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All Journal International Journal of Electrical and Computer Engineering IAES International Journal of Artificial Intelligence (IJ-AI) Jurnal Teknologi Dan Industri Pangan Jurnal Pustakawan Indonesia ComEngApp : Computer Engineering and Applications Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences TELKOMNIKA (Telecommunication Computing Electronics and Control) Jurnal Ilmu Komputer dan Agri-Informatika Jurnal Ilmiah Kursor Biogenesis: Jurnal Ilmiah Biologi Jurnal Teknologi Informasi dan Ilmu Komputer Journal of ICT Research and Applications International Journal of Advances in Intelligent Informatics Indonesian Journal of Biotechnology Seminar Nasional Informatika (SEMNASIF) Sosio Konsepsia Khazanah Informatika: Jurnal Ilmu Komputer dan Informatika Jurnal Teknologi dan Sistem Komputer Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi Jurnal Penelitian Pendidikan IPA (JPPIPA) Kinetik: Game Technology, Information System, Computer Network, Computing, Electronics, and Control ILKOM Jurnal Ilmiah Jurnal Nasional Pendidikan Teknik Informatika (JANAPATI) Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika Jurnal Jamu Indonesia Journal of Electronics, Electromedical Engineering, and Medical Informatics VISI PUSTAKA: Buletin Jaringan Informasi Antar Perpustakaan JURNAL Al-AZHAR INDONESIA SERI SAINS DAN TEKNOLOGI Indonesian Journal of Electrical Engineering and Computer Science Nusantara Science and Technology Proceedings Bioinformatics and Biomedical Research Journal Jurnal Pustakawan Indonesia Jurnal Nasional Teknik Elektro dan Teknologi Informasi J-Icon : Jurnal Komputer dan Informatika Indonesian Journal of Jamu
Wisnu Ananta Kusuma
Department Of Computer Science, Faculty Of Mathematics And Natural Sciences, IPB University, Jl Meranti Kampus IPB Dramaga, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Sistem Berbasis Pengetahuan Tumbuhan Obat Pusat Studi Biofarmaka Fazriani, Aini; Kusuma, Wisnu Ananta; Batubara, Irmanida
Jurnal Jamu Indonesia Vol. 4 No. 1 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i1.88

Abstract

Jamu terdiri atas berbagai macam tumbuhan obat yang diolah. Tumbuhan obat memiliki kandungan senyawa metabolit sekunder yang berperan sebagai khasiat. Pengetahuan tumbuhan obat beserta senyawanya perlu dikembangkan lagi menjadi pengetahuan eksplisit yang lebih spesifik dan mudah dimengerti sehingga berguna untuk masyarakat. Maka dari itu perlu mengembangkan sistem untuk digunakan oleh masyarakat sehingga pengobatan dengan tanaman obat lebih populer di kalangan masyarakat luas. Penelitian yang dilakukan mengenai manajemen pengetahuan berbasis ontologi terkait dengan tumbuhan obat dan senyawa. Penelitian ini menggunakan pendekatan proses manajemen pengetahuan model SECI, selain itu pengembangan ontologi menggunakan metode Ontology building life cycle, sedangkan bahasa representasi yang digunakan adalah Resource Description Framework (RDF) dan Web Ontology Language (OWL) dengan toolsProtégé5.0. Pengembangan model ontologi dengan bahasa representasi RDF/OWL dapat menghasilkan pengetahuan dengan melakukan query menggunakan SPARQL. Hasil query tersebut dapat digunakan untuk diimplementasikan pada mobile.
Identification of Java Tea Adulteration by Babadotan and Tekelan using Machine Learning Ary Prabowo; Wisnu Ananta Kusuma; Annisa; Mohamad Rafi
Jurnal Jamu Indonesia Vol. 7 No. 3 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i3.273

Abstract

Java Tea (Orthosiphon aristatus) is a common herbal medicinal plant that functions as a health treatment and treats various diseases. The high demand for Java Tea causes high prices and a decrease in the amount of medicinal plant raw materials, causing various quality control problems such as the content of various bioactive components and adulteration from babadotan and tekelan. So far, the detection of adulteration has been carried out by various analyzes, including chemical analysis and statistical methods to process data. The data used is of high dimension with a very high-density level, thus causing difficulties in classification. The mixed data of Orthosiphon aristatus consists of 1201 features with a total sample of 216. This study uses a Random Forest (RF) method with a total of 100 trees, and the RF method is combined with the Recursive Feature Elimination (RFE) method. In the RF and RFE that can be produced, the optimum value for the number of features is 244. The experimental evaluation results revealed that the proposed method could achieve a high accuracy of 81.82% in identifying Orthosiphon aristatus.
Identification and Analysis of Potential Breast Anticancer Agents in Pogostemon Cablin through Network Pharmacology Azzahra, Syarifah Fathimah; Harnelly, Essy; Subianto, Muhammad; Kusuma, Wisnu Ananta; Sari, Widya
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.7049

