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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Science and Technology Indonesia Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Journal of Halal Science and Research Journal of Food and Pharmaceutical Sciences
Any Guntarti
Fakultas Farmasi Universitas Ahmad Dahlan, Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Other

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Uji Aktivitas Penangkapan Radikal Bebas Ekstrak Etanol Daun Mangkokan (Nothopanax scutellarium (Burm.f) Merr.) Menggunakan Metode DPPH (1,1-Difenil-2-Pikrilhidrazil) dengan Variasi Suhu Pengeringan farida, fitri; guntarti, any
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 4 No 2 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.377 KB) | DOI: 10.22236/farmasains.v4i2.3362

Abstract

Mangkokan leaves contains flavonoids that are known as natural antioxidant source. The aim of this study is to find the effect of drying temperature variations towards free radical scavenging activity of mangkokan leaves. Mangkokan leaves macerated with 96% ethanol and dried at 40oC, 50oC, and 60oC. Then were macerated with ethanol 96%. Antioxidant activity tested by DPPH method and quercetin was used as positive control. Dry shrinkage with temperatures at 40oC, 50oC, and 60oC were: (9.25 ± 0.276)%; (8.76 ± 0.348)% and (7.97 ± 0.372)%, respectively. Water content at 40oC, 50oC and 60oC were: (5.13 ± 0.575)%; (4.53 ± 0.512)% and (4.04 ± 0.575)%, respectively. The antioxidant potency of 96% ethanolic mangkokan leaves by ES50 value at drying temperatures 40oC, 50oC, 60oC and quercetin were (1.75 ± 0.058); (2.39 ± 0,089); (5.38 ± 0,078) mg/ml and (9.16x10-4 ± 4.36x10-5) mg/ml. Ethanolic extract of mangkokan leaves which dried at 40oC has biggest radical DPPH scavenging activity but much weaker than quercetin.  
Authentication of Wild Boar Meat in Meatball Formulation Using Differential Scanning Calorimetry and Chemometrics Guntarti, Any; Rohman, Abdul; Martono, Sudibyo; Yuswanto, Agustinus
Journal of Food and Pharmaceutical Sciences Vol 5, No 1 (2017): J. Food Pharm. Sci (January-April)
Publisher : Fakultas Farmasi, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.177 KB) | DOI: 10.14499/jfps

Abstract

Bakso or meatball is one of the Indonesian favorite foods, commonly made from beef. This food is quite popular among Indonesian societies. Due to the high price of beef, unethical producers may adulterate beef with wild boar meat (WBM). In this study, the potential use of differential scanning calorimetry (DSC) combined with multivariate calibration was used to verify adulteration of WBM in meatball formulation. Oil extracted from WBM is characterized by significantly different cooling and heating DSC thermal profiles. The change of characteristic exothermic and endothermic event in oil with increasing crystallization, melting enthalpy and developing both process over a narrower temperature range is investigated. In this research, we developed DSC and multivariate calibration of Partial Least Square (PLS) calibration to analyze WBM in beef meatball. Meanwhile, the chemometrics of Principle Componen Analysis (PCA) is used to classify WBM and beef in the meatball. The validation model using crystalization profiles yield the coefficient of determination (R2) of 0.999 for the correlation between actual value of WBM (x-axis) and DSC predicted value (y-axis) with equation of y= 0.9999 x + 0.0027, root mean square error of cross validation (RMSECV) of 0.380%, and root mean square error of prediction (RMSEP) of 0.203%. PCA is successfully used for classification of WBM in beef meatball. DSC in combination with PLS and PCA can be an alternative technique for analysis of WBM in meatball.Key words: Differential scanning calorimetry, Wild bear meat, Crystallization profile, Melting profile, Partial least square.
PENETAPAN KADAR ß-KAROTEN PADA BEBERAPA JENIS CABE (Genus Capsicum) DENGAN METODE SPEKTROFOTOMETRI TAMPAK Tri Octaviani; Any Guntarti; Hari Susanti
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.451 KB) | DOI: 10.12928/pharmaciana.v4i2.1566

