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All Journal PAUD Teratai Microbiology Indonesia Medical Journal of Indonesia The Indonesian Biomedical Journal Paediatrica Indonesiana Eksakta : Berkala Ilmiah Bidang MIPA Majalah Kedokteran Andalas Jurnal Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat The New Ropanasuri Journal of Surgery Jurnal Kesehatan Tambusai eJournal Kedokteran Indonesia Makara Journal of Science MEDICINUS The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Hewan Jurnal Penyakit Dalam Indonesia Journal of Clinical Microbiology and Infectious Diseases
Anis Karuniawati
Departemen Mikrobiologi Klinik, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia – RSUPN Dr. Cipto Mangunkusumo, Jakarta
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Third-Generation cephalosporins (3GC) and Fluoroquinolones (FQ) Co-Resistance in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli (ESBL-Ec) from Clinical and Community Isolates Febrianti, Tati; Puspandari, Nelly; Karuniawati, Anis
EKSAKTA: Berkala Ilmiah Bidang MIPA Vol. 24 No. 04 (2023): Eksakta : Berkala Ilmiah Bidang MIPA (E-ISSN : 2549-7464)
Publisher : Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Negeri Padang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24036/eksakta/vol23-iss04/462

Abstract

The growing AMR issue affects the current antimicrobial therapy recommendations, particularly for broad-spectrum antibiotics, like third-generation cephalosporins (3GC) and fluoroquinolones (FQ). Actually, the inappropriate use of both antibiotics in clinical and community settings increase the resistance of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-Ec). Although ESBL-Ec is used as a surveillance indicator of bacterial resistance, but currently studies related to 3GC-FQ co-resistance among clinical and community (including human and wastewater samples) based ESBL-Ec isolation, have not been widely carried out. The objective of this study was to analyze the possibility and mechanism of 3GC-FQ co-resistance among ESBL-Ec, in human clinical and communal isolates from previous published research. Out of 257 articles screened, four studies in accordance with our study are included in the analysis. The result indicated that ESBL-Ec derived from all sample sources had 3GC-FQ co-resistance. According to two studies reviewed, blaCTX-M was the most predominant ESBL gene, while the FQ-associated resistant gene dominated by qnr family genes. Resistant genes and co-resistant ESBL-Ec can be spread rapidly through plasmids.
Genotypic pattern of fluoroquinolone resistance among extended-spectrum beta-lactamase-producing Escherichia coli Febrianti, Tati; Puspandasari, Nelly; Febriyana, Dwi; Weaver, Tom; Karuniawati, Anis
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247544

Abstract

BACKGROUND Fluoroquinolone (FQ) is one of the therapeutic options for treating extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (ESBL-Ec) infection, but its use could increase the resistance level of ESBL-Ec. This study aimed to analyze the resistant genes responsible for ESBL production and FQ resistance among the ESBL-Ec isolated from healthy humans and communal wastewater. METHODS This was an observational study using stored isolates and laboratory data. Genome sequencing was done on 43 E. coli DNA isolates before resistance genes, mutations, and high-risk clones were examined through bioinformatic data analysis. RESULTS The analysis of 39 ESBL-Ec isolates showed ESBL genes, including blaCTX-M-55 (56%), blaCTX-M-15 (31%), and blaCTX-M-27 (8%). ESBL-Ec isolates exhibited mutations in gyrA (54%), gyrB (0%), parC (28%), and parE (10%). Plasmid-mediated quinolone resistance genes detected included qnrS1 (54%), qnrS13 (13%), qnrB2 (3%), aac(6’)-Ib-cr5 (3%), qepA (0%), and oqxAB (0%). ESBL and FQ resistance genes were simultaneously detected in 33 ESBL-Ec isolates, with high-risk clones identified as ST155, ST10, ST23, ST38, ST131, and ST69 Cplx. CONCLUSIONS ESBL and FQ resistance genes were simultaneously detected in ESBL-Ec isolated from healthy humans and communal wastewater.
Respiratory Syncytial Virus (RSV): Virologi, Patogenesis, Respon Imun, dan Vaksin Pada Dewasa Resti H. Lestari; Fariz Nurwidya; Anis Karuniawati
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/n0vpzd50

