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All Journal Jurnal Kebidanan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Jamu Indonesia Jurnal Midpro Jurnal Surya Journal of halal product and research (JHPR) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Farmagazine Jurnal Farmasi RENATA Jurnal Pengabdian Masyarakat Kita Semua Journal of Clinical Pharmacy and Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian Kunir: Jurnal Farmasi Indonesia (KJFI) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Kusumo, Djati Wulan
Program Studi Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Lamongan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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AKTIVITAS ANTIDIABETES BEBERAPA FRAKSI DAUN MIMBA (Azadirachta indica) SECARA IN VITRO BERDASARKAN PENGHAMBATAN ENZIM α-AMILASE Nailus Amany Melinda; Djati Wulan Kusumo; Diah Indah Kumala Sari
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.28301

Abstract

Diabetes mellitus merupakan penyakit yang ditandai dengan adanya peningkatan kadar glukosa darah karena tubuh tidak dapat menghasilkan atau menggunakan insulin dengan baik. Salah satu tanaman herbal yang dapat menurunan kadar glukosa dalam darah adalah tanaman mimba (Azadirachta indica). Daun mimba telah diketahui memiliki senyawa flavonoid yang sangat berpotensi dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui potensi antidiabetes dari fraksi daun mimba (Azadirachta indica) dengan variasi pelarut berbeda dalam menghambat enzim α-amilase. Daun mimba diekstraksi dengan metode maserasi menggunakan metanol kemudian dipartisi cair-cair dengan pelarut n-heksan etil asetat dan metanol. Fraksi n-heksan, etil asetat dan metanol daun mimba yang diperoleh dilakukan skrining fitokimia dan uji in vitro terhadap enzim α-amilase menggunakan substrat pati beras dan reagen dinitrosalisilat (DNS). Penghambatan enzim α-amilase dilakukan dengan variasi konsentrasi sampel yaitu 200; 400; 600; 800 dan 1000 ppm. Analisis data dilakukan secara deskriptif dengan menghitung nilai % inhibisi dan IC50. Hasil penelitian menunjukkan adanya kandungan senyawa alkaloid dan terpenoid pada fraksi n-heksan; flavonoid dan tanin pada fraksi etil asetat; serta flavonoid, tanin, saponin dan alkaloid pada fraksi metanol. Nilai IC50 fraksi etil asetat didapatkan sebesar 54,85 μg/ml dengan kategori kuat dan metanol sebesar 132,26 μg/ml dengan kategori sedang, sedangkan fraksi n-heksan didapatkan nilai penghambatan sebesar 33,82% pada konsentrasi 600 ppm. Fraksi n-heksan tidak dapat diukur nilai IC50nya karena adanya perbedaan polaritas antara fraksi n-heksan dengan enzim α-amilase sehingga tidak dapat bercampur dengan baik. Fraksi etil asetat menunjukkan penghambatan paling tinggi dibandingkan dengan fraksi lainnya.
Effectiveness of Citronella and Basil Essential Oil Spray as Repellents against Aedes aegypti Mosquitoes: Efektivitas Spray Minyak Atsiri Serai Wangi Dan Daun Kemangi Sebagai Repellent Nyamuk Aedes Aegypti Qomariyah, Laila Nurul; Kusumo, Djati Wulan; Pratiwi, Elasari Dwi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16499

