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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Althea Medical Journal Journal of Biomedicine and Translational Research The Indonesian Biomedical Journal Majalah Patologi Indonesia Medica Hospitalia PREPOTIF : Jurnal Kesehatan Masyarakat Medica Arteriana (Med-Art) Diponegoro International Medical Journal (DIMJ) Indonesian Journal of Cancer Zona Kebidanan : Program Studi Kebidanan Universitas Batam Indonesian Journal of Biomedicine and Clinical Sciences Ophthalmologica Indonesiana Acta Odontologica Indonesia

Hermawan Istiadi

Unknown Affiliation

Author-ID : 289958

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 32 Documents Claim Missing Document

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Pengaruh Ekstrak Daun Wungu Terhadap Luas Islet Pankreas Tikus Wistar Diabetes Melitus Excelinda, Tifanni; Istiadi, Hermawan; Retnoningrum, Dwi; Hendrianingtyas, Meita
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang : Diabetes melitus merupakan kumpulan gejala gangguan metabolik dengan prevalensi penyandang yang masih terus meningkat. Faktor lingkungan, gaya hidup, maupun genetik dapat menyebabkan kerusakan sel pankreas maupun resistensi insulin yang kemudian bermanifestasi sebagai diabetes melitus. Daun wungu (Graphytophyllum pictum (L.) Griff) mengandung metabolit aktif seperti flavonoid yang merupakan antioksidan untuk mencegah destruksi dan meregenerasi sel pankreas penderita diabetes melitus. Tujuan : Membuktikan adanya perbedaan ukuran luas islet pankreas tikus Wistar diabetes melitus yang mendapatkan ekstrak daun wungu (Graphtophyllum pictum (L.) Griff) setelah perlakuan dengan kontrol. Metode : Penelitian true experimental dengan menggunakan desain Post-Test Only Control Group Design. Sampel 24 ekor tikus Wistar jantan dengan kriteria tertentu dibagi secara acak menjadi 4 kelompok. Kontrol negatif (K-1) diberikan aloksan dan kelompok perlakuan 1 (K-2), perlakuan 2 (K-3), dan perlakuan 3 (K-4) masing-masing diberikan aloksan dan ekstrak daun wungu 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Glukosa darah diperiksa pada hari ke-4 untuk memastikan tikus sudah diabetes melitus dan dilanjutkan perlakuan selama 14 hari. Terminasi dan pengambilan organ dilakukan pada hari ke-15. Data berupa luas islet pankreas kemudian dianalisis menggunakan uji Kruskal-Wallis dan uji Mann-Whitney. Hasil: Berdasarkan uji Kruskal-Wallis didapatkan perbedaan luas islet pankreas yang bermakna (p = 0,000) antar kelompok. Pada uji Mann-Whitney didapatkan peningkatan luas islet pankreas yang signifikan (p = 0,000) pada seluruh kelompok perlakuan terhadap kontrol negatif. Rerata luas islet pankreas berbanding lurus dengan peningkatan dosis pemberian ekstrak daun wungu. Kesimpulan : Terdapat perbedaan ukuran luas islet pankreas yang signifikan pada seluruh kelompok perlakuan terhadap kontrol negatif. Kata Kunci : Daun wungu; luas islet pankreas; diabetes melitus

Pengaruh Ekstrak Daun Wungu Terhadap Kadar Malondialdehid Darah Pada Tikus Diabetes Militus Elnitiarta, Jasmine; Istiadi, Hermawan; Hendrianingtyas, Meita; Retnoningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang: Diabetes melitus (DM) merupakan penyakit kronik dengan gejala glukosa darah yang tinggi (hyperglycaemia) dimana terjadi peningkatan biomarker stress oksidatif yaitu MDA. Daun wungu (Graptophyllum pictum (L.) Griff) memiliki alkaloid dan flavonoid yang bersifat antioksidan untuk mengurangi radikal bebas.Tujuan: Mengetahui pengaruh ekstrak daun wungu (Graptophyllum pictum (L.) Griff) terhadap kadar malondialdehid darah pada tikus Wistar yang diinduksi aloksan.Metode: Desain percobaan menggunakan post-test only control group design. Penelitian ini menggunakan tikus wistar jantan sebanyak 24 ekor yang dibagi menjadi 6 tikus setiap kelompok. Kelompok kontrol negatif diberikan aloksan, kelompok perlakuan 1, kelompok perlakuan 2, dan kelompok perlakuan 3 diberikan ekstrak daun wungu dengan dosis 50, 100 dan 200 mg/kgBB peroral kemudian kadar glukosa darah diperiksa untuk memastikan bahwa tikus sudah diabetes melitus. Setelah tikus diabetes melitus, dilakukan tindakan tiap kelompok. Pada hari ke-14 tikus diambil data kadar malondialdehid darahnya. Data diuji dengan uji normalitas Saphiro-Wilk. Pada penelitian ini data terdistribusi normal (p>0.05) sehingga dilakukan uji ANOVA kemudian dilakukan uji post-hoc. Hasil: Didapatkan penurunan kadar MDA darah pada tikus yang diberikan daun wungu. Hasil signifikan didapatkan antara kelompok perlakuan 3 dengan kelompok kontrol negatif dan kelompok perlakuan lainnya. Kesimpulan: Daun wungu dengan berbagai dosis dapat menurunkan kadar malondialdehid darah pada tikus DM.

