Claim Missing Document
Check
Articles

Found 11 Documents
Search
Journal : Jurnal Epidemiologi Kesehatan Komunitas

Antibacterial Activity from Temulawak Extract (Curcuma xanthorrhiza Roxb) on Growth Inhibition of Staphylococcus epidermidis In Vitro Ni Wayan Mutiara Warmasari; Desak Ketut Ernawati; Agung Wiwiek Indrayani; Ni Wayan Sucindra Dewi; I Made Jawi
Jurnal Epidemiologi Kesehatan Komunitas Vol 5, No 1: Februari 2020
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.357 KB) | DOI: 10.14710/jekk.v5i1.6909

Abstract

Background: Infection is one of the main causes of disease in tropical regions like Indonesia. One of them can be caused by bacterial infection of Staphylococcus epidermidis. Staphylococcus epidermidis is an opportunistic bacterium that attacks individuals when the body's immune system is weak. The incidence of bacterial resistance to antibiotics that already exist so that requires an alternative treatment, one of which is the use of temulawak rhizome extract (Curcuma xanthorrhiza Roxb). Temulawak rhizome is one of the spices which is still often used as traditional medicine among Indonesian people. Temulawak rhizome extract is known to have a variety of chemical contents with active compounds in the form of essential oils xanthorrhizol and curcumin which can affect the rate of bacterial growth.Methods: This study aims to determine the antibacterial activity of temulawak rhizome extract on the growth of Staphylococcus epidermidis bacteria in vitro. The method used in this study is the true experimental post test only control group design. Samples were divided into four treatment concentrations such as the extract concentration of 25%, 50%, 75%, and 100% of temulawak rhizome which was tested by agar diffusion method (Kirby-Bauer).Result: The results of the analyze of variant (ANOVA) test showed a significant difference (p = 0,000). The temulawak extract could inhibit bacterial growth with a medium inhibitory response (5-10 mm). Temulawak rhizome extract showed the greatest inhibition at 100% concentration with an average inhibition zone diameter of 9.20 mm.Conclusion : The extract of temulawak rhizome has antibacterial activity. The higher concentration of temulawak rhizome extract (Curcuma xanthorrhiza Roxb), the greater ability to inhibit the growth of Staphylococcus epidermidis bacteria. 
Protective Effect of Lemon (Citrus limon L.) Ethanol Extract Cream as an Antioxidant Against Exposure to Ultraviolet B Rays in the Skin of Male Wistar (Rattus norvegicus) Rats Dewa Ayu Putu Sri Ista Dewanti; Desak Ketut Ernawati; Agung Wiwiek Indrayani; Ni Wayan Sucindra Dewi; I Made Jawi
Jurnal Epidemiologi Kesehatan Komunitas Vol 5, No 1: Februari 2020
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.746 KB) | DOI: 10.14710/jekk.v5i1.6910

Abstract

Background: Indonesia is an archipelagic country and one of the tropical countries that get sun exposure all the time. Sun exposure can have beneficial and detrimental effects in life. Exposure to radiation can cause acute effects in the form of erythema through the inflammatory process. Antioxidants are substances that can protect the body from damage caused by ROS. Natural antioxidants can be found in vegetables and fruits, one of which comes from lemon extract (Citrus limon L.). Lemon extract is known to have various chemical contents with active compounds in the form of flavonoids and phenols which can act as antioxidants. The aim of this research was to determine the protective effect that can be produced by lemons on UVB exposure in the skin of male wistar rats.Methods: This research uses the true experimental post test only control group design method. Samples were divided into three treatment concentrations, namely ethanol extract of lemon 5%, 10%, and 20%.Result: After testing for normality, the significance value was obtained (p <0.05). Based on the results of the normality and homogeneity test, the results of the data distribution are not normal and the homogeneous tests of the hypotheses used are the Kruskal-Wallis non-parametric test. Kruskal-Wallis non-parametric test results showed a significant difference with the significance value (p = 0.001). The best degree of erythema score was found in the cream of 10% ethanol extract of lemon with an average of 0.8 ± 0.84.Conclusion : The ethanol extract of lemon (Citrus limon L.) cream in a certain dosage has a significant effect on reducing the erythema degree score in the back skin of male Wistar rats (Rattus norvegicus) after exposure to UVB rays.
Comparison of Antibacterial Activity of Sambiloto (Andrographis paniculata) Ethanol and Water Stem Extract Against Methicillin-Resistant Staphylococcus aureus (MRSA) ATCC 3351 In Vitro Ni Wayan Sinta Devi Arini; Bagus Komang Satriyasa; I Made Jawi; Agung Wiwiek Indrayani
Jurnal Epidemiologi Kesehatan Komunitas Vol 5, No 2: Agustus 2020
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v5i2.6908

