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All Journal Jurnal Ilmu Dasar Jurnal Sains Dasar Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat PROSIDING SEMINAR KIMIA KOVALEN: Jurnal Riset Kimia Jurnal Kimia Mulawarman Science and Technology Indonesia JURNAL ATOMIK Jurnal Sustainable: Jurnal Hasil Penelitian dan Industri Terapan Bisma: Jurnal Bisnis dan Manajemen Spektrum Analisis Kebijakan Pendidikan BISMA (Bisnis dan Manajemen) VALUE: Journal of Business Studies Kubis
Chairul Saleh
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Social Sciences Other

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Journal : PROSIDING SEMINAR KIMIA

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TEST PHYTOCHEMICAL, TOXICITY AND ANTIBACTERIAL ACTIVITY FRACTION LEAF EXTRACT VARIOUS MAHANG (M acarang apruinosa (Miq.) Mull. Arg.) AGAINST Escherichia coli AND Staphylococcus aureus Mustafidah -; Chairul Saleh; Alimuddin -
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2014
Publisher : PROSIDING SEMINAR KIMIA

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Phytochemical, to xicity and antibacterial act ivity tests of total extract, fractions of n-heksana, ethyl acetate and ethanol-water fro m mahang leaf (Macaranga pruinosa (M.) M. A.) fro m KRUS (Kebun Raya Unmul Samarinda), East Kalimantan has been carried out. Based on the secondary metabolites phytochemical test of the (Macaranga pruinosa (M.) M. A.) leaf show that total extract is contain alkaloid and steroid. n-hexane fraction is contain alkaloid and steroid. Ethyl acetate fract ion is contain steroid. Ethanol-water fract ion is contain alkaloid and phenolic. Brine shrimp lethality test values obtained Lethal Concentration 50 % (LC 50 ) total extract 27,5036 ppm , n-heksana fraction 12,0773 pp m, ethyl acetate fraction 23719,2305 ppm and ethanol-water fraction 250,0384 ppm. Antibacteria act ivity test of extracts for Staphylococcus aureus bacteria (positive Gram) and Escherichia coli (negative Gram) minimum inhibitor consentration of 0-1 % (b/v) fro m ext ract fractions of n-heksana and fractions ethyl acetate for Staphylococcus aureus bacteria and fractions ethyl acetate for Escherichia coli bacteria.
STUDI DOCKING MOLEKULAR SENYAWA KUERSETIN DAN HESPERITIN SEBAGAI INHIBITOR SEL KANKER DENGAN AUTODOCK VINA Hevin Muttaqin; Chairul Saleh; Rahmat Gunawan
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2013
Publisher : PROSIDING SEMINAR KIMIA

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Kuersetin dan Hesperitin merupakan turunan dari senyawa Flavonoid yang berbeda kelas, Kuersetin kelas Alkohol, sedangkan Hesperetin kelas Alkanon. Docking Molekular, suatu ilmu penelitian secara in silico atau via perangkat lunak (program komputer) dan ditujukan untuk memprediksikan interaksi antara ligan (key) dengan reseptor (lock) dari ikatan hidrogen yang terbentuk. Autodock VINA adalah salah satu program Docking Molekular yang ada, diciptakan oleh Dr. Oleg Trott untuk meningkatkan efisiensi waktu pengerjaan dan akurasi dalam analisa. Dalam penelitian ini masing-masing dari senyawa Kuersetin dan Hesperitin akan di-Docking terhadap dua macam contoh reseptor, sel kanker otak (1S63) dengan ligan aslinya 778 dan sel kanker paru-paru (2ITO) dengan ligan aslinya IRESSA, terlebih dahulu dilakukan optimasi geometri, minimisasi energi juga validasi metode. Penelitian iniditujukan untuk menjelaskan perbandingan Kuersetin, Hesperitin dan ligan-ligan asli sebagai kandidat bahan obat anti kanker. Percobaan Docking, memberikan hasil Kuersetin dan Hesperitin membentuk ikatan hidrogen terhadap asam amino dari masing-masing reseptor. Hal ini menunjukkan bahwa Kuersetin dan Hesperitin memiliki kemampuan sebagai inhibitor, terutama pada sel kanker paru-paru (2ITO), karena potensi keduanya lebih baik dari ligan IRESSA. Walaupun Kuersetin dan Hesperitin tak memiliki potensi lebih baik dari ligan 778 pada sel kanker paru-paru, keduanya masih dapat digunakan sebagai bahan obat alternatif dari anti kanker.
UJI FITOKIMIA, TOKSISITAS DAN AKTIVITAS ANTIOKSIDAN ALAMI DAUN TUMBUHAN KELAKAI (Stenochlaena palustris) DENGAN METODE DPPH Bonita Tahir; Chairul Saleh; Subur P Pasaribu
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2013
Publisher : PROSIDING SEMINAR KIMIA