Abstract

Breast cancer is one of the highest known causes of death in Indonesia, especially for women. Pogostemon cablin Benth is one of the Aceh's endemic herbal plants that has been studied to have potential such as anti-inflammatory, antiproliferative, antioxidant, antimicrobial, and proapoptotic. Network pharmacology approach was conducted to explore and analyze the potential of P. cablin as an anti-breast cancer. P. cablin plant compounds were obtained from GCMS and breast cancer genes data were obtained from OMIM, GeneCard, and DisGeNet databases. Target proteins and pathways involved were identified using STRING-DB and Metascape. Network analysis was performed using Cytoscape. A total of 65 plant compounds with 554 target proteins and 1854 disease genes were obtained. Based on the results of combining protein targets using Venn diagrams, 138 overlapping proteins between drug compounds and breast cancer disease targets were identified. Based on KEGG and GO analysis, P. cablin is known to have potential in breast cancer treatment/therapeutic mechanisms. Based on the "compound-protein target-pathway" multi-target mechanism, pogostol; 1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, [1ar-(1aα,4aα,7β,7aβ,7bα)]-; 3-Hexen-1-ol, 2,5-dimethyl-, acetate, (Z)-, 5β,7βH,10α-Eudesm-11-en-1α-ol; Acetic acid, 3-hydroxy-6-isopropenyl-4,8a-dimethyl 1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl ester; and Humulenol-II interacts with proteins that play a significant role in breast cancer, which are MAPK1, EGFR, TNF, AKT1, and JAK2. Hence, it can be concluded that P. cablin has good potential to be a source of therapeutic treatment against breast cancer. However, it needs to be tested clinically to further determine the effects of this P. cablin compound.
Ontology Data Modeling of Indonesian Medicinal Plants and Efficacy Afifa, Rizky Maulidya; Kusuma, Wisnu Ananta; Annisa, Annisa
INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi Vol 6 No 2 (2022): August 2022
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/intensif.v6i2.17987

Abstract

People use medicinal plants for as early prevention and treating disease. Medicinal plants must be careful not to cause side effects, so knowledge is needed. Medicinal plant knowledge is stored using an ontology data model. In some ontology studies, there are still shortcomings in managing information, namely the absence of a relationship between scientific terms related to medicinal plants and phrases already known to the public. Hence, it is necessary to have this relationship. In other studies, there is no information related to disease protein, so this research also develops ontologies to enrich knowledge about medicinal plants and their efficacy. Based on the results, the developed ontology test can build a relationship between scientific terms of therapeutic pants and phrases that are known to the public. The public also knows which proteins affect a disease, so public knowledge about medicinal plants is getting wider.
Co-Authors Abdul Aziz Abdul Rahman Saleh Adrianus, Albert Afifa, Rizky Maulidya Agus Buono Ahmad, Tarmizi Aini Fazriani Aisah Rini Susanti Alami, Tegar Ali Djamhuri Annisa Annisa Annisa , Annisa Annisa Annisa Annisa Annisa Annisa Annisa Annisa Annisa Anton Suryatama Arini Aha Pekuwali Arini Pekuwali Arwan Subakti Ary Prabowo Ary Prabowo Auliatifani, Reza Auliya Ilmiawati Auriza Rahmad Akbar Azizah, Norma Nur Azzahra, Syarifah Fathimah Badollahi Mustafa Badrut Tamam Bahrul Ulum Budi Tjahjono Dahrul Syah Diah Handayani Dian Indah Savitri Dian Kartika Utami Essy Harnelly Fadli , Aulia Fahrury Romdendine, Muhammad Farhan Ramadhani , Hilmi Farit Mochamad Afendi Farohaji Kurniawan Fatriani, Rizka Fazriani, Aini Firman Ardiansyah Ginoga, Muh Fadhil Al-Haaq Halida Ernita Handayani, Vitri Aprilla Handayani, Vitri Aprilla Hanifah Nuryani Lioe Hardi, Wishnu Hasibuan, Lailan Sahrina Hendra Rahmawan Hendra Rahmawan Hera Dwi Novita Heru Sukoco Imas Sukaesih Sitanggang Indra Astuti Ira Maryati Irfan Wahyudin Irma Herawati Suparto Irman Hermadi Irmanida Batubara Irvan Lewenusa ISKANDAR ZULKARNAEN SIREGAR Isnan Mulia Janti G. Sudjana Jaya Sena Turana Joni Prasetyo Kana Saputra S Kangko, Danang Dwijo Karlisa Priandana Khaydanur Khaydanur Khaydanur, Khaydanur Laela Wulansari Larasati Larasati Lina Herlina Tresnawati Listina Setyarini Lusi Agus Setiani M. Rafi Maggy T. Suhartono Mala Nurilmala Medria Kusuma Dewi Hardhienata Mohamad Rafi Mohamad Rafi Mohamad Rafi Mohammad Romano Diansyah Mohammad Romano Diansyah Muchlishah Rosyadah Muhammad Asyhar Agmalaro Muhammad Subianto Mulyati Mulyati Mushthofa Muttaqin, Muhammad Rafi Nasution, Tegar Alami Nengsih, Nunuk Kurniati Norma Nur Azizah Nunuk Kurniati Nengsih Nur Choiriyati Nurdevi Noviana Ovi Sofia Pramita Andarwati Prihasuti Harsani Priyo Raharjo Pudji Muljono Purnajaya, Akhmad Rezki Purnomo, Tsania Firqin Ramadhanti, Nabila Sekar Ramdan Satra Ratu Mutiara Siregar Refianto Damai Darmawan Refianto Damai Darmawan Resnawati Reza Auliatifani Rif’ati, Lutfah Ronald Marseno Rosy Aldina Rosyadah, Muchlishah Rudi Heryanto SATRIYAS ILYAS Septaningsih, Dewi Anggraini Siti Syahidatul Helma Sony Hartono Wijaya Sri Nurdiati SUHARINI, YUSTINA SRI Sulistyo Basuki Sulistyo Basuki Supriyanto, Arif Syahid Abdullah Syarifah Aini Syukriyansyah Taufik Djatna Toni Afandi Tsania Firqin Purnomo Usman, Muhammad Syafiuddin Wa Ode Rahma Agus Udaya Manarfa Wahjuni, Sri Widya Sari Wijaya, Eko Praja Hamid Wina Yulianti Wishnu Hardi Wulansari, Laela Yandra Arkeman Yessy Yanitasari Yudhi Trisna Atmajaya Yulianah Yulianah Yunita Fauzia Achmad Zulkarnaen, Silvia Alviani