PERBEDAAN RIWAYAT PENYAKIT TIROID TERDAHULU, METASTASIS DAN ABNORMALITAS PEMERIKSAAN ULTRASONOGRAFI ANTARA PASIEN KARSINOMA TIROID PAPILER KLASIK DAN VARIAN FOLIKULER DI RSUP Dr. KARIADI SEMARANG Firdauzi Putri, Nabila Zenska; Istiadi, Hermawan; Wikanta, Edmond Rukmana; Miranti, Ika Pawitra
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Papillary thyroid carcinoma (PTC) is the most common carcinoma, accounting for more than 90% of all malignancies, where the most variants are classic papillary thyroid carcinoma and follicular variant papillary thyroid carcinoma (PTCVF). The characteristics of previous thyroid disease history, regional metastases, and ultrasound examination results can influence the clinical examination between the two variants of PTC, namely classic PTC and PTCVF. Aim: Understanding the differences in the history of previous thyroid disease, metastases, and ultrasound examination abnormalities between Classical Papillary Carcinoma and Follicular variants at Dr. Kariadi Hospital, Semarang. Methods: A cross sectional study with consecutive sampling method in classic PTC and PTCVF patients in Dr. Kariadi Hospital, Semarang who was diagnosed in the period January to June 2019. In this study, the number of samples obtained was 18 medical records with classic PTC cases and 20 medical records with PTCVF cases. The dependent variables, namely history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities, all of which were on an ordinal scale, were analyzed using non-parametric chi-square test and Fisher's Exact test. Results: In the non-parametric chi-square test and Fisher's Exact test, the results were not significant (p = 0.474), regional metastases were not significant (p = 0.359), ultrasound size abnormalities were not significant (p = 0.323), and abnormalities. ultrasound nodal was not significant (p = 0.595). Conclusion: There was no statistically significant difference in the history of previous thyroid disease, regional metastases, and ultrasound examination abnormalities between classic PTC and PTCVF patients at Dr. Kariadi Hospital, Semarang.

PERBEDAAN USIA, UKURAN MAKROSKOPIS TUMOR, DAN PROFIL HORMON ANTARA PASIEN KARSINOMA TIROID PAPILER KLASIK DAN VARIAN FOLIKULER DI RSUP DR KARIADI SEMARANG Nabila, Alin; Istiadi, Hermawan; Wikanta, Edmond Rukmana; Miranti, Ika Pawitra; Puspasari, Dik
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: New cases of Papillary Thyroid Carcinoma and Carcinoma patients at Dr. Kariadi Hospital, Semarang is quite high, where the most types are Classical Papillary Thyroid Carcinoma and Follicular Variant Papillary Thyroid Carcinoma. On the other hand, in diagnosing PTC, histopathological examination which is a gold standard sometimes has a subjective value. Therefore, it is necessary to have a correlation with the clinical characteristics of the patient in order to get a correct diagnosis. Aim: Understanding the differences in age characteristics, tumor macroscopic size and hormone profile between Classical Papillary Thyroid Carcinoma and Follicular Variant patients at Dr. Kariadi Hospital, Semarang. Method: Analytic observational research with cross sectional design. The number of samples was 38 medical records in which 18 cases of Classic Papillary Thyroid Carcinoma and 20 cases of Follicular Variant Papillary Thyroid Carcinoma. Data with a nominal scale, namely age were analyzed using the Fisher exact test, while the data with a numerical scale, namely the macroscopic size of the tumor and the hormone profile, were tested for normality of Saphiro Wilk then continued with the Mann-Whitney test. Result: Based on the Fisher exact test, there was significant difference (p = 0,009) between age characteristics and Classical Papillary Thyroid Carcinoma and Follicular Variant. In the Mann-Whitney test there was no significant difference (p = 0.3) between the macroscopic size of the classical papillary carcinoma and follicular variant and there was no significant difference TSHs (p = 0.501) and fT4 (p = 0.953) hormone profiles between Classic Papillary Thyroid Carcinoma and Follicular Variants. Conclusion: There was significant difference between the characteristics of age at diagnosis, and there was no significant difference between the macroscopic size of the tumor and the hormonal profile of Classical Papillary Carcinoma and Follicular Variants in Dr. Kariadi Hospital, Semarang.

