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All Journal JURNAL GIZI INDONESIA Media Penelitian dan Pengembangan Kesehatan Acta Interna : The Journal of Internal Medicine Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Medical Journal of Indonesia Jurnal NERS Indonesian Journal of Biotechnology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Universa Medicina JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Gizi Klinik Indonesia Journal Of Nursing Practice Indonesian Journal of Rheumatology JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Pedagogi dan Pembelajaran Nutrisia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Media Farmasi Indonesia Berita Kedokteran Masyarakat Journal of Tropical Pharmacy and Chemistry

Nyoman Kertia

Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan, Universitas Gadjah Mada, Yogyakarta

Author-ID : 297573

Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Impulsivity and novel object recognition test of rat model for vascular cognitive impairment after antipsychotics treatment Ronny T Wirasto; Irwan Supriyanto; Arif Prassetyo; Nunu N Madjid; Susini R Sari; Baiq R Rhadianaa; Heru Yulianto; Nur Arfian; Nyoman Kertia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 48, No 3 (2016)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACTVascular cognitive impairment (VCI) is a common condition in which no standard treatment has been approved. VCI is often accompanied by behavioral problems which require psychiatric interventions. The common therapeutic agent used for the acute management is antipsychotic injections. Current findings showed that atypical antipsychotic possess better safety profile for treating behavioral problems related to VCI compared to typical antipsychotic. In this study, we induced VCI in Sprague Dawley rats between 6-8 weeks old using bilateral carotid communist artery occlusion technique. The subjects were divided into 4 treatment groups: sham, olanzapine, haloperidol, and risperidone groups. Subjects received intramuscular injections of subsequent drugs for 3 days post VCI induction. Impulsive behavior and object recognition were examined using cliff jumping test and novel object recognition test. The analyses results showed that impulsive behavior was lower in the olanzapine and haloperidol groups compared to sham group, although it was not statistically significant (p = 0.651). The results also showed that there were no significant differences in the time spent exploring old and novel objects in all groups (p = 0.945;0.637 respectively). In conclusion, antipsychotic injection might not be effective to control impulsive behavior post VCI induction.

Studi pharmacovigilance obat di puskesmas X Yogyakarta mustika muthaharah; Dyah Aryani Perwitasari; Nyoman Kertia
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACTÂ The increasingÂ use of herbal medicine in community also increase adverse event and toxicity report. Adverse events and toxicity can be detected with pharmacovigilance system. Adverse Drug Reaction (ADR) of herbal medicines are rarely studied in Indonesia. With the increasing use of herbal medicines in Indonesia, pharmacovigilance studies are necessary to detect the incidence of ADR. The purpose of this study is to describe the incidence of ADR on the use of herbal medicines. This research is a descriptive study using retrospective data. Research was conducted for 3 months by taking 10-month retrospective data backward using medical record. Interviews were conducted to identify the occurrence of ADR and assessment of quality of life using Naranjo algorithm.The result showed that three (13.63%) of 22 patients experiencing the ADR with probability of probable categories (1) and possible (2). The symptom of ADR that showed was the increased frequency of defecation, decreased in stool consistence and diuresis.The results of this study concluded that there are ADR event in patients who have been prescribed herbal medicine in Public Health Center X Yogyakarta.Â Keywords: ADR, herbal medicine, pharmacovigilance.

Studi Pharmacovigilance Obat Herbal Di Puskesmas Kasihan II Bantul Nur Mahdi; Dyah Aryani Perwitasari; Nyoman Kertia
Media Farmasi: Jurnal Ilmu Farmasi Vol 13, No 1: Maret 2016
Publisher : Universitas Ahmad Dahlan

