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Ariastuti, Reni

Universitas Sahid Surakarta

Author-ID : 2641248

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UJI SIFAT FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN SIRIH CINA Paperomia pellucida L Zulaika, Laili nur; Qonitah, Fadilah; Ariastuti, Reni
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 1 No. 02 (2023): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/69wa9r92

Bakteri Propionibacterium acnes merupakan salah satu bakteri penyebab jerawat. Masker gel peel-off merupakan salah satu sediaan yang dapat digunakan untuk menjaga kesehatan kulit dari jerawat. Daun sirih cina (Paperomia pellucida L) mengandung senyawa alkaloid, flavonoid saponin dan tanin yang merupakan tanaman yang efektif terhadap bakteri penyebab jerawat (P. acnes). Penelitian ini bertujuan untuk menformulasikan sediaan masker gel peel-off ekstrak etanol daun sirih cina. Sediaan masker gel peel-off dibuat 4 formula dengan konsentrasi daun sirih cina sebesar 0%, 10%, 15% dan 20%. Uji sifat fisik yang diamati adalah organoleptis, pH, homogenitas, daya sebar, daya lekat, viskositas dan uji waktu mengering. Hasil penelitian diperoleh bahwa sediaan masker gel pell-off ekstrak etanol daun sirih cina pada formula 0,1,2,3 mempunyai sifat fisik yang baik, memenuhi standar sifat fisik yang ditetapkan. Penelitian ini dapat disimpulkan bahwa masker gel peel-off ekstrak etanol daun sirih cina memiliki sifat fisik yang baik, memenuhi standar sifat fisik yang ditetapkan untuk sediaan masker gel peel-off.

GAMBARAN FAKTOR YANG MEMPENGARUHI PILIHAN KONSUMEN TERHADAP PEMBELIAN OBAT BEBAS DI APOTEK “X” SURAKARTA Manek, Yohanes Stephen; Ariastuti, Reni; Sakti Pambudi, Risma
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 1 No. 02 (2023): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/rxy3t589

Over the counter drugs are drugs that can be purchased freely at drug stores such as pharmacies, supermarkets, and drug stores. Drug selection can be influenced by several factors such as drug effectiveness, price, packaging design, safety, brand, promotions and recommendations from other parties. People often get drug information through other and print or electronic media advertisements, which are the most impressive types of information and are easy to understand. This research aims to determine factors that influence consumer choices regarding purchasing over-the-counter drugs at drug store "X" in Surakarta. The research used a cross sectional descriptive method. Primary data was collected through direct observation regarding the description of factors that influence the purchase of over-the-counter drugs without a doctor's prescription at the drugstore. Data was taken from 100 consumer respondents from an "X" drug store in Surakarta. Research data was processed using the Microsoft Excel application. The results show that the factors that influence consumer choices in purchasing over thecounter drugs at drug store "X" Surakarta is the effectiveness at 74.80%, safety at 73.88%, packaging design at 74.2 %, price at 74.4%, brand at 74.95%, promotion at a 73.10% and recommendation from other parties at 70.2%. Based on the results, it can be concluded that the biggest factor influencing consumers in choosing drugs at the drug store "X" Surakarta is the brand factor with an average of 74.95%.

EVALUASI SIFAT FISIK SEDIAAN FACIAL WASH EKSTRAK ETANOL DAUN SIRIH CINA (Paperomia pellucidaL.)SEDIAAN FACIAL WASH EKSTRAK ETANOL DAUN SIRIH CINA (Paperomia pellucidaL.) Santika, Maria; Qonitah, Fadilah; Ariastuti, Reni
FARMESTRA: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia Vol. 2 No. 02 (2024): Farmestra: Jurnal Pelayanan dan Teknologi Kefarmasian Indonesia
Publisher : Melekliterasi Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66340/0s6vh950