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The phytochemical test, brine shrimp lethality test and activity antioxidant test and secondary metabolits of kelakai(Stenochlaena Palustris) leaves have been researched. The leaves samples are extract with solvent methanol by masseration method and that is concentrated by using rotary evaporator. The methanol crude extract obtained are fractioned with solvent n-hexane and. Solvent ethyl acetat.Based on secondary metabolits phytochemical test of kelakai leaves showed that methanol raw extract contains steroid, alkaloid and flavonooid. n-hexane fraction extract contains steroid and alkaloid Ethyl acetat fraction extract contains alkaloid, steroid, flavonoid and saponin.In brine shrimp lethality test, the increase larvae death and data was yielded recorded and processed using SAS Probit Analysis to determine the lethal concentration 50 % (LC 50 ) value. The results of this test obtained data and showed that the most active fraction is ethyl acetat fraction extract withvalue of LC 50 was equel to 88,8477 ppm.Based on the antioxidant activity conducted by scavenging activity of DPPH usedspectrophotometry. Based on the result be held researched was obtained that Inhibition Concentration 50% (IC 50 ) that methanol raw extract value of 185,92 ppm, n-hexane fraction value of 520,64 ppm and athyl acetat fraction 107,49 ppm and vitamin C is value of 3,064 ppm, can be axpressed that the result of this test showed that the most active fraction is ethyl acetat with value of IC 50 equel to 107,49 ppm.
Activity Test Of Ethanol and n-Hexane Fraction Of African Leaves (Vernonia amygdalina Delile) as Antihyperuricemia On Male Mice Induced by Potassium Oksonat Deni Karisnawati; Saibun Sitorus; Chairul Saleh
PROSIDING SEMINAR KIMIA PROCEEDING OF INTERNATIONAL CONFERENCE 2015
Publisher : PROSIDING SEMINAR KIMIA

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Antihyperuricemia activity tests have conductedon aethanolandn-hexane fraction Africanleaves (Vernonia amygdalina Delile). Hyperuricemia is a condition in which uric acid levels in the blood increases due to the high consumption of purine converted to uric acid by xanthine oxidase. Antihyperuricemia activity test of ethanolic and n-hexane fraction of African leaves (Vernonia amygdalina Delile) conducted on male white mice with variation in doses of 6, 11 and 22 mg/kg BW and variation of measurement time of 1, 2, 3 and 4 hours after administration of the extract orally. Data were analyzed with ANOVA and continued with Duncan test. Ethanolic fraction 11 mg/kg is the most effective fraction lower uric acid levels by 54.62% compared to alupurinol 300 mg/kg BW which lower uric acid levels by 56.91%. Phytochemical screening showed that the ethanolic fraction of African leaves contains triterpenoids, steroids, phenolics, flavonoids and saponins whereas n-hexane fraction containing alkaloids, steroids and flavonoids. These results show the extracts of African leaves have antihiperurisemia activity.
PROFIL TUMBUHAN SIKKAM (Bischovia javanica Blume) Karolina Sinukaban; Chairul Saleh; Daniel Daniel
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2019
Publisher : PROSIDING SEMINAR KIMIA