Abstract

Background: In 2023, Dengue Fever cases in Indonesia reached 35,694 cases from January to May. Dengue Fever is caused by the bite of Aedes aegypti mosquitoes. Mosquito control efforts have been widely conducted, including the use of chemical insecticides. The use of chemical insecticides can lead to environmental contamination and cause skin irritation. An alternative approach that can be taken is to use natural insecticides. One of the natural insecticides that can be used as a repellent is citronella and basil essential oils. Citronella and basil essential oils contain geraniol and citronellal, which can cause mortality in mosquitoes. This study intends to evaluate the effectiveness of a spray mixture of basil leaves and citronella essential oil as a mosquito repellent. Materials and Methods: Aedes aegypti mosquitoes, basil leaf essential oil, citronella essential oil, propylene glycol, glycerin, butylated hydroxytoluena and etanol 96% v/v. Subsequently, an evaluation of physical properties was conducted, including organoleptic testing, pH, and viscosity evaluation, as well as irritation and repellent activity test. Results: The spray formulations in the control and F1 are clear in color, while F2 and F3 are clear with a slightly yellowish hue. The scent produced has the characteristic smell of citronella. The pH and viscosity tests resulted in pH values consistent with the skin's pH range of 4.5-7 and viscosity within the range of 1-1000 Cp. The spray formulation did not irritate after 48 hours of observation. The results of the effectiveness test indicate that F2 can protect against mosquito bites for 1 hour, while F3 can protect for 3 hours. Conclusion: Citronella essential oil and basil leaves are effective as a repellent for the Aedes aegypti mosquito for 3 hours of use in concentration 15%.
Perilaku ibu dalam pemanfaatan persalinan penundaan pemotongan tali pusat sampai 24 jam Desi Nurlaela Mulyana; Umi Salamah; Djati Wulan Kusumo
Jurnal Kebidanan Vol 9, No 2 (2020): August 2020
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.9.2.2020.163-172

Abstract

The method of delaying cutting the umbilical cord after the baby is born and letting the cord out completely and then cut after 24 hours has not been implemented in all health facilities. Klinik Utama Anny Rahardjo has been implementing since 2012. The purpose of this research is to know the mother's behavior in the utilization of delivery delay cutting of the umbilical cord up to 24 hours at Klinik Utama Anny Rahardjo East Jakarta in 2017. The method used in this research is a descriptive qualitative method of describing mothers who have utilized this delivery at Klinik Utama Anny Rahardjo. This study amounted to 13 people consisting of 7 informants and 6 key informants. The result of research that mother's behavior is good enough, age, job, distance, and cost don't influence mother's behavior, while education, knowledge, attitude, family support, and health worker influence mother's behavior, in the utilization of delivery delay cord cutting up to 24 hours. It is suggested for Klinik Utama Anny Rahardjo to provide more information so that the mother's knowledge is better, for other researchers it is suggested that the research method use quantitative to get more samples, and for health service to follow up the development of science in the field of this method of delivery.
Narrative Review of Anti-Retrovirals Used in COVID-19 Treatment Aditya Sindu Sakti; Irma Susanti; Djati Wulan Kusumo
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 3 No. 2 (2024): Oktober : Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v3i2.54

Abstract

The COVID-19 pandemic has necessitated the exploration of various therapeutic strategies, including the repurposing of existing antiviral drugs. This narrative review examines the use of anti-retroviral agents in the treatment of COVID-19, focusing on their mechanisms of action, efficacy, and safety profiles. Key antiretrovirals discussed include Remdesivir, Lopinavir/Ritonavir, Ribavirin, Oseltamivir, Favipiravir, and Sofosbuvir. These agents primarily act by inhibiting RNA-dependent RNA polymerase (RdRp), a critical enzyme in the replication cycle of SARS-CoV-2. Clinical trials and in vitro studies have provided mixed results regarding their effectiveness, with some agents showing promise in reducing mortality and improving recovery times, while others have demonstrated limited efficacy. The review highlights the urgent need for further clinical research to optimize antiviral regimens and improve patient outcomes in the ongoing battle against COVID-19.
ARTICLES REVIEW: Ethno-Pharmaceutical Study of Medicinal Plants for Care and Treatment of Wounds in Indonesia: Systematic Data Search and Preclinical Review Kusumo, Djati Wulan; Erlita Layina Sulistiyowati; Habibatur Rohmah; Nailus Amany Melinda
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.232

