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All Journal HAYATI Journal of Biosciences Archive of Community Health Buletin Udayana Mengabdi E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia Indonesian Journal of Cancer Syntax Literate: Jurnal Ilmiah Indonesia Media Kesehatan Politeknik Kesehatan Makassar JPSCR : Journal of Pharmaceutical Science and Clinical Research ISM (Intisari Sains Medis) : Jurnal Kedokteran Open Access Indonesian Journal of Medical Reviews Indonesian Journal of Cancer Journal of Global Pharma Technology Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Indonesian Journal of Biomedicine and Clinical Sciences
I Gusti Ayu Artini
Bagian Farmakologi Fakultas Kedokteran, Universitas Udayana
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Effect of Stevia (Stevia rebaudiana Bertoni) Leaf Extract Cream on Transforming Growth Factor-β1 Levels and Collagen Amount in the Skin of Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Febrina, Jessica; Muliarta, I Made; Wahyuniari, Ida Ayu Ika; Sumadi, I Wayan Juli; Linawati, Ni Made; Artini, I Gusti Ayu
HAYATI Journal of Biosciences Vol. 33 No. 2 (2026): March 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.2.435-444

Abstract

Ultraviolet B (UVB) exposure is a major cause of skin aging, leading to collagen degradation and wrinkles due to free radical damage. Stevia (Stevia rebaudiana Bertoni) has antioxidant properties that may counteract this by preserving Transforming Growth Factor-β1 (TGF-β1), essential for collagen synthesis. This study evaluated the effects of stevia leaf extract cream on TGF-β1 and collagen levels in male Wistar rats. Thirty rats were divided into five groups: K0 (no UVB, no cream), K1 (base cream), P1 (2.5% stevia cream), P2 (5% stevia cream), and P3 (10% stevia cream). Groups K1, P1, P2, and P3 were exposed to a cumulative UVB exposure of 840 mJ/cm2 over four weeks. The TGF-β1 levels measured by ELISA did not differ significantly among groups (p>0.05). However, collagen levels, assessed using Picro Sirius Red staining, varied significantly (p<0.05). The K1 exhibited significantly lower collagen compared to K0 (p=0.003), whereas the P2 group effectively prevented collagen degradation compared to K1 (K1: 65.87% vs. P2: 77.92%; p = 0.005). While stevia leaf extract cream did not prevent TGF-β1 reduction, it demonstrated a clear protective effect against UVB-induced collagen loss. Among the tested concentrations, 5% stevia leaf extract cream was the most effective in preserving dermal Collagen, highlighting its potential as a topical agent for preventing photoaging and maintaining skin structural integrity.
The Effect of Flaxseed (Linum usitatissimum) Ethanol Extract on LDL Cholesterol Levels and Foam Cell Number in the Aorta of Male Wistar Rats (Rattus norvegicus) Fed A High-Fat and High-Fructose Diet Marcella, Marzha; Wihandani, Desak Made; Artini, I Gusti Ayu; Sumadi, I Wayan Juli; Dwipayana, I Made Pande; Sriwidyani, Ni Putu
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.100142

Abstract

A diet high in saturated fat and fructose leads to dyslipidemia, increasing atherosclerosis risk. Although lipid-lowering medications are available, they have certain limitations. Flaxseed, rich in ALA, lignans, and phytosterols, may improve lipid profiles and act as an antioxidant. This study evaluated the effectiveness of flaxseed in preventing LDL cholesterol elevation and aortic foam cell formation in male Wistar rats fed a high-fat, high-fructose (HFHF) diet.This actual experimental study used a post-test-only control group design for 35 days. Twenty-five male Wistar rats were randomly assigned to five groups: N (normal control, standard diet), K (negative control, HFHF diet), and three treatment groups (P1, P2, P3, HFHF diet) receiving flaxseed ethanol extract at doses of 200, 400, and 800 mg/kgBW/day. LDL cholesterol levels (mg/dL) and aortic foam cell counts (cells/HPF) were measured. Data were analyzed using Shapiro-Wilk and Levene tests for normality and homogeneity, followed by one-way ANOVA, Kruskal-Wallis, and Tukey-HSD post hoc tests. LDL cholesterol levels in groups N, P1, P2, and P3 were significantly lower than in group K (p = 0.007), with P2 showing the most significant inhibition (p = 0.035). Foam cell counts were lower in treatment groups than in group K (p = 0.257), but no significant differences were found among them. Flaxseed (Linum usitatissimum) ethanol extract at 400 mg/kgBW/day was the most effective in preventing an increase in LDL cholesterol. However, the extract at all three doses was ineffective in preventing an increase in aortic foam cells in male Wistar rats (Rattus norvegicus) fed an HFHF diet.
Co-Authors Agung Nova Mahendra Agung Wiwiek Indrayani Anak Agung Gede Eka Septian Utama Ari Wibawa Arina Papita Simanungkalit Cokorda Istri Ajeng Prameswari Desak Ketut Ernawati Desak Made Wihandani Dewi, Anak Ayu Nyoman Trisna Narta Dharmajayanti, Ida Ayu Laksmi Diksha, I Gusti Ngurah Ariestha Satya Dinda Paramaningtyas Sudibya Fatimah S, Sitti Febrina, Jessica Gede Denny Wiradarma Gede Parta Kinandana Grudug, Kadek Agastya Widya Sedana I Dewa Gede Alit Kamayoga I Gusti Ayu Agung Anindya Maharani I Gusti Ayu Eka Arirahmayanti I Gusti Made Aman I Gusti Made Gde Surya Chandra Trapika I Kadek Dwi Putra Diatmika I Made Jawi I MADE MULIARTA . I Made Niko Winaya I Made Pande Dwipayana I Nyoman Adi Putra I Wayan Adi Pranata I Wayan Juli Sumadi I.A.A. Widhiartini Ida Ayu Citra Ratnasari Ida Ayu Eka Pradnya Paramita Dewi Paramita Dewi Ida Ayu Ika Wahyuniari Kadek Meitri Ariyantini Kadek Novi Anggreni Kartiga Silvaraju M Widnyana Made Aditya Prawira Arthawan Made Ayu Nadine Indira Surya Made Cindy Widya Murthi Made Hendra Satria Nugraha Made Satria Ambarsika Made Virgo Baharirama Marcella, Marzha Nabila Putri Rachmawati Negara, Anak Agung Gede Angga Puspa Ni Komang Artini Yanti Ni Komang Ayu Juni Antari Ni Luh Nopi Andayani Ni Made Linawati Ni Putu Devi Purnamayanti Ni Putu Sriwidyani Ni Wayan Mira Resdiani Ni Wayan Tianing Nila Wahyuni Pande Putu Karina Candra Putu Aditya Mahardika Putu Ayu Sita Saraswati Putu Ayunia Laksmita Putu Diah Saraswati Rahayu Putu Yunita Primasari Rizki Mega Aprilia Saputri, Desi Mevlana Theresia Fitri Hakna Sihombing Trapika, I Gusti Made Gde Surya Chandra Winaya, I Made Nico Wuga, Kristina Supartin Monika