Abstract

Respiratory syncytial virus (RSV) is classified within the Pneumoviridae family, genus Orthopneumovirus. RSV is a single-stranded, negative-sense RNA virus and has two genotypes, A and B. It is primarily associated with lower respiratory tract infections, including bronchiolitis and bronchopneumonia, and is a common cause of hospitalization in infants, elderly individuals, and immunocompromised patients. RSV also has the potential to become systemic infection. Symptoms of RSV infection, such as fever, cough, sore throat, and runny nose, are usually mild in adults. However, in some cases, especially for specific high-risk individuals, the infection can become severe enough to require hospitalization, and complications may lead to death. Understanding the pathogenesis and immune response to RSV are crucial for recognizing the virus’s effects and potential risks. This literature review covers the virology, pathogenesis, immune response, and recent advancements in RSV vaccine development in adult populations. Comprehensive knowledge of RSV is essential for developing effective prevention and treatment strategies.
DETEKSI BRUCELOSIS PADA SUSU SAPI DENGAN UJI POLYMERASE CHAIN REACTION (PCR) M. Noor, Susan; Sudharmono, Pratiwi; Kusumawati, Asmarani; Karuniawati, Anis
Jurnal Kedokteran Hewan Vol 9, No 1 (2015): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v9i1.2795

Abstract

Penelitian ini bertujuan mendeteksi brucelosis pada sampel susu sapi dengan uji polymerase chain reaction (PCR) dan membandingkan tingkatsensitivitas dan spesifisitasnya dengan metode milk ring test (MRT). Sebanyak 24 sampel susu sapi yang dikoleksi secara aseptik dari lapang diuji PCR dan MRT. Hasil pengujian menunjukkan bahwa 79,17% (19/24) sampel susu positif brucelosis dengan uji PCR dan 83,33% (20/24) dengan uji MRT. Sensitivitas dan spesifisitas PCR mendeteksi brucelosis masing-masing sebesar 75 dan 100% dibandingkan dengan uji MRT.
PERBANDINGAN ANTARA MESIN SEMI-OTOMATIS UNTUK UJI KEPEKAAN ANTIBIOTIK KOLISTIN DENGAN BROTH MICRODILUTION SEBAGAI BAKU EMAS Fitriah, Laela; Hasanah, Lili; Maretti, Nadia; Karuniawati, Anis
Jurnal Kesehatan Tambusai Vol. 6 No. 4 (2025): DESEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i4.34532

Abstract

Kolistin merupakan salah satu antibiotik pilihan terakhir yang efektif melawan infeksi bakteri Gram-negatif yang resisten terhadap semua antibiotik. Uji kepekaan antibiotik kolistin saat ini masih menjadi tantangan, karena tidak ada metode pengujian yang terstandar. Tujuan studi ini adalah  membandingkan mesin semi otomatis penguji kepekaan antibiotik kolistin (yang diwakili oleh mesin Vitek®2) dengan broth microdilution (BMD) sebagai baku emas. Metode Penelusuran artikel dilakukan di tiga pangkalan data yaitu Pubmed, Wiley dan Scopus sesuai dengan pertanyaan klinis. Skrining artikel menggunakan kriteria inklusi, mengecek kelengkapan artikel, serta membaca artikel keseluruhan untuk mendapatkan artikel yang sesuai. Artikel dinilai kualitasnya berdasarkan validitas, kepentingan dan aplikabilitas.  Hasil dari penelusuran didapatkan lima artikel dari database dan artikel dari google scholar tidak didapatkan artikel yang memenuhi kriteria eligibilitas. Sehingga telaah kritis dilakukan pada kelima artikel tersebut. Hasil telaah pada 3 artikel tersebut adalah Essential agreement (EA) < 90% dan Categorical agreement (CA) > 90%. Artikel lainnya menyebutkan ketidak-konsistenan hasil uji pada isolat E. coli dan K. pneumoniae. Nilai VME didapatkan pada kelima studi dianggap kurang baik pada uji kepekaan menggunakan mesin semi otomatis. Kesimpulan dari penelitian ini ialah pemeriksaan uji kepekaan kolistin dengan metode semi otomatis tidak dapat dijadikan pemeriksaan alternatif uji kepekaan kolistin karena  kurang sesuai dengan hasil yang didapatkan dengan metode BMD.
PEMERIKSAAN MIKROBIOLOGI PADA ASPERGILOSIS PULMONAL Sari, Rifta; Arfan, Ahmad; Karuniawati, Anis; Haryanto, Budi
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.54309