Abstract

Ethnopharmacy study is an approach used to explore local knowledge of a particular community in the use of medicinal plants. This article discusses treatment methods and medicinal plants used for the treatment and care of wounds in several regions in Indonesia. In addition, this study is also useful to find out drugs from natural ingredients related to their bioactivity. The method used is literature study, while the data used are articles, databases and textbooks published from 2011-2021. Literature information searches are carried out using electronic search engines for articles and research journals published on several sites, such as Google, Pubmed, NCBI, Elsevier, and others. The results of the data obtained concluded that there were 27 types of plant species that were used traditionally and 15 who have already undergone preclinical testing for wound treatment and care.
Differences in levels of knowledge of FSTP students (Faculty of Science, Technology, and Education) and FEB (Faculty of Economics and Business) Muhammadiyah Lamongan University about criteria halal of skincare products Febrianti, Krisma; Handayani, Riana Prastiwi; Mahaputra Kusuma Negara, Sri Bintang Sahara; Kusumo, Djati Wulan
Journal of Halal Product and Research (JHPR) Vol. 7 No. 1 (2024): Driving Global Halal Value Chain, What Should We Do?
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jhpr.vol.7-issue.1.76-82

Abstract

Skincare has become a daily necessity for students especially Muslims, who must pay attention to the halalness of the skincare products used, because it has been regulated in Islam regarding halal and haram consumption. Student knowledge greatly influences halal in the selection of skincare products to be used. This study aims to determine the difference in the level of knowledge of FSTP and FEB students at Muhammadiyah Lamongan University. The research design used is descriptive comparative with purposive sampling technique. Data collection was carried out prospectively, from collecting questionnaire data that met the inclusion and exclusion criteria. The research instrument used was a closed questionnaire consisting of respondents' personal data and statements related to the criteria for halal skincare products. The results obtained from this study are the level of knowledge in the good category at FSTP as much as 60.52% and FEB as much as 76.6%, the sufficient category at FSTP as much as 38.6% and FEB as much as 21.28%, the poor category at FSTP as much as 0 .88% and FEB as much as 1.12%. The data obtained was then processed using SPSS with the Mann Whitney Test and obtained a p-value of 0.063 (> 0.05). In conclusion, there is a significant difference between the level of knowledge of FSTP and FEB regarding the criteria for halal skincare products.
Level of knowledge of FIKES students (Faculty of Health Sciences) Muhammadiyah Lamongan University about halal skincare products Fiely, Fawwas; Handayani, Riana Prastiwi; Yuliandhari, Rully; Kusumo, Djati Wulan
Journal of Halal Product and Research (JHPR) Vol. 7 No. 1 (2024): Driving Global Halal Value Chain, What Should We Do?
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jhpr.vol.7-issue.1.52-58

Abstract

The majority of the religion adhered to by the population in Indonesia is Islam, where in Islam it has been ordered to all Muslims to consume, utilize and use something that is halal and also good including skincare. Skincare is a product of skin care outside the body with certain functions. However, people's knowledge of using halal skincare is still low, this is evidenced by the fact that they are still allowed to use skincare that does not have halal certification because these products are commonly used. This study aims to determine the level of knowledge of students of the Faculty of Health Sciences (FIKES) Muhammadiyah Lamongan University about halal skincare. This study used a descriptive observational research design, and the sample for this study was 2022 FIKES students, a total of 390 students. Sampling technique using purposive sampling. The instrument used was a closed questionnaire in the form of Google form. The results showed that the knowledge level of FIKES students about halal skincare was in the good category of 47.69%, the sufficient category was 46.16%, the less category was 6.15%. It can be concluded that the knowledge level of FIKES students at Muhammadiyah Lamongan University about halal skincare is in the good category.
EFFECT OF HAIR TONIC COMBINATION OF CINNAMOMUN ESSENSIAL OIL AND CANDLENUT ESSENSIAL OIL HAIR GROWTH IN VIVO Mutamimmah, Siti; Pratiwi, Elasari Dwi; Kusumo, Djati Wulan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1610

