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All Journal Hemera Zoa POROS TEKNIK The Indonesian Biomedical Journal Sari Pediatri Universa Medicina Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Jurnal Kreativitas PKM Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL KESEHATAN BHAKTI HUSADA Bioscientia Medicina : Journal of Biomedicine and Translational Research COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat eJournal Kedokteran Indonesia Makara Journal of Health Research Folia Medica Indonesiana
Ahmad Aulia
Department Of Histology, Faculty Of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PCS-5 Nitric Oxide Induced Basal Cell Hyperplasia and Lamina Propria Elongation in Rat Gastroesophageal Junction Tena Djuartina; Bambang Pontjo Priosoeryanto; Ari Fahrial Syam; Ahmad Aulia; Tri Isyani Tungga Dewi
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

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Abstract

NO (Nitric Oxide) is an inorganic compound composed of nitrogen and oxygen, NO is also produced in various places on various types of mammalian cells. NO as a radical compound is important in mediating physiological and pathological events in mammals including humans [1].GEJ (gastroesophageal junction) is a transition zone between the surface of esophagus which is covered by stratified squamous epithelium to the gastric mucosa which consists of simple columnar epithelium (z-line), where circular muscle of esophagus fuse with oblique muscle and lipid layer of the gaster. At the lower part of GEJ, there is the lower esophageal sphincter (LES) that not only allow food to move into stomach and works as an exit passage of the gas, but also inhibit reflux of any substances that potentially can cause harm to the esophagus [2].Petersson et al, found that chronic exposure to cytotoxic levels of NO can cause inflammation, intestinal metaplasia and neoplasia. Although it is known that gastric acid, pepsin and bile acids can cause adenocarcinoma of distal esophagus and GEJ, NO exposure and nitrosative stress role in this phenomenon is yet to be fully understood and further study is needed [3].The purpose of this was to identify and compare the histopathological changes occurring in GEJ in relation to administration of physiological concentration of nitrate dissolved in HCl and ascorbic acid. As such, the animal model used in this study can be used to study and represent the changes microscopically, because obtaining a full thickness biopsy from a human subject can be difficult to perform.
Co-Authors . Iskandarsyah Adiningsih Srilestari Ahani, Ardhi Rahman Amirulloh , Muhamad Ari Fahrial Syam Aria Kekalih Asrinda, Indria Bambang Pontjo Priosoeryanto Banifade, Fadlil Malik Barasila, Atikah Chalida Budi Wiweko Chandra, Inria Christina Simadibrata Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Cosphiadi Irawan Fasha, Iqbal Fitriani, Elies Goenarjo, Roman Hakim, Al Rasyid Maulana Hasan Mihardja Imelda Rosalyn Sianipar Irena Ujianti Jeanne Adiwinata Pawitan Jusman, Sri Widia Azraki Lailan Safina Nasution Lestari, Novi Lina Marlina Makkiyah, Feda Anisah Melva Louisa Mila Maidarti Mohamad Sadikin Murti Andriastuti, Murti Murti, Krishna Aditya Natalia, Zellah Fransisca Neng Tine Kartinah Almuktabar Ni Ken Ritchie, Ni Ken Nimas Ayu Nirwanti Nur Aditya, Robby Nurhadi Ibrahim Patwa Amani, Patwa Prathita, Yana Aurora Puspita Eka Wuyung Radiana Dhewayani Antarianto Sabita, Rifqi Salim Harris, Salim Santoso, Dewi Irawati Soeria Sarifudin sarifudin, Sarifudin Simadibrata, Christina Lanny Sophie Yolanda Sudaryat , Sudaryat Suratih, Ni Made Desy Tena Djuartina, Tena Tri Isyani Tungga Dewi Tyas, Nike Estu Renaning Viventius, Yoshua Wahyunia Likhayati Septiana Wahyuningsih Djaali Widyaprastuti, Hermin Yani, Sri