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All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Journal of the Medical Sciences (Berkala Ilmu Kedokteran) VISIKES Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Masyarakat Media Ilmu Keolahragaan Indonesia Jurnal Keolahragaan GIZI INDONESIA Jurnal Gizi Klinik Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of Food and Culinary Journal of Community Empowerment for Health Jurnal Dunia Gizi Pena Medika : Jurnal Kesehatan Makara Journal of Health Research SWARNA Medika Respati : Jurnal Ilmiah Kesehatan JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Arta Farmawati
Departemen Biokimia Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan Universitas Gadjah Mada
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Journal : Pena Medika : Jurnal Kesehatan

 1 
Polimorfisme Gen Ferroportin (FPN1) Q248H dan Karakteristik Sosial Ekonomi Ibu Hamil dengan Anemia di Surakarta Nor Istiqomah; Vitria Sari Dewi; Arta Farmawati; Ahmad Hamim Sadewa; Yuliana Heri Soesilo; Kusumadewi Eka Damayanti; Dono Indarto
Pena Medika Jurnal Kesehatan Vol 4, No 1 (2013): PENA MEDIKA JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v4i1.284

Abstract

Background: Iron deficiency anemia in pregnancy remains an important health problem in Indonesia. Ferroportin (FPN1) is one of important gene in iron metabolism encodes ferroportin for iron absorption, release, and recycle inside the body. The polymorphism of FPN1 Q248H alters negative charge of the amino acid sequence positively, hence influenced its ubiquitination and degradation. Beside of that, the high prevalence of anemia not only caused by genetics, nutrition, physiology of each pregant women, but also demographic factor and sosio-economic burden of family. This research will study the polymorphism of ferroportin Q248H and demographic character in pregnant women in Surakarta.Methods: The study using descriptive analytic case-control approach. The data used were from questionaire and blood sampling whose counted for screening anemia in private laboratorium. Pregnant women who had intention and had 10-25 week in pregnant were selected to be research subject.  FPN1 Q248H polymorphism were determined using PCR-RFLP method. Analysis Chi-square dan Independent t-test used to conclude the relationship between each variable to anemic state of pregnant women in Surakarta. A p<0.05 was considered as significant. The study using decriptive analytic design method. Results: Prevalence of anemia in Surakarta is 25.7% with 80.7% have mild anemia. There was no varian in FPN1 Q248H. Majority of pregnant women in group of anaemia have demographic character like 20-25 old, multigravid, last education in High School, housewife, their income range from Rp 500.000,00 to Rp 1.000.000,00, and consume Fe tablet. The bivariat analysis show no statistical significancy of parity, maternal age, education, income, and comsumption of iron tablet to state of anaemia (p>0.05).Conclusions: The FPN1 Q248H polymorphism was not a risk factor for iron deficiency anemia in pregnant women, likewise socio-economic factors had no significant role to incidence of anemia in Surakarta. Keywords: Anemia in pregnancy, Ferroportin (FPN1) Q248H polymorphism, Socio-Economic
Polimorfisme Gen Ferroportin (FPN1) Q248H dan Karakteristik Sosial Ekonomi Ibu Hamil dengan Anemia di Surakarta Istiqomah, Nor; Dewi, Vitria Sari; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Pena Medika Jurnal Kesehatan Vol 4, No 1 (2013): PENA MEDIKA JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v4i1.284