Abstract

Hair loss, often called alopecia, is characterized by excessive hair loss. One way to treat hair loss is to use hair tonic preparation. This study aimed to determine the effect of a combination of hair tonic cinnamon essential oil and candlenut essential oil on hair growth. The research method used included physical evaluation of the hair tonic preparation formulation by examining the physical quality, homogeneity, pH, viscosity, and stability of the hair tonic preparation. The effectiveness of hair growth was evaluated in vivo in rabbits. Its effectiveness measures hair growth and weight. Based on the results of the tests on the physical characteristics and physical stability of the hair tonic preparation, a combination of cinnamon essential oil and candlenut essential oil at concentrations of 0% (F0), 2.5% (F1), 5% (F2), and 7.5% (F3) was used. in organoleptic testing, the homogeneity, pH, and viscosity met the specified characteristics and stability requirements. The results of research testing the effectiveness of hair growth showed that the hair tonic combination of cinnamon essential oil and candlenut essential oil is effective for good hair growth in formula 3, with a hair length of 8 mm and a hair mass of 213.8 mg on day 21. Keywords: Candlenut essential oil, Cinnamon essential oil, Hair growth, Hair tonic, In vivo
Kajian Literatur: Aplikasi Sejumlah Metode Ekstraksi Modern Untuk Mengekstraksi Senyawa Fenolik dari Bahan Alam Firdiyansyah, Moh. Rofiqi; Sakti, Aditya Sindu; Kusumo, Djati Wulan; Amin, Muhammad Saiful
Jurnal Farmasi (Journal of Pharmacy) Vol 13, No 2 (2024)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v13i2.289

Abstract

Senyawa fenolik merupakan senyawa yang diperoleh dari bahan alam atau tumbuhan sebagai respons terhadap stres lingkungan. Senyawa ini memiliki manfaat sebagai antioksidan, komponen dari senyawa ini memiliki pernakan penting sebagai agen pencegah dan pengobatan untuk beberapa gangguan penyakit seperti asteriosklerosis, disfungsi pada otak, diabetes dan kanker. untuk mendapatkan senyawa fenolik yang berkhasiat dari bahan alam perlu dilakukan suatu metode ekstraksi, metode ekstraksi modern merupakan metode ekstraksi yang digunakan untuk mengefisienkan proses ekstraksi itu sendiri dengan menggunakan sejumlah alat teknologi. Review artikel ini bertujuan untuk mengetahui metode ekstraksi modern yang dapat digunakan untuk mengekstraksi senyawa fenolik dari bahn alam. Proses review article ini dilakukan dengan seksama secara komprehensif dengan menggunakan berbagai data base seperti Google Scholar, Pubmed, Science Direct, Portal Garuda, NCBI dan BMC dengan menggunakan kata kunci “Senyawa fenolik”, “Microwave Assisted Extraction”, “Enzyme Assisted Extraction”, “High Hydrotastic Pressure Extraction”, “Ultrasonic Assisted Extraction”, “Pressure Liquid Extraction”, “Pressure Extraction Fluid” dan “Metode ekstraksi modern”. Hasil review menunjukkan metode ekstraksi yang paling optimal untuk mengekstraksi total kadar senyawa fenolik yaitu dengan metode Microwave Assisted Extraction (MAE) pada daya 600 watt selama 4 menit dengan menggunakan pelarut etanol 70% dapat menghasilkan total kadar senyawa fenolik sebesar 199.4 mgGAE/g pada tanaman kulit buah delima (Punica granatum L).
PENDAMPINGAN SERTIFIKASI HALAL REGULER PADA UNIT GIZI PUSKESMAS GLAGAH KABUPATEN LAMONGAN Wulan Kusumo, Djati; Muzayinatun Niswah, Farokhah; Susanti, Irma; Prastiwi Handayani, Riana; Afizal, Aditya; Nisa, Nadlifatun; Mega Irfani, Iftinan; Ayu Febrianti, Risma; Agung Suryani, Kinanti
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 12 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v%vi%i.%p