Abstract

Beta carotene is provitamin essential role for vitamin A formation. Most of vitamin Asources are ß-carotene. In the body, ß-carotene will be converted into vitamin A. Chilies areconsidered as one of the essential food. Chillies are known as very good sources of ß-carotene.Therefore, it is important to conduct a research in order to observe the content of ß-carotene inthe chillies using visible spectrophotometry. Fresh chillies were extracted with a mixture ofhexane:acetone:ethanol (2:1:1) v/v using a maceration method. After the extraction process wascomplete, aquabidest was added. The extraction result was non-polar phase. It was separatedand evaporated. The residue was further subjected to qualitative and quantitative analysis102 Pharmaҫiana, Vol. 4, No. 2, 2014: 101-109obtained. Qualitative analysis by using Carr-Price method. Determination of ß-carotene wasconducted using visible spectrophotometry method at 452,4 nm. The qualitative test resultsshowed that the Capsicum annuum L. Var. abreviatum Fingerhuth, Capsicum annuum L. Var.Longum sendt) and Capsicum frutescens L. contain ß-carotene. From the research, it wasobtained that the average levels of ß-carotene on the Capsicum annuum L. Var. abreviatumFingerhuth was (10,54±0,07) mg/100g, Capsicum annuum L. Var. Longum sendt was(5,57±0,13) mg/100g and Capsicum frutescens L. was about (0,36±0,01) mg/100g. Statisticalanalysis using LSD test of ß-carotene levels in the Capsicum annuum L. Var. abreviatumFingerhuth, Capsicum annuum L. Var. Longum sendt) and Capsicum frutescens L. weresignificantly different at P of 0.05.
PENGARUH UKURAN PARTIKEL BERAS HITAM (Oryza sativa L.) TERHADAP RENDEMEN EKSTRAK DAN KANDUNGAN TOTAL ANTOSIANIN Ria Maulida; Any Guntarti
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.845 KB) | DOI: 10.12928/pharmaciana.v5i1.2281

Abstract

Black rice has been tested for its high anthocyanin content. Black rice can be one of the potential sources of anthocyanin. Particle size is one of factors which influences amount of isolated  biocompound  in maceration process. Decreasing particle size can increase the amount of isolated  biocompound and extract yield value. The high value of extract yield shows effectiveness of maceration process. In this research, particle size variation has been done maceration process for investigating its influence on black rice extract yield and total anthocyanin content of maceration  result. This study used black rice ( Oryza sativa L.) from Beringharjo market, Yogyakarta. Maceration  with solvent of ethanol 96% add ed HCl 37% until pH 1,0(1:6) is done for 6 x 24 hours, with particle  size variation: mesh 20/40, 40/60 and whole bran of black rice. Data of extract yield and total  anthocyanin content are analyzed by using one-way ANOVA with confidence level 95%. The results  revealed that extract yield and total anthocyanin content of black rice extract with particle size  variation: mesh 20/40, 40/60 and whole bran of black rice intact 6%; 16%; 11,26%; and  30,76 mg/100  g; 1167,80 mg /100 g; 322,23 mg/100 g, respectively. There is significant difference  between  tested groups (P< 0,05). We concluded that particle size of black rice influences extract yield  and total anthocyanin content of maceration result.
Uji Aktivitas Penangkapan Radikal Bebas Ekstrak Etanol Daun Mangkokan (Nothopanax scutellarium (Burm.f) Merr.) Menggunakan Metode DPPH (1,1-Difenil-2-Pikrilhidrazil) dengan Variasi Suhu Pengeringan fitri farida; any guntarti
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 2 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.377 KB) | DOI: 10.22236/farmasains.v4i2.3362

