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All Journal HAYATI Journal of Biosciences VALENSI Microbiology Indonesia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Journal of Medicine and Health Chimica et Natura Acta JURNAL SAINS INDONESIA Jurnal Pendidikan Kimia (JPKim) Communications in Science and Technology Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Abdimas Kartika Wijayakusuma JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Pengabdian Mandiri Acta Medical and Health Sciences (AMHS) Journal of Medicine and Health
KHOMAINI HASAN
Faculty Of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Veterinary Other

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A mini review of haloalkane dehalogenase: From molecular characterization to applications Hasan, Khomaini
Communications in Science and Technology Vol 3 No 1 (2018)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.583 KB) | DOI: 10.21924/cst.3.1.2018.70

Abstract

Haloalkane dehalogenases (HLDs) are hydrolytic enzymes that catalyze a removal of halogenated species in many toxic halogenated compounds. These enzymes belong to hydrolase family that mostly adopt a typically a/b hydrolase structure. They have many potential applications, such as industrial biocatalysis, pharmaceutics, biosensors, or detoxification of chemical weapons. In this review, structure, mechanism and applications of these enzymes will be discussed.
Anti-HIV Transcriptase Herbs: A Review Hasan, Khomaini; N Ferdianti, Fine; P Y Paryati, Sayu
ACTA Medical Health Sciences Vol. 2 No. 2 (2023): ACTA Medical Health Sciences
Publisher : ACTA Medical Health Sciences

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Abstract

To date, combination antiretroviral (ARV) medication is considered the most effective treatment for people infected with the Human Immunodeficiency Virus (HIV). The primary purpose of ARV administration is to reduce the viral load, thereby enhancing HIV patients' immunological condition and minimizing mortality from opportunistic infections. Nowadays, a combination of NRTI (nucleoside analog reverse transcriptase inhibitor) and NNRTI (non-nucleoside analog reverse transcriptase inhibitor) is accepted therapy for HIV patients. Both have a mechanism for inhibiting the reverse transcriptase (RT) enzyme during viral replication. Reverse transcriptase (RT) is an enzyme that plays a role in the reverse transcription stage of the virus reproduction process. HIV RT converts proviral RNA into DNA, and the copy infects the host or target cell. The use of RT inhibitors for HIV-infected patients is becoming more common. Many investigations were conducted on plants that have the potential to operate as anti-HIV RT. In this review, we go over some of the potential herbs that serve as RT inhibitors. In this literature review, a search was carried out with the help of several search engines that matched the criteria, namely reverse transcriptase herbal inhibitors for HIV. The author came to the conclusion that there were 18 plants with relatively high activity as anti-HIV medicines with varied traits and working mechanisms from 162 papers gathered based on keywords. Furthermore, the findings of this study will serve as the foundation for the development of anti-HIV herbs as well as a source of antiretroviral therapy ingredients in the future.
Sequence-Structure Based Comparison of Structurally Homologous Thermophilic and Mesophilic Polyethylene Terephthalate (PET) Hydrolases Hasan, Khomaini; Ulfah, Maria; Nurhayati, Niknik; Sabbathini, Gabriela Christy; Wulandari, Sri Rezeki; Putra, I Gede Eka Perdana; Helianti, Is
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.348-356

Abstract

Protein structure has a direct impact on thermostability. Deviations in the primary sequence can affect structural changes, leading to alterations in thermostability properties. However, the molecular basis of protein thermostability is unspecified; thus, elucidation of key factors that role particular protein thermostability is required when engineering proteins to be thermostable. To address this challenge, the amino acid composition, hydrophobicity/hydrophilicity ratio, cysteine bridges, and intrinsic features of two structurally homologous but different thermostability, poly(ethylene terephthalate) hydrolase (PETase) were compared. According to the findings, thermostable and thermolabile PETases have similar folds, compactness, and disulfide bridges. Interestingly, an abundance gap of aromaticity, hydrophobic cluster area, polar amino acid and hydrogen bond network compositions demonstrated dominant trends of variations for both PET hydrolases, indicating a pivotal role of these features in the thermostability of PET hydrolase. Furthermore, increased hydrophobic amino acid frequency in the inner surface of thermostable proteins contributed significantly to thermostability by forming more internal hydrophobic interactions and a less hydrophobic patch. There are no consistent trends in insertions and deletions between both PETases. Taken together, these observations demonstrate that hydrophobicity and hydrogen bond networks are essential factors in thermostability of thermostable PETase.
Pelatihan Skrining Stunting Bagi Kader Posyandu Di Kota Cimahi Handayani, Dewi Ratih; Andrian R, Andri; Mutiara, Dinar; Septiadi, Endry; Indriyana, Sri Quintina; Rochmah, Elly Noer; Inayati, Iis; Ratunanda, Susanti; Fiddiyanti, Ilma; Hasan, Khomaini; Achmad, Nurjannah
Jurnal Abdimas Kartika Wijayakusuma Vol 5 No 3 (2024): Jurnal Abdimas Kartika Wijaya Kusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v5i3.698