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is penicillin and cephalosporine resistant Staphylococcus aureus which is a major cause of nosocomial infection. Various studies have been conducted for resistant cases, especially herbs which have antibacterial activity. Sambiloto (Andrographis paniculata) is an example of herb which has antibacterial activity due to the presence of andrographolide. Andrographolide soluble in ethanol and poorly in water, while extraction with alcohol causes andrographolide’s degradation. This study aimed to investigate the antimicrobial activity of ethanol and water stem extract and compare them against MRSA ATCC 3351 in vitro.Methods: This is an experimental study with a post-test only control group design and conducted by disc diffusion technique to obtain an inhibition zone against MRSA.Result: The result of this study showed the mean inhibitory zone of ethanol stem extract was 5,87mm, 6,77mm, 7,87mm respectively for 25%, 50%, and 100% concentrations, while 1% concentration did not show antibacterial activity. Water stem extract at 1%, 25%, 50%, and 100% concentrations showed mean inhibitory zone was at 4,57mm, 7,17mm, 8,67mm, and 9,67mm respectively.Conclusion: Ethanol and water stem extract showed antibacterial activity against MRSA. The independent sample t-test didn’t show a difference between ethanol and water stem extract of Andrographis paniculata toward MRSA (p>0,05).
Small Interfering RNA (siRNA) of Mini circle DNA Transfection (McD) is Encapsulated by Gold Nanoparticles from Folate’s Receptors of Gold Conjugation as Curative Therapy for Non-Small’s Cell of Lung Cancer agung wiwiek indrayani; I Gusti Ayu Sitti Sadvika; I Gede Wikania Wira Wiguna; Ni Putu Sri Indrani Remitha; I Gede Krisna Arim Sadeva; Anak Agung Bagus Putra Indrakusuma; Putri Ayu Wulandari; Ni Wayan Sucindra Dewi
Jurnal Epidemiologi Kesehatan Komunitas Vol 6, No 2: Agustus 2021
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v6i2.9140

Abstract

Background: Lung cancer is one of the non-communicable diseases that have an increasing number of events that each year with a mortality rate of 18.4% and an incidence of 11.6%, occupies the top position based on GLOBOCAN data in 2018. One of management in the NSCLC is currently in the form of surgery and adjuvant therapy such as chemotherapy, radiotherapy and target therapy. However, there were weaknesses and limitations in care for its patients therefore development of curative therapy for NSCLC’s patients were needed.  The aim of this review is to learn and investigate about the potential of siRNA that is transfected into McD and folate receptors alpha-conjugated gold nanoparticle encapsulation as a therapeutic opportunity that could be developed as a treatment in management of NSCLC.Method: The writing method used in this review article was the study method of literature.  The used data comes from 45 of relevant literature sources and was arranged systematically in accordance with the topic of the problem discussed, along with the inclusion and exclusion criteria.Result: This treatment could increase gene transfection, siRNA biodistribution in organs, reduced KRAS, Bcl-2, and VEGF expression.  Moreover, siRNA had entered phase III clinical trials and FOLR1 antibodies were in phase II of clinical trials.Conclusion: Utilization of siRNA specifically was designed for three genes such for KRAS, VEGF and Bcl-2 which were three genes that played a role in the pathogenesis of NSCLC, could be the right modality choice for treatment of NSCLC. 
Prevalence of Genu Valgum in Children Aged 10-12 Years with Excessive Body Weight (Overweight/Obesity) in Sanur Kaja Village, Denpasar Vidya Rahmayunissa Swandi Putri; Ni Wayan Tianing; Agung Wiwiek Indrayani; Ari Wibawa; Sayu Aryantari Putri Thanaya
Jurnal Epidemiologi Kesehatan Komunitas Vol 5, No 2: Agustus 2020
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v5i2.7727