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Penelitian tentang uji toksisitas dan uji aktivitas antioksidan ekstrak kulit batang tumbuhan sikkam (Bischovia javanica Blume) telah dilakukan. Hasil dari uji fitokimia pada kulit batang tumbuhan sikkam mengandung senyawa metabolit sekunder yaitu senyawa fenolik, flavonoid dan triterpenoid. Berdasarkan hasil uji toksisitas dengan metode BSLT (Brine Shrimp Lethality Test) pada ekstrak kasar metanol diperoleh nilai LC50 sebesar 56,92 ppm yang menunjukkan tingkat toksisitas yang toksit sehingga dapat dimanfaatkan sebagai obat antikanker. Berdasarkan hasil uji aktivitas antioksidan dengan metode DPPH menunjukkan pada ekstrak kasar metanol diperoleh nilai IC50 sebesar 9,1878 ppm. Dari hasil uji antioksidan diketahui bahwa pada ekstrak kasar metanol kulit batang tumbuhan sikkam memiliki aktivitas antioksidan yang sangat kuat dengan nilai IC50 sebesar 9,1878 ppm. Kata Kunci: Sikkam (Bischofia javanica Blume), Uji Fitokimia, Uji Toksisitas, Uji Aktivitas Antioksidan, DPPH (1,1-diphenyl-2-picrylhidrazyl)
UJI TOKSISITAS DAN PENENTUAN AKTIVITAS ANTIOKSIDAN DENGAN METODE DPPH DARI METABOLIT SEKUNDER FRAKSI n-HEKSAN, ETIL ASETAT DAN METANOL-AIR DAUN SISIK NAGA (Drymoglossum piloselloides [Linn.] Pr.) Erwin -; Dwi Fitria Sari; Chairul Saleh
PROSIDING SEMINAR KIMIA SEMINAR NASIONAL KIMIA 2013
Publisher : PROSIDING SEMINAR KIMIA

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Phytochemical, toxicity test had been done that used Brine shrimp (Brine shrimp lethality test) and antioxidant activity test using methanol extract from sisik naga leaf (Drymoglossum piloselloides (Linn). Pr) fraction that taken from Kutai Kartanegara, East Kalimantan. Sisik naga leaf was extracted by methanol and then concentrated using rotary evaporator. Then that crude extract was fractioned by n-hexane, ethyl acetate and methanol-water. Based on phytochemical test of the sisik naga leaf show that crude methanol extract, n-hexane fraction and ethyl acetate fraction was contain alkaloid, flavonoid and steroid at methanol-water fraction was contain alkaloid and phenol. Brine shrimp lethality test show that lethality level of Artemia Salina (L) that used Probit SAS Analyze to determine value of Lethal Concentration 50% (LC 50 ). The test showed that the most active was crude n-Hexane extract with LC 50 value of 0,0910 ppm. Antioxidant activity test of extracts from crudge methanol and some variations fractioned using DPPH radical reduction (2,2 '-diphenyl-1-picrylhydrazil) using Spectrophotometer. The test showed that the most active and recommended to used as antioxidant is methanol-water fraction with IC 50 values is at 74.51 ppm and LC 50 values is at 87749.9219 ppm.
ANTIHYPERGLYCEMIC TEST OF ETHANOL EXSTRACT OF DURIAN (Durio zibethinus Murr.) PEEL AGAINTS MALE MICE (Mus Musculus) Hamsiana -; Rudi Kartika; Chairul Saleh
PROSIDING SEMINAR KIMIA PROCEEDING OF INTERNATIONAL CONFERENCE 2015
Publisher : PROSIDING SEMINAR KIMIA

