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All Journal Medical Journal of Indonesia Journal of Dentistry Indonesia Paediatrica Indonesiana Molecular and Cellular Biomedical Sciences (MCBS) Alami Journal (Alauddin Islamic Medical) Journal Majalah Kedokteran Andalas Majalah Patologi Indonesia Indonesian Journal of Cancer eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Ening Krisnuhoni
Department Of Anatomic Pathology, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Journal of Dentistry Indonesia

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Oral Hairy Leukoplakia: Clinical Indicator of an Immunosuppressive Condition and Challenges in Patient Management Agustina, Yohana Alfa; Wardhany, Indriasti Indah; Wimardhani, Yuniardini Septorini; Krisnuhoni, Ening; Iamaroon, Anak
Journal of Dentistry Indonesia Vol. 23, No. 2
Publisher : UI Scholars Hub

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Abstract

Oral hairy leukoplakia (OHL) is defined as an asymptomatic white patch with vertical corrugation pattern the lateral borders of the tongue, that is associated with Epstein-Barr Virus (EBV) infection. Generally, it is related to immunosuppressive condition found in HIV-positive patients and patients undergoing immunosuppressive therapy. Sometimes, its clinical appearances could mimic other white lesions. Although most OHL cases are found in HIV seropositive individuals, finding in the immunocompetent individuals has also been reported. Appropriate clinical evaluations and laboratory investigations are important for patient’s comprehensive management. Objective: To report a finding of oral hairy leukoplakia as a clinical indicator of an immunosuppressive condition in otherwise a clinically healthy-looking individual and to discuss the challenges on patient management. Case Report: A 40 yearold man presented with asymptomatic, bilateral homogenous white hyperkeratotic plaques with a hairy appearance located on the dorsal of the tongue, extended to the lateral tongue mucosa. The patient failed to remember the lesion’s first appearance, until three weeks before a visit. Working diagnosis of OHL was made with differential diagnoses including white sponge nevus, leukoplakia and oral lichen planus. Histopathological assessment was consistent with OHL. Challenges on patient management include identifying possible risk factors and assuring patient for HIV testing. Conclusion: This case reported findings of OHL as the first clinical indicator of immunosuppressive condition that might be related to HIV-infection.
Co-Authors Abdul Aziz Rani Abdul Aziz Rani Abdullah, Arman Adel ACHMAD FAUZI Achmad Fauzi Adang Bachtiar Agustina, Yohana Alfa Ahmad Aulia Jusuf Ahmad Soefyani Alan R. Tumbelaka Alif Gilang Perkasa Ari Fahrial Syam Arie Permata Warastridewi Arman Adel Abdullah Aru W. Sudoyo Ary H. Reksodiputro Arya Govinda Badriul Hegar Bethy Hernowo Chudahman Manan Chudahman Manan Chyntia Olivia Maurine Dadang Makmun Dadang Makmun Daldiyono Daldiyono Daldiyono Daldiyono Daldiyono Hardjodisastro Darmawan Kartono David Handojo Muljono Devy Serevina Dewantoro, Okto Dhuhani, Ika Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Diah Rini Handjari Dyonesia Ary Harjanti Eka Susanto Elisabeth Indria Sari Elisabeth Indria Sari Erni Erfan, Erni Esti DS Soetrisno Farida Briani Sobri Fili Sufangga Flora Dameria Handayani, Liza Handjari, Diah R. Hanifah Oswari Hutapea, Yuliance Nurhawati I Gusti Ayu Sri Mahendra Dewi I Made Gotra Iamaroon, Anak Ifransyah Fuadi Ifransyah Fuadi, Ifransyah Indriasti Indah Wardhany Irsan Hasan Irwina Eka Deraya Iskandar, Rizka Puteri Jelita Inayah Sari Juwita Cresti Rahmaania Kaka Renaldi Kharia Utia Kuntjoro Harimurti Kusmardi Kusmardi Kusmardi Kusmardi Kusmardi Suid Lia Mulyani Liem, Isabella Kurnia Liza Handayani Lugyanti Sukrisman Lydia D Simatupang Lydia Kencana Manatar, Amelia Fossetta Marcellus Simadibrata Marcellus Simadibrata Marini Stephanie Marini Stephanie Marini Stephanie Marini Stephanie Murdani Abdullah Murdani Abdullah Murdani Abdullah Nafrialdi Nafrialdi Nelly Tandiari Ni Putu Ekawati Nita Afriani Nunung Ainur Rahmah Nur Rahadiani Nur Rahadiani Nur Rahadiani Nur Rahadiani Nurdin, Wildawati Nurjati C Siregar Okto Dewantoro Paskarani, Putu Erika Patria Wardana Yuswar Paulus Kusnanto Primariadewi Rustamadji Prisscila, Jessica Puspita Eka Wuyung Puspita Eka Wuyung Puspita Eka Wuyung Rabbinu Rangga Pribadi Rahadiani, Nur Rahmaania, Juwita Cresti Reni Oktavina Ria Kodariah Ria Kodariah Rino Alvani Gani Rino Alvani Gani Rino Alvani Gani Rizka Puteri Iskandar Santoso Cornain Santoso Cornain Sari, Elisabeth Indria Saut Horas Hatoguan Nababan Seruni Tyas Khairunissa Sobri, Farida Briani Sonar Soni Panigoro Sufangga, Fili Tandiari, Nelly Velma Herwanto Velma Herwanto Vera Yuwono Welly Hartono Ruslim Wildawati Nurdin Wirasmi Marwoto Wirasmi Marwoto Wiwit Ade Fidiawati Yonathan, I Wayan Murna Yuniardini Septorini Wimardhani Yuswar, Patria Wardana Zakiyah Zakiyah