Abstract

Background: Overweight/obesity is a global health problem, both in developed and developing countries and the number of overweight/obese people increases every year. Being overweight during childhood increases the risk of obesity in adulthood and can lead to musculoskeletal disorders, one of which is genu valgum. The purpose of this study was to determine the prevalence of genu valgum in children aged 10-12 years who are overweight/obese in Sanur Kaja Village, Denpasar.Methods: This study was an observational study with a cross-sectional design conducted at elementary schools in Sanur Kaja Village in April 2019. The sampling technique used was purposive sampling. A total of 78 children were included in this study. The univariate analysis in this study was genu valgum, overweight/obesity, age, and gender.Result: The prevalence of genu valgum in children aged 10-12 years in Sanur Kaja Village was 46.7% in overweight children and 53.3% in obese children, with 30 people (38.5%) experiencing genu valgum out of the total sample of 78 people (100%).Conclusion: Based on the result of this study, the incidence of genu valgum was higher in children aged 10-12 years who were obese compared to children with overweight body mass index.  It is recommended that children who are obese and overweight to control their eating patterns, maintain normal body weight, and do enough physical activity.
The Correlation Between Body Fat Percentage and Peak Expiratory Flow in Children Aged 10-12 Years At SD Negeri 8 Dauh Puri Ni Wayan Melyani Indahswari; Agung Wiwiek Indrayani; Ari Wibawa; Sayu Aryantari Putri Thanaya
Jurnal Epidemiologi Kesehatan Komunitas Vol 4, No 2: Agustus 2019
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.102 KB) | DOI: 10.14710/jekk.v4i2.5271

Abstract

Background: The accumulation of fat decreases lung function. Peak expiratory flow is an indicator for assessing pulmonary function and can be used to identify the narrowing or obstruction of the airway. This study aimed to examine the correlation between body fat percentage and peak expiratory flow in children aged 10-12 years.Methods: This study was an analytical study with a cross-sectional design carried out in March 2019 at SD Negeri 8 Dauh Puri, Denpasar. Sampling was done by simple random sampling, and 84 samples were recruited who met the inclusion and exclusion criteria. Body fat percentage was measured using Bioelectric Impedance Analysis, while peak expiratory flow was measured using Peak Flow Meters. Data analysis was done using the Pearson Correlation test..Result: The Pearson Correlation Test showed a negative weak correlation between the percentage of body fat and peak expiratory flow with p=0.009 and a correlation coefficient of -0.284. It can be interpreted that the higher the body fat percentage, the higher the value of peak expiratory flow.Conclusion : There is a significant correlation between body fat percentage and peak expiratory flow in children aged 10-12 years at SD Negeri 8 Dauh Puri.
Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner I Nengah Raka Swastika; Ni Ketut Ristiani; Adrian Wiryanata Gorintha; Agung Wiwiek Indrayani
Jurnal Epidemiologi Kesehatan Komunitas Vol 6, No 2: Agustus 2021
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v6i2.12190