Abstract

Mangkokan leaves contains flavonoids that are known as natural antioxidant source. The aim of this study is to find the effect of drying temperature variations towards free radical scavenging activity of mangkokan leaves. Mangkokan leaves macerated with 96% ethanol and dried at 40oC, 50oC, and 60oC. Then were macerated with ethanol 96%. Antioxidant activity tested by DPPH method and quercetin was used as positive control. Dry shrinkage with temperatures at 40oC, 50oC, and 60oC were: (9.25 ± 0.276)%; (8.76 ± 0.348)% and (7.97 ± 0.372)%, respectively. Water content at 40oC, 50oC and 60oC were: (5.13 ± 0.575)%; (4.53 ± 0.512)% and (4.04 ± 0.575)%, respectively. The antioxidant potency of 96% ethanolic mangkokan leaves by ES50 value at drying temperatures 40oC, 50oC, 60oC and quercetin were (1.75 ± 0.058); (2.39 ± 0,089); (5.38 ± 0,078) mg/ml and (9.16x10-4 ± 4.36x10-5) mg/ml. Ethanolic extract of mangkokan leaves which dried at 40oC has biggest radical DPPH scavenging activity but much weaker than quercetin.
Analisis Profil Minyak Atsiri Daun Kayu Putih (Melaleuca leucadendra L.) dan Produk di Pasaran Irfan, Nawwar; Nurani, Laela Hayu; Guntarti, Any; Salamah, Nina; Edityaningrum, Citra Ariani
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5785

Abstract

Minyak kayu putih merupakan salah satu minyak atsiri yang biasa digunakan dalam sehari-hari. Produksi dalam negeri hanya dapat memproduksi minyak kayu putih 650 ton/tahun dari permintaan kebutuhan dalam negeri dalam setahun sebesar 3.500 ton sehingga memacu pemalsuan. Penelitian ini bertujuan untuk membandingkan profil minyak kayu putih hasil destilasi dengan minyak kayu putih yang ada di pasaran berdasarkan mutu Standar Nasional Indonesia (SNI). Destilasi minyak atsiri dilakukan dengan 5 kg daun kayu putih menggunakan metode destilasi uap air selama 3 hari didapatkan rendemen sebesar 2,32%. Minyak kayu putih hasil destilasi dan minyak produk A, B dan C dilakukan pengujian profil minyak berdasarkan SNI 06-3954-2006 meliputi warna, bau, bobot jenis, indeks bias, kelarutan dalam etanol 70%, dan profil KLT. Hasil pengamatan organoleptis minyak hasil destilasi, produk A, B, dan C memiliki perbedaan warna, bobot jenis, dan kelarutan dalam etanol 70% serta tidak ada perbedaan bau dan indeks bias. Hasil penelitian menunjukkan adanya perbedaan profil minyak produk A, B, dan C yang tidak memenuhi SNI pada pengujian bobot jenis pada produk C. KLT dengan menggunakan fase diam silika gel GF254 dan fase gerak Toluen (100%). Profil KLT pada produk C tidak terlihat noda yang sama dengan standar eucalyptol yang diperlihatkan oleh minyak lainnya. Keywords: Analisis profil, Minyak kayu putih, SNI 06-3954-2006
Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro Aristiani, Windy; Desvita, Widea Rossi; Khayatulisma, Dika; Edityaningrum, Citra Ariani; Guntarti, Any; Nurani, Laela Hayu
Journal of Food and Pharmaceutical Sciences Vol 12, No 1 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10887