Kejadian Reaksi Obat yang Tidak Dikehendaki (ROTD) dari obat-obat herbal merupakan hal yang masih jarang diteliti di Indonesia. Gaya hidup kembali ke alam menjadi cukup popular saat ini, sehingga masyarakat kembali memanfaatkan berbagai bahan alam, termasuk pengobatan dengan tumbuhan obat atau herbal. Dengan meningkatnya penggunaan obat herbal di Indonesia, maka diperlukan pemantauan keamanan pada obat-obat herbal.Â Tujuan penelitian ini adalah mengetahui gambaran kausalitas kejadian ROTD serta mengetahui kualitas hidup pasien yang mendapatkan resep obat herbal. Penelitian ini menggunakan rancangan observasional deskriptif, pengambilan data secara consecutive sampling secara prospektif. Pengambilan data selama dua bulan saat penelitian berlangsung, setelah itu dianalisis kejadian ROTD dan tanpa ROTD serta dinilai kualitas hidup pasien. Instrumen yang digunakan untuk menganalisis adalah algoritma Naranjo dan kuesioner SF-36. Hasil wawancara kepada 25 subyek penelitian pada pengamatan prospektif dan retrospektif, subyek yang melaporkan adanya kejadian ROTD sebanyak 3 subyek (12%). Sebanyak 2 subyek dengan kategori possible (mungkin) dan 1 subyek dengan kategori probable (cukup mungkin). ROTD yang muncul adalah gatal-gatal, nyeri pinggang, mual, ngantuk dan dada berdebar. Kesimpulan dari penelitian ini adalah terdapat kejadian ROTD pada pasien yang diberikan terapi herbal, gambaran kausalitas kejadian ROTD adalah kategori possible dan probable.Â Kata kunci: pharmacovigilance, reaksi obat yang tidak dikehendaki, obat herbal.

PENGARUH KOMBINASI EKSTRAK TEMULAWAK, JAHE, KEDELAI DAN KULIT UDANG TERHADAP FUNGSI HATI DAN GINJAL DIBANDINGKAN DENGAN NATRIUM DIKLOFENAK PADA PENDERITA OSTEOARTRITIS Nyoman Kertia; Nastiti Hemas M.; Dewa Ayu G. N.
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Objectives To evaluate the effect of Curcuma xanthorrhyza Roxb extract, ginger, soybean and shrimp shell in combination compared to diclofenac sodium to liver and kidney function of patients with osteoarthritis. Methods twenty one subjects randomly allocated to different groups (Trial and control = diclofenac group). The trial group were treated by the combination of 50 mg temulawak extract, 100 mg ginger, 50 mg soybean and 100 mg shrimp shell three times daily while the control groupwere treated by 25 mg diclofenac sodium three times daily for a couple of week. Blood sample was obtained before and after two weeks therapy to determine the liver enzymes SGOT and SGPT and also serum ureum and creatinin in order to monitor the kidney function. The study was a prospective randomized open end blinded evaluation (PROBE). Result both trial and diclofenac group show significantly increase of SGOT levels (p<0.05) but the difference change among these groups are not significant (p=0.312). In the trial group there was decreasing of SGPT level (p=0.871) whereas there was an increase in level of SGPT in diclofenac group (p=1.000) although the difference between these two was not statistically significant (p=0.912). The change of serum ureum and creatinin level were not significantly different in trial group compared to diclofenac (p>0.05). In the trial group there was decreasing of serum ureum level although not significant (p=0.214). Both trial and diclofenac group showed no statistically significant increasing of creatinin serum levels (p>0.05). Conclusion there is no statistically difference effect between using the combination of temulawak extract, ginger, soybean and shrimp shell compared to diclofenac sodium toward liver and kidney function of osteoarthritis patients during this two weeks treatment.

Effects of Centella asiatica L. Capsul on Muscle Disfunction on Elderly People I Dewa Putu Pramantara; Nyoman Nyoman Kertia; Mae Sri Hartati Wahyuningsih; Nur Arfian
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pegagan (Centella asiatica L) has been traditionally used to treat wounds, disordered nerve system, blood circulation, and prevent muscle disorders. Extract of Pegagan was considered safe and non-toxic as the acuut and chronic toxicity tests on male SD rats were not significant. It meant that further study was potential to be proceeded. Study of C.asiatica on muscle function of the elderly has not been done, therefore this study is aimed to observe effects of C.asiatica extract on muscle masses, holding hands, walking speed (4.57 meter), walking test (6 minutes), and Time Up and Go test of the elderly. This study is designed for clinical double blind study with 2 groups of people, these are C. asiatica (18 people) treated with capsul (550 mg C. asiatica extract/day for 90 days) and placebo (17 people). This study is performed in the RSUP Dr. Sardjito hospital at the geriatric division. Subjects for this study were healthy elderly people and fit with the criteria of subjects for experiment. Result of the study, muscle masses do not decrease and all the measurements are not different with that of placebo. Except that the walking speed (6 minutes) of the treated subjects is better than that of the placebo. The conclusion of the study, the capsul containing C. asiatica extract (550 mg, once a day for 90 days) increases the strengh of hands holding, and the walking test (6 minutes) almost twice better than that of the placebo although the muscle masses does not increase significantly.

