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All Journal Pharmaciana: Jurnal Kefarmasian Prosiding Indonesian Journal of Chemistry CARADDE: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Serambi Abdimas Jurnal Pengabdian Masyarakat Bangsa Molekul: Jurnal Ilmiah Kimia Fokus Bisnis: Media Pengkajian Manajemen dan Akuntansi Indonesian Journal of Chemical Science JURNAL REKAYASA KIMIA & LINGKUNGAN
Undri Rastuti
Jurusan Kimia, Fakultas MIPA Universitas Jenderal Soedirman
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Phytochemicals and toxicity of ketapang fruit flesh (Terminalia catappa. Linn) using the BSLT method Senny Widyaningsih; Mochamad Chasani; Undri Rastuti; Umi Salamah
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.064 KB) | DOI: 10.12928/pharmaciana.v12i3.22219

Abstract

Ketapang is widely used in traditional medicine. Parts of ketapang plant, such as roots, leaves, and bark, are known to have biological activities such as antioxidant, antimicrobial, anti-inflammatory, and anticancer. However, no biological activity has been reported on the flesh of the ketapang fruit. This research was conducted to obtain phytochemicals and toxicity information of ketapang fruit flesh as an anticancer medicine. Toxicity indicates the potential for a chemical compound to cause damage to living organisms, while phytochemicals indicate a group of compounds that have biological activity. Extraction of ketapang fruit flesh was carried out using various solvents, both polar and non-polar solvents, methanol, n-hexane, and ethyl acetate. The toxicity test used the Brine Shrimp Lethality Test (BSLT) method, while phytochemicals tests used the thin layer chromatography (TLC), in which identification of bioactive compounds of ketapang pulp extract used UV-Visible and FTIR spectroscopy. The results showed that the ketapang fruit flesh extract was toxic to Artemia salina Leach shrimp larvae. The most toxic was ethyl acetate extract, with an LC50 value was 17,171 ppm. The phytochemicals screening showed that ethyl acetate extract of the ketapang fruit flesh contained flavonoid, alkaloid, phenolic, terpenoid, and saponin compounds. Tracing using UV-Vis shows the presence of conjugated double bonds which refer to flavonoid compounds, as well as the IR spectrum which indicates the presence of a typical functional group of flavonoid compounds.
Analisis Rantai Nilai (VCA) Budidaya Tanaman Nilam dengan Pemodelan System Thinking Vensim PLE x 32 Sutarmin Sutarmin; Undri Rastuti
Fokus Bisnis Media Pengkajian Manajemen dan Akuntansi Vol. 21 No. 2 (2022): Fokus Bisnis
Publisher : LP3M Universitas Putra Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32639/fokbis.v21i2.180

Abstract

Indonesia merupakan negara yang kaya akan sumber daya, baik sumber daya mineral maupun sumber daya hayati. Salah satu sumber daya hayati Indonesia adalah dihasilkannya nilam yang merupakan bahan baku utama minyak atsiri nilam. Industri minyak nilam Indonesia memiliki potensi yang sangat besar, namun pengembangan industri ini berjalan lambat. Hal ini disebabkan oleh berbagai permasalahan yang berasal dari lingkup industri minyak atsiri sendiri. Salah satu permasalahan dari industri inVai adalah tidak stabilnya bahan baku. Penelitian ini bertujuan untuk memetakan aktifitas budidaya tanaman nilam melalui pemodelan kualitatif dengan menggunakan software vensim PLE x 32. Dengan pemodelan tersebut dapat diketahui bahwa aktifitas utama dalam budidaya nilam terdiri dari 8 aktivitas utama, yaitu (1) Penyiapan tenaga kerja, (2) Penyiapan bibit, (3) Penyiapan lahan, (4) Penanaman, (5) Pemeliharaan, (6) Pemupukan, (7) Pemanen dan (8) Penjualan kepada pengepul bahan atau UKM pemilik penyulingan minyak daun nilam.
FORMULATION AND NANOEMULSION OF NUTMEG ESSENTIAL OIL (Myristica fragrans Houtt.) AND SUNSCREEN ACTIVITY TEST USING UV-VIS SPECTROPHOTOMETRY Sheiliyani, Cindy; Hidayat, Arif Nur; Rastuti, Undri; Chasani, Moch; Diastuti, Hartiwi
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 5 No. 2 (2023): Juli - Desember 2023
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v5i2.7871

