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All Journal Eduhealth Medical Journal of Indonesia Elementary: Islamic Teacher Journal QUALITY Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Paediatrica Indonesiana GIZI INDONESIA EKONOMIS : Journal of Economics and Business Jurnal Pengabdian Masyarakat AbdiMas JURNAL PEMASARAN KOMPETITIF At-Tajdid : Jurnal Pendidikan dan Pemikiran Islam Jurnal Graha Pengabdian International Journal Of Science, Technology & Management (IJSTM) JOURNAL LA MEDIHEALTICO Indonesian Journal of Adult and Community Education (IJACE) PUCUK : Jurnal Ilmu Tanaman Amorti: Jurnal Studi Islam Interdisipliner Journal of Economics and Policy Studies (JEPS) Global Komunika : Jurnal Ilmu Sosial dan Ilmu Politik Journal of Data Analytics, Information, and Computer Science (JDAICS) Babakti : Journal of Community Engangement JIKI
Agus Firmansyah
Prodi D III Keperawatan Fakultas Ilmu Kesehatan, Universitas Pesantren Tinggi Darul Ulum Jombang
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Journal : Paediatrica Indonesiana

 1 
Gut dysbiosis as a risk factor of neonatal sepsis among preterm infants Marsubrin, Putri Maharani Tristanita; Hikmahrachim, Hardya Gustada; Rohsiswatmo, Rinawati; Yulindhini, Maya; Firmansyah, Agus
Paediatrica Indonesiana Vol. 65 No. 2 (2025): March 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.2.2025.96-102

Abstract

Background Preterm infants are at high risk of developing sepsis. An imbalance between the normal gut and pathogenic microbiomes, known as dysbiosis, has been proposed as a condition that leads to neonatal sepsis. Objective To assess for an association between gut dysbiosis and neonatal sepsis. Methods A prospective cohort study was conducted involving very preterm or very low birth weight infants admitted to the Neonatal Unit, Cipto Mangunkusumo Hospital, Jakarta, from November 2019 to January 2021. The primary outcome was proven and/or clinical neonatal sepsis. The independent variable was gut dysbiosis, defined as a ratio of normal-to-pathogenic gut microbiome <1.0. Gut microbiome analysis was performed using a polymerase chain reaction test from a fecal specimen. Multivariate analysis using multiple logistic regression was conducted with adjustments for potential confounders. Results Forty-three infants were recruited during the study period, with a median gestational age of 30 (range 25-36) weeks and birth weight of 1,170 (range 630-1855) grams. Among them, 28 (65.1%) infants had dysbiosis and 25 (58.2%) developed sepsis. The incidence of sepsis was higher among infants with dysbiosis (20 infants; 71.4%) than those without dysbiosis (5 infants; 33.3%). Dysbiosis and hemodynamically significant patent ductus arteriosus increased the risk of sepsis, with aOR 6.93 (95%CI 1.04 to 46.14; P=0.045) and aOR 22.7 (95%CI 1.45 to 355.29; P=0.026), respectively, after adjusting for sex, birthweight, maternal and infant morbidities, as well as maternal and infant vitamin D status. Conclusion Gut dysbiosis is a risk factor for neonatal sepsis. Maintaining the balance of the gut microbiome is essential from the first day of life.
Carnitine and Infant Formulas Firmansyah, Agus
Paediatrica Indonesiana Vol. 30 No. 5-6 (1990): May-June 1990
Publisher : Indonesian Pediatric Society

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Abstract

Carnitine (gamma-trimethylamino-beta­ hydroxybutyric acid) is a quaternary amine which is capable of forming esters with a variety of acyl groups and was first iden­tified by Gulawitsch and Krimberg in 1905. Carnitine deficiency was first noted by Fraenkel (1984) who observed that if cer­tain insects were fed a diet free of carnitine, they would die in four to five weeks. Since that time, intensive studies had been done and led to suggestion that a primary func­tion of carnitine was as a carrier molecule translocating long-chain fatty acids across the inner mitochondrial membrane to the matrix, where they underwent beta-oxida­tion (Friedman and Fraenkel, 1955). Carnitine is plentiful in human milk and milk-based infant formulas; however, it is lacking in supplemented soy formulas. Since newborn infant may not fully capable of synthesizing carnitine, they must receive an adequate intake of carnitine through the diet. This article describes some aspects of carnitine with special reference to the role of carnitine on fat metabolism.
Co-Authors Abdul Ghofar Ahmad Supriyadi Ali Sungkar Amrizal Amrizal Andreyatsha, Andreyatsha Armanda, Selvy Asih, Siti Wulan Asri Rasad Aswitha Boediharso Badriul Hegar Bibit Sudarsono Clara M Kusharto Daldiyono Harjodisastro Deddy S Putra Dewanto, Naomi E.F. Dwi Prasetyo Dwirini Retno Gunarti Edward Bahar Endi Ridwan F M Susanto Feerzet Achmad Fitranita, Vika Ghurroh, Shofi Ruhani U Hardinsyah Herman Suryadi Herri Susanto Hikmahrachim, Hardya Gustada Ikbal Rachmat Jahja Umar, Jahja Jarwinda, Jarwinda Jayawarsa, A.A. Ketut Kurniawan , Rio L Gaol, Wita Fricilia Madjid, Adnan Maratis, Jerry Marsubrin, Putri Maharani Tristanita Muhammad Alfatih Muhammad Iqbal Mulya Rahma Karyanti, Mulya Rahma Mulyo Wiharto Muzal Kadim Nani Dharmasetiawani Navalino, Djoko Nugraheni, Yumidiana Tya Pramita G D Puspitaloka Mahadewi, Erlina Rinawati Rohsiswatmo Rinjiani, Septiwi Rio Kurniawan Risatianti Kolopaking, Risatianti Rulina Suradi, Rulina Rustadi Sosrosumihardjo Rusyadi, Refky Saptawati Bardosono Sari, Nadia Roosmalita Satria, Arysca Wisnu Septilia I. Wanandi Setianingrum, Nur Siti B. Kresno Sudigdo Sastroasmoro Suharto Suharto Suhartono Suherman, Anisah Dayanti Sulaiman, Ali Khotib Supriyanto, Taufik Suryanto, Ido Sylvia, Teny Toruan, Tahan S.L. Trina Astuti Umi Fahmida Uyu Wahyudin Wisanto , Margono Wisanto, Margono Yudiyanto, Ade Rachmat Yulindhini, Maya Yulistiani, Indriati