If dirt on the face is not cleaned over time, it will accumulate into blackheads and pimples. Acne can also occur due to underlying blockage and inflammation, usually caused by the bacteria Propionibacterium acnes. Ethanol extract of Chinese betel leaves contains alkaloids, tannins, lipids and essential oils which have antibacterial properties. The aim of this research is to find out whether the facial wash formulation can meet the requirements for a good physical properties test and to find out whether the Chinese betel leaf extract (Paperomia pellucida L. Kunth) facial wash preparation has inhibitory power against P.acnes. This research is experimental research. Physical property tests carried out include organoleptic, pH, foamability and viscosity tests. Antibacterial activity testing was carried out using the diffusion method. Facial wash preparations from Chinese betel leaf extract (Paperomia pellucida L. Kunth) are made with concentrations of 0% (F0), 10% (F1), 15% (F2), 20% (F3). The results of the antibacterial activity test were tested using one way anova statistics. The research results showed that the facial wash preparation met the requirements for a good physical properties test and there was no significant difference between the formulas. The average results of the positive control antibacterial activity test for clindamycin had an inhibitory power of 19.53 ± 0.38 mm (strong), the facial wash preparation of Chinese betel leaf ethanol extract with a concentration of 10% was 8.90 ± 0.97 mm ( moderate), 15% concentration 12.00 ± 0.24 mm (strong), 20% concentration 13.33 ± 0.38 mm (strong), and negative control 0 ± 0 (not inhibiting. This study can be concluded that facial wash ethanol extract of Chinese betel leaves can inhibit antibacterial activity and the significant value is 0.000 <0.05, which means there is a difference in each concentration with the positive control

Uji kandungan fenolik total dan aktivitas antioksidan ekstrak etanol biji kelor (Moringa Oleifera L.) dan daun sirih cina (Peperomia Pellucida L.) Hafidz, Rosyadah; Abdul, Ahwan; Ariastuti, Reni Ariastuti
Borobudur Pharmacy Review Vol 5 No 1 (2025): January- June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v5i1.13260

Moringa seed (Moringa oleifera L.) and Chinese betel leaf (Peperomia pellucida L.) extracts obtained using ethanol contain phenolic compounds that function as natural antioxidant compounds. research aimed to quantify the overall phenolic content and assess the antioxidant activity of both extracts using Folin-Ciocalteu and DPPH techniques. The extraction process was performed using the maceration technique with 96% ethanol as the solvent, after which analysis It was performed to determine the overall concentration of phenolic compounds and IC50 a measurement that served as an index of antioxidant power. The findings showed that the extract from Chinese betel leaves had a higher a total phenolic content of 91.02 mg gallic acid equivalents (GAE) was recorded. compared to Moringa seeds which had 54.90 mg GAE/g±0.47. Antioxidant activity testing revealed that the IC50 value of Chinese betel leaf extract reached 3,349 ppm, while moringa seed extract showed an IC50 value of 4,701 ppm. For comparison, vitamin C had a lower IC50 of 1,988 ppm. With IC50 values below 50 ppm, both extracts are categorized as very strong antioxidants.

PENERAPAN REAKTOR BIOGAS FIXED DOME DALAM PENGOLAHAN LIMBAH PETERNAKAN MENJADI SUMBER ENERGI TERBARUKAN DI DESA BRAJAN, BOYOLALI Ariastuti, Reni; Qonitah, Fadilah; Indriastiningsih, Erna; Widagdo, Arisena; Nabila, Jihan
Kumawula: Jurnal Pengabdian Kepada Masyarakat Vol 8, No 2 (2025): Kumawula: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kumawula.v8i2.57988

The potential natural resources of Brajan Village, Mojosongo, Boyolali include the availability of fertile rice fields covering an area of 166.651 hectares, almost 60% of the total area. Residents utilize this potential for farming and animal husbandry. These activities produce various kinds of waste, including post-harvest waste and livestock manure. The waste produced is generally unused or disposed of by residents. Starting from the large amount of existing potential, Sahid University Surakarta held community service activities aimed at reducing environmental pollution caused by untreated waste, as well as making the waste more useful and economically valuable. This activity was carried out by constructing a fixed dome biogas reactor and continued with training on the application of using the reactor to process livestock manure into biogas and organic compost from bio-slurry. In this service activity, the team provided a biogas reactor installation to one of the Brajan Village residents as a grant recipient. In addition, support in the form of chopping machines and agricultural tools was also provided to Gapoktan members as farming and composting equipment. Training activities were also conducted to increase the knowledge of Brajan Village residents regarding biogas and compost. This community service activity was considered successful and well-targeted because, after participating in the training, the residents' knowledge level regarding biogas and compost, which was initially classified as fair, improved to a very good level. Moreover, agricultural and livestock waste that was previously discarded now has higher economic value because it can be processed into biogas and compost. Potensi sumber daya alam Desa Brajan, Mojosongo, Boyolali berupa ketersediaan lahan persawahan subur seluas 166,651 Hektar, hampir 60% dari luas total wilayah. Potensi tersebut dimanfaatkan warga untuk bertani dan berternak, dari aktivitas tersebut menghasilkan berbagai macam limbah, diantaranya limbah pasca panen dan kotoran ternak. Limbah yang dihasilkan pada umumnya tidak dimanfaatkan/dibuang oleh warga. Berawal dari banyaknya potensi yang ada, Universitas Sahid Surakarta mengadakan kegiatan pengabdian yang bertujuan untuk mengurangi pencemaran lingkungan akibat limbah yang tidak tertangani, serta menjadikan limbah lebih bermanfaat dan bernilai ekonomis. Kegiatan ini dilakukan dengan pembuatan reaktor biogas teknologi fixed dome dan dilanjutkan pelatihan aplikasi penggunaan reaktor dalam mengolah kotoran ternak menjadi biogas dan komos organik dari bio-slurry. Pada kegiatan pengabdian ini, tim pengabdi memberikan instalasi reaktor biogas kepada salah satu warga Desa Brajan sebagai penerima hibah. Selain itu bantuan berupa mesin pencacah dan alat pertanian juga diberikan kepada anggota gapoktan sebagai sarana bertani dan membuat kompos. Kegiatan pelatihan juga dilakukan untuk meningkatkan pengetahuan warga Desa Brajan terkait biogas dan kompos. Kegiatan pengabdian ini dinilai berhasil dan tepat sasaran karena setelah mengikuti pelatihan tigkat pengetahuan warga terkait biogas dan kompos yang awalnya tergolong cukup menjadi sangat baik. Di samping itu, limbah pertanian dan peternakan yang dibuang begitu saja sekarang menjadi lebih bernilai ekonomis karena mampu diolah menjadi biogas dan kompos.