Abstract

Nutmeg essential oil (Myristica fragrans Houtt) is a natural ingredient that has potential as a sunscreen. This research aims to formulate and characterize nutmeg essential oil nanoemulsion and test the sunscreen activity of nutmeg essential oil and its nanoemulsion. The essential oil and nanoemulsion formulas were made with 5 variations of essential oil concentrations namely F0 (0%), F1 (1%), F2 (2%), F3 (4%) and F4 (6%). The nanoemulsion characterization includes organoleptic test, pH measurement, nanoemulsion type examination, viscosity measurement, percent transmittance test, particle size distribution measurement, centrifugation test, freez-thaw cycle test. Testing the potential of sunscreen was carried out using a UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank. The results of the nanoemulsion organoleptic characterization showed a clear and stable appearance. Measurements of pH, type of nanoemulsion, viscosity, percent transmittance, and particle size of nanoemulsion preparations showed good results and were in accordance with the parameters. The nutmeg essential oil nanoemulsion had better SPF, %Te and %Tp values than the essential oil. Nanoemulsion preparations that had the best sunscreen activity in this study were F4 (6%) with an SPF value of 1.538; %Te value of 37.375%; and %Tp value of 80.732%.
Formulation, Characterization, and Sunscreen Potential Evaluation of Nutmeg Leaf Essential Oil Nanoemulsions (Myristica fragrans Houtt.) Rastuti, Undri; Widyaningsih, Senny; Chasani, Mochammad; Habibie, Ranti Kamila; Elly, Vani Fitria Rosita; Zia, Sity Khalidah
Molekul Vol 18 No 3 (2023)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2023.18.3.6872

Abstract

Nutmeg leaf essential oil (Myristica Fragrans Houtt.) is one of the natural ingredients which have antioxidant activity and potential as a sunscreen. The research aims to formulate nutmeg leaf essential oil nanoemulsion, characterize, and determine its potency as a sunscreen. Nutmeg leaf essential oil nanoemulsion was formulated with 1; 3; and 5 mL of oil content with two variations of surfactant. The characterization included organoleptic, pH, viscosity, %T, nanoemulsion type, droplet size, thermodynamic and centrifugation stability tests. Evaluation was conducted using UV-Vis spectrophotometer at a wavelength range of 290-400 nm with ethanol as a blank and non-nano-emulsified as a comparison. The result showed that the nutmeg leaf essential oil nanoemulsion had clear and stable appearance, safe for skin, viscosity values of <200 mPas, %T values of near 100%, nanoemulsions type of o/w, and particles size of <200 nm. The evaluation showed that the sunscreen activities of nutmeg leaf oil nanoemulsion was higher than non-nano-emulsified. The highest sunscreen activity was the formula A nanoemulsion which an oil content of 5 mL and had an SPF value of 1.475; %Te value of 50.571%; and %Tp value of 77.218%. The nanoemulsion sunscreen activity of formula A was categorized as a regular suntan
Antibacterial Test of The Essential Oil Fractions of Citronella (Cymbopogon nardus L.) Against Escherichia coli and Application as Hand Sanitizer Formulation Rastuti, Undri; Lestari, Puji; Hidayatullah, Rafly; Habibie, Ranti Kamila
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.9773