Abstract

Aspergilosis pulmonal merupakan infeksi jamur oportunistik yang disebabkan oleh Aspergillus spp. dan memiliki spektrum klinis luas, mulai dari bentuk alergi, kronik, hingga invasif yang mengancam jiwa. Peningkatan jumlah pasien imunokompromais, penyakit paru kronis, serta penggunaan kortikosteroid jangka panjang berkontribusi terhadap meningkatnya insidensi aspergilosis paru. Diagnosis penyakit ini masih menjadi tantangan karena gejala klinis dan temuan radiologis sering tidak spesifik serta menyerupai penyakit paru lain, seperti tuberkulosis dan keganasan paru. Artikel ini bertujuan untuk mengkaji secara komprehensif pemeriksaan mikrobiologi pada aspergilosis pulmonal, meliputi pemeriksaan mikroskopis langsung, kultur jamur, identifikasi spesies, uji kepekaan antijamur, pemeriksaan serologi, serta deteksi molekuler. Metode yang digunakan adalah studi kepustakaan dengan pendekatan deskriptif naratif terhadap literatur ilmiah nasional dan internasional sepuluh tahun terakhir. Hasil kajian menunjukkan bahwa pemeriksaan mikrobiologi memegang peranan penting dalam menunjang diagnosis aspergilosis pulmonal, namun harus diinterpretasikan bersama data klinis dan radiologis untuk membedakan kolonisasi, kontaminasi, dan infeksi aktif. Cairan bronchoalveolar lavage (BAL) merupakan spesimen terbaik untuk berbagai metode diagnostik. Kombinasi pemeriksaan kultur, serologi, dan biomarker jamur seperti galaktomanan dapat meningkatkan akurasi diagnosis dan membantu penatalaksanaan yang tepat.
Co-Authors . Andriansjah Ade Dharmawan Amalia Almira Amarila Malik Amin Soebandrio Andi Annisa Rusyda Khafiyani Andi Yasmon Andra Aswar Andra Aswar, Andra Angky Budianti Anwar S. Ibrahim Aprilia Rakhmawati Ardiana Kusumaningrum Arfan, Ahmad Ari Fahrial Syam Ari Prayitno Aria Kekalih Aryo Tedjo Asmarani Kusumawati Asmarani Kusumawati Augustine Natasha Aulia Rizki Bachti Alisyahbana Badriul Hegar Badriul Hegar Bambang Madiyono Budi Haryanto Burhanuddin Iskandar Ceva W. Pitoyo Chairunissa T. Rizal Cleopas Martin Rumende Cleopas Martin Rumende Delly Chipta Lestari Delly Chipta Lestari Delly Chipta Lestari Delly Chipta Lestari Delly Chipta Lestari Dimas Seto Prasetyo Dwiana Ocviyanti E. Risdiyani Em Yunir Em Yunir, Em Erwin Christian Susanto Esthika Dewiasty Esthika Dewiasty, Esthika Falasiva, Rezyta Fariz Nurwidya Febrianti, Tati Febriyana, Dwi Fitriah, Laela Futihati Ruhama Zulfa Gestina Aliska Gortap Sihotang Hana Paraswati Putri Handaya, Adeodatus Y. Hasanah, Lili Hindra Irawan Satari Ida Parwati Ika Ningsih Indah S. Widyahening Iswanto, J. Joyce Bratanata Joyce Bratanata, Joyce Kambang Sariadji Khie Chen Kuntjoro Harimurti Linosefa Linosefa Lucky Hartati Moehario Manuel Lamberto Willem Mboeik Martin Hartiningsih Mboeik, Manuel Lamberto Willem Muhammad K Azwar, Muhammad K Mulya Rahma Karyanti, Mulya Rahma Mulyadi M. Djer Muziasari, Windi Nabila Maudy Salma Nadia Maretti Nasution, Safruddin Nelly Puspandari Nie Nie Nina Dwi Putri Nuraini I Susanti Permatasari, Tri Wijayanti Pratama Wicaksana Pratiwi Pujilestari Sudarmono Pratiwi Sudharmono Pratiwi Sudharmono, Pratiwi Prawoto Prawoto Prawoto Prawoto Pujilestari, Ratih Purwantyastuti Purwantyastuti Puspandasari, Nelly Rakhmawati, Aprilia Resti H. Lestari Reynaldo Reynaldo Reynaldo Reynaldo, Reynaldo Rezyta Falasiva Riamin Sitorus Rianto Setiabudi, Rianto Rida Tiffarent Rosdiana Irawati Rudyanto Sedono Rudyanto Sedono Rudyanto Sedono, Rudyanto S. Nilawati Santya Fatma Dewi Sari Wiraswasty Sari, Rifta Saunar, Rofy S. Shindy Claudya Aprianti Simanjuntak, Glory Gelarich Sitorus, Truly Panca SJATHA, FITHRIYAH Subari A. Riyanto Sudigdo Sastroasmoro Sukman T. Putra Sunarno Sunarno Susan M. Noor Susan M. Noor, Susan Susan Maphilindawati Noor Susanti, Nuraini I Susanti, Nuraini I Susanto, Erwin Christian Sweety Pribadi SYADZA RHIZKY PUTRI AKHMAD T. M. Sudiro Teguh Harjono Karjadi Teguh Harjono Karjadi, Teguh Harjono TETSUHIRO MATSUZAWA Thomas Robertus Tjampakasari, Conny Riana Toar J.M. Lalisang TOHRU GONOI Tony Loho Trisni U Dewi, Trisni U Truely Panca Sitorus Usman, Nurhayat Weaver, Tom Wia Melia Windi Muziasari Yefta Moenadjat Yeva Rosana Yulia R. Saharman Yulia Rosa Saharman