Antiinflamatory and antidepressive activities of Extract Curcuma xanthorrhiza Roxb in Systemic Lupus Erythematosus Maria Caecilia Setiawati; Zulies Ikawati; I Nyoman Kertia
Indonesian Journal of Pharmacy Vol 28 No 3, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Systemic Lupus Erythemathosus is an autoimmune, inflammatory, chronic disorder characterized by multiorgan system involvement. Depression and anxiety are frequent complaints among patients with lupus erythematosus, so antidepressive treatment should be an important element of the therapy of patients with lupus erythematosus. Research into curcumin’s potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. 4-weeks double-blind, placebo-controlled clinical trial was conducted in 14 SLE patients (10 as treatment group and 4 as control group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration was measured in the serum subjects before and after treatment. Correlation between TNF α concentration and BDI was assessed. After 4 weeks treatment, the TNF α concentration from subjects in treatment group were significantly lower than before ( p <0.001) but the BDI score were not significantly lower than before (p = 0.059). The TNF α concentration and BDI score showed positive correlation, p = 0,024. This study demonstrate that Curcuma xanthorrhiza Roxb extract can decrease serum TNF α concentration and reduce clinically symptoms of depression in SLE patients

SIDE EFFECTS MONITORING OF TEMULAWAK RHIZOME, GINGER, SOYBEAN AND SHRIMP SHELL EXTRACTS IN COMBINATION COMPARED TO DICLOFENAC SODIUM IN OSTEOARTHRITIS PATIENTS Haslinda Haslinda; Nyoman Kertia; Arif Nurrochmad
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 3, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.98

Non-steroidal anti-inflammatory drugs such as diclofenac sodium were common drug given worldwide to reduce pain in osteoarthritis. The long-term used of diclofenac sodium side effects was on liver, kidney, gastrointestinal and other organs. The earlier study result have shown the effectiveness of the combination of temulawak rhizome extract, ginger, soy and shrimp shells in osteoarthritis patients. This third phase of clinical study purpose was to monitor the side effects of temulawak rhizome, ginger, soybean and shrimp shells extract in combination compared to diclofenac sodium in patients with osteoarthritis. Forty seven patients with knee osteoarthritis diagnosed by American College of rheumatology criteria were included in this study. This subject were devided randomly into two groups to receive either the combination of temulawak rhizome 100 mg, ginger 100 mg, soy 50 mg and shrimp shells 50 mg extract (n=23) or diclofenac sodium 25 mg (n = 24) three times a day orally for 14 days. The side effect that were monitored were side effect that appear in the gastrointestinal organs, cardiovascular, central nervous system and other organs for 14 days therapy and laboratory tests of SGOT, SGPT, creatinin serum, urea, hemoglobin, leukocytes and platelets were performed before and after 14 days. Chi-Square test were used to evaluate the side effects and independent t test or Mann-Whitney tests were used to evaluate changes of levels of SGOT, SGPT, serum creatinine, serum urea, hemoglobin, leukocytes and platelets before and after intervention. Percentage of side effects on the gastrointestinal organs, cardiovascular, central nervous system and other organs in combination of ginger rhizome 100 mg, 100 mg of ginger, 50 mg of soy and 50 mg of shrimp shell extract group was not significantly different compared to diclofenac sodium 25 mg. SGPT activity in trial group was decrease significantly (p <0.05) compared to diclofenac sodium 25 mg but no significant difference in liver function (SGOT), kidney function (creatinine and urea), and bone marrow function (hemoglobin, leukocytes, and platelets).Keywords: Osteoarthritis, combination of temulawak rhizome, ginger, soy and shrimp shells, diclofenac sodium, side effects, liver function, kidney function and bone marrow.

