confirm that lactoferrin can reduce cholesterol and triglyceride levels.

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