GAMBARAN HISTOPATOLOGI KULIT TIKUS WISTAR PADA PERIODE DEKOMPOSISI TERHADAP SUHU UDARA YANG BERBEDA Elim, Marlion Anthonius; Rohma, Intarniati Nur; Haryanto, Julia Ike; Istiadi, Hermawan
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

LATAR BELAKANG : Salah satu tujuan pemeriksaan forensik pada jenazah adalah menentukan perkiraan waktu kematian. Perubahan pada tubuh manusia setelah mati dapat berkontribusi dalam penentuan waktu kematian, namun hal ini cukup sulit bila kondisi jenazah sudah memasuki tahap pembusukan. Banyak metode telah dikembangkan untuk penentuan waktu kematian secara kuantitatif. Jaringan kulit merupakan bagian paling luar dari tubuh manusia yang juga mengalami perubahan setelah kematian sehingga dapat digunakan sebagai petunjuk waktu kematian tanpa melakukan insisi yang luas pada tubuh. TUJUAN : Penelitian ini bertujuan untuk mengetahui pengaruh suhu udara yang berbeda pada periode dekomposisi terhadap gambaran histopatologi kulit tikus wistar. Periode dekomposisi yang dipakai adalah 24, 48 dan 72 jam. Suhu yang dipakai adalah suhu rata-rata di kota Semarang tahun 2019 yaitu pada suhu 180C, 280C dan 390C. METODE : Penelitian analitik deskriptif dengan pendekatan ekperimental menggunakan kulit tikus wistar sebagai sampel. Sampel kemudian di analisa secara Patologi Anatomi dengan pewarnaan HE, dilihat epidermis, dermis, folikel rambut dan kelenjar sebasea dalam 5 lapang pandang besar untuk melihat derajat kerusakan menurut Carsana (0-5), kemudian dikategorikan menjadi kategori ringan, sedang dan berat. Data kemudian diolah dengan SPSS for windows versi 15. HASIL : Perbadingan derajat kerusakan histopatologi kulit pada periode dekomposisi 24, 48 dan 72 jam terhadap suhu udara memberikan hasil yang signifikan dengan nilai p<0,05. Demikian juga dengan hasil uji kelompok suhu dibandingkan dengan periode dekomposisi memberikan hasil yang signifikan pada suhu 280C dan 390C. KESIMPULAN : Penelitian ini menunjukan peningkatan suhu udara dan periode dekomposisi berbanding lurus dengan gambaran kerusakan histopatologi kulit.

Correlation Between Testosterone Level With HBA1C Level As Glycemic Control Marker Among Type 2 Diabetes Mellitus Patient Halim, Fenny; Listiana, Devia Eka; Karlowee, Vega; Istiadi, Hermawan; Prasetyo, Awal; Astuti, Meira Dewi Kusuma
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.959

BACKGROUND: Helicobacter pylori is classified as a grade 1 carcinogen by the International Agency for Research on Cancer. Identification of Helicobacter pylori infection is crucial for the prevention of malignancy. Immunohistochemistry is more specific and sensitive than modified Giemsa because it based on the antigen- antibody binding so it can exclude other organisms. However, it can be expressed in all species of Helicobacter genus. OBJECTIVE: To compare the identification methods of Helicobacter spp in stomach biopsy between modified Giemsa and immunohistochemistry. METHOD: This research was a cross-sectional study. There were 64 biopsies taken by simple random sampling. They consisted of 32 positive and 32 negative Helicobacter spp based on the interpretation of modified Giemsa. Statistical analysis using x2 test. RESULT: The number of atypical Helicobacter spp was 42.%. The number of samples that received Proton Pump Inhibitor (PPI) therapy was 93.75%. Helicobacter spp was positive in 31 samples and negative in 33 samples based on the interpretation of immunohistochemistry staining. There was no significant difference (p=0.617) between the identification results of Helicobacter spp using immunohistochemistry compared to the Modified Giemsa at both 400x and 1000x magnification. CONCLUSION: Modified Giemsa is still reliable for identifying Helicobacter spp, especially in classical form, compared to immunohistochemistry. Due to the administration of PPI, there are a lot of cases with atypical form of Helicobacter spp which can be differentiated into coccoid form and intraepithelial located. Immunohistochemistry staining is useful in identify these cases.

