Claim Missing Document
Check
Articles

From Tradition to Translation: A Systematic Review on the Pharmacological Actions of Eugenol Extracted from Ocimum Plants in Oxidative Stress, Inflammation, and Diabetes Mellitus Permatananda, Pande Ayu Naya Kasih; I Wayan Putu Sutirta Yasa; I Wayan Sumardika; Made Ratna Saraswati; I Gde Suranaya Pandit
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1302

Abstract

Background: Ocimum species, commonly known as basil, have a rich history in traditional medicine for various ailments. Eugenol, a primary bioactive compound found in several Ocimum species, has garnered significant scientific attention for its potential therapeutic properties. This systematic review aimed to comprehensively evaluate the pharmacological actions of eugenol extracted from Ocimum plants in the context of oxidative stress, inflammation, and diabetes mellitus. Methods: A systematic literature search was conducted across major scientific databases for studies published between 2013 and 2024 that investigated the effects of eugenol derived from Ocimum plants on oxidative stress, inflammation, and diabetes mellitus. The search strategy included keywords such as "eugenol," "Ocimum," "antioxidant," "anti-inflammatory," and "antidiabetic." Inclusion criteria for studies involving in vitro, in vivo, and clinical studies that specifically examined the pharmacological actions of eugenol extracted from Ocimum species in the aforementioned conditions. Data on study design, intervention, outcomes, and key findings were extracted and synthesized narratively. Results: The review identified ten key studies that met the inclusion criteria. These studies collectively suggested that eugenol extracted from Ocimum plants exhibited significant antioxidant activity by scavenging free radicals and enhancing endogenous antioxidant enzymes. Furthermore, eugenol demonstrated anti-inflammatory effects by modulating pro-inflammatory cytokines and inhibiting key inflammatory pathways such as NF-κB and COX. In the context of diabetes mellitus, studies indicated that eugenol could improve glucose metabolism by enhancing insulin sensitivity, protecting pancreatic beta cells, and inhibiting carbohydrate metabolizing enzymes. Conclusion: This systematic review provided a comprehensive overview of the pharmacological actions of eugenol extracted from Ocimum plants in mitigating oxidative stress, inflammation, and diabetes mellitus. The findings from the included studies supported the traditional uses of Ocimum species and highlighted the therapeutic potential of eugenol as a natural agent in managing these conditions. Further well-designed clinical trials are warranted to validate these preclinical findings and translate them into clinical applications.
Program Pengabdian Masyarakat dalam Rangka Pencegahan Kecelakaan Rumah Tangga pada Anak di Desa Bayung Gede, Kintamani : Pengabdian Pande Ayu Naya Kasih Permatananda; I Gde Suranaya Pandit; Desak Putu Citra Udiyani; Putu Nita Cahyawati; Asri Lestarini
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 3 No. 4 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 3 Nomor 4 (April 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v3i4.1119

Abstract

Anak-anak merupakan korban tersering dari kecelakaan rumah tangga, yang sebagian besar terjadi pada anak-anak yang hidup di negara miskin dan berkembang. Pencegahan dan kontrol kecelakaan rumah tangga pada anak di bawah 5 tahun disebutkan cukup efektif dalam mehurunkan mortalitas akibat kecelakaan. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan keluarga dalam melakukan pencegahan kecelakaan rumah tangga. Metode transfer ilmu pengetahuan yang digunakan dalam kegiatan ini meliputi penyuluhan kelas besar pada perwakilan keluarga di Desa Bayung Gede dan pendampingan keluarga kepada 5 keluarga binaan yang terpilih. Evaluasi dilakukan sebanyak 2 kali, yaitu setelah penyuluhan kelas besar berupa pertanyaan pilihan ganda, dan setelah pendampingan keluarga berupa observasi checklist perilaku ya atau tidak. Hasil program pengabdian masyarakat di Desa Bayung Gede ini cukup baik. Penyuluhan kelas besar mampu meningkatkan pemahaman peserta mengenai pencegahan kecelakaan rumah tangga pada anak. Pendampingan kepada lima keluarga binaan berhasil mengidentifikasi perilaku-perilaku yang keliru dan kembali memberi penekanan untuk penerapan perilaku preventif yang lebih optimal. Ke depan, diharapkan adanya langkah yang kolaboratif dan berkesinambungan untuk dapat mewujudkan lingkungan rumah yang aman bagi anak.
Phytochemical and Antioxidant Capacity Test on Turmeric Extract (Curcuma Longa) Traditionally Processed in Bali Permatananda, Pande Ayu Naya Kasih; Aryastuti, Anak Agung Sri Agung; Cahyawati, Putu Nita; Udiyani, Desak Putu Citra; Wijaya, D.; Pandit, I Gde Suranaya; Wirajaya, Anak Agung Ngurah Mayun
Bali Membangun Bali: Jurnal Bappeda Litbang Vol 1 No 2 (2020): August 2020
Publisher : Badan Riset dan Inovasi Daerah Provinsi Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51172/jbmb.v1i2.115