Uji Aktivitas Tabir Surya Gel Ekstrak Etanol Daun Jeruk Purut (Citrus hystrix DC) qonitah, fadilah; Ariastuti, Reni; Maharani, Pratiwi
FASKES : Jurnal Farmasi, Kesehatan, dan Sains Vol. 3 No. 1 (2025): Bulan Juli 2025, FASKES : Jurnal Farmasi, Kesehatan, dan Sains
Publisher : Program Studi Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32665/faskes.v3i1.5218

Latar belakang: Tabir Surya adalah produk kosmetik yang memiliki kemampuan untuk melindungi kulit dari sinar ultraviolet matahari. Daun jeruk purut mengandung senyawa flavonoid yang diduga mampu berfungsi sebagai pelindung dari sinar matahari. Tujuan: Penelitian ini dilakukan untuk mengevaluasi apakah gel ekstrak etanol dari daun jeruk purut dapat memberikan perlindungan terhadap sinar matahari, yang diukur melalui nilai SPF (Sun Protection Factor), persentase transmisi eritema, dan pigmentasi kulit. Empat formula gel dibuat dengan konsentrasi sebesar 0% (FI), 0,5% (FII), 1% (FIII), dan 1,5% (FIV). Metode: Efektivitas tabir surya dalam gel diuji secara in vitro menggunakan spektrofotometer UV Vis. Data dianalisis dengan metode analisis one-way ANOVA. Hasil: Hasil menunjukkan bahwa nilai SPF rata-rata dari formula gel I hingga IV adalah 0,67±0,01 (tanpa perlindungan), 6,32±0,05 (perlindungan ekstra), 12,94±0,05 (perlindungan maksimal), dan 16,20±0,01 (perlindungan ultra). Nilai persentase eritema adalah 0,92±0,002, 0,42±0,002, 0,18±0,000, 0,11±0,000 (sunblock), sementara nilai transmisi pigmentasi adalah 0,94±0,002, 0,54±0,001, 0,36±0,000, 0,23±0,000 (sunblock). Hasil menunjukkan bahwa formula II, III, dan IV memiliki aktivitas perlindungan terhadap sinar matahari, dengan SPF tertinggi terdapat pada formula IV. Simpulan dan saran: Ada perbedaan aktivitas tabir surya yang signifikan antara setiap formula yang diuji (nilai p-value <0,05)

Sinergi Ekstrak Buah Cengkeh (Syzygium Aromaticum) Dengan Amoksisilin dan Siprofloksasin Terhadap Bakteri Resisten Patandung, Rosliana; Ariastuti, Reni; Subiyanto, Abyasa Fajari; Ilmi, Ibnul
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8614