Abstract

Pemanfaatan posyandu dalam mengatasi stunting masih menjadi ujung tombak bagi pemerintah di Indonesia. Kader posyandu merupakan penggerak utama seluruh program yang perlu dilaksanakan oleh Posyandu terutama dalam menurunkan dan mencegah stunting. Kegiatan pengabdian masyarakat yang dilakukan berupa pelatihan/ pembimbingan skrining stunting dan focus group discussion (FGD) tentang stunting pada kader posyandu di Kota Cimahi. Sasaran pada pelatihan ini adalah para kader di Kota Cimahi, yang diwadahi oleh forum Kota Sehat Kota Cimahi. Pada pelatihan ini, kader diberikan terlebih dahulu materi tentang stunting menggunakan media power point melalui pertemuan secara daring termasuk diskusi, kemudian mereka melakukan latihan pemeriksaan antropometri dengan baik dan benar, dan memasukkan hasil pengukuran TB dan BB ke dalam kurva WHO. Selain itu para kader yang telah dibagi menjadi kelompok kecil melakukan FGD terkait hal-hal yang menjadi masalah pada saat pelaksanaan yang difasilitasi oleh seorang dosen FK Unjani. Peserta pelatihan yang hadir sebanyak 71 orang, terdiri atas laki-laki dan perempuan. Hasil pelatihan skrining stunting berdasarkan nilai aktivitas rata-rata nilai peserta adalah baik, nilai post-test menunjukan kenaikan.
Hypolipidemic Effects of Pea Protein Hydrolysates on Lipid Profile and Uric Acid in Cisplatin-Induced Nephropathy Rats Meilinah Hidayat; Sijani Prahastuti; Andreas A Soemardji; Khomaini Hasan; Gabriella Audrey; Janifer Gabriella; Petrisia Luvina; Cicilia Liempapas; et al
Journal of Medicine and Health Vol 2 No 3 (2019)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i3.1234