Abstract

Purpose: The purpose of this study was to determine the ways and objectives of the use of turmeric by Balinese, as well as the phytochemical content and antioxidant capacity of turmeric extract which is traditionally processed in Bali. Research methods: The method and purpose of utilizing turmeric were obtained through observation and interviews with 900 Balinese respondents. Quantitative phytochemical tests include starch, protein, flavonoid, tannin, phenol and vitamin C levels and qualitatively for the presence of triterpenes, steroids, alkaloids, and saponins. Antioxidant capacity was measured using the DPPH method. Findings: Through this research, we found there were only 36.8% of respondents had ever used turmeric as a traditional medicine. Utilization of turmeric was mostly in the form of loloh or traditional drinks. Phytochemical test results showed turmeric extract had 67.38% starch, 3.42% protein, 2709.39 mg/100 gr flavonoids, tannins 291.64 mg/100gr, phenol 1584.04 mg/100 gr, and vitamin C 0.06 mg/100gr. Qualitatively, turmeric extract contained triterpenes, alkaloids, and saponins, but did not contain steroids. The antioxidant capacity of turmeric extract was 70.9 mg/L GAEAC. Implications: Turmeric extract is a traditional medicine made from nature that is most commonly used by Balinese and very potential to be developed as an antibacterial, antioxidant, anti-inflammatory, or other benefits that still need further investigation.
Chemical and Microbiological Characteristics of Sei-Pindang Tuna Fish I Gde Suranaya Pandit; Pande Ayu Naya Kasih Permatananda; I Nengah Suaria
Formosa Journal of Multidisciplinary Research Vol. 2 No. 12 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v2i12.7258

Abstract

Pindang is a fishery processing product that plays an important role in post-harvest activities. Pindang products have a relatively short shelf life, namely less than 2 days at room temperature. Smoking is a drying technique used to maintain the shelf life of fish by using wood fuel as a smoke producer. Pindang tuna that has undergone the smoking process is given the name Sei-Pindang Ikan Tongkol. The aim of this research is to determine the chemical and microbiological characteristics of Sei-Pindang Tuna Fish. The results showed that sei-pindang tuna had a water content of 44.69 ± 0.66%, histamine content of 11.88 ± 1.12 mg N/100 g, total volatile bases content of 43.23 ± 0.22 mg N/100 g and the total number of bacteria was 2.1 x104 ± 1.2 x103 cfu/g.
LAW ENFORCEMENT OF ILLEGAL BUSINESS TRANSACTION ON THE BORDER AREA BETWEEN INDONESIA AND TIMOR LESTE IN A DILEMMA Mahendrawati, NLM; Pandit, I Gde Suranaya; Sujana, IN; Nahak, S; Soares, C.A.; Telman, A. M.
Jurnal Hukum dan Peradilan Vol 10 No 1 (2021)
Publisher : Pusat Strategi Kebijakan Hukum dan Peradilan Mahkamah Agung RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25216/jhp.10.1.2021.115-138

Abstract

This study is a type of empirical legal study conducted based on the discrepancy between the existing provisions and theories and the legal facts occurring among the society, that is, the transaction of goods carried out by crossing the border between two countries.Any hindering obstacles and barricades to the law enforcement over illegal businesses can be settled through social and cultural, economic, political, and security approaches. Alternative solutions that should be applied in dealing with such legal issues can be establishing buildings in the border area, which are specifically directed to help accelerate the handling of three fundamental problems faced in the scope of the development of the border area in question, one of which is delimitation and delineation aspects of the state's boundaries, the aspect of affirming national borders on watershed areas between Indonesia and Timor Leste, the aspect of development discrepancy in the form of fulfilling infrastructure needs in the economic field to foster opportunities for the border areas to participate and compete amid both global and regional markets.
Ulasan: Beberapa Jamur Liar yang Berpotensi Menyebabkan Keracunan di Indonesia Permatananda, Pande Ayu Naya Kasih; Pandit, I Gede Suranaya; Putra, Ivan Permana
Al-Kauniyah: Jurnal Biologi Vol. 18 No. 1 (2025): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v1i1.34781