Abstract

ABSTRACT. Hand sanitizer is an essential item during the COVID-19 pandemic, posing potential side effects when containing synthetic ingredients. Therefore, this study aimed to replace hand sanitizer formulation with Citronella essential oil (Cymbopogon nardus L.). Essential oil was fractioned into 3 components, namely F1 (67.07% of limonene), F2 (92.39% of citronellal), and F3 (62.41% of geraniol) while evaluation was conducted on antibacterial properties against E. coli. Antibacterial test was performed using the well diffusion method, showing inhibition zone diameters of 7.40, 10.76, and 8.30 mm for F1 to F3 fractions, respectively. The results showed that F2, selected as the reference for hand sanitizer formulation, had the most potential antibacterial activity and a MIC of 3.125%. Comparative test with commercial alternatives, including hedonic, characteristic, and antibacterial activity test, were conducted to assess the formulated hand sanitizer. F2 was discovered to have an inhibition zone diameter of 29.56 mm as opposed to 9.06 mm of commercial hand sanitizer. Based on hendonic test, hand sanitizer formulated with citronella oil had a distinct smell, which was less preferred than lime fragrance. Keywords: Antibacterial, Escherichia coli, and sanitizer, citronella essential oil.
Toxicity Test of Nanoemulsions of Nutmeg Fruits and Leaves Essential Oil against Artemia salina Leach and Its Cytotoxicity Test against Breast Cancer Cells T47D Rastuti, Undri; Diastuti, Hartiwi; Widyaningsih, Senny; Chasani, Moch; Sheiliyani, Cindi; Rahmasari, Anisa; Fajriyah, Bunga Sita Roihanul; Mesayu, Puspa Rahma; Habibie, Ranti Kamila
Indonesian Journal of Chemistry Vol 24, No 5 (2024)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.91077

Abstract

Nutmeg (Myristica fragrans Houtt) is a widely known spice plant, which has been reported to offer several benefits. Therefore, this study aims to develop and analyze nanoemulsions of nutmeg leaves and fruit essential oil, as well as determine their toxicity and cytotoxicity. Nanoemulsions were formulated with varying concentrations of essential oil, including 0, 1, 2, 4, and 6%. Characterization included organoleptic assessment, pH measurement, type examination, viscosity testing, transmittance analysis, particle size distribution measurement, centrifugation, and freeze-thaw cycle test. Toxicity testing results using the brine shrimp lethality test (BSLT) showed that nanoemulsions were toxic except NF F4 with high toxicity. Cytotoxicity testing on T47D breast cancer cells showed moderate activity for NF F4 nanoemulsions (IC50: 34.363 ppm), while NL nanoemulsions were deemed inactive (IC50: 33576.430 ppm). In addition, the organoleptic characteristics of all nanoemulsions were stable, and most parameters met the desired standards. Based on the results, further studies exploring nanoemulsions with natural products must be carried out to determine their advantages, specifically in the development of sciences.
Pelatihan Manajemen dan Hibah Alat Huller Sebagai Upaya Meningkatkan Produktivitas dan Kapasitas Greenbean pada KUB Lulumpang Kec. Salem Kab. Brebes Rastuti, Undri; Purwanto, Purwanto; Yunanto, Ary; Sutarmin, Sutarmin; Fajriyah, Bunga Sita Roihanul; Alriski, Mochammad Fadhil Niko; Saputra, Dimas; Safitri, Fanti Indriana
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 10 (2024): Desember
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i10.1686

Abstract

Kecamatan Salem merupakan wilayah dengan perkebunan dan produksi kopi tertinggi di Kabupaten Brebes. Kelompok usaha bersama (KUB) Lulumpang menjadi salah satu tim yang aktif mengolah kopi hasil perkebunan  kopi di kecamatan salem. Produk yang dibuat oleh KUB Lulumpang berupa kopi bubuk yang diberi nama Kopi Salem. Namun saat ini permintaan greenbean lebih diminati oleh konsumen. Proses produksi greenbean di KUB Lulumpang masih dilakukan secara manual sehingga menjadi kendala dalam pemenuhan kualitas dan kuantitas greenbean sehingga diperlukan inovasi peningkaan kualitas dan kuantitas greenbean. Tim PKM-BR Unsoed mengkaji dan menerapkan teknologi tepat guna dengan mengadakan pelatihan manajemen usaha dan strategi daya saing serta hibah alat pengubas kulit ari biji kopi kering (huller). Penerapan teknologi meningkatkan efisiensi waktu dan kapasitas produksi sebesar 90% dan meningkatkan nilai harga jual hingga 53,85%. 
Inovasi Primer dalam Agribisnis Kopi Robusta untuk meningkatkan Produk Unggulan Daerah Kabupaten Brebes Rastuti, Undri; Sutarmin, Sutarmin; Purwanto, Purwanto; Pratiwi, Umi; Saputra, Dimas; Pratama, Biang; Agustin, Ririn
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 1 (2025): Maret
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i1.2161