Abstract

Background: Iron deficiency anemia in pregnancy remains an important health problem in Indonesia. Ferroportin (FPN1) is one of important gene in iron metabolism encodes ferroportin for iron absorption, release, and recycle inside the body. The polymorphism of FPN1 Q248H alters negative charge of the amino acid sequence positively, hence influenced its ubiquitination and degradation. Beside of that, the high prevalence of anemia not only caused by genetics, nutrition, physiology of each pregant women, but also demographic factor and sosio-economic burden of family. This research will study the polymorphism of ferroportin Q248H and demographic character in pregnant women in Surakarta.Methods: The study using descriptive analytic case-control approach. The data used were from questionaire and blood sampling whose counted for screening anemia in private laboratorium. Pregnant women who had intention and had 10-25 week in pregnant were selected to be research subject.  FPN1 Q248H polymorphism were determined using PCR-RFLP method. Analysis Chi-square dan Independent t-test used to conclude the relationship between each variable to anemic state of pregnant women in Surakarta. A p<0.05 was considered as significant. The study using decriptive analytic design method. Results: Prevalence of anemia in Surakarta is 25.7% with 80.7% have mild anemia. There was no varian in FPN1 Q248H. Majority of pregnant women in group of anaemia have demographic character like 20-25 old, multigravid, last education in High School, housewife, their income range from Rp 500.000,00 to Rp 1.000.000,00, and consume Fe tablet. The bivariat analysis show no statistical significancy of parity, maternal age, education, income, and comsumption of iron tablet to state of anaemia (p>0.05).Conclusions: The FPN1 Q248H polymorphism was not a risk factor for iron deficiency anemia in pregnant women, likewise socio-economic factors had no significant role to incidence of anemia in Surakarta. Keywords: Anemia in pregnancy, Ferroportin (FPN1) Q248H polymorphism, Socio-Economic
Co-Authors . Sunarti . Wulandari Abdul Wahab Abdul Wahab Abrory Agus Cahya Pramana Ahmad Ghozali Ahmad Hamim Sadewa Ainun Nisa Amir, Safrullah Anggi Laksmita Dewi Aulia R, Deby Ayu Dwi Silvia Putri Bayu Sigha Iswara Bernadeta M Wara Kushartanti Bernadette Josephine Istiti Kandarina Bira Arumndari Nurrahma Bira Arumndari Nurrahma Brilliant Alendra Adianfra Deby Aulia R Deby Aulia R, Deby Deby Aulia Rahmi Deby Aulia Rahmi Desty Ervira Puspaningtyas Dianandha Septiana Rubi Dianandha Septiana Rubi Dina Septari Anindyah Dina Septari Anindyah Dono Indarto Dono Indarto DONO INDARTO Dwi Lestari Dwi Lestari Dwi Novitasari Edilburga Wulan Saptandari Emy Huriyati Emy Huriyati Enrique Aldrin Fatwa Sari Tetra Dewi Faurina Risca Fauzia Febri Indah Widhowati Gandes Retno Rahayu Ghozali, Ahmad Gita Trisna Gita Trisna Gita Trisna Gita Trisna, Gita Hadi, Novian Swasono Hanifah, Wafiq Harumi P, Made Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti, Irmayanti Irwan Supriyanto James Degnan Khrisnawati, Putri Kurniati Dwi Utami Kusuma, Rio Jati Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Lily Arsanti Lestari Maatita, Marcellino Made Harumi P Made Harumi P, Made Made Harumi Padmaswari Made Harumi Padmaswari Maria Dara Novi Handayani, Maria Dara Novi Martalena B Purba Martalena Br Purba Martalena Br Purba, Martalena Br Mega Febia Suryajayanti Mohamad Fay Faizal Nadia Yasmine Nastiti, Fithratun Ngadikun - Ngadikun Ngadikun Nisa, Ainun Noor Rochman Hadjam Noor Rochman Hadjam Noor Rochman Hadjam, Noor Rochman Nor Istiqomah Nor Istiqomah Nor Istiqomah Novian Swasono Hadi Novidiyanto Novidiyanto Novidiyanto, Novidiyanto Nur Arfiyan Nur Arfiyan Nur Imma Fatimah Harahap Nurahma, Bira Arumndari Nyoman Odiyana P G Nyoman Odiyana P G, Nyoman Nyoman Odiyana Prayoga Griadhi Nyoman Odiyana Prayoga Griadhi Odiyana P G, Nyoman Pramudji Hastuti Pramudji Hastuti Prasetyastuti Prasetyastuti - Prasetyastuti - Prasetyastuti Prasetyastuti Prattama Santoso Utomo Prima Dhewi Ratrikaningtyas Putri Khrisnawati Putri Khrisnawati, Putri Rachmadya Nur Hidayah Ratika Marchelaona Rilani Riskiyana Risky Oktriani Safrullah Amir Sarah Safira Umarghanies Sarair Maulidya Silvi Lailatul Mahfida Siti Rahmah Projosasmito Siti Wahyuningsih Sri Wahyuni Sunarti Sunarti Sunarti Sunarti Sunarti Sunarti Sunarti Susetyowati Sutiani, Harni Suyanti, Eri Dwi Sylvia Putri Synta Haqqul Fadlilah Tangkari, Kabir Ardiansyah Tasmini Tasmini Tasmini Tasmini Toto Sudargo Toto Sudargo Tri Ratnaningsih Trisna, Gita Tsani, Salma Mutiara Tyas, Jurnalis Gempaning Umarghanies, Sarah Safira Vitria Sari Dewi Vitria Sari Dewi Wasilah Rochmah Wiryatun Lestariana Wiryatun Lestariana, Wiryatun Yafi Surya Permana Yogik Onky Silvana Wijaya Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Soesilo Yuni Afriani Yuni Afriani Yuni Afriani Yuni Afriani Yuni Afriani, Yuni Zaenudin Zaenudin Zainal Arifin Nang Agus Zunamilla Khairia