Abstract

AbstrakJamur merupakan fungi dengan bentuk makroskopik yang terdistribusi pada berbagai relung ekologi. Pemanfaatan jamur sebagai bahan pangan dan medis telah dilakukan sejak lama di seluruh dunia, termasuk Indonesia. Namun, karena secara morfologi tubuh buah jamur sering kali terlihat identik antara satu dengan lainnya, keracunan jamur menjadi resiko yang sering muncul. Hingga saat ini catatan keragaman, potensi pemanfaatan, dan informasi mengenai keracunan jamur liar di Indonesia masih sangat minim. Ulasan ini bertujuan untuk memberikan informasi beberapa jamur liar beracun (hasil penelitian penulis, diskusi dengan penggiat jamur, dan studi literatur) yang dilengkapi dengan deskripsi jamur sebagai media diseminasi ilmu mikologi. Sebanyak 11 kelompok jamur diuraikan pada tulisan ini yaitu Amanita spp., Chlorophyllum molybdites, Clarkeindat trachodes, Cantharocybe cf. virosa, dan Coprinus spp. Pada fase tua, Gymnopilus sp., Inocybe sp., Lepiota sp., Panaeolus sp., Podostroma cornu-damae, dan Scleroderma spp.Beberapa jamur tersebut telah dilaporkan menyebabkan keracunan hingga kematian di Indonesia. Sebagian besar kasus keracunan terjadi akibat kesalahan identifikasi beracun sebagai jamur edible. Namun, beberapa  genus jamur yang dilaporkan juga memiliki spesies yang bisa dikonsumsi pada jenis yang tepat atau umur tubuh buah. Identifikasi yang baik dan pengalaman saat merambah jamur liar merupakan salah satu cara untuk membedakan jamur liar beracun dan konsumsi.AbstractMushrooms are macroscopic forms of fungi that are distributed in various ecological niches. The utilization of mushrooms as food and medical ingredients has been done for a long time all over the world, including Indonesia. However, because morphologically the fruiting bodies of mushrooms often look identical to each other, mushroom poisoning is a risk that often arises. Until now, records of diversity, potential utilization, and information on wild mushroom poisoning in Indonesia are still minimal. This review aims to provide information on several poisonous wild mushrooms (the results of the author's research, discussions with mushroom activists, and literature studies) equipped with mushroom descriptions as a medium for disseminating mycological science. A total of 11 groups of fungi are described in this paper, namely Amanita spp., Chlorophyllum molybdites, Clarkeindat trachodes, Cantharocybe cf. virosa, and Coprinus spp. in the old phase, Gymnopilus sp., Inocybe sp., Lepiota sp., Panaeolus sp., Podostroma cornu-damae, and Scleroderma spp. Some of these fungi have been reported to cause poisoning and death in Indonesia. Most of the poisoning cases occurred due to misidentification of the poisonous mushrooms as edible mushrooms. However, some of the reported fungal genus mushrooms also have species that can be consumed at the right type or age of the fruiting body. Good identification and experience when foraging for wild mushrooms is one way to differentiate between poisonous and edible wild mushrooms.
Quality Evaluation of Frigate Mackarel Fish Pindang and Flying Fish Pindang from Fish Processing Centers in Kusamba Village, Klungkung Regency, Bali Pandit, I Gde Suranaya
AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Vol. 7 No. 2 (2023)
Publisher : Asia Pacific Network for Sustainable Agriculture, Food and Energy (SAFE-Network)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29165/ajarcde.v7i2.274

Abstract

Pindang is one of the traditional processed products derived from fish. Various types of fish can be processed into pindang, namely frigate mackerel fish, flying fish, sardinella, tuna, mackarel, cakalang and milkfish. Various types of fish cause various types of processing are carried out by the community and will eventually produce different quality. The purpose of this study was to evaluate and analyze the chemical, microbiological and organoleptic quality produced. Quality evaluation in comparative experimental research by comparing the quality of frigate mackarel fish pindang with flying fish. Parameters evaluated included chemical parameters, namely water content, salt content, histamine content, total volatile bases content, and trimethylamine content, microbiological parameters such as the number of bacteria, as well as organoleptic parameters including appearance, smell, texture, and taste. Based on the results of the study, the quality of frigate mackerel pindang with flying fish had significantly different qualities, especially in chemical assessment and organoleptic assessment.
Pelatihan Pemilahan Sampah dan Eco Enzyme Guna Pengembangan dan Menggagas Rumah Kompos Menjadi Wahana Eduwisata Di Gianyar Bali Permatananda, Pande Ayu Naya Kasih; Pandit, I Gede Suranaya; Dewi, Ni Wayan Erly Sintya; Aryastuti, Anak Agung Sri Agung
Welfare : Jurnal Pengabdian Masyarakat Vol. 1 No. 2 (2023): Welfare : June 2023
Publisher : Fakultas Ekonomi dan Bisnis Islam, IAIN Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/welfare.v1i2.531