Antibiotic resistance is a serious global health threat, leading to increased morbidity, mortality, and economic burden due to the reduced effectiveness of infection therapy. One promising strategy to overcome this problem is the combination of antibiotics with natural phytochemical compounds that can enhance antibacterial activity. This study aimed to evaluate the synergistic potential between the ethanol extract of clove fruits (Syzygium aromaticum) and the antibiotics amoxicillin and ciprofloxacin against resistant Staphylococcus aureus and Escherichia coli. The study was conducted in vitro, including clove fruit extraction using 70% ethanol, determination of the minimum inhibitory concentration (MIC) by microdilution, and combination testing using the checkerboard assay to calculate the Fractional Inhibitory Concentration (FIC) index. The results showed that clove extract exhibited antibacterial activity with MIC values of 2000 µg/mL against S. aureus and 4000 µg/mL against E. coli. The combination of clove extract with amoxicillin produced a ΣFIC value of 0.25 (strong synergy), while the combination with ciprofloxacin yielded a ΣFIC of 0.50 (additive effect). These findings indicate that phytochemical constituents in clove, particularly eugenol, may enhance bacterial membrane permeability, thereby strengthening antibiotic activity. This study demonstrates the potential of clove extract as a natural adjuvant to improve the efficacy of antibiotics against resistant bacteria. The practical implication of this result is the opportunity to develop phytochemical–antibiotic combination formulations in pharmaceutical dosage forms that are more efficient and sustainable.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI MARKISA UNGU (Passiflora edulis Sims) TERHADAP Propionibacterium acnes: ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF PURPLE PASSION FRUIT SEEDS (Passiflora edulis Sims) AGAINST Propionibacterium acnes Rifani, Inesta; Ariastuti, Reni; Qonitah, Fadilah
JFL : Jurnal Farmasi Lampung Vol. 14 No. 2 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/3413qz27

Inflammation of the hair follicles and sebaceous glands causes acne, a common skin disorder often triggered by bacterial infections such as Propionibacterium acnes. This study aims to determine the antibacterial activity of an ethanolic extract of purple passion fruit seeds against Propionibacterium acnes. The extraction process was carried out by maceration using 96% ethanol. The antibacterial activity of the extract was tested using the disk diffusion method (Kirby-Bauer) at concentrations of 10%, 20%, and 30%, with positive control (clindamycin) and negative control (1% DMSO) for comparison. Antibacterial activity was measured based on the inhibition zone diameter. The data obtained were then statistically analyzed using a one-way ANOVA test with a 95% confidence level. The extract yield was 5.78% and contained chemical compounds such as flavonoids, alkaloids, tannins, saponins, and terpenoids. The antibacterial test results showed inhibition zones for the 10%, 20%, and 30% extract concentrations and the positive control (clindamycin) of (6.45 ± 1.86) mm (moderate activity), (10.38 ± 0.29) mm (strong activity), (12.21 ± 1.21) mm (strong activity), and (17.78 ± 0.55) mm, respectively. Statistically, there was a significant difference in antibacterial activity between the samples (p-value < 0.05). In conclusion, the ethanolic extract of passion fruit seeds possesses antibacterial properties effective against Propionibacterium acnes.. Keywords: antibacterial, seed, Passiflora edulis Sims, Kirby_bauer, acne

SKRINING FITOKIMIA SENYAWA METABOLIT SEKUNDER PADA EKSTRAK KLOROFORM DAUN KELOR Fadilah Qonitah; Deby Mariska Sune; Reni Ariastuti
Praeparandi : Jurnal Farmasi dan Sains Vol 8 No 1 (2024): Praeparandi : Jurnal Farmasi dan Sains
Publisher : Fakultas Farmasi Universitas YPIB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58365/4vvh1m27

Daun kelor (Moringa oleifera L.) merupakan tanaman yang banyak dikenal masyarakat Indonesia. Daun kelor dikenal sebagai tumbuhan yang kaya akan manfaat seperti antioksidan, antikanker, anti-inflamasi, antidiabetes, dan agen antimikroba. Salah satu metode yang dapat digunakan untuk mengetahui senyawa metabolit sekunder yang terkandung dalam suatu tanaman sehingga tanaman tersebut dapat dimanfaatkan sebagai obat adalah skrining fitokimia. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder yang terkandung dalam ekstrak kloroform daun kelor. Metode yang digunakan untuk mengekstraksi daun kelor pada penelitian ini adalah metode maserasi menggunakan pelarut kloroform dengan perbandingan 1:5 (b/v). Senyawa metabolit sekunder dalam ekstrak kloroform daun kelor dianalisis secara kualitatif menggunakan pereaksi FeCl3 untuk uji fenolik, uji taubeck untuk flavonoid, pereaksi dragendorf dan mayer untuk uji alkaloid, uji busa untuk alkaloid, dan pereaksi FeCl3 1% untuk uji tanin. Uji fenolik menghasilkan larutan hitam pekat, uji flavonoid menghasilkan floresensi kuning, uji alkaloid tidak menghasilkan endapan, uji saponin tidak terbentuk busa stabil, dan uji tannin menghasilkan warna hijau kehitaman. Berdasarkan hasil skrining fitokimia tersebut, dapat disimpulkan bahwa ekstrak kloroform daun kelor positif mengandung senyawa fenolik, flavonoid dan tanin.