Abstract

Semua produk makanan dan minuman wajib bersertifikat halal, termasuk produk yang dihasilkan oleh pelayanan kesehatan seperti Puskesmas. Sampai saat ini, jumlah Unit Gizi Puskesmas maupun Rumah Sakit yang bersertifikat halal masih sedikit. Sehingga kegiatan Pengabdian kepada Masyarakat (PkM) ini penting dilakukan karena Puskemas Glagah Kabupaten Lamongan akan menjadi Puskesmas pertama yang bersertifikasi halal pada unit gizinya. Melalui sertifikasi halal, Puskesmas dapat mewujudkan pelayanan unggul dan memberikan kepuasan pelayanan kepada pasien. Tujuan kegiatan PkM adalah melakukan sosialisasi pentingnya sertifikasi halal pada Unit Gizi Puskesmas Glagah Kabupaten Lamongan guna meningkatkan pelayanan kepada masyarakat dan mendampingi penyusunan dokumen manual sistem jaminan halal unit gizi Puskesmas Glagah Kabupaten Lamongan untuk mendapatkan sertifikat halal dari Badan Penyelenggara Jaminan Produk Halal (BPJPH). Kegiatan PkM ini dilakukan melalui 4 tahapan utama, yaitu sosialisasi, pelatihan, penerapan teknologi, pendampingan, dan evaluasi kegiatan. Hasil kegiatan menunjukkan bahwa pegawai Puskemas mengalami peningkatan pengetahuan khususnya terkait konsep halal yang sesuai serta mengetahui pentingnya dan kewajiban sertifikasi halal di Indonesia, khususnya pada makanan dan minuman, termasuk pada unit pelayanan kesehatan seperti Puskemas. Sistem Jaminan Produk Halal (SJPH) yang sebelumnya belum sempurna dilakukan, sekarang telah mengalami peningkatan dan sesuai dengan standar BPJPH.
Co-Authors Aditya Sindu Sakti Aditya Sindu Sakti Afizal, Aditya Agung Suryani, Kinanti Anggraini, Risma Dwi Ayu Febrianti, Risma Chasanah, Uswatun Damayanti, Dora Desi Nurlaela Mulyana Devi Ristian Octavia Dewi Indah Ayu Ardiyanti Fistalia Diah Indah Kumala Sari Elasari Dwi Pratiwi ELASARI DWI PRATIWI, ELASARI DWI Emilia Rahmawati Erlita Layina Sulistiyowati Erma Kusuma Ningrum Fachry Abda El Rahman Febrianti, Krisma Fida, Ayu fidayanti Fiely, Fawwas Firdiyansyah, Moh. Rofiqi Fransisca Dita Mayangsari Habibatur Rohmah Handayani, Riana Prastiwi Irma Susanti Irma Susanti, Irma Jazilah Khikmia Suwandi Khusnul Khotimah Kintoko Kintoko Kintoko Kintoko Maulidwina Bethasari Mega Irfani, Iftinan MIFTAKHUL JANNAH Muhammad Syaiful Amin Muldiyana, Tya Mulyana, Desi Nurlaela Mutamimmah, Siti Muzayinatun Niswah, Farokhah Nadif Tuzairoh Nailus Amany Melinda Nisa, Nadlifatun Nurkhasanah Nurkhasanah Prastiwi Handayani, Riana Pulhehe, Hasni Qomariyah, Laila Nurul Sakti, Aditya Sindu Salma Nur Azizah Sari, Diah Indah Kumala Sindu Sakti, Aditya Siswanto, Rizki Ananda Sri Bintang Sahara Mahaputra Kusumanegara Susanti Susanti Tri Puspita Yuliana Umi Salamah Umi Salamah Urmatul Waznah Yuli Nurullaili Efendi, Yuli Nurullaili Yuliandhari, Rully Yulianita Pratiwi Indah Lestari Zurotul Muarifah