Comparing the Pulmonary-Spirometry In Laboratory Workers Who Wear Acchadana® and KN95® Masks Nurkholis, Fathur; Ariani, Resti; Prasetyo, Awal; Puspita`, Rina; Sadhana, Udadi; Miranti, Ika Pawitra; Istiadi, Hermawan
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1076

BACKGROUND : The upper respiratory tract is susceptible to inflammation caused by exposure to airborne contaminants, particularly chemical irritants. Inhaled irritant gases can lead to various symptoms and adverse reactions in the respiratory tract. Laboratory workers are at a high risk of respiratory tract inflammation due to exposure to volatile chemicals. The use of personal protective equipment (PPE), such as masks, is essential to prevent inflammation and protect the respiratory tract. Lung function tests using spirometry, including Forced Vital Capacity (FVC), Forced Expiratory Volume in One Second (FEV1.0), and Peak Expiratory Flow (PEF), can help identify abnormalities in lung function. AIMS : The primary objective of this investigation is to juxtapose the pulmonary conditions of laboratory workers before and after the utilization of KN95® masks and Acchadana® masks. METHOD : The study design was a Randomized Control Trial, and the subjects were divided into two groups: the control group wearing KN95 masks and the treatment group wearing Acchadana® herbal masks. Spirometry measurements were taken before and after using the masks, and statistical analysis was conducted to compare the results. RESULT : The results showed that both mask groups experienced improvements in lung function parameters after using the masks. However, the KN95 mask group showed better lung conditions compared to the Acchadana® mask group. CONCLUSION : Spirometry tests conducted on lab workers revealed improved lung function metrics (including FVC, FEV1.0, and PEF) following the usage of KN95 masks and Acchadana® herbal masks. The KN95 mask users exhibited superior respiratory health compared to the other group in this investigation.

Co-Authors Almaz, Ayyasi Izaz Anna Mailasari kusuma Dewi Ardiani, Zefania Regina Arga Purlina Wijayanti Ariani, Resti Arianto, Adi Arief Wildan Arief Wildan, Arief Arinta Puspita Wati, Arinta Puspita ARNILA NOVITASARI Astika Widy Utomo Astuti, Meira Dewi Kusuma Astuti, Ratih Kusuma Awal Prasetyo Darmawati Ayu Indraswari Devia Eka Listiana, Devia Eka Dharma, Andhika Guna Dik Puspasari, Dik Dwi Pudjonarko Eka Yudhanto Elim, Marlion Anthonius Elnitiarta, Jasmine Excelinda, Tifanni Fauzi, Muhammad Iqbal Fifin Luthfia Rahmi Firawan, Kurnia Nisa Putri Firdauzi Putri, Nabila Zenska FRANSISKA BANJARNAHOR Hadi Hadi Halim, Fenny Halleyantoro, Ryan Hamidiyah, Silpi Haryanto, Julia Ike Ida Ayu Putu Sri Widnyani Ignatius Riwanto, Ignatius Ika Pawitra Miranti Ika Pawitra Miranti Ilham, Dimas Muhammad Intan Rahmania Eka Dini Jenifer Marsela Tarius Jessica Yolanda Hadisusanto Kanti Yunika Karlowee, Vega Kesumayadi, Irfan Kusuma, Ira Anggar Maftikhati, Dora Maharani Maharani Maharani, Maharani Margareth, Ezra Meita Hendrianingtyas Muniroh, Muflihatul Nabila, Alin Neni Susilaningsih Nugroho, Trilaksana Nuh Gusta Ady Yolanda Nurkholis, Fathur Oedijani Santoso Prabowo, Erik Purnawati, Ratna Dama Puspita`, Rina Rahmi, Fifin L Retnoningrum, Dwi Riski Prihatningtias Riski Prihatningtias, Riski Rizqa Wahyuni Rohma, Intarniati Nur RR. WIDYASTUTI PASPARINI Sadana, Aqsa Aufa Syauqi SALMAH ALAYDRUS Saubig, Arnila Novitasari Selamat Budijitno Sudarmanto, Alif Muhammad Trilaksana Nugroho Trimahendra, Alfin Ihza Tun Paksi Sareharto Udadi Sadhana, Udadi Utami, Asih Ratna Widodo Sarjana AS, Widodo Widyarini, Andriati Nadhilah Wikanta, Edmond Rukmana Yan Wisnu Prajoko Yora Nindita

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