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Diabetes mellitus (DM) is a metabolic disorder and characterized by hyperglycemic circumstances. Hyperglycemic is a condition where the glucose levels ini the blood increased dramatically. One of the pharmacological therapy ia to use ofdrugs that can reduse glucose levels in the blood. Phytochemical test and antihyperglicemic activity from durian (Durio zibethunus Murr.) peel have been carried out. Durio zibethinus Murr. peel was macerated with ethanol 96% then concentrated with rotary evaporators. It obtained rendemen 13.33% . Based on the test result of phytochemistry of secondary metabolites compounds from durian peel showed that etahanol extract containing flavonoid, alkaloid, fenolik, triterpenoid and saponin. Antihyperglicemic activity test use animal test male mice that is injected aloksan. Measurement of blood sugar levels using glucometer and glucose test strip. From antihyperglicemic test it showed that the effectiveness of blood sugar level doses of 36 mg/kg BW from the
SKRINING FITOKIMIA DAN POTENSI AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL DAUN SINGKIL (Premna corymbose Roxb & Willd.) DENGAN METODE DPPH (1,1-diphenyl-2-picrylhydrazil ): A MINI REVIEW Dewi, Camelia Eugenia; Saleh, Chairul; Daniel, Daniel; Magdaleni, Agustina R.
PROSIDING SEMINAR KIMIA Vol 2 No 2 (2024): Prosiding SNKT III 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Singkil leaves (Premna corymbose Roxb & Willd.) are a plant that is widely found in Kalimantan, and usually grows in the yard of houses or plantations. A research on phytochemicals screening and antioxidant activity test of singkil leaves (Premna corymbose Roxb & Willd.) using DPPH (1,1- diphenyl-2-picrylhydrazyl) method had been conducted. Test for alkaloids, triterpenoids/steroids, phenolic, flavonoids, saponins, and quinone were included in phytochemical screening. The results of the literature show that the methanol extract exhibits antioxidant activity in the strong category, which has an IC50 value of 20.66 μg/ml. Methanol extract of singkil leaves (Premna corymbose Roxb & Willd.) has potential as an antioxidant. Keywords: Singkil leaves (Premna cordifolia Roxb.), phytochemical screening, antioxidant, DPPH
REVIEW ARTIKEL: PENAPISAN FITOKIMIA DAN POTENSI AKTIVITAS BIOLOGIS TANAMAN BAJAKAH (Uncaria cordata (Lour.) Merr.) Farhany, Farhany; Saleh, Chairul; Daniel, Daniel
PROSIDING SEMINAR KIMIA Vol 2 No 2 (2024): Prosiding SNKT III 2023
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Bajakah (Uncaria cordata (Lour.) Merr.) is an endemic plant to Kalimantan which is widely used as medicine. Various studies have been conducted regarding the phytochemical content and biological activity of Bajakah. Phytochemical screening was carried out for the content of alkaloids, flavonoids, polyphenols, triterpenoids, steroids, saponins, and tannins. Literature studies show that Bajakah has antioxidant activity within ethanol fraction with a very strong capacity as indicated by an IC50 value of 49.22 ppm, within the nhexane fraction with a medium capacity as indicated by an IC50 value of 108.22 ppm, and within ethyl acetate fraction with a medium capacity as indicated by an IC50 value of 130.30 ppm. Bajakah is also known to have antihyperuricemia activity by reducing uric acid levels at extract doses of 5.3 mg/30gBW, 10.6 mg/30gBW, and 21.2 mg/30gBW. Anticholesterol activity was indicated by reducing cholesterol levels at extract doses of 5.3 mg/30grW (11.45%), 10.2 mg/30grW (12.89%), and 21.2 mg/30grW (21.05%). Antiinflammatory activity was showed by testing the ethyl acetate extract of Bajakah stem at doses of 200 and 400 mg/kgBW. The acute toxicity test showed an LD50 value of >5000 mg/kgBW; indicating that the butanol fraction of Bajakah is relatively harmless and has potential as a standardized herbal medicine (OHT). Keywords : Uncaria cordata (Lour.) Merr.), phytochemical screening, bioassay
SKRINING FITOKIMIA DAN POTENSI ANTIBAKTERI EKSTRAK ETANOL DAUN SIRIH HUTAN (Piper aduncum L.) TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus : A MINI REVIEW Sanjaya, I Made Duwi; Purba, Ritson; Saleh, Chairul