Abstract

Background: Coronary heart diseases (CHD) is a disorder that caused by blockage of coronary arteries due to the process of atherosclerosis which disrupts the blood supply to the heart muscle. According to Sample Registration System (SRS) Indonesia in 2014, CHD is a second highest cause of death after stroke that is 12,9% of all cause of death in Indonesia. Therefore, this study aims to examining the effect of soybean extract encapsulated with Self Microemulsifying Drug Delivery System (SMEDDS) on LDL levels in coronary heart model rats. Based on various study, isoflavone aglycone genistein is the main flavonoid in soybean seed that has potential as an antioxidant. To increase bioavailability of aglycone isoflavones, a SMEDDS is needed. In this regard, the purpose of this reseach is to examine the potential of soybean seed (Glycine soja) extract to reduced cholesterol in CHD.Methods: The method used is a literature review with literature sources in the form of relevant articles from the search engines, namely Google Scholar, Pubmed, ScienceDirect, and Research Gate. Inclusion criteria included journals containing the keywords “soybean (Glycine soja)”, “Coronary Heart Disease”, “SMEDDS”, and “genistein isoflavone aglycone”.Result: Isoflavone aglycone as an potential antioxidant that is able to bind free radicals and and also lowering LDL, Triglycerides, and glucose levels in hyperglycemic states and increasing HDL.Conclusion : Soybean seed extract with SMEDDS encapsulation have a potential to decrease LDL level in coronary heart disease.
Potensi Kombinasi Adenosine Diphosphate-Ribosylation Like 4c Antisense Oligonuclotide-1316 dengan Polyamidoamine Dendrimer Generasi 4-Anti Surfactant Protein B sebagai Terapi Adenokarsinoma Paru Adrian Wiryanata Gorintha; Andrea Ivena; Putu Aprilyanti Aristadewi; Agung Wiwiek Indrayani
Jurnal Epidemiologi Kesehatan Komunitas Vol 7, No 1: Februari 2022
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v7i1.12497

Abstract

Background: Lung cancer is a disease of the respiratory system that gets special attention because the World Health Organization (WHO) has reported that in 2018, lung cancer was the cancer with the highest number of morbidity and mortality rate in the world. There are several types of lung cancer, one of which is adenocarcinoma, which accounts for about 40% of all lung cancers. In its management, cancer cells often develop resistance to EGFR TKI drugs while Cisplatin and Crizotinib have quite dangerous side effects, namely bradycardia to cardiotoxicity.Methods: The method used is a literature review with literature sources in the form of relevant article from search engine such as Pubmed and Google Scholar that contain keyword “ARL4C ASO-1316”, “lung adenocarcinoma”, “PAMAM Dendrimer Generasi 4” and “anti SFTPB antibody”.Result: The ability of ARL4C ASO-1316 in inhibiting the division and migration of lung adenocarcinoma cells has been proven in vivo and in vitro so that it can provide hope in the form of new modalities in the treatment of lung adenocarcinoma. In addition, the combination with the PAMAM Dendrimer G4-Anti SFTPB carrier can increase the ability to deliver ARL4C ASO-1316 to reach target tissues rapidly and can provide maximum effect in the treatment of lung adenocarcinoma.Conclusion : Adenosine diphosphate-ribosylation like 4c antisense oligonuclotide-1316 with polyamidoamine dendrimer generation 4-anti surfactant protein b should provide novel approaches and new insights for lung adenocarcinoma.
The Relationship Between Smartphone Addiction and Forward Head Posture in Junior High School Students in North Denpasar Nanda Putra Wiguna; Nila Wahyuni; Agung Wiwiek Indrayani; Ari Wibawa; Sayu Aryantari Putri Thanaya
Jurnal Epidemiologi Kesehatan Komunitas Vol 4, No 2: Agustus 2019
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.194 KB) | DOI: 10.14710/jekk.v4i2.5268