Abstract

Kopi merupakan salah satu komoditas unggulan yang memiliki nilai ekonomi tinggi dan berperan penting dalam perekonomian di Indonesia. Sebagai produsen kopi terbesar keempat di dunia, Indonesia dikenal dengan berbagai jenis kopi khas, salahsatunya jenis robusta. Namun, meskipun kopi Indonesia memiliki potensi besar di pasar global, masih banyak tantangan yang dihadapi dalam pengembangan agribisnis kopi, seperti rendahnya produktivitas, kualitas yang belum konsisten, serta kurangnya akses ke pasar internasional yang lebih luas. Usaha Mikro, Kecil dan Menengah (UMKM) Kopi Salem (Kopi Guwek) di Desa Bentarsari, Kecamatan Salem, bersama Kelompok Tani Berkah Bumi Langit (Berbulan) menghadapi berbagai tantangan dalam pengolahan kopi robusta. Pengupasan kopi cherry masih dilakukan secara manual menggunakan lumpang dan alu, yang memakan banyak waktu dan tenaga serta menghasilkan greenbean berkualitas rendah. Proses pengeringan manual juga terdampak saat musim hujan. Melalui program Pemberdayaan Mitra Usaha Produk Unggulan Daerah (PM-UPUD) 2024, tim pengabdian berupaya meningkatkan kapasitas produksi dan kualitas kopi dengan memberikan hibah alat seperti greenhouse kapasitas 1 ton, mesin pulper (250 kg/j), huller (250 kg/j) untuk meningkatkan kualitas proses produksi kopi dari hulu sampai ke hilir. Selain itu, pelatihan manajemen bisnis dan strategi pemasaran juga diberikan, guna meningkatkan kesejahteraan petani dan mendukung program pemerintah dalam menjadikan kopi sebagai produk unggulan Kabupaten Brebes.
Peningkatan Agribisnis Kopi dengan Penyuluhan Kajian Kopi Robusta pada UMKM Berbulan dan UMKM Kopi Guwek Kecamatan Salem-Brebes Rastuti, Undri; Sutarmin, Sutarmin; Purwanto, Purwanto; Pratiwi, Umi; Saputra, Dimas; Pratama, Biang; Agustin, Ririn
Jurnal Serambi Abdimas Vol 6 No 01 (2025): Jurnal Serambi Abdimas
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.sa.2025.6.01.13146

Abstract

Abstrak – Kopi merupakan salah satu komoditas unggulan di Indonesia yang sangat menarik untuk dieksplorasi lebih jauh. Di Indonesia, tepatnya di Kecamatan Salem-Kabupaten Brebes, sebagai salah satu kecamatan penghasil kopi di Kabupaten Brebes dan sebagai pemasok kopi di daerah-daerah pulau jawa. Permasalahan yang dihadapi dengan pemahaman yang kurang tentang tanaman kopi, mengakibatkan berpengaruh pada kualitas kopi dan manajemen pemasaran. Oleh karena itu diperlukan suatu program penyuluhan untuk meningkatkan pemahaman petani kopi dalam menjalankan agribisnis tanaman kopi. Kegiatan Pengabdian Kepada Masyarakat (PKM) dilakukan tim pengabdi Pemberdayaan Mitra Usaha Produk Unggulan Daerah (PMUPUD) Universitas Jenderal Soedirman dan Universitas Peradaban Bumiayu. Kegiatan ini bertema tentang Peningkatan Agribisnis Kopi dengan Penyuluhan Kajian Kopi Robusta pada UMKM Berbulan dan UMKM Kopi Guwek Kecamatan Salem-Brebes menggunakan penyuluhan dalam bentuk kegiatan sharing dan diskusi. Peserta kegiatan penyuluhan diikuti oleh 39 peserta yang terdiri dari UMKM Berbulan dan UMKM Kopi Gowek Kecamatan Salem. Permasalahan yang terjadi yaitu kurangnya pemahaman tentang tanaman kopi seperti cara penanaman yang baik, cara pemeliharaan dan cara penanggulangan hama tanaman kopi. Hasil kegiatan penyuluhan dari tes awal dan tes akhir pemahaman peserta penyuluhan menunjukkan terjadi peningkatan pemahaman peserta pada pamahaman cara penanggulangan hama tanaman kopi yang baik.
Kojic Acid from the Ethyl Acetate Fraction of Terminalia catappa Linn Fruit Flesh and its anti-cancer activity against HeLa cells Chasani, Moch.; Widyaningsih, Senny; Rastuti, Undri; Hanafi, Muhammad; Fauzi, Kevin Azhar; Azahra, Silena
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.13579

