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Journal : Narra J

Factors associated with the incidence of young-onset colorectal cancer: A cross-sectional study Sianturi, Natallina; Dahlia, Debie; Edison, Chiyar
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2853

Abstract

The factors associated with the incidence of young-onset colorectal cancer (YO-CRC) remain uncertain and are continuously being studied. The aim of this study was to investigate the factors associated with the incidence of young-onset colorectal cancer. This cross-sectional study examined multiple factors (demographic status, medical comorbidities, smoking, alcohol intake, nighttime sleep duration, family history of cancer, sedentary behavior, daily consumption of fried foods, fast food, and processed meat) among 171 patients from two cancer referral hospitals in Jakarta, Indonesia. Logistic regression analysis revealed that the low-income group had a higher risk of YO-CRC compared to high-income group (p=0.004). Those with comorbid diseases such as inflammatory bowel disease, diabetes, or high cholesterol were more likely to develop YO-CRC compared to those without these conditions (p=0.002). Frequent consumption of processed meat (vs seldom) (p=0.003) and fried food (vs no consumption) (p=0.001) were associated with higher risk. Those with high sedentary behavior (vs low) (p=0.021) also had higher risk of YO-CRC. Notably, nighttime sleep emerged as the strongest predictor (odds ratio (OR): 10.462). These findings underscore the need for targeted public health interventions promoting adequate sleep, healthy diets, and active lifestyles, particularly among Indonesian youth and low-income groups. Further studies are recommended to investigate these associations in larger and more diverse populations across Indonesia.
Co-Authors Aat Djanatunisah Aat Djanatunisah Achir Yani S. Hamid Achmad Fauzi Kamal Agung Waluyo Anastania, Yeane Anis Ika Nur Rohmah Apriyanti, Efa Ardiyati, Adelina Vidya Arisanty, irma Puspita Aryani, Denissa Faradita Besral . Dandi Oka Subantara Dayan Hisni Denissa Faradita Aryani Dewi Gayatri Dewi Irawaty Dewi Irawaty Dhika Ayu Kurnia Dian Ayubi Dikha Ayu Kurnia Dikha Ayu Kurnia Elly Nurachmah Enggarwati, Pandan Eti - Sumartiyah Etty Rekawati Evi Martha Fauzi Kamal, Achmad Fina Mahardini Gatra Satria Gultom, Yunisar Gupta, Prateek Helen, Helen I Made Kariasa I Putu Adi Suryawan I Putu Adi Suryawan I Putu Adi Suryawan Idia Indar Anggraeni Irmariani Irbar Kurnia, Dhika Ayu Lestari Sukmarini Lestari Sukmarini Liya Arista Maria, Riri Maria, Riri Melawati, Wati Muchtaruddin Mansyur Muhammad Mulyadi Pranata Nafi'ah, Rizka Hayyu Nekka Juliani Nila Indrayati Noor Diani Noor, M. Fakhruddin Nori Widiowati Widiowati Pertiwi, Ni Wayan Astiti Pradana Soewondo Priyanto Priyanto Priyanto Priyanto Priyanto Ratna Aryani Ratna Aryani Ratna Aryani Retnoningrum, Dwi Ria Desnita Ridho Kunto Prabowo Rif'atul Fani Rima Novia Putri Rinda Apriani Riri Maria Rosina Tarigan Rr. Tutik Sri Hariyati S., Chiyar Edison Sali Rahadi Asih Salim Harris Sandra Sandra Sany, Puti Rahmitha Saptawati Bardosono Sari, Lia Novita Setyowaty Sianturi, Natallina Sihombing, Yulia Siska Rahmadiya Sri Hartati Pratiwi Sri Yona Sucipto Dwitanta Sukma Wicaturatmashudi Syafa'atun Mirzanah Toar JM Lalisang Toar JM Lalisang Tommy Indra Tri Antika Rizki Kusuma Putri Wicaturatmashudi, Sukma Yeni Rustina Yunisar Gultom Yunizar Gultom