Abstract

ABSTRACTBackground:Nowadays, the smartphone has become an important requirement. The number of smartphone users and the duration of smartphone use is increasing rapidly, and the side effects can be detrimental one of them is forward head posture. The prevalence of forward head posture is greater women (24.1%) than men (9.1%).Methods:This study was an analytical observational study with a cross-sectional design.This research was conducted in April 2019 in SMP Negeri 2 Denpasar and SMP Negeri 4 Denpasar andincluding 56 samples, who were recruited through simple random sampling.Variables studied are smartphone addition was measured using the Smartphone Addiction Scale questionnaire, and forward head posture was measured by measuring craniovertebral angles. Data analysis was done using the Chi-Square test. Result: Based on this study, smartphone addiction was related to forward head posture. The research shows that as many as 45 samples had Smartphone Addiction (80.35%) while those who had forward head posture were 29 samples (51.78%).Conclusion : Ignorance of how to sort and choose the effects of globalization, especially smartphone use, which can lead to posture disorders. The factor recognized factors for the occurrences of the forward head posture the lack of education about ergonomic positions when using a smartphone. Parents are advised to set the right smartphone usage for children as early as possible.
Kualitas Tidur Buruk Memperlambat Waktu Reaksi Visual pada Mahasiswa Program Studi Sarjana Fisioterapi Fakultas Kedokteran Universitas Udayana Hafizh Marin; Agung Wiwiek Indrayani; Made Hendra Satria Nugraha; I Made Krisna Dinata
Jurnal Epidemiologi Kesehatan Komunitas Vol 8, No 2 : Agustus 2023
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v8i2.18047