Abstract

ABSTRACT. The ethyl acetate fraction of Terminalia catappa Linn. fruit flesh has anti-cancer activity against HeLa cells, with IC50 value is =165.37 ppm. The aim of this research is to isolate active anticancer compound from the ethyl acetate fraction of T. catappa fruit flesh. Anti-cancer active compounds from the ethyl acetate fraction of T. catappa fruit flesh were purified using column chromatography and continued with recrystallization. The compound isolate from the ethyl acetate fraction is clear yellowish crystals and has a melting point 150 ± 2 oC, has anti-cancer activity against HeLa cells of IC50 =413.695 ppm. Results of molecular structure identification using UV spectroscopy; FTIR; 1HNMR, 13CNMR and LC-MS are thought to be the compound 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4- one (Kojic acid) with a molecular weight of 142.36 gram/mol. The Kojic acid content in T. catappa Linn fruit flesh was found to provide information on the potential use of T. catappa fruit flesh extract in the pharmaceutical and cosmetics industries. Keywords: Anticancer activity, HeLa cells, Kojic acid, T. catappa Linn.
Co-Authors Aditya Mahendra, Ryan Agustin, Ririn Aji, Naufal Ikhsan Bayu Akhhila, Nilta Alriski, Mochammad Fadhil Niko Ananda, Naufal Chessa Aqila, Shafa Arif Nur Hidayat, Arif Nur Arrafi, Fatur Sakti ary yunanto Az Zahra, Widya Alecia Azahra, Silena Chasani, Moch Damayanti, Yulia Dian Riana Ningsih Dian Riana Ningsih Dwi Kartika Eka Prasasti Nur Rachmani Elly, Vani Fitria Rosita Fahriansyah, Anas Fajriyah, Bunga Sita Roihanul Fauzi, Kevin Azhar Febrianti, Nida Fadilah Habibie, Ranti Kamila Haqqi, Syafi Millatal Hartiwi Diastuti Hartiwi Diastuti Hastuti, Shinta Nur Heny Ekowati Hidayatullah, Rafly Idha, Rafifah Irmanto Irmanto Istiqomah, Titi Syarifatul Jumina Jumina Jumina Jumina Khalidah Zia, Sity Mesayu, Puspa Rahma Moch. Chasani Mochamad Chasani Mochammad Chasani Muhammad Hanafi Muskitta, Kezia Rastya Mitzi Lael Naufan, Muhammad Zulva Nevitasari, Noor Ramadhani Permana, Afri Pratama, Biang PUJI LESTARI Purwanto Purwanto Purwati Purwati Purwati Purwati Putra, Febian Abiysa Putra, Novendra Ronaldo Rahmasari, Anisa Riawan, Athifa Nayla Nafisa Ridlwan Kamaludin Rizal, Soca Allan Ryan Aditya Mahendra Sabirin Matsjeh Sabirin Matsjeh Safitri, Fanti Indriana Sandika, Kevin Farih Saputra, Dimas Senny Widyaningsih Senny Widyaningsih Senny Widyaningsih Sheiliyani, Cindi Sheiliyani, Cindy Shofiyyah, Asy Syifa Sity Khalidah Zia Sulaeman, Uyi Sutarmin Sutarmin, Sutarmin Suyata Suyata Tahapti, Pelita Theresa, Esa Bilqis Sasa Umi Pratiwi, Umi Umi Salamah Uyi Sulaeman Uyi Sulaeman Widhiatmoko Herry Purnomo Zia, Sity Khalidah