Abstract

The usage of Cisplatin (CP) can cause side effects such as toxicity and impaired kidneyfunction. Poor kidney function causes dyslipidemia and hyperuricemia. Researchers in Canadastate that pea protein hydrolysates can improve kidney function. The aim was to examine thehypolipidemic effect of 8 types of pea protein hydrolysate on lipid profiles and uric acid in CPinduced rats in purpose to find protein sources origin of Indonesia for kidney therapy. This is atrue experimental study using fifty female Wistar rats divided into 10 treatment groups.Weadministered 8 types of pea protein hydrolysate for 30 days. On day 7 all rats (except negativecontrol) were induced CP intraperitoneally. Study parameters was evaluated on days 12 and30. In general, all treatments showed good hypolipidemic effects, and differed significantly fromCP group (p <0.01). The group that showed lowest total cholesterol, LDL and triglycerideresults is yellow pea protein hydrolysate Neutrase; HDL: green peas protein hydrolysatebromelain, uric acid: protein hydrolysate of pea protein isolate bromelain. As conclusion,protein hydrolysates of pea has good hypolipidemic effects on Lipid profile and Uric Acid inCP-induced nephropathy Rats. Keywords: protein hydrolysates, green peas, neutrase, bromelain, lipid profiles
KADAR SITOKIN IL-6 DAN IFN-α PADA MENCIT GALUR BALB/c YANG DIIMUNISASI VAKSIN MULTIEPITOP COVID-19 Safari, Ardhi Ryanto; Anggraeny, Dian; Hasan, Khomaini; Paryati, Sayu Putu Yuni
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 3 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Penelitian ini bertujuan untuk mengevaluasi efektivitas vaksin multiepitope COVID-19 dengan adjuvan kitosan terhadap kadar IL-6 (interleukin-6) dan IFN-α (interferon-alpha) pada mencit galur BALB/c. Studi ini melibatkan empat kelompok perlakuan, yaitu kontrol negatif, kontrol positif, vaksin tanpa adjuvan kitosan, dan vaksin dengan adjuvan kitosan. Pengukuran kadar IL-6 dan IFN-α dilakukan menggunakan metode immunoassay. Hasil penelitian menunjukkan bahwa pemberian vaksin multiepitope dengan tambahan adjuvan kitosan tidak memiliki pengaruh signifikan terhadap kadar IFN-α maupun IL-6 jika dibandingkan dengan kelompok kontrol. Temuan ini menunjukkan bahwa kitosan sebagai adjuvan berperan penting dalam meningkatkan respons imun adaptif sambil meminimalkan inflamasi. Formulasi vaksin ini memiliki potensi sebagai kandidat vaksin COVID-19 yang efektif dengan profil keamanan yang baik, meskipun diperlukan penelitian lebih lanjut untuk mengonfirmasi efektivitasnya pada manusia. Kata kunci : COVID-19, IL-6, IFN-α, kitosan, vaksin DOI : 10.35990/mk.v8n3.p287-298
Co-Authors Achmad, Nurjannah Akmal Dhaffa Ulhaq Amallia Ardila Putri Andreanus Andaja Soemardji Andreas A Soemardji Andrian R, Andri Ania Kurniawati Purwa Dewi Arsyad Parama Santosa Audrey, Gabriella Budiantoro, Ogi Cicilia Liempapas D Agus Yusuf Wildan Daswara Djajasasmita Desi Veronika Pardosi DESSY NATALIA Dewi R Handayani Dian Anggraeny Eka Noneng Nawangsih Elly Noer Rochmah, Elly Noer Endry Septiadi Endry Septiadi et al Evi Sovia FERNITA PUSPASARI Gabriella Audrey Gabriella, Janifer Handayani, Dewi Ratih I Gede Eka Perdana Putra, I Gede Eka Perdana Iis I Rakhmat Iis Inayati Rahmat Ilma Fiddiyanti Iman Permana Maksum IMAN PERMANA MAKSUM Iman Permana Maksum Iman Permana Maksum IMAN PERMANA MAKSUM Iman Permana Maksum Inayati, Iis Indarti Trimurtini Indriyana, Sri Quintina IS HELIANTI Janifer Gabriella Liempapas, Cicilia Luvina, Petrisia Maria Ulfah Meilinah Hidayat MEILINAH HIDAYAT Mohammad Yusuf Muhammad Fadhil Z, Rusdi Noor Rosa (p:43-50) Murniaty Simorangkir Mutiara, Dinar N Ferdianti, Fine NIKNIK NURHAYATI Ogi Budiantoro OGI BUDIANTORO P Y Paryati, Sayu Pertiwi, Wulan Petrisia Luvina Purba Upay Ratunanda, Susanti Riezki Amalia Rini Roslaeni Sabbathini, Gabriela Christy Safari, Ardhi Ryanto SARONOM SILABAN Saronom Silaban Saronom Silaban Sayu Putu Yuni Paryati Sayu Putu Yuni Paryati Septiadi, Endry Shabarni Gaffar Shabarni Gaffar -, Shabarni Gaffar SHABARNI GHAFFAR Sigit Sasongko Sijani Prahastuti Sijani Prahastuti Sijani Prahastuti Siska Telly Pratiwi Soemardji, Andreas A SOETIJOSO SOEMITRO Soetijoso Soemitro Soetijoso Soemitro Soetijoso Soemitro Soetijoso Soemitro Sutan Bagas Prakasa SUTARYA ENUS Sutarya Enus Sutarya Enus Sutarya Enus Toto Subroto Upay, Purba WANGSA TIRTA ISMAYA Welly Ratwita Wulan Pertiwi Wulandari, Sri Rezeki Yudith Y Kusmala Yudith Yunia K Yulistio Hanif