Perubahan kadar hemoglobin akibat terapi kurkuminoid ekstrak rimpang kunyit dibandingkan natrium diklofenak pada penderita osteoartritis Nyoman Kertia; Ahmad Husain Asdie; Wasilah Rochmah; Marsetyawan Marsetyawan
Jurnal Gizi Klinik Indonesia Vol 7, No 3 (2011): Maret
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.17756

Background: In general, patients with osteoarthritis require long live treatments, especially anti-infammatory drugs. Non steroidal anti infammatory drugs are mostly follow by some side effects such as dyspepsia and gastrointestinal bleeding. The use of natural medicine for rheumatic diseases have commonly been practiced worldwide.Objectives: To learn the changes of hemoglobin level due to treatment with curcuminoid from Curcuma domestica Val. rhizome extract compared to diclofenac sodium as anti-infammatory agent for the treatment of osteoarthritis.Methods: This research is a prospective randomized open end blinded evaluations (PROBE). Patients treated with 30 mg curcuminoid from Curcuma domestica Val. rhizome extract or 25 mg diclofenac sodium three times daily for 4 weeks respectively.The hemoglobin level was checked before and after treatment. Results: A total of 80 patients with knee osteoarthritis participated in this study. There was no signifcant difference in the frequency of sex, educational level, duration of suffering, percentage of co-morbidities in both groups. There was no signifcant different of hemoglobin level before treatment between both treatment group. The hemoglobin level was increase signifcantly in curcuminoid treatment groups while no signifcant change in diclofenac group. Treatment with curcuminoid increasing the hemoglobin level signifcantly compare to diclofenac sodium (p=0.03).Conclusion: Treatment with curcuminoid from Curcuma domestica Val. rhizome increasing the hemoglobin level signifcantly compare to diclofenac sodium treatment for osteoarthritis.

Status gizi berhubungan positif dengan derajat nyeri sendi penderita osteoartritis lutut Nyoman Kertia
Jurnal Gizi Klinik Indonesia Vol 8, No 3 (2012): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18210

Background: Knee osteoarthritis (OA) is a common disorder that is associated with significant morbidity, disability, and medical costs, particularly in its advanced stages. While the cause of knee OA remains unclear, it has been associated with various risk factors, such as age, sex, genetic predisposition, biomechanical, and obesity. Pain in osteoarthritis occurs due to combination of various factors. Pain significantly increases the medical and non medical cost in OA. Data showed that obesity will increase the mechanical stress and pain of knee OA. However, uncertainty remains regarding potential relationship between body mass index (BMI) and pain in osteoarthritis. Moreover, since obesity is one of modifiable and preventable risk factors for the onset and progression of the disease, it is important to know the correlation between BMI and severity of pain in knee OA.Objectives: To investigate the relationship between body mass index and severity of joint pain in knee osteoarthritis.Methods: A cross sectional study was conducted and subjects were osteoarthritis patients in rheumatology clinic of Sardjito general hospital. Body mass index and visual analogue scale (VAS) score were measured. Correlation between BMI and VAS score were analyzed by bivariate correlation test.Results: There were 80 patients with osteoarthritis who participated in the study. Mean BMI was 26.36 +4.23 kg/m2 and VAS score was 52.40+24.53 mm. The correlation test showed that there was a positive but non significant correlation between BMI and VAS scores (r = 0,11; p = 0,33).Conclusion: There was a positive but non significant correlation between body mass index and the severity of joint pain in knee osteoarthritis.