Abstract

(1) Background: Cervical cancer ranks as the fourth most prevalent cancer globally and in Asia, standing as the second most common in Indonesia. Despite its efficacy, doxorubicin chemotherapy is associated with significant side effects. To mitigate these adverse effects, a promising approach involves combining conventional drugs with curcumin. Both curcumin and doxorubicin have demonstrated cytotoxic effects against cervical cancer (HeLa). This research aims to determine the synergistic effect of the combination of doxorubicin and curcumin on HeLa and safety in normal cells (Vero cells). (2) Methods: This study adopted an experimental design utilizing doxorubicin and curcumin samples with HeLa and Vero cells. The investigation was initiated with cytotoxic and combination tests using the MTT method. The obtained results included IC50 values and combination indices, and the analysis involved a comparative examination of outcomes between HeLa and Vero cells. (3) Results: Cytotoxic tests revealed IC50 values for doxorubicin and curcumin on HeLa cells, measured in 2,17 ± 0,06 and 26,37 ± 2,00 µg/mL, and 17,32 ± 1,99 and 181,88 ± 30,48 µg/mL on Vero cells. Combination test results were represented by combination index .(4) Conclusions: The synergistic effect is observed at the combination of curcumin at a concentration of 9 μg/mL and doxorubicin at a concentration of 0,125 μg/mL, resulting in a combination index of 0,50. These findings suggest a promising avenue for enhancing the therapeutic potential of doxorubicin in cervical cancer treatment while minimizing adverse effects.
The Hepatoprotective Effect of Moringa oleifera Leaves on Male Wistar Rat Induced Streptozotocin-Nicotinamide Bachri, Moch Saiful; Nurani, Laela Hayu; Edityaningrum, Citra Ariani; Ma'ruf, Muhammad; Sulistyorini, Dwi Agustin; Amelia, Rizki; Hidayati, Sholihatil; Sulistyawati, Rini; Guntarti, Any
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.90806

Abstract

Diabetes mellitus is a disease characterized by uncontrolled increases in blood sugar levels, which can cause complications in the liver. Disorder liver disease can be seen from the increasing SGOT, SGPT activity, and the number of necrosis cells in the liver. Moringa leaves contain the flavonoid quercetin with antidiabetic and antioxidant activity. This research aimed to determine the effect of administering the ethyl acetate fraction of Moringa leaves on SGOT activity, SGPT, and liver histopathology in rat induced by streptozotocin and nicotinamide. Moringa leaves macerated with 80% ethanol and fractionated with ethyl acetate were used. The research subjects were 30 rats divided into six groups. The rats were induced with streptozotocin at a dose of 65 mg/kgBW and nicotinamide 100 mg/kgBW for five days, then treated for ten days. Serum SGOT and SGPT activity were measured using a Microlab 300 Semi-Automated at a wavelength of 340 nm. Histopathological observations were carried out when the rats were dislocated, their livers were taken, and then preparations were made using Hematoxylin Eosin (HE) staining. Data were analyzed using the SPSS One Way ANOVA method, followed by the Tukey test with a confidence level of 95%. The results of the study showed that administration of Ethyl Acetate Fraction of Moringa oleifera (EA-MO) could reduce the levels of SGOT, SGPT, and the number of liver necrosis cells in rats induced by streptozotocin and nicotinamide.
AUTHENTICATION OF PATCHOULI OIL FROM VARIOUS GROWING REGIONS USING GC-MS METHOD WITH CHEMOMETRIC COMBINATION ON THE PRODUCTS IN THE MARKET Nurani, Laela Hayu; Guntarti, Any; Milanie, Rida Dwi; Gandjar, Ibnu Gholib; Rais, Ichwan Ridwan; Prasasti, Dian; Edityaningrum, Citra Ariani
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10523

Abstract

Adulteration in patchouli oil trade is an ancient practice, where additional substances like turpentine oil are added to increase volume and odor. Therefore, this research aimed to determine the composition of patchouli oil, considering variations in growing regions and potential adulteration in the products available in the market. The analysis was carried out using the Gas Chromatography-Mass Spectrormetry (GC-MS) method with a Principal Component Analysis (PCA) chemometric combination for authentication. The sample obtained from Bantul, Kulon Progo, and Purworejo was isolated through steam and water distillation. Subsequently, it was tested in accordance with SNI standard 06-2385-2006 and analyzed using GC-MS. The results were compared to the products on the market and processed using multivariate chemometric, namely PCA with Minitab 19 software. GC-MS analysis showed the presence of various compounds contained in the oil, including alcohol, alpha-guaiene, beta-humulene, seychellene, trans-caryophyllene, neoalloocimene, and beta-patchoulene. The combination of GC-MS and PCA chemometrics was able to distinguish patchouli oil from others and the products available on the market. PCA chemometric analysis showed that the patchouli oil from various growing regions had the same chemical components as essential oil. Furthermore, PCA chemometric analysis of market products also showed similar results but varied significantly from turpentine oil. This showed that the patchouli oil product available on the market did not contain turpentine oil.
Purity Analysis of Sesame Oil Extracted from Sesamum indicum L. Using the ATR-FTIR Method Mahendra, Muhammad Reza; Salamah, Nina; Guntarti, Any
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.50102