Abstract

The government system in Indonesia, the village or ward, is the lowest organizational unit of government. The rural population is the essential capital of development. If the rural population can be fostered as well as possible, then it is hoped that it will become a very valuable human resource for development. In this regard, the government establishes policies, especially in the area of equal distribution of opportunities to obtain education and information for all Indonesians, that are directed at increasing the nation's intelligence and increasing the ability to participate in development activities. Batu Putih Kenek is a village area with a population that is classified as not too dense. Through the latest data obtained from the village office and the results of interviews with the head and village officials, we obtained data on the population of Batu Putih Kenek Village, namely 2,965 people, with details by gender, namely male population = 1,390 people and female population = 1,573. In implementing the village library, many obstacles arise, among them inadequate human resource competence, low public interest in reading, a limited number of collections, and the most dominant problem, the limited budget for the development of the library itself. Even though the library has a significant and strategic role as a partner in supporting the national goal, namely educating the nation's youth, the allocation of funds for library development still needs to be improved. Because this problem is fundamental in nature, it directly impacts all library development programs at all types and levels, especially at the village or ward library level.
EDUKASI DAN DEMONSTRASI PENATALAKSANAAN LUKA DI DESA BAYUNG GEDE, KINTAMANI Permatananda, Pande Ayu Naya Kasih; Pandit, I Gde Suranaya; Riandra, Ni Putu Indah Kusumadewi; Cahyawati, Putu Nita; Lestarini, Asri
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1608

Abstract

Bayung Gede Village is a tourist village that located in the Kintamani area and included in the cycling tourism route in Bali. Apart from that, Bayung Gede village is belong to one of vulnerable areas to rabies in Bali. This community service activity was carried out to enhance the understanding and skills of Bayung Gede Village residents in managing wounds, including the bite wounds of rabies infectious animals. The activities were started with socialization, initial discussions with partners, and the preparation of infrastructure. The provision of material was conducted through socialization, counseling methods, and wound demonstration. The monitoring and evaluation of activities is seen from three indicators, including input, process, and output indicators. In terms of input, the activity was successful as planned and attended by 15 participants who were village apparatus and villagers of Bayung Gede. Seeing from the process indicators, the participants looked enthusiastic and following the entire activity from start to finish. This activity also met the output indicators, with the majority of participants (>90%) answered the entire posttest question correctly. Through this community service, all participants are expected to independently apply all the knowledge and skills acquired from all the process and able to disseminate to other residents.
EDUKASI PENCEGAHAN DEMAM BERDARAH DENGUE MELALUI BUDIDAYA TANAMAN PENGUSIR NYAMUK DI KELURAHAN PEDUNGAN, BALI Permatananda, Pande Ayu Naya Kasih; Pandit, I Gde Suranaya; Cahyawati, Putu Nita; Aryastuti, Anak Agung Sri Agung; Lestarini, Asri
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2024): Volume 5 No. 3 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i3.28354

Abstract

Prevalensi Demam Berdarah Dengue (DBD) di Kota Denpasar, termasuk Kelurahan Pedungan terus mengalami peningkatan setiap tahunnya. Hingga saat ini belum ada terapi definitif untuk mengatasi penyakit ini, sehingga pencegahan dinilai menjadi upaya yang paling baik dalam manajemen DBD. Kegiatan ini menggunakan metode edukasi dalam bentuk penyuluhan dan demonstrasi dengan topik pencegahan DBD, terutama melalui penggunaan tanaman pengusir nyamuk. Kegiatan ini dihadiri oleh 5 peserta yang sangat antusias mengikuti kegiatan ini dari awal hingga akhir. Edukasi yang diberikan dinyatakan efektif dan berhasil meningkatkan pengetahuan peserta dengan nilai rata-rata pretest sebesar 48 poin dan nilai rata-rata posttest sebesar 100 poin. Seluruh peserta berhasil menjawab seluruh pertanyaan posttest dengan benar. Ke depan, kegiatan ini diharapkan dapat diselenggarakan secara berkala dan menyentuh berbagai lapisan masyarakat.