Skrining Fitokimia Sediaan Infusa Kombinasi Daun Ciplukan, Bunga Kamilen dan Daun Stevia Sriwidyawati A. Solong; Reni Ariastuti; Khotimatul Khusna
Jurnal Mahasiswa Ilmu Kesehatan Vol. 2 No. 3 (2024): Juli: Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v2i3.1621

Ciplukan leaves, kamilen flowers, and stevia leaves are widely used herbal plants known for their pharmacological activities, which are mainly attributed to the presence of secondary metabolite compounds. These compounds play an important role in providing therapeutic effects such as antioxidant, anti-inflammatory, and antimicrobial properties. One approach to enhancing the effectiveness of these plants is by combining them into a single preparation. This study aims to identify the content of secondary metabolite compounds in a combined infusion (infusa) of ciplukan leaves, kamilen flowers, and stevia leaves. The research method used is a laboratory experimental approach, which includes plant determination, preparation of infusion, and phytochemical screening. The infusion process is carried out to extract active compounds using water as a solvent under controlled conditions. The phytochemical screening is conducted to qualitatively detect the presence of various bioactive compounds. The results of the screening on three formulations (F1, F2, and F3) show that all infusa preparations contain several important secondary metabolites, including alkaloids, flavonoids, saponins, tannins, and terpenoids. These findings indicate that the combination of the three herbal plants has the potential to provide enhanced pharmacological effects due to the diversity of active compounds present in the formulation.

Co-Authors abdul, ahwan Abdul, Ahwan Aginta Wigunavi Ahwan Ahwan - Alvina Nia Diani Alvina Nia Diani Anik Suwarni Anniez Rachmawati Musslifah Arinta Mayang Astri Charolina Atik Aryani Azizah, Reyza Nur Cahyani, Tiwi Nur Chintya Rahma Ardistafani Dahlia, Ajeng Debi Ariyanti Deby Mariska Sune Desi Riyana Dewi, Anita Oktaviana Trisna Dhea Asyifa Nurmalika Dunung Kusumawati Dyah Ayu Lestari Elisa Fransiska Evelyne Henny Lukitasari Fadilah Qonitah Fadilah Qonitah Fadilah Qonitah Fadilah Qonitah Fadilah Qonitah Fadilah Qonitah Fadilah Qonitah Firra Lurenza Pratiwi Fransiska, Elisa Hafidz, Rosyadah Hanafi, Affan Haris, Rif Atiningtyas Heni Rusita Husna, Khotimatul Idris Yani Pamungkas Ilmi, Ibnul Indriastiningsih, Erna Indriyati . Indriyati . Jihan Aulia Kusumasari Kairul Anam Khotimatul Husna Khotimatul Khusna Khotimatul Khusna Khusna, Khotimatul Kornelia Bariap Apot Leila Irna Luthfy Machfiroh Setianing Hati Maharani, Pratiwi Mahmudah, Endar Asih Manek, Yohanes Stephen N, Yarsis Septiardi Nabila, Jihan Nisa Aulia Agtri Novitasari, Nur Cahyani Nur Afika Nur Cahyani Nur Ilah Rahmadani Nuzulia Sari Asyifa' Nuzulul Ulmiyah Ramadhan Patandung, Rosliana Pratiwi Maharani, Nurul Astia Wuri Puspita, Syilvia Endah Raden Roro Karina Pambudi Ricard Nixon Holo Rida Ludfi Aprinuha Rif Atiningtyas Rif Atiningtyas Haris Rifani, Inesta Rini, Helviana Rista Risma Sakti Pambudi Rita Septiana Rizal, Rafli Adnan Rosliana Patandung Rosyadah Hafidz Santika, Maria Septiningrum, Chintya Hayu Sinta Mei Enjelina Sriwidyawati A. Solong Subiyanto, Abyasa Fajari Suwardi Suwardi Suwardi Syahnaz Sanjiwani Agatha Ruth Mahawikan Syaifur Rahman Syilvia Endah Puspita Tantri Sudar Wati Tika Dwiyanti Tri Na'imah Verina Widianti Putri Vitri Dyah Herawati Vitri Dyah Herawati Widagdo, Arisena Widiyono, Widiyono Yarsis Septiardi N Yuliyanti, Andini Dwi Yusuf Muamar Bashori Zulaika, Laili nur Zuliana Styarini Zuriyah, Putri

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