PROSIDING SEMINAR KIMIA Vol 3 No 1 (2024): Prosiding SNK 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Sirih hutan is a plant that belongs to the genus Piper and is found in many tropical areas, especially in tropical Asia. Sirih contains essential oils composed of betlephenol, cavikol, sesquiterpenes, hydroxycavikol, cavibetol, estragol, eugenol, and carvakrol which against Gram positive bacteria and Gram negative bacteria. Antibacterial activity test of ethanol extract of sirih hutan (Piper aduncum L.) has been conducted. This study aims to determine secondary metabolite compounds contained in sirih hutan leaves and potential as antibacterials, determined using the disc diffusion method. From the results of phytochemical tests, secondary metabolite compounds contained in sirih hutan are obtained in the form of alkaloids, steroids, phenolics, flavonoids, tannins, quinones and saponins. The results of the literature showed that sirih hutan leaf ethanol extract had antibacterial activity with the highest concentration used at 60% and the diameter of the inhibitory zone formed in Escherichia coli and Staphylococcus aureus was 14 mm. Keywords : Antibacterial, Forest Betel, Phytochemical Screening
Co-Authors Agung Prasetyo Agus Priono Ajeng Kartini Akbar, Fath Ali Alimuddin - Alimuddin - Alimuddin Alimuddin Alpina Nora Kaban Ami, Suyatmi Ana Arum Sari Ana Arum Sari, Ana Arum Ardiansyah - Ardiansyah - Arifah, Churniati Nur Arwidhiah, Nanda Ary Rizki Darmawi Ary Rizki Darmawi, Ary Rizki Aulia Husna Rabbani Azhar Seli Apriani Azhar Seli Apriani, Azhar Seli Barikah, Kuni Z. Bastara, Dimas B. Bohari Yusuf Bonita Tahir Daniel Daniel - Daniel - Daniel -, Daniel Daniel Daniel Daniel Daniel Daniel Daniel Daniel Tarigan Deni Karisnawati Dessy Karlina Desy Ridho Rahayu Dewi, Camelia Eugenia Djihan Ryn Pratiwi, Djihan Ryn Dwi Fitria Sari Dwi Perwitasari Wiryaningtyas, Dwi Perwitasari Eci Endang Sinulingga Eko Haryanto Eko Haryanto Elean, Samuel Elok Sri Utami Ema Desia Prajitiasari Erwin - Erwin - Erwin E Erwin Erwin Erwin Erwin Erwin Erwin Eva Marliana, Eva Fadillah, Fahmi Farhany, Farhany Farida Amir Farida Amir, Farida Fauziah, Nadiya Ayu Hairani, Rita Hammamiyah, Ulinnuha Hamsiana - Hevin Muttaqin Husnul Chatimah Indra Masmur Izkia Mawaddah Jaya, Edi Novian Juwita, Retno Karolina Sinukaban Ketut Indraningrat KHOIRUN NISAK Krishnabudi, N. G Kusumaningrum, Indah Yulia Kusumawardani, Niken Lembang, Darmita Tiku Lilik Farida Lutfiana Devi Kurnia M.Riza Agus Pramana Magdaleni Agustina Rahayu Magdaleni, Agustina R. Magdaleni, Agustina Rahayu Marsella, Virna Rindra Masmur, Hestina Medi Hendra, Medi Mira Wahyuni Mira Wahyuni, Mira Muhammad Rivai Mujahidin1, Muhamad Mustafidah - Mustafidah -, Mustafidah Mutma Inna Nadhirah - Natalia, Princessa Noor Hindryawati, Noor Nugraheni, Dyah Ayu Nur Aina Nur Aini Haryati Nuranda, Apri Nyoman Gede Krishnabudi Oman, Aries Panannangan, Josua K. Pangaribuan, Fransiscus X. Rico Pindan, Neli Peni Prabowo, Rachmat Prabowo, Rachmat Udhi Pratiwi, Ricka Indria Precelia, Sari Clara Priyanto, Fajar Wahyu Purnamie Titisari Purwanti, Gettik Andri Puspita, Leonita Dwi Puspitasari, Intan Dessy Rachman, Ferry Aditya RAHMAT GUNAWAN Rahmat Gunawan Ramadhan, Aulia Ravensca, Irene Rindawati, Novi Ritbey Ruga Ritson Purba, Ritson Rochman, Mayasari Azhari Rohmat Hidayat Rohmat Hidayat Rudi Kartika, Rudi Ruga, Ritbey Ryn Pratiwi, Djihan Saibun Sitorus Sandra, Putri Ayu Sanjaya, I Made Duwi Septi Roro Liniawati Shadrina, Alyani Nur Simatupang, Eliene Br. Siti Maimunah Sitompul, Citra Uli Soma, Yolanda V. A Subagyono, RR Dirgarini Julia Nurlianti Subur P Pasaribu Sulistiawati, Iqlimah Sulistiyawati, Rizki Ramadhani Sumarni, Feni Sunardi Sunardi Susanto, Arnis Budi Syafriyanti, Yuly T, Nurnaningsi Theresia Susetyarsi Tri Novianti Tria Annisa Rizky Tria Apriliana, Tria Ulfa Mutia Ulfa Mutia, Ulfa Ulfa, Yulyanti Sartika Utami, Diandra Weningtyas Wahyu Pratama Wajdie, Farid Winni Astuti Winni Astuti, Winni Yuli Yana