Status ketersediaan makanan dan status gizi ibu sebagai faktor risiko kegemukan pada anak prasekolah Yunita Indah Prasetyaningrum; Nyoman Kertia; I Made Alit Gunawan
Jurnal Gizi Klinik Indonesia Vol 13, No 2 (2016): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.23291

Background: Childhood obesity is a strong predictor of adult obesity incidence and can increase risk factors for getting chronic diseases. The causes of obesity are multifactor, determined by genetic and food environment changes. Risk factors believed to be the cause of obesity are home food availability status and maternal obesity.Objective: To analyze the risk of home food availability status and maternal obesity to obesity in preschool children aged 3-5 years. Method: This study was a matched case-control study. The case of this study was obese preschool children (Z-score WHZ > 2 SD) and control of this study was non-obese preschool children (Z-score WHZ -2 ≤ SD ≤ 2). Control group was taken by an age and gender matching with the case group. Based on the nutritional status screening result of 53 early childhood education (ECD) schools on 13 sub-districts in Kota Yogyakarta, there were 101 obese children and 101 non-obese children. Those schools were chosen by cluster sampling method and PPS (Probability Proportional to Size). Besides, information about home food availability status and maternal obesity was collected using questionnaire. The data were analyzed using McNemar test and conditional logistic regression. Results: Home food availability status (OR = 1.85; p=0.03; 95% CI=1.08-3.16) and maternal obesity (OR=2.5; p=0.003; 95% CI=1.37-4.55) were the most dominant risk factor related to the incidence of obesity in preschool children aged 3-5 years.Conclusion: Home food availability status and maternal obesity significantly increase the risk for getting obese in preschool children aged 3-5 years.

Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achadiono, Deddy Achadiono, Dedy Nurwachid Agus Setiyono Ahmad Husain Asdie Ahmad Husain Asdie Ahmad Husain Asdie Arif Nurrochmad Arif Prassetyo Arina Syarifa Fadlilah Asdie, Achmad Husain Ayu Paramaiswari Ayu Paramaiswari Baiq R Rhadianaa Bambang Udji Djoko Rianto Bambang Udji Djoko Riyanto, Bambang Udji Djoko Cleopas Martin Rumende Danang ., Danang Deddy Nur Wachid Deddy Nur Wachid Achadiono Deddy Nur Wachid Akhadiono Deddy Wachid Achadiyono Dewa Ayu G. N. Dewa Ayu G. N., Dewa Ayu Dyah Ariani Perwitasari Dyah Aryani Perwitasari Ema Madyaningrum Endang Mahati Eny Catur, Eny F, Melani Farah Nuriannisa Gede Kambayana Gunawan, I Made Alit Hangga Harinawantara Harry Isbagio Haslinda Haslinda Haslinda Haslinda, Haslinda Heru Yulianto I Dewa Putu Pramantara I Made Alit Gunawan I Made Alit Gunawan Ika Puspitaningrum Imono A.D., Imono Indwiani Astuti Irwan Supriyanto Kartyanto, Adhita Khasana, Tri Mei Krishnan, P N Lily Arsanti Lestari Lisnawati Rachmadi M. Marsetyawan Mae Sri Hartati Wahyuningsih Maria Caecilia Nanny Setiawati Maria Caecilia Setiawati Marsetyawan -, Marsetyawan Marsetyawan Marsetyawan Marsetyawan Marsetyawan Mohammad Robikhul Ikhsan Mufrod ., Mufrod Mustika Muthaharah mustika muthaharah Mustika Muthaharah muthaharah, mustika N. Setiawati, M. Caecilia Nastiti Hemas M. Nastiti Hemas M., Nastiti Hemas Nugroho, Dhite Nunu N Madjid Nur Arfian Nur Mahdi Nurrochmad, Arif P N Krishnan Poerwono Rahardjo Pratiwi, Woro Rukmi Probosuseno Probosuseno Probosuseno Probosuseno, Probosuseno Rianto Setiabudy Rochmach, Wasilah Ronny T Wirasto Sinarta, Armin SRI SETIYARINI, SRI Srinalesti Mahanani, Srinalesti Sugeng Sugeng Supanji, Supanji Susini R Sari Tri Mei Khasana W.N., Meika Wachid, Deddy Nur Wasilah Rochmah Wasilah Rochmah Wasilah Rochmah Wibowo, Suryo Anggoro Kusumo Widhiarta, Putu Raka Wiwekananda, Ketut Shri Satya Wiwin Lismidiati Yogiswara, Komang Satvika Yolanda Dyah Kartika Yuliani, Kartika Yulyani Werdhiningsih Z, Ikawati Zulies Ikawati

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