Abstract

Background: College students are one of the groups that have a high risk of experiencing sleep deprivation and sleep disorders. In medical students, this is due to the high duration and intensity of education. Poor sleep quality causes impaired cognitive function, one of which is decreased reaction time. Students with faster reaction times have better cognitive status and academic performance. This study aims to determine how the relationship of sleep quality to reaction time with the type of simple reaction time (SRT) and choice reaction time (CRT) experiment in physiotherapy student at faculty of medicine, university of udayana.Methods: The cross-sectional study was conducted with simple random sampling technique. 45 students participated in this study. Sleep quality was measured with Pittsburgh Sleep Quality Index (PSQI) and reaction time using Deary-Liewald reaction time task with SRT and CRT types of experiment. Bivariate analysis was performed using the Spearman rho test.Result: 21 people (46.7%) had good sleep quality and 24 people (53.3%) had poor sleep quality. The results showed that there was a relationship between sleep quality and reaction time using CRT (p = 0.003) and there was no relationship between sleep quality and reaction time using SRT (p = 0.084).Conclusion: Poor sleep quality resulted in decreased reaction time with the CRT experiment type. The authors suggests research with different methods and populations, also add more control variables.
Co-Authors Adhitya, I Putu Gde Surya Adrian Wiryanata Gorintha Adrian Wiryanata Gorintha Agung Nova Mahendra Agus Eka Darwinata Agus Indra Yudhistira Diva Putra Agus Indra Yudhistira Diva Putra Aloysius Ivander Wirayudha Widjaja Aman, IGM Amaze Grace Davidz Morato Anak Agung Bagus Putra Indrakusuma Anak Agung Bagus Putra Indrakusuma Anak Agung Gde Putra Wiraguna Anak Agung Gede Angga Puspa Negara Anak Agung Gede Eka Septian Utama Anak Agung Gede Eka Septian Utama Andrea Ivena Anggi Amanda Triana Devy Ari Wibawa Ari Wibawa Aria Wibawa Ath-Thahirah, Aisyah Syahidah Bagus Komang Satriyasa Bagus Naibaho Desak Ketut Ernawati Dewa Ayu Putu Sri Ista Dewanti Dewi, Anak Ayu Nyoman Trisna Narta Dewi, Luh Putu Widya Amritha Dewi, Ni Wayan Sucindra Dewi, Rani Nafisa Dhumaranang, Hyangayu Dedari Dian Arisanti, Ni Kadek Dyan Amalina Pratiwi Els, Vanessa Emily Devina Kartawijaya Faradilah Destyana Fiqhi Dhamiery Haniefah Effendi Gede Parta Kinandana Hafizh Marin I Dewa Gede Alit Kamayoga I Dewa Putu Sutjana I Gede Aswin Parisya Sasmana I Gede Krisna Arim Sadeva I Gede Wikania Wira Wiguna I Gede Wikania Wira Wiguna I Gusti Ayu Artini I Gusti Ayu Bulan Sistayani I Gusti Ayu Gita Widyaswari I Gusti Ayu Sitti Sadvika I Made Jawi I Made Krisna Dinata I Made Niko Winaya I Nengah Raka Swastika I Nengah Raka Swastika I Nyoman Adi Putra I Putu Eka Widyadharma I Putu Gde Surya Adhitya I Putu Gede Adiatmika I Putu Yudi Pramana Putra I Wayan Putu Sutirta Yasa I Wayan Sumardika I Wayan Weta Indratmo, Novea Irawan, Angeline Aprilia Isa Cahya Permadi Junior, Darren Kamayoga, I Dewa Gede Alit Komang Githa Pradnyamitha Dewi L. Ade Sintia Devi Luh Putu Happy Sandha Luh Putu Ratna Sundari Luh Putu Ratna Sundari Luh Putu Sudi Wahyuni Made Edwin Sridana Made Hendra Satria Nugraha Made Indira Dianti Sanjiwani Made Indira Dianti Sanjiwani Mardaningrat, Kadek Herdana Vildan Milhanah Milhanah Nanda Putra Wiguna Natasya Pramatya Putri Negara, Anak Agung Gede Angga Puspa Ni Kadek Dian Arisanti Ni Ketut Risitani Ni Ketut Ristiani Ni Ketut Ristiani Ni Komang Ayu Juni Antari Ni Luh Guantari Ni Luh Nopi Andayani Ni Made Adi Tarini Ni Made Dwi Sandhiutami Ni Made Intansari Tri Buana Ni Made Maya Risna Ayu Ni Made Wira Tania Astarini Ni Nyoman Tri Eka Buanasari Ni Putu Sri Indrani Remitha Ni Putu Venaya Sidarthayani Ni Wayan Melyani Indahswari Ni Wayan Mutiara Warmasari Ni Wayan Sinta Devi Arini Ni Wayan Sri Wahyuni Sri Wahyuni Ni Wayan Sucindra Dewi Ni Wayan Tianing Ni Wayan Tianing Nila Wahyuni Nila Wahyuni Nugraha, Boya Nyoman Budhi Wirananda Setiawan Nyoman Budhi Wirananda Setiawan Nyoman Ririn Chandrika Sari Prasetyo, Arsya Hayyu Pratiwi, Kadek Prastiti Surya Putrawan, Ida Bagus Indra Shadnyana Putri Ayu Wulandari Putri, Gita Almira Putri, Kadek Wina Santhya Putu Aprilyanti Aristadewi Putu Ayu Bintang Anjali Putu Ayu Wulan Purnama Dewi Putu Savitri Priutami Putu Sutha Nurmawan Putu Wisnu Arya Wardana Riska Damayanti Sitompul Rizaldy Pinzon Sari, Ni Wayan Puspita Sayu Aryantari Putri Thanaya Thomas Eko Purwata Tracey Odella Jiraldi Akemah Tresnayanthi, Kadek Ayu Sri Vania Rau, Chiquita Putri Vidya Rahmayunissa Swandi Putri Vingky Winda Astiti Vittala, Govinda Widyaswari, Ni Made Arindra Wimpie I Pangkahila Winanti, Kadek Dinda Ayu Sri Witri Okta Maruli Y, Yudiyanta Yundari, Yundari Zidni Sadati Maulana Aden