Abstract

Sesame seeds (Sesamum indicum L.) are a plant that produces the most important and oldest oil known to man. Apart from being rich in nutrients, sesame consists of important functional components such as sesamin, sesamolin, sesamol, sesaminol, sesamolin phenol, and other lignan-like active ingredients and can trigger the motive to produce sesame oil by adulteration in order to achieve market desires. The aim of this research is to identify the purity of sesame oil and analyze it using the ATR-FTIR method to detect and prevent counterfeiting. Testing the characteristics of sesame oil can be adjusted to the quality requirements that have been set, one of which is the Indonesian National Standard (SNI) so that the quality of sesame oil circulating on the market is guaranteed. This research is non-experimental research. Sesame seed oil resulting from pressing is based on the test requirements of SNI 01-4468-1998 including the physico-chemical properties test. The results of the sesame seed oil profile are that the sesame seed oil extraction yield is 29.265%, the sesame oil is bright yellow in color, has a distinctive smell, specific gravity (20oC) 0.9237± 0.0057, refractive index 1.4702 ± 0.0005, peroxide value 2 ± 0.0577 meqO2/Kg, iodine value 107.1 ± 0.5773, and acid number 0.224 ± 0.0577. Based on the research results, it can be concluded that the pressed sesame seed oil has met the requirements of the SNI 01-4468-1998 test, and from the functional groups that appear in the ATR-FTIR it can be concluded that the pressed sesame oil contains methyl ester group compounds.
Co-Authors Abdul Rohman Abidin, Muhamad Ali Zainal Abidin, Muhamad Ali Zainal Agsari, Aulia Dwi Agustinus Yuswanto, Agustinus Ajeng Dian Pertiwi, Ajeng Dian Aldri Frinaldi Alifiya, Fhahira Anwar, Shinta Desy Anwar, Shinta Desy Aprilia Kusbandari, Aprilia Ar Rahma, Nur Aulia Ardianti, Agustina Aristiani, Windy Atmadja, Dimas Azzahra, Fara Citra Ariani Edityaningrum, Citra Daud, Intan Dian Prasasti farida, fitri FATMAWATI, ARUM Firda Rahmadani, Firda Firdaus, Rizqi Amalia fitri farida Hari Susanti Hari Susanti Haryati, Husnul Hidayati, Sholihatil Hikmah, Nazila Nur Husna, Muhimmatul Ibnu Gholib Gandjar Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ichwan Ridwan Rais Iin Narwanti Iis Wahyuningsih Irfan, Nawwar Islamy, Muhammad Rido Islamy, Muhammad Rido Jamhari Jamhari Jaya, Farida Kamal, Zainul Khairurrizki, Amanda Khayatulisma, Dika Kurniawan, Muhammad Fariez Laela Hayu Nurani Lalu Muhammad Irham Mahendra, Muhammad Reza Milanie, Rida Dwi Moch Saiful Bachri Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mukti Utomo, Adhitya Ilham Mustofa Ahda Narwanti, Iin Nina Salamah Nur Ismiyati Prativi, Seshilia Rarasati Putri, Hilma Putri, Hilma Rasyidah, Ilmiyatun Ria Maulida Rini Sulistyawati Rizki Amelia Rohmiati, Rohmiati Rohmiati, Rohmiati Ruliyani, Anita Rustandi, Tedi Sembiring, Rinawati Siti Rofida Sudibyo Martono Sugiyanto - Sulistyorini, Dwi Agustin Tri Octaviani Uddin, ABM Helal Warsi Warsi Warsi, Warsi Wati, Wahyu Irna Widea Rossi Desvita Widi Astuti, Silvia Ferry Wulandari, Rizkiyanti Yuningtyas, Ratna